TDR Targets

Basic information

Technical information

TDR Targets ID: 824580
Name: N-[2-(4-ethoxyphenyl)ethyl]-4-[5-(4-ethoxyphe nyl)-1,2-oxazol-3-yl]butanamide
MW: 422.517 | Formula: C25H30N2O4
H donors: 1 H acceptors: 2 LogP: 4.56 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)CCNC(=O)CCCc1noc(c1)c1ccc(cc1)OCC
InChi: 1S/C25H30N2O4/c1-3-29-22-12-8-19(9-13-22)16-17-26-25(28)7-5-6-21-18-24(31-27-21)20-10-14-23(15-11-20)30-4-2/h8-15,18H,3-7,16-17H2,1-2H3,(H,26,28)
InChiKey: MXGXEVFJJYJDKN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(4-ethoxyphenyl)ethyl]-4-[5-(4-ethoxyphenyl)isoxazol-3-yl]butanamide
N-[2-(4-ethoxyphenyl)ethyl]-4-[5-(4-ethoxyphenyl)-3-isoxazolyl]butanamide
N-[2-(4-ethoxyphenyl)ethyl]-4-[5-(4-ethoxyphenyl)isoxazol-3-yl]butyramide
C637-0151
NCGC00110852-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine protein kinase	0.0475	0.3262	0.3262
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.046	0.3158	0.3306
Trichomonas vaginalis	AGC family protein kinase	0.1362	0.9554	1
Echinococcus granulosus	nervana 2	0.0892	0.622	0.622
Brugia malayi	Carboxylesterase family protein	0.1425	1	1
Entamoeba histolytica	protein kinase 2, putative	0.0902	0.6293	0.6587
Onchocerca volvulus		0.0241	0.1604	1
Schistosoma mansoni	serine/threonine protein kinase	0.047	0.3231	0.3231
Echinococcus granulosus	serine threonine protein kinase nrc	0.0902	0.6293	0.6293
Trichomonas vaginalis	AGC family protein kinase	0.047	0.3231	0.3382
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0241	0.1604	0.1604
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0087	0.0091
Trypanosoma brucei	Histone methylation protein DOT1, putative	0.0059	0.0316	0.0331
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.1362	0.9554	0.9554
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0241	0.1604	0.5
Brugia malayi	p70 ribosomal S6 kinase beta	0.1362	0.9554	0.9554
Echinococcus granulosus	WGR domain containing protein	0.0112	0.0691	0.0691
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0902	0.6293	0.6587
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0241	0.1604	0.5
Trypanosoma brucei	Protein arginine N-methyltransferase 1 catalytic subunit	0.0039	0.0171	0.0179
Loa Loa (eye worm)	AGC/PKN protein kinase	0.047	0.3231	0.3231
Trypanosoma cruzi	Histone-lysine N-methyltransferase, H3 lysine-76 specific	0.0059	0.0316	0.0237
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0241	0.1604	0.1604
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.5804	0.5804
Trypanosoma cruzi	Histone methylation protein DOT1, putative	0.0059	0.0316	0.0237
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.047	0.3231	0.3231
Echinococcus multilocularis	histone h3 methyltransferase	0.0466	0.3198	0.3198
Entamoeba histolytica	protein kinase, putative	0.1362	0.9554	1
Entamoeba histolytica	hypothetical protein	0.0027	0.0087	0.0091
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.047	0.3231	0.3231
Entamoeba histolytica	hypothetical protein	0.0027	0.0087	0.0091
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0025	0.0072	0.0072
Onchocerca volvulus	DNA ligase 3 homolog	0.0047	0.0231	0.095
Echinococcus granulosus	serine/threonine protein kinase	0.0902	0.6293	0.6293
Onchocerca volvulus		0.0241	0.1604	1
Leishmania major	hypothetical protein, conserved	0.0059	0.0316	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0902	0.6293	0.6293
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0241	0.1604	0.5
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0361	0.2453	0.2568
Schistosoma mansoni	serine/threonine protein kinase	0.047	0.3231	0.3231
Echinococcus granulosus	para nitrobenzyl esterase	0.0241	0.1604	0.1604
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0361	0.2453	0.2453
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0902	0.6293	1
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0198	0.1302	0.1847
Schistosoma mansoni	serine/threonine protein kinase	0.047	0.3231	0.3231
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0087	0.0091
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0241	0.1604	0.1604
Toxoplasma gondii	histone arginine methyltransferase PRMT1	0.0025	0.0072	0.0076
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0025	0.0072	0.0072
