Detailed information for compound 824300

Basic information

Technical information
  • TDR Targets ID: 824300
  • Name: N-(4-chlorophenyl)-2-[[5-(3,4-dimethylphenyl) sulfonyl-4-oxo-3H-pyrimidin-2-yl]sulfanyl]ace tamide
  • MW: 463.958 | Formula: C20H18ClN3O4S2
  • H donors: 2 H acceptors: 6 LogP: 4.63 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Cl)CSc1ncc(c(n1)O)S(=O)(=O)c1ccc(c(c1)C)C
  • InChi: 1S/C20H18ClN3O4S2/c1-12-3-8-16(9-13(12)2)30(27,28)17-10-22-20(24-19(17)26)29-11-18(25)23-15-6-4-14(21)5-7-15/h3-10H,11H2,1-2H3,(H,23,25)(H,22,24,26)
  • InChiKey: VKYBTMYEGCWDPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-chlorophenyl)-2-[[5-(3,4-dimethylphenyl)sulfonyl-4-oxo-3H-pyrimidin-2-yl]thio]acetamide
  • N-(4-chlorophenyl)-2-[[5-(3,4-dimethylphenyl)sulfonyl-4-keto-3H-pyrimidin-2-yl]thio]acetamide
  • N-(4-chlorophenyl)-2-[[5-(3,4-dimethylphenyl)sulfonyl-4-oxo-3H-pyrimidin-2-yl]sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0031 0.0374 0.1771
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0179 0.3372 0.7673
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.1182 0.5602
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0048 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.3372 0.3339
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0118 0.007
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0067 0.11 0.1095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1182 0.1139
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0782 0.4812
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0031 0.0374 0.2133
Schistosoma mansoni cpg binding protein 0.0029 0.0317 0.027
Schistosoma mansoni hypothetical protein 0.0019 0.0122 0.0074
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0118 0.0077
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0031 0.0374 0.2133
Giardia lamblia Histone methyltransferase HMT1 0.0028 0.0302 0.7193
Leishmania major arginine N-methyltransferase-like protein 0.0067 0.11 0.6894
Schistosoma mansoni hypothetical protein 0.0023 0.0206 0.0158
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.8001 0.8
Entamoeba histolytica hypothetical protein 0.0117 0.211 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1182 0.1139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0374 0.0358
Trichomonas vaginalis esterase, putative 0.0071 0.1182 1
Schistosoma mansoni hypothetical protein 0.0408 0.8001 0.7991
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0031 0.0374 0.0592
Brugia malayi RNA recognition motif domain containing protein 0.0187 0.3526 0.8025
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0187 0.3526 0.8024
Echinococcus granulosus survival motor neuron protein 1 0.023 0.4393 0.439
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.2725 0.62
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0118 0.056
Trypanosoma cruzi arginine N-methyltransferase, type III 0.005 0.0747 0.077
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0118 0.0113
Schistosoma mansoni cpg binding protein 0.003 0.0351 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.056
Plasmodium falciparum thioredoxin reductase 0.0091 0.1574 1
Leishmania major arginine N-methyltransferase, type I 0.005 0.0747 0.4582
Giardia lamblia NADH oxidase lateral transfer candidate 0.0031 0.0374 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0179 0.3372 0.3368
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.056
Trichomonas vaginalis glutathione reductase, putative 0.0031 0.0374 0.2401
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0118 0.0262
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0374 0.1771
Onchocerca volvulus 0.0121 0.2192 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.056
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.1182 1
Brugia malayi hypothetical protein 0.0052 0.0782 0.1775
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0207 0.3927 0.4348
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0091 0.1574 0.171
Loa Loa (eye worm) protein arginine N-methyltransferase 0.005 0.0747 0.1691
Brugia malayi TAR-binding protein 0.0187 0.3526 0.8025
Echinococcus granulosus thioredoxin glutathione reductase 0.0091 0.1585 0.1581
Toxoplasma gondii bicoid-interacting protein BIN3 0.005 0.0747 0.2217
Trypanosoma brucei Thiopurine S-methyltransferase (TPMT), putative 0.0053 0.0808 0.3828
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0683 0.1543
Echinococcus granulosus dnaJ subfamily B 0.0408 0.8001 0.8
Loa Loa (eye worm) glutathione reductase 0.0091 0.1574 0.3575
Mycobacterium tuberculosis Probable oxidoreductase 0.023 0.4395 0.4873
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0118 0.0077
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0031 0.0374 0.1032
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0048 0.0043
Echinococcus granulosus protein arginine methyltransferase 0.0067 0.11 0.1095
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0206 0.0201
Mycobacterium tuberculosis Conserved protein 0.0071 0.1182 0.1271
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0171 0.3202 0.3199
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0117 0.211 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.005 0.0747 0.5914
Loa Loa (eye worm) hypothetical protein 0.0071 0.1182 0.2682
Echinococcus granulosus protein arginine N methyltransferase 7 0.005 0.0747 0.0742
