Detailed information for compound 824544

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 348.786 | Formula: C19H13ClN4O
  • H donors: 1 H acceptors: 3 LogP: 4.24 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C(=O)Nc1ccc(cc1)c1cn2c(n1)nccc2
  • InChi: 1S/C19H13ClN4O/c20-15-4-1-3-14(11-15)18(25)22-16-7-5-13(6-8-16)17-12-24-10-2-9-21-19(24)23-17/h1-12H,(H,22,25)
  • InChiKey: MEPPDHWRDRUXKL-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0541 0.6705 0.9975
Entamoeba histolytica zinc finger protein, putative 0.0026 0.0216 0.0364
Loa Loa (eye worm) hypothetical protein 0.0023 0.0179 0.0253
Echinococcus multilocularis tankyrase 0.0026 0.0216 0.0321
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0067 0.0738 0.1098
Trypanosoma cruzi DNA topoisomerase II, putative 0.013 0.1533 0.2212
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0069 0.076 0.1049
Leishmania major mitochondrial DNA topoisomerase II 0.0464 0.5735 0.8506
Schistosoma mansoni endoplasmin 0.0025 0.021 0.0313
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0024 0.019 0.027
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0346 0.4244 1
Trypanosoma brucei DNA topoisomerase IA, putative 0.0057 0.0616 0.0831
Echinococcus multilocularis heat shock protein 0.0025 0.021 0.0313
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0541 0.6705 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0081
Echinococcus granulosus tankyrase 0.0026 0.0216 0.0321
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.021 0.0221
Giardia lamblia DNA topoisomerase III 0.0057 0.0616 0.2946
Loa Loa (eye worm) hypothetical protein 0.0152 0.1806 0.2677
Schistosoma mansoni tankyrase 0.0026 0.0216 0.0321
Brugia malayi GRF zinc finger family protein 0.0057 0.0616 0.0904
Brugia malayi kinase, mitochondrial precursor 0.0025 0.021 0.03
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0081
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0079 0.0892 0.1327
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0045 0.0461 0.0599
Echinococcus granulosus heat shock protein 0.0025 0.021 0.0313
Onchocerca volvulus Tankyrase homolog 0.0026 0.0216 0.0695
Echinococcus granulosus protein kinase c epsilon type 0.0009 0.0009 0.0014
Entamoeba histolytica hypothetical protein 0.0026 0.0216 0.0364
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0055 0.0582 0.0915
Echinococcus granulosus Protein kinase C brain isozyme 0.0032 0.0295 0.0439
Leishmania major S-adenosylmethionine decarboxylase 0.0541 0.6705 1
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0057 0.0616 0.0916
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0216 0.0695
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0057 0.0616 0.0916
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0097 0.1117 0.1662
Schistosoma mansoni enhancer of zeste ezh 0.0067 0.0738 0.1098
Trypanosoma brucei heat shock protein, putative 0.0025 0.021 0.0221
Giardia lamblia DNA topoisomerase III 0.0057 0.0616 0.2946
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0067 0.0738 0.1098
Toxoplasma gondii DNA topoisomerase 2, putative 0.0188 0.2255 0.3864
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0541 0.6705 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0025 0.021 0.067
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0025 0.021 0.0148
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0803 1 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0025 0.021 0.0313
Trichomonas vaginalis heat shock protein, putative 0.0025 0.021 0.067
Echinococcus granulosus protein arginine methyltransferase 0.0097 0.1117 0.1662
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0057 0.0616 0.252
Loa Loa (eye worm) hypothetical protein 0.013 0.1533 0.227
Schistosoma mansoni histone J3 methyltransferase 0.0542 0.6721 1
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.019 0.2284 0.3343
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0152 0.1806 0.2624
Trypanosoma brucei heat shock protein, putative 0.0025 0.021 0.0221
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0541 0.6705 1
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0057 0.0616 0.0916
Echinococcus granulosus poly (ADP ribose) polymerase 0.0054 0.0569 0.0846
Leishmania major DNA topoisomerase 1A 0.0057 0.0616 0.0624
Entamoeba histolytica DNA topoisomerase III, putative 0.0057 0.0616 0.1321
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0025 0.021 0.0148
Echinococcus multilocularis nibrin 0.0014 0.0064 0.0095