Loa Loa (eye worm)	acetylcholinesterase 1	0.1425	1	1
Trichomonas vaginalis	AGC family protein kinase	0.1362	0.9554	1
Plasmodium falciparum	protein arginine N-methyltransferase 1	0.0025	0.0072	0.0115
Echinococcus multilocularis	neuroligin	0.0241	0.1604	0.1604
Echinococcus multilocularis	tankyrase	0.0027	0.0087	0.0087
Brugia malayi	Carboxylesterase family protein	0.0241	0.1604	0.1604
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0892	0.622	0.622
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0241	0.1604	0.1604
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.5804	0.5804
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0056	0.0294	0.0294
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.047	0.3231	0.3231
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0475	0.3262	0.3262
Echinococcus granulosus	histone h3 methyltransferase	0.0466	0.3198	0.3198
Loa Loa (eye worm)	AGC/AKT protein kinase	0.1362	0.9554	0.9554
Leishmania major	hypothetical protein, conserved	0.0047	0.0231	0.7303
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.047	0.3231	0.3231
Loa Loa (eye worm)	carboxylesterase	0.0241	0.1604	0.1604
Trichomonas vaginalis	AGC family protein kinase	0.1362	0.9554	1
Loa Loa (eye worm)	hypothetical protein	0.0466	0.3198	0.3198
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1302	0.1302
Schistosoma mansoni	serine/threonine kinase	0.047	0.3231	0.3231
Echinococcus multilocularis	protein kinase c epsilon type	0.0475	0.3262	0.3262
Brugia malayi	Protein kinase domain containing protein	0.047	0.3231	0.3231
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0241	0.1604	0.1679
Leishmania major	arginine N-methyltransferase-like protein	0.0025	0.0072	0.2287
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0902	0.6293	1
Echinococcus granulosus	Glutaredoxin protein 5	0.0892	0.622	0.622
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1604	0.1604
Loa Loa (eye worm)	tnks protein	0.0027	0.0087	0.0087
Schistosoma mansoni	atypical protein kinase C	0.0474	0.3256	0.3256
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0112	0.0691	0.0691
Echinococcus multilocularis	nervana 2	0.0892	0.622	0.622
Echinococcus granulosus	nervana 2	0.0892	0.622	0.622
Schistosoma mansoni	BC026374 protein (S09 family)	0.0241	0.1604	0.1604
Echinococcus granulosus	protein arginine N methyltransferase 8	0.0025	0.0072	0.0072
Schistosoma mansoni	serine/threonine protein kinase	0.0498	0.343	0.343
Brugia malayi	protein kinase C II.	0.0475	0.3262	0.3262
Loa Loa (eye worm)	carboxylesterase	0.0241	0.1604	0.1604
Schistosoma mansoni	histone J3 methyltransferase	0.0466	0.3198	0.3198
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0083	0.0484	0.0484
Schistosoma mansoni	serine/threonine-protein kinase	0.0902	0.6293	0.6293
Loa Loa (eye worm)	hypothetical protein	0.1425	1	1
Onchocerca volvulus		0.0241	0.1604	1
Brugia malayi	hypothetical protein	0.0039	0.0171	0.0171
Echinococcus multilocularis	serine:threonine protein kinase N2	0.047	0.3231	0.3231
Leishmania major	hypothetical protein, conserved	0.0059	0.0316	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0902	0.6293	0.6293
Trichomonas vaginalis	AGC family protein kinase	0.1362	0.9554	1
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1604	0.1604
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0902	0.6293	0.6587
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.047	0.3231	0.3231
Leishmania major	DNA repair protein, putative	0.0047	0.0231	0.7303
Trypanosoma cruzi	DNA repair protein, putative	0.0047	0.0231	0.0098
Echinococcus multilocularis	acetylcholinesterase	0.1425	1	1
Trypanosoma brucei	DNA repair protein, putative	0.0047	0.0231	0.0242
Schistosoma mansoni	acetylcholinesterase	0.0241	0.1604	0.1604
Echinococcus multilocularis	protein arginine N methyltransferase 8	0.0025	0.0072	0.0072
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0198	0.1302	0.1302
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0171	0.0171
Echinococcus multilocularis	carboxylesterase 5A	0.1425	1	1
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.047	0.3231	0.3231
Loa Loa (eye worm)	AGC/NDR protein kinase	0.047	0.3231	0.3231
Brugia malayi	WGR domain containing protein	0.0198	0.1302	0.1302