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.056
Loa Loa (eye worm) hypothetical protein 0.0071 0.1182 0.2682
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0205 0.0459
Schistosoma mansoni tar DNA-binding protein 0.0187 0.3526 0.3495
Plasmodium falciparum glutathione reductase 0.0091 0.1574 1
Schistosoma mansoni hypothetical protein 0.0101 0.178 0.174
Trypanosoma cruzi Thiopurine S-methyltransferase (TPMT), putative 0.0053 0.0808 0.0836
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0118 0.056
Trypanosoma brucei unspecified product 0.0019 0.0118 0.056
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1182 1
Brugia malayi beta-lactamase 0.0071 0.1182 0.2686
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0031 0.0374 0.5
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0207 0.3927 0.4348
Leishmania major hypothetical protein, conserved 0.0071 0.1182 0.7431
Schistosoma mansoni hypothetical protein 0.0047 0.0683 0.0637
Brugia malayi isocitrate dehydrogenase 0.0015 0.0048 0.0103
Brugia malayi hypothetical protein 0.0033 0.0412 0.0931
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.056
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0067 0.11 0.1057
Plasmodium falciparum thioredoxin reductase 0.0031 0.0374 0.2133
Treponema pallidum NADH oxidase 0.0031 0.0374 0.5
Schistosoma mansoni hypothetical protein 0.0047 0.0683 0.0637
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0782 0.0808
Echinococcus multilocularis histone lysine N methyltransferase SETD2 0.0086 0.147 0.1466
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0179 0.3372 0.3368
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0118 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.056
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.2725 0.6198
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0048 0.0043
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0031 0.0374 0.0369
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0067 0.11 0.9229
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0118 0.0113
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0118 0.0459
Schistosoma mansoni hypothetical protein 0.0506 1 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0048 0.0043
Plasmodium falciparum histone-lysine N-methyltransferase SET2 0.0028 0.0302 0.1663
Mycobacterium tuberculosis Conserved protein 0.0071 0.1182 0.1271
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0374 0.0358
Trypanosoma brucei protein arginine n-methyltransferase 7 0.005 0.0747 0.3542
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0782 0.0808
Trichomonas vaginalis mercuric reductase, putative 0.0031 0.0374 0.2401
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0207 0.3927 0.8545
Plasmodium vivax hypothetical protein, conserved 0.0071 0.1182 0.2063
Echinococcus granulosus histone lysine N methyltransferase SETD2 0.0086 0.147 0.1466
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0067 0.11 0.1057
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0118 0.056
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0117 0.211 1
Schistosoma mansoni hypothetical protein 0.0047 0.0687 0.0642
Schistosoma mansoni cpg binding protein 0.003 0.0351 0.0304
Schistosoma mansoni tar DNA-binding protein 0.0187 0.3526 0.3495
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0257
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.3372 0.3339
Mycobacterium ulcerans methyltransferase 0.0053 0.0808 0.6481
Echinococcus granulosus GPCR family 2 0.0047 0.0683 0.0678
Loa Loa (eye worm) hypothetical protein 0.0047 0.0683 0.1543
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0048 0.0229
Loa Loa (eye worm) hypothetical protein 0.0071 0.1182 0.2682
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0031 0.0374 0.2401
Echinococcus multilocularis protein arginine N methyltransferase 7 0.005 0.0747 0.0742
Loa Loa (eye worm) hypothetical protein 0.0147 0.2725 0.6198
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.0374 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0118 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.056
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0317 0.0711
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.178 0.4047
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0171 0.3202 1
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.1182 1
Leishmania major trypanothione reductase 0.0091 0.1574 1
Schistosoma mansoni tar DNA-binding protein 0.0187 0.3526 0.3495
Plasmodium vivax glutathione reductase, putative 0.0091 0.1574 0.2776
Brugia malayi glutathione reductase 0.0091 0.1574 0.3578
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0118 0.0077
Echinococcus multilocularis GPCR, family 2 0.0047 0.0683 0.0678
Echinococcus granulosus dna polymerase kappa 0.0019 0.0118 0.0113
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0067 0.11 0.9229
Trypanosoma brucei trypanothione reductase 0.0091 0.1574 0.7459
Mycobacterium tuberculosis Probable dehydrogenase 0.0207 0.3927 0.4348
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.005 0.0747 0.5914
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0031 0.0374 0.1771
Trypanosoma cruzi arginine N-methyltransferase, type I 0.005 0.0747 0.077
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0118 0.0257
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0067 0.11 0.1057