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0025 0.021 0.0443
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0025 0.021 0.0148
Schistosoma mansoni heat shock protein 0.0025 0.021 0.0313
Leishmania major arginine N-methyltransferase-like protein 0.0097 0.1117 0.1396
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0464 0.5735 0.8539
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0216 0.0695
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0055 0.0582 0.0854
Entamoeba histolytica hypothetical protein 0.0054 0.0569 0.1209
Plasmodium vivax heat shock protein 86, putative 0.0025 0.021 0.0148
Brugia malayi topoisomerase 0.0014 0.0064 0.0081
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0025 0.021 0.0259
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0152 0.1806 0.4168
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0025 0.021 0.0259
Loa Loa (eye worm) hypothetical protein 0.0263 0.3205 0.4762
Leishmania major hypothetical protein, conserved 0.0045 0.0461 0.0386
Echinococcus granulosus protein kinase C gamma type 0.0028 0.0251 0.0373
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0188 0.2255 1
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0055 0.0582 0.0781
Plasmodium falciparum endoplasmin, putative 0.0025 0.021 0.0148
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0097 0.1117 0.4806
Loa Loa (eye worm) hypothetical protein 0.0025 0.021 0.03
Entamoeba histolytica hypothetical protein 0.0026 0.0216 0.0364
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0346 0.4244 0.6314
Trichomonas vaginalis DNA topoisomerase II, putative 0.0188 0.2255 1
Trypanosoma cruzi DNA topoisomerase III, putative 0.0057 0.0616 0.0831
Trypanosoma brucei DNA topoisomerase ii 0.0464 0.5735 0.8539
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0025 0.021 0.0148
Trichomonas vaginalis endoplasmin, putative 0.0025 0.021 0.067
Brugia malayi Carm1-pending protein 0.0055 0.0582 0.0854
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0188 0.2255 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0216 0.0695
Giardia lamblia DNA topoisomerase II 0.0162 0.1938 1
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.013 0.1533 0.2212
Loa Loa (eye worm) tnks protein 0.0026 0.0216 0.0308
Plasmodium vivax DNA topoisomerase II, putative 0.0188 0.2255 0.2206
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0057 0.0616 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0216 0.0695
Toxoplasma gondii DNA topoisomerase family protein 0.0057 0.0616 0.0974
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0216 0.0695
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0025 0.021 0.0443
Trypanosoma brucei heat shock protein, putative 0.0025 0.021 0.0221
Echinococcus multilocularis histone h3 methyltransferase 0.0542 0.6721 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0359 0.4415 0.7672
Loa Loa (eye worm) hypothetical protein 0.0542 0.6721 1
Mycobacterium leprae Probable two-component sensor kinase 0.0025 0.021 0.0443
Schistosoma mansoni topbp1 0.0014 0.0064 0.0095
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0055 0.0582 0.0867
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0069 0.076 0.1049
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0216 0.0695
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0541 0.6705 1
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0188 0.2255 0.3346
Plasmodium falciparum DNA topoisomerase 2 0.0188 0.2255 0.2206
Trichomonas vaginalis sensor histidine kinase, putative 0.0025 0.021 0.067
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0464 0.5735 1
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0069 0.076 0.1049
Loa Loa (eye worm) heat shock protein 90 0.0025 0.021 0.03
Toxoplasma gondii heat shock protein 90, putative 0.0025 0.021 0.0259
Echinococcus multilocularis protein arginine methyltransferase 0.0097 0.1117 0.1662
Leishmania major DNA repair protein, putative 0.0045 0.0461 0.0386
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0055 0.0582 0.0781
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0216 0.0695
Echinococcus granulosus methyltransferase protein 5 0.0055 0.0582 0.0867
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0346 0.4244 0.6314
Plasmodium falciparum DNA gyrase subunit B 0.0803 1 1
Mycobacterium ulcerans two component regulator - sensor kinase 0.0025 0.021 0.0148
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0025 0.021 0.0148
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0025 0.021 0.067
