Detailed information for compound 82469

Basic information

Technical information
  • TDR Targets ID: 82469
  • Name: 3-(4-chlorophenyl)-N-[(2R,3R)-3-(2,4-difluoro phenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan -2-yl]-1,2,4-oxadiazole-5-carboxamide
  • MW: 474.848 | Formula: C21H17ClF2N6O3
  • H donors: 2 H acceptors: 6 LogP: 3.05 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1noc(n1)C(=O)N[C@@H]([C@@](c1ccc(cc1F)F)(Cn1ncnc1)O)C
  • InChi: 1S/C21H17ClF2N6O3/c1-12(27-19(31)20-28-18(29-33-20)13-2-4-14(22)5-3-13)21(32,9-30-11-25-10-26-30)16-7-6-15(23)8-17(16)24/h2-8,10-12,32H,9H2,1H3,(H,27,31)/t12-,21-/m1/s1
  • InChiKey: SLVXSNLLEAGDAQ-XUSGNXJCSA-N  

Network

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Synonyms

  • 3-(4-chlorophenyl)-N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1,2,4-triazol-1-yl)propyl]-1,2,4-oxadiazole-5-carboxamide
  • AIDS-035119
  • AIDS035119
  • 1,2,4-Oxadiazole-5-carboxamide, 3-(4-chlorophenyl)-N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus peroxidasin 0.0079 0.0368 0.1814
Entamoeba histolytica diacylglycerol kinase, putative 0.0042 0.0176 0.3907
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Trichomonas vaginalis MYB72, putative 0.0094 0.045 0.9947
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0089 0.8904
Loa Loa (eye worm) hypothetical protein 0.0277 0.1418 0.8631
Onchocerca volvulus 0.0079 0.0368 1
Echinococcus multilocularis protein jagged 1 0.0025 0.0086 0.0404
Echinococcus granulosus neurogenic locus protein delta 0.0025 0.0086 0.0404
Schistosoma mansoni peroxidasin 0.0079 0.0368 0.1814
Brugia malayi hypothetical protein 0.0026 0.0089 0.0522
Onchocerca volvulus 0.0012 0.0013 0.0234
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0038 0.0745
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.006 0.0269 0.1319
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0013 0.019
Echinococcus multilocularis protein jagged 2 0.0025 0.0086 0.0404
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.004 0.3702
Schistosoma mansoni notch 0.0025 0.0086 0.0404
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0013 0.019
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0042 0.0176 0.0854
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0147 0.0713
Brugia malayi Protein kinase domain containing protein 0.006 0.0269 0.1586
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0028 0.0099 0.047
Brugia malayi protein kinase C3,putative 0.0044 0.0183 0.1077
Echinococcus granulosus protein jagged 2 0.0025 0.0086 0.0404
Schistosoma mansoni unc-13 (munc13) 0.0051 0.0223 0.1087
Brugia malayi Calcium binding EGF domain containing protein 0.0025 0.0086 0.0505
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0183 0.0889
Loa Loa (eye worm) RasGEF domain-containing protein 0.0042 0.0176 0.107
Onchocerca volvulus Peroxidasin homolog 0.0079 0.0368 1
Trichomonas vaginalis MYB, putative 0.0095 0.0452 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0005 0.0002
Schistosoma mansoni hypothetical protein 0.0042 0.0176 0.0854
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0013 0.0903
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0013 0.0078
Echinococcus granulosus N chimaerin 0.0042 0.0176 0.0854
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0013 0.0293
Echinococcus multilocularis neural cadherin 0.0025 0.0086 0.0404
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0042 0.0176 0.0854
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0388 0.2008 1
Brugia malayi p70 ribosomal S6 kinase beta 0.006 0.0269 0.1586
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Trichomonas vaginalis AGC family protein kinase 0.006 0.0269 0.5904
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0287 0.1472 0.8957
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Leishmania major calcium-translocating P-type ATPase 0.0028 0.0099 1
Trichomonas vaginalis chromobox protein, putative 0.0043 0.018 0.3926
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0094 0.045 1
Echinococcus granulosus protein jagged 1 0.0025 0.0086 0.0404
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0089 0.0302
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0016 0.0038 0.0846
Loa Loa (eye worm) Notch2 0.0025 0.0086 0.0521
Onchocerca volvulus 0.0025 0.0086 0.2229
Brugia malayi E1-E2 ATPase family protein 0.001 0.0006 0.0037
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.006 0.0269 0.1637
Schistosoma mansoni hypothetical protein 0.0025 0.0086 0.0404
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Loa Loa (eye worm) hypothetical protein 0.0042 0.0176 0.107
Echinococcus multilocularis fat cadherin tumor suppressor 0.0025 0.0086 0.0404
Entamoeba histolytica protein kinase, putative 0.006 0.0269 0.5978
Schistosoma mansoni vav2 0.0042 0.0176 0.0854
Entamoeba histolytica hypothetical protein 0.0037 0.0147 0.3277