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0142	0.0905	0.0905
Trichomonas vaginalis	AGC family protein kinase	0.047	0.3231	0.3382
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0056	0.0294	0.0294
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0087	0.0091
Echinococcus granulosus	BC026374 protein S09 family	0.0241	0.1604	0.1604
Echinococcus granulosus	protein arginine methyltransferase	0.0025	0.0072	0.0072
Brugia malayi	Histone-lysine N-methyltransferase, H3 lysine-79 specific	0.0466	0.3198	0.3198
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0087	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1604	0.1604
Trichomonas vaginalis	AGC family protein kinase	0.1362	0.9554	1
Toxoplasma gondii	AGC kinase	0.1362	0.9554	1
Trypanosoma cruzi	Histone methylation protein DOT1, putative	0.0059	0.0316	0.0237
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.047	0.3231	0.3231
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0241	0.1604	0.1604
Echinococcus multilocularis	acetylcholinesterase	0.1425	1	1
Echinococcus granulosus	protein kinase C gamma type	0.0495	0.3404	0.3404
Brugia malayi	Protein kinase c protein 2	0.0038	0.0169	0.0169
Entamoeba histolytica	protein kinase, putative	0.047	0.3231	0.3382
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0375	0.2554	0.2673
Giardia lamblia	Kinase, AGC PKA	0.0902	0.6293	0.5
Trypanosoma brucei	rac serine-threonine kinase, putative	0.1362	0.9554	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0087	0.0091
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0361	0.2453	0.2453
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0087	0.0091
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1425	1	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0241	0.1604	0.1604
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0902	0.6293	1
Trypanosoma cruzi	Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative	0.0047	0.0231	0.0098
Entamoeba histolytica	hypothetical protein	0.0027	0.0087	0.0091
Echinococcus granulosus	tankyrase	0.0027	0.0087	0.0087
Entamoeba histolytica	zinc finger protein, putative	0.0027	0.0087	0.0091
Echinococcus multilocularis	protein arginine methyltransferase	0.0025	0.0072	0.0072
Trypanosoma brucei	histone-lysine n-methyltransferase	0.0059	0.0316	0.0331
Schistosoma mansoni	serine/threonine protein kinase	0.0498	0.343	0.343
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0025	0.0072	0.0076
Echinococcus granulosus	neuroligin	0.0241	0.1604	0.1604
Trichomonas vaginalis	AGC family protein kinase	0.1362	0.9554	1
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0361	0.2453	0.2453
Echinococcus granulosus	Protein kinase C brain isozyme	0.0498	0.343	0.343
Schistosoma mansoni	gliotactin	0.0241	0.1604	0.1604
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1604	0.1604
Brugia malayi	Tnks protein	0.0027	0.0087	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0087	0.0091
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0171	0.1112	0.1112
Echinococcus granulosus	protein kinase c epsilon type	0.0475	0.3262	0.3262
Echinococcus multilocularis	serine:threonine protein kinase 38	0.047	0.3231	0.3231
Entamoeba histolytica	arginine N-methyltransferase protein, putative	0.0039	0.0171	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1604	0.1604
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0025	0.0072	0.0076
Echinococcus granulosus	carboxylesterase 5A	0.1425	1	1
Entamoeba histolytica	protein kinase, putative	0.1362	0.9554	1
Loa Loa (eye worm)	hypothetical protein	0.047	0.3231	0.3231
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0902	0.6293	0.6293
Schistosoma mansoni	serine/threonine protein kinase	0.047	0.3231	0.3231
Entamoeba histolytica	hypothetical protein	0.0027	0.0087	0.0091
Loa Loa (eye worm)	hypothetical protein	0.1425	1	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.0241	0.1604	0.1679
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.5804	0.5804
Onchocerca volvulus		0.0241	0.1604	1
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1604	0.1604
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0025	0.0072	0.0076
Trypanosoma cruzi	histone-lysine N-methyltransferase, putative	0.0059	0.0316	0.0237
Echinococcus granulosus	acetylcholinesterase	0.1425	1	1