Chlamydia trachomatis DNA gyrase subunit B 0.0527 0.652 0.6498
Mycobacterium leprae Probable two component sensor kinase MprB 0.0025 0.021 0.0443
Schistosoma mansoni topbp1 0.0014 0.0064 0.0095
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0541 0.6705 0.9975
Echinococcus granulosus poly (ADP ribose) polymerase 0.0107 0.1245 0.1852
Loa Loa (eye worm) TOPoisomerase family member 0.0188 0.2255 0.3346
Brugia malayi WGR domain containing protein 0.0346 0.4244 0.6309
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0097 0.1117 0.106
Toxoplasma gondii bicoid-interacting protein BIN3 0.0055 0.0582 0.0915
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0009 0.0014
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.021 0.0221
Brugia malayi Pax transcription activation domain interacting protein 0.0014 0.0064 0.0081
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.021 0.0783
Echinococcus granulosus poly adp ribose polymerase 2 0.019 0.2284 0.3398
Brugia malayi heat shock protein 90 0.0025 0.021 0.03
Leishmania major arginine N-methyltransferase, type I 0.0055 0.0582 0.0573
Leishmania major hypothetical protein, conserved 0.0069 0.076 0.0846
Echinococcus multilocularis serine threonine protein kinase 0.0028 0.0251 0.0373
Brugia malayi DKFZp564C0469 protein 0.0014 0.0064 0.0081
Chlamydia trachomatis DNA topoisomerase I 0.0057 0.0616 0.0556
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0541 0.6705 1
Leishmania major DNA topoisomerase III, putative 0.0057 0.0616 0.0624
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0097 0.1117 0.1662
Brugia malayi hypothetical protein 0.0014 0.0064 0.0081
Onchocerca volvulus 0.0057 0.0616 0.252
Brugia malayi hypothetical protein 0.0152 0.1806 0.2677
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0542 0.6721 1
Brugia malayi Endoplasmin precursor 0.0025 0.021 0.03
Leishmania major DNA topoisomerase ii 0.013 0.1533 0.2036
Loa Loa (eye worm) hypothetical protein 0.013 0.1533 0.227
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0097 0.1117 0.106
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0097 0.1117 0.1662
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0803 1 1
Loa Loa (eye worm) Carm1-pending protein 0.0055 0.0582 0.0854
Brugia malayi DNA topoisomerase III beta-1 0.0057 0.0616 0.0904
Entamoeba histolytica heat shock protein 90, putative 0.0025 0.021 0.0351
Brugia malayi SET domain containing protein 0.0067 0.0738 0.1086
Echinococcus granulosus heat shock protein 90 0.0025 0.021 0.0313
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0014 0.0064 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0216 0.0695
Echinococcus granulosus protein arginine N methyltransferase 7 0.0055 0.0582 0.0867
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0097 0.1117 0.4806
Schistosoma mansoni endoplasmin 0.0025 0.021 0.0313
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0097 0.1117 0.1662
Schistosoma mansoni DNA ligase IV 0.0014 0.0064 0.0095
Trypanosoma cruzi DNA topoisomerase III, putative 0.0057 0.0616 0.0831
Echinococcus granulosus protein arginine N methyltransferase 8 0.0097 0.1117 0.1662
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0069 0.076 0.1049
Brugia malayi DNA topoisomerase III 0.0057 0.0616 0.0904
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0188 0.2255 0.3355
Echinococcus multilocularis RNA directed DNA polymerase 0.0023 0.0179 0.0266
Brugia malayi Probable DNA topoisomerase II 0.0188 0.2255 0.3346
Schistosoma mansoni chromosome transmission fidelity factor 0.0014 0.0064 0.0095
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0025 0.021 0.067
Echinococcus multilocularis rho GTPase activating protein 20 0.0057 0.0616 0.0916
Trichomonas vaginalis receptor histidine kinase, putative 0.0025 0.021 0.067
Echinococcus multilocularis protein kinase c epsilon type 0.0009 0.0009 0.0014
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0025 0.021 0.0221
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0276 0.3373 1
Trypanosoma brucei heat shock protein, putative 0.0025 0.021 0.0221
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0081
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0541 0.6705 0.9975
Brugia malayi WGR domain containing protein 0.019 0.2284 0.3389
Trypanosoma cruzi DNA topoisomerase II, putative 0.013 0.1533 0.2212
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0025 0.021 0.0148
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0025 0.021 0.0148
