Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0402 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0249 | 0.5726 | 0.5726 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0402 | 1 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0402 | 1 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0402 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0402 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0126 | 0.2307 | 0.2307 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0402 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0402 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0249 | 0.5726 | 0.5726 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0402 | 1 | 1 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0402 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0402 | 1 | 1 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0402 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0402 | 1 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0402 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0402 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0249 | 0.5726 | 0.5726 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0402 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0402 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.6532 | 0.6532 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0249 | 0.5726 | 0.5726 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0402 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.