Brugia malayi	hypothetical protein	0.0241	0.1604	0.1604
Entamoeba histolytica	protein kinase, putative	0.0015	0.0005	0.0006
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.047	0.3231	0.3231
Schistosoma mansoni	tankyrase	0.0027	0.0087	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0065	0.0065
Echinococcus multilocularis	rac serine:threonine kinase	0.0902	0.6293	0.6293
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0198	0.1302	0.1302
Echinococcus multilocularis	serine:threonine protein kinase N2	0.047	0.3231	0.3231
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0056	0.0294	0.0294
Trypanosoma cruzi	Protein kinase B	0.0902	0.6293	1
Echinococcus multilocularis	serine threonine protein kinase	0.0495	0.3404	0.3404
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1604	0.1604
Trypanosoma brucei	Histone-lysine N-methyltransferase, H3 lysine-76 specific	0.0059	0.0316	0.0331
Brugia malayi	Protein kinase domain containing protein	0.047	0.3231	0.3231
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0198	0.1302	0.1847
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0231	0.0231
Brugia malayi	Carboxylesterase family protein	0.0241	0.1604	0.1604
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0892	0.622	0.622
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.0025	0.0072	0.0072
Onchocerca volvulus		0.0241	0.1604	1
Echinococcus granulosus	RNA directed DNA polymerase	0.0024	0.0065	0.0065
Trichomonas vaginalis	AGC family protein kinase	0.1362	0.9554	1
Echinococcus multilocularis	nervana 2	0.0892	0.622	0.622
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0024	0.0065	0.0065
Echinococcus granulosus	NDR protein kinase	0.047	0.3231	0.3231
Brugia malayi	Carboxylesterase family protein	0.0241	0.1604	0.1604
Leishmania major	histone-lysine N-methyltransferase, putative	0.0059	0.0316	1
Echinococcus multilocularis	RNA directed DNA polymerase	0.0024	0.0065	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0087	0.0091
Loa Loa (eye worm)	carboxylesterase	0.1425	1	1
Toxoplasma gondii	hypothetical protein	0.0059	0.0316	0.0331
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.047	0.3231	0.3231
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0087	0.0091
Trypanosoma brucei	Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative	0.0047	0.0231	0.0242
Brugia malayi	Protein kinase domain containing protein	0.1362	0.9554	0.9554
Echinococcus granulosus	acetylcholinesterase	0.1425	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0091	0.0091
Plasmodium vivax	protein arginine N-methyltransferase 1, putative	0.0025	0.0072	0.0115
Echinococcus multilocularis	protein kinase c iota type	0.0474	0.3256	0.3256
Echinococcus multilocularis	Glutaredoxin protein 5	0.0892	0.622	0.622
Entamoeba histolytica	hypothetical protein	0.0039	0.0171	0.0179
Mycobacterium ulcerans	carboxylesterase, LipT	0.0241	0.1604	0.5
Echinococcus granulosus	poly adp ribose polymerase 2	0.0198	0.1302	0.1302
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0902	0.6293	1
Trichomonas vaginalis	AGC family protein kinase	0.047	0.3231	0.3382
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1843	0.1843
Echinococcus granulosus	protein kinase c iota type	0.0474	0.3256	0.3256
Brugia malayi	Carboxylesterase family protein	0.0241	0.1604	0.1604
Trichomonas vaginalis	AGC family protein kinase	0.047	0.3231	0.3382
Echinococcus granulosus	serine:threonine protein kinase N2	0.047	0.3231	0.3231
Brugia malayi	WGR domain containing protein	0.0361	0.2453	0.2453
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0035	0.0143	0.0143
Brugia malayi	Hr1 repeat family protein	0.047	0.3231	0.3231
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0498	0.343	0.343
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0198	0.1302	0.1362
Entamoeba histolytica	hypothetical protein	0.0056	0.0294	0.0308
Entamoeba histolytica	protein kinase, putative	0.1362	0.9554	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0241	0.1604	0.1604
Echinococcus multilocularis	para nitrobenzyl esterase	0.0241	0.1604	0.1604

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (binding)	= 0.4467 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1326858
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 824580