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0057 0.0616 0.0831
Schistosoma mansoni DNA topoisomerase II 0.0188 0.2255 0.3355
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0032 0.0295 0.0439
Leishmania major hypothetical protein, conserved 0.0069 0.076 0.0846
Trypanosoma brucei DNA topoisomerase III, putative 0.0057 0.0616 0.0831
Loa Loa (eye worm) hypothetical protein 0.0026 0.0223 0.0318
Giardia lamblia Pms1-like protein 0.0025 0.021 0.0783
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0188 0.2255 1
Plasmodium vivax endoplasmin, putative 0.0025 0.021 0.0148
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0097 0.1117 0.4806
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0055 0.0582 0.0573
Echinococcus granulosus poly ADP ribose polymerase 1 0.0346 0.4244 0.6314
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0057 0.0616 0.0974
Mycobacterium ulcerans DNA topoisomerase I 0.0057 0.0616 0.0556
Leishmania major histone-lysine N-methyltransferase, putative 0.0069 0.076 0.0846
Trypanosoma brucei Heat shock protein 83, putative 0.0025 0.021 0.0221
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0025 0.021 0.0221
Echinococcus granulosus RNA directed DNA polymerase 0.0023 0.0179 0.0266
Trypanosoma brucei heat shock protein, putative 0.0025 0.021 0.0221
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.021 0.0148
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.021 0.0221
Plasmodium vivax DNA topoisomerase 3, putative 0.0057 0.0616 0.0556
Trypanosoma brucei DNA topoisomerase III, putative 0.0057 0.0616 0.0831
Echinococcus multilocularis replication factor c subunit 1 0.0014 0.0064 0.0095
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0025 0.021 0.0148
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0025 0.021 0.067
Trypanosoma cruzi DNA repair protein, putative 0.0045 0.0461 0.0599
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0069 0.076 0.1049
Onchocerca volvulus DNA ligase 3 homolog 0.0045 0.0461 0.1815
Mycobacterium ulcerans putative regultory protein 0.0025 0.021 0.0148
Trypanosoma brucei DNA topoisomerase II beta, putative 0.013 0.1533 0.2212
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0295 0.0439
Trypanosoma brucei heat shock protein, putative 0.0025 0.021 0.0221
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.021 0.0221
Schistosoma mansoni poly [ADP-ribose] polymerase 0.019 0.2284 0.3398
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0025 0.021 0.067
Echinococcus granulosus poly (ADP ribose) polymerase 0.0054 0.0569 0.0846
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0055 0.0582 0.2368
Leishmania major DNA topoisomerase III, putative 0.0057 0.0616 0.0624
Schistosoma mansoni pyruvate dehydrogenase 0.0025 0.021 0.0313
Schistosoma mansoni protein arginine n-methyltransferase 0.0055 0.0582 0.0867
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0055 0.0582 0.0781
Trypanosoma brucei poly(adp-ribose) polymerase 0.019 0.2284 0.3343
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0057 0.0616 0.0916
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0081
Brugia malayi Tnks protein 0.0026 0.0216 0.0308
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0164 0.1961 0.2918
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0025 0.021 0.0148
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0025 0.021 0.0221
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0055 0.0582 0.2368
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0188 0.2255 0.3355
Trypanosoma cruzi DNA topoisomerase III, putative 0.0057 0.0616 0.0831
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0541 0.6705 0.9975
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0057 0.0616 0.252
Entamoeba histolytica hypothetical protein 0.0152 0.1806 0.4168
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0057 0.0616 0.0904
Entamoeba histolytica hypothetical protein 0.0026 0.0216 0.0364
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0464 0.5735 0.8539
Entamoeba histolytica heat shock protein 90, putative 0.0025 0.021 0.0351
Echinococcus granulosus WGR domain containing protein 0.0107 0.1245 0.1852
Echinococcus granulosus nibrin 0.0014 0.0064 0.0095
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0025 0.021 0.067
Trypanosoma brucei DNA repair protein, putative 0.0045 0.0461 0.0599
Trypanosoma brucei heat shock protein 90, putative 0.0025 0.021 0.0221
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0264 0.3211 0.3168
Echinococcus multilocularis heat shock protein 90 0.0025 0.021 0.0313