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.005 0.0747 0.5914
Trypanosoma cruzi trypanothione reductase, putative 0.0091 0.1574 0.168
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0118 0.0113
Schistosoma mansoni tar DNA-binding protein 0.0187 0.3526 0.3495
Brugia malayi hypothetical protein 0.0117 0.211 0.48
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0118 0.0262
Mycobacterium tuberculosis Conserved protein 0.0071 0.1182 0.1271
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.0374 0.0358
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1182 1
Loa Loa (eye worm) hypothetical protein 0.023 0.4393 1
Schistosoma mansoni protein arginine n-methyltransferase 0.0171 0.3202 0.3169
Toxoplasma gondii histone lysine methyltransferase SET2 0.0028 0.0302 0.0804
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0374 0.1771
Echinococcus multilocularis dna polymerase eta 0.0019 0.0118 0.0113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0374 0.0358
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0374 0.0358
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.0374 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1182 1
Plasmodium falciparum glutathione reductase 0.0031 0.0374 0.2133
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0782 0.3708
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.3372 0.3339
Trypanosoma cruzi arginine N-methyltransferase, type I 0.005 0.0747 0.077
Loa Loa (eye worm) hypothetical protein 0.0071 0.1182 0.2682
Brugia malayi beta-lactamase family protein 0.0071 0.1182 0.2686
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.1182 0.2682
Schistosoma mansoni hypothetical protein 0.0086 0.147 0.1429
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0374 0.0358
Toxoplasma gondii NADPH-glutathione reductase 0.0031 0.0374 0.1032
Brugia malayi CXXC zinc finger family protein 0.0029 0.0317 0.0716
Echinococcus multilocularis tar DNA binding protein 0.0187 0.3526 0.3523
Echinococcus multilocularis histone lysine N methyltransferase SETD2 0.0028 0.0315 0.0309
Brugia malayi Carm1-pending protein 0.0171 0.3202 0.7287
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.1182 0.1271
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0179 0.3372 0.3368
Toxoplasma gondii thioredoxin reductase 0.0091 0.1574 0.4838
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.1182 0.1271
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.005 0.0747 0.2217
Schistosoma mansoni tar DNA-binding protein 0.0187 0.3526 0.3495
Loa Loa (eye worm) hypothetical protein 0.0052 0.0782 0.1771
Echinococcus granulosus protein arginine N methyltransferase 8 0.0067 0.11 0.1095
Plasmodium vivax variant-silencing SET protein, putative 0.0028 0.0302 0.0462
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.1182 0.1271
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0683 0.0678
Brugia malayi Thioredoxin reductase 0.0091 0.1574 0.3578
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0067 0.11 0.9229
Toxoplasma gondii ABC1 family protein 0.0071 0.1182 0.3595
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0207 0.3927 0.4348
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0687 0.1558
Loa Loa (eye worm) thioredoxin reductase 0.0091 0.1574 0.3575
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.056
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0782 0.2328
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0171 0.3202 0.3199
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0048 0.0229
Loa Loa (eye worm) hypothetical protein 0.0101 0.178 0.4044
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0067 0.11 0.1914
Brugia malayi RNA binding protein 0.0187 0.3526 0.8025
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.4393 0.439
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0683 0.0678
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0925 0.278
Onchocerca volvulus 0.0071 0.1182 0.4612
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0118 0.056
Onchocerca volvulus 0.0071 0.1182 0.4612
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0048 0.0043
Loa Loa (eye worm) RNA binding protein 0.0187 0.3526 0.8024
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.0374 0.0327
Leishmania major hypothetical protein, conserved 0.0053 0.0808 0.4978
Onchocerca volvulus 0.0047 0.0687 0.1971
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.005 0.0747 0.3158
Loa Loa (eye worm) hypothetical protein 0.0091 0.1584 0.3598
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0782 0.4812
Trypanosoma cruzi hypothetical protein 0.0464 0.9132 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0118 0.0459
Echinococcus multilocularis cpg binding protein 0.003 0.0351 0.0345
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0206 0.0201
Schistosoma mansoni hypothetical protein 0.0047 0.0683 0.0637
Echinococcus multilocularis protein arginine methyltransferase 0.0067 0.11 0.1095
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.056
Echinococcus granulosus dna polymerase eta 0.0019 0.0118 0.0113
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.2725 0.62
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0207 0.3927 0.4348
Mycobacterium ulcerans hypothetical protein 0.0071 0.1182 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1182 0.1248
Loa Loa (eye worm) Carm1-pending protein 0.0171 0.3202 0.7285