Leishmania major hypothetical protein, conserved 0.0026 0.0089 0.8885
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0013 0.0021 0.008
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0269 0.1319
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Echinococcus granulosus neural cadherin 0.0025 0.0086 0.0404
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0082 0.1728
Echinococcus multilocularis Diacylglycerol kinase theta 0.0042 0.0176 0.0854
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Echinococcus multilocularis geminin 0.0175 0.0877 0.4352
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0368 0.224
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0013 0.019
Brugia malayi Ras association domain family 1 isoform A 0.0042 0.0176 0.1036
Loa Loa (eye worm) notch protein 0.0025 0.0086 0.0521
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0013 0.019
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0016 0.0038 0.0167
Echinococcus granulosus chromobox protein 1 0.0072 0.0332 0.1631
Loa Loa (eye worm) hypothetical protein 0.0042 0.0176 0.107
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase A CtpF 0.0011 0.0012 0.0002
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0006 0.0037
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0082 0.0484
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0028 0.0099 0.0094
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0089 0.8904
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1361 0.7167 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0016 0.0038 0.1262
Schistosoma mansoni chromobox protein 0.0012 0.0013 0.0042
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Trichomonas vaginalis AGC family protein kinase 0.006 0.0269 0.5904
Echinococcus multilocularis neurogenic locus notch protein 0.0025 0.0086 0.0404
Trichomonas vaginalis cation-transporting ATPase, putative 0.0016 0.0038 0.0745
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0042 0.0176 0.107
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0013 0.0031
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0013 0.0021 0.008
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0095 0.0452 1
Brugia malayi hypothetical protein 0.0017 0.004 0.0235
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0332 0.73
Brugia malayi hypothetical protein 0.001 0.0005 0.0028
Entamoeba histolytica protein kinase, putative 0.006 0.0269 0.5978
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Loa Loa (eye worm) hypothetical protein 0.0016 0.0038 0.0232
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0028 0.0099 0.047
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.006 0.0269 0.1637
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Brugia malayi Delta serrate ligand family protein 0.0025 0.0086 0.0505
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1895 1 1
Leishmania major calcium motive p-type ATPase, putative 0.0013 0.0021 0.1544
Echinococcus granulosus Chromo domain 0.0012 0.0013 0.0042
Echinococcus multilocularis Chromo domain 0.0012 0.0013 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0102 0.2173
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0038 0.0745
Echinococcus granulosus protein kinase C gamma type 0.0345 0.1783 0.8877
Trypanosoma brucei P-type H+-ATPase, putative 0.001 0.0006 0.0063
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0013 0.0021 0.0357
Entamoeba histolytica hypothetical protein 0.0012 0.0013 0.0293
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0016 0.0038 0.0846
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0013 0.0021 0.008
Leishmania major calcium-transporting ATPase, putative 0.0013 0.0021 0.1544
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0066 0.6519
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0534 0.2784 0.278
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0013 0.019
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0013 0.0021 0.008
Echinococcus granulosus NDR protein kinase 0.006 0.0269 0.1319
Schistosoma mansoni ATPase 0.0028 0.0099 0.047
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0013 0.019
Schistosoma mansoni unc-13 (munc13) 0.0051 0.0223 0.1087
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0013 0.0031
Echinococcus granulosus serine:threonine protein kinase N2 0.006 0.0269 0.1319
Brugia malayi RhoGAP domain containing protein 0.0042 0.0176 0.1036
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0042 0.0176 0.0854
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0082 0.0384
Entamoeba histolytica hypothetical protein 0.0037 0.0147 0.3277
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0013 0.019
Echinococcus multilocularis serine:threonine protein kinase 38 0.006 0.0269 0.1319
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0017 0.0043 0.4115