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0136 0.1608 0.2382
Mycobacterium ulcerans DNA gyrase subunit B 0.0803 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0081
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0097 0.1117 0.1857
Trypanosoma brucei heat shock protein, putative 0.0025 0.021 0.0221
Schistosoma mansoni hypothetical protein 0.0055 0.0582 0.0867
Trypanosoma brucei histone-lysine n-methyltransferase 0.0069 0.076 0.1049
Trypanosoma brucei developmentally regulated phosphoprotein 0.0025 0.021 0.0221
Plasmodium vivax hypothetical protein, conserved 0.0025 0.021 0.0148
Entamoeba histolytica DNA topoisomerase II, putative 0.0188 0.2255 0.5242
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0025 0.021 0.0148
Trypanosoma brucei heat shock protein 90, putative 0.0025 0.021 0.0221
Schistosoma mansoni heat shock protein 0.0025 0.021 0.0313
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0025 0.021 0.0148
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0055 0.0582 0.0781
Trypanosoma cruzi Heat shock protein 83, putative 0.0025 0.021 0.0221
Brugia malayi hypothetical protein 0.0014 0.0064 0.0081
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0057 0.0616 0.0916
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0025 0.021 0.0313
Trypanosoma brucei heat shock protein, putative 0.0025 0.021 0.0221
Echinococcus granulosus histone h3 methyltransferase 0.0542 0.6721 1
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0295 0.0439
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0055 0.0582 0.2368
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0057 0.0616 0.0831
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0057 0.0616 0.1669
Loa Loa (eye worm) DNA topoisomerase III 0.0057 0.0616 0.0904
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0055 0.0582 0.1241
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0081
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0055 0.0582 0.0915
Treponema pallidum DNA topoisomerase I (topA) 0.0057 0.0616 0.0556
Echinococcus granulosus replication factor c subunit 1 0.0014 0.0064 0.0095
Loa Loa (eye worm) endoplasmin 0.0025 0.021 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0216 0.0695
Entamoeba histolytica hypothetical protein 0.0026 0.0216 0.0364
Echinococcus granulosus poly (ADP ribose) polymerase 0.0054 0.0569 0.0846
Brugia malayi Protein arginine N-methyltransferase 0.0055 0.0582 0.0854
Plasmodium falciparum heat shock protein 90 0.0025 0.021 0.0148
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0264 0.3211 0.3168
Trichomonas vaginalis heat shock protein, putative 0.0025 0.021 0.067
Toxoplasma gondii hypothetical protein 0.0069 0.076 0.1228
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.019 0.2284 0.3398
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.021 0.0221
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0025 0.021 0.0148
Entamoeba histolytica DNA topoisomerase III, putative 0.0057 0.0616 0.1321
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0152 0.1806 0.2624
Loa Loa (eye worm) SET domain-containing protein 0.0067 0.0738 0.1086
Toxoplasma gondii heat shock protein HSP90 0.0025 0.021 0.0259
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0188 0.2255 0.3346
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0055 0.0582 0.0867
Plasmodium vivax DNA gyrase subunit B, putative 0.0803 1 1
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0803 1 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0025 0.021 0.0313
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.019 0.2284 0.3343
Loa Loa (eye worm) hypothetical protein 0.019 0.2284 0.3389
Loa Loa (eye worm) hypothetical protein 0.0045 0.0461 0.0674
Plasmodium falciparum DNA topoisomerase 3, putative 0.0057 0.0616 0.0556
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0152 0.1806 0.2624
Mycobacterium ulcerans two component sensor kinase MprB 0.0025 0.021 0.0148
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0069 0.076 0.1049
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0045 0.0461 0.0599
Brugia malayi Protein kinase c protein 2 0.0027 0.0234 0.0335
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0023 0.0179 0.0266
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0055 0.0582 0.0867
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0055 0.0582 0.0781

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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