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0179 0.3372 0.3368
Brugia malayi SET domain containing protein 0.0091 0.1584 0.3601
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1182 0.1248
Brugia malayi beta-lactamase family protein 0.0071 0.1182 0.2686
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0118 0.056
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0117 0.211 0.227
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.1182 0.1271
Loa Loa (eye worm) hypothetical protein 0.0117 0.211 0.4797
Mycobacterium ulcerans beta-lactamase 0.0071 0.1182 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.023 0.4395 0.4873
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0287 0.5545 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0205 0.0459
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.1182 0.1177
Echinococcus multilocularis geminin 0.0506 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1182 1
Schistosoma mansoni hypothetical protein 0.0047 0.0683 0.0637
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.1182 0.1271
Brugia malayi Protein arginine N-methyltransferase 0.005 0.0747 0.1695
Loa Loa (eye worm) hypothetical protein 0.0071 0.1182 0.2682
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.1182 0.1177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0374 0.0358
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0067 0.11 0.6894
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0031 0.0374 0.2133
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0374 0.0358
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0067 0.11 0.3335
Mycobacterium tuberculosis Probable reductase 0.0207 0.3927 0.4348
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0118 0.0078
Echinococcus granulosus methyltransferase protein 5 0.005 0.0747 0.0742
Schistosoma mansoni hypothetical protein 0.0506 1 1
Mycobacterium ulcerans lipase LipD 0.0071 0.1182 1
Loa Loa (eye worm) beta-lactamase 0.0071 0.1182 0.2682
Echinococcus granulosus tar DNA binding protein 0.0187 0.3526 0.3523
Brugia malayi hypothetical protein 0.023 0.4393 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0683 0.1548
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0031 0.0374 0.0369
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0683 0.1548
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0031 0.0374 0.2401
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1057 0.1013
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.023 0.4395 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0031 0.0374 0.0365
Echinococcus multilocularis thioredoxin glutathione reductase 0.0091 0.1585 0.1581
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0683 0.0678
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0031 0.0374 0.2133
Echinococcus granulosus histone lysine N methyltransferase SETD2 0.0028 0.0315 0.0309
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.0374 0.0844
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.023 0.4395 0.4873
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0683 0.0678
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.1182 0.1271
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0782 0.1336
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.1182 0.2686
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.1182 0.1271
Loa Loa (eye worm) hypothetical protein 0.0071 0.1182 0.2682
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0031 0.0374 0.2401
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0048 0.0103
Trypanosoma cruzi Thiopurine S-methyltransferase (TPMT), putative 0.0053 0.0808 0.0836
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0118 0.0078
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0117 0.211 0.227
Leishmania major hypothetical protein, conserved 0.0052 0.0782 0.4812
Echinococcus granulosus cpg binding protein 0.003 0.0351 0.0345
Schistosoma mansoni survival motor neuron protein 0.0047 0.0687 0.0642
Schistosoma mansoni DNA polymerase eta 0.0019 0.0118 0.007
Loa Loa (eye worm) TAR-binding protein 0.0187 0.3526 0.8024
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1182 1
Mycobacterium tuberculosis Conserved protein 0.0053 0.0808 0.0851
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0374 0.0358
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0118 0.0077
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.005 0.0747 0.077
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0048 0.0043
Trypanosoma brucei Thiopurine S-methyltransferase (TPMT), putative 0.0053 0.0808 0.3828
Leishmania major DNA polymerase kappa, putative 0.0019 0.0118 0.0459
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0179 0.3372 0.7671
Plasmodium vivax thioredoxin reductase, putative 0.0091 0.1574 0.2776
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0048 0.0098
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0374 0.2133
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0374 0.2133
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0031 0.0374 0.0592
Onchocerca volvulus 0.0071 0.1182 0.4612
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.005 0.0747 0.4582
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.8969 1
Schistosoma mansoni hypothetical protein 0.005 0.0747 0.0702

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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