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.008
Brugia malayi EGF-like domain containing protein 0.0025 0.0086 0.0505
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0368 0.224
Onchocerca volvulus 0.0025 0.0086 0.2229
Brugia malayi Cadherin domain containing protein 0.0025 0.0086 0.0505
Onchocerca volvulus Peroxidase homolog 0.0079 0.0368 1
Plasmodium vivax calcium-transporting ATPase, putative 0.0028 0.0099 1
Brugia malayi Blistered cuticle protein 3 0.0079 0.0368 0.2169
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0016 0.0038 0.0746
Trichomonas vaginalis AGC family protein kinase 0.006 0.0269 0.5904
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0005 0.003
Echinococcus multilocularis Rac GTPase activating protein 1 0.0042 0.0176 0.0854
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0013 0.019
Trichomonas vaginalis MYB3r3, putative 0.0094 0.045 0.9947
Loa Loa (eye worm) hypothetical protein 0.0042 0.0176 0.107
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0021 0.1694
Loa Loa (eye worm) AGC/AKT protein kinase 0.006 0.0269 0.1637
Onchocerca volvulus 0.0042 0.0176 0.4711
Schistosoma mansoni hypothetical protein 0.0037 0.0147 0.0713
Echinococcus multilocularis fibropellin Ia 0.0025 0.0086 0.0404
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0013 0.019
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0051 0.0223 0.1087
Echinococcus granulosus geminin 0.0175 0.0877 0.4352
Onchocerca volvulus 0.0051 0.0223 0.5996
Schistosoma mansoni diacylglycerol kinase theta 0.0042 0.0176 0.0854
Brugia malayi EGF-like domain containing protein 0.0025 0.0086 0.0505
Onchocerca volvulus Dual oxidase homolog 0.0079 0.0368 1
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0028 0.0099 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0094 0.045 0.9947
Echinococcus multilocularis raf serine:threonine protein kinase 0.0042 0.0176 0.0854
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0042 0.0176 0.0854
Onchocerca volvulus Peroxidasin homolog 0.0079 0.0368 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0013 0.019
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0039 0.0122
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0013 0.004
Loa Loa (eye worm) raf kinase 0.0042 0.0176 0.107
Onchocerca volvulus 0.0079 0.0368 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0094 0.045 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0005 0.0001
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0013 0.019
Brugia malayi Pleckstrin Homology Domain 0.0042 0.0176 0.1036
Brugia malayi Hr1 repeat family protein 0.006 0.0269 0.1586
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0029
Schistosoma mansoni cell polarity protein 0.0025 0.0086 0.0404
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0021 0.1694
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1895 1 1
Echinococcus granulosus bloom syndrome protein 0.0025 0.0082 0.0386
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0089 0.8904
Brugia malayi diacylglycerol kinase 0.0042 0.0176 0.1036
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0005 0.0002
Brugia malayi hypothetical protein 0.0037 0.0147 0.0869
Trichomonas vaginalis AGC family protein kinase 0.006 0.0269 0.5904
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Entamoeba histolytica protein kinase, putative 0.001 0.0004 0.01
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0164 0.3564
Entamoeba histolytica hypothetical protein 0.0012 0.0013 0.0293
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0164 0.3564
Echinococcus multilocularis notch 0.0025 0.0086 0.0404
Trichomonas vaginalis pc-MYB2, putative 0.0094 0.045 0.9947
Brugia malayi protein kinase C II. 0.0111 0.0541 0.3186
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0019 0.0054 0.0326
Echinococcus multilocularis protein kinase c epsilon type 0.0111 0.0541 0.2675
Schistosoma mansoni hypothetical protein 0.0025 0.0086 0.0404
Brugia malayi EGF-like domain containing protein 0.0025 0.0086 0.0505
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0094 0.045 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.006 0.0269 0.1637
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0016 0.0038 0.0033
Echinococcus granulosus myotubularin protein 13 0.0042 0.0176 0.0854
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0016 0.0038 0.0167
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0534 0.2784 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0013 0.0293
Echinococcus multilocularis neurogenic locus protein delta 0.0025 0.0086 0.0404
Echinococcus multilocularis neurogenic locus protein delta 0.0025 0.0086 0.0404
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0021 0.0364
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0368 0.2169
Plasmodium vivax P-type ATPase4, putative 0.0028 0.0099 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0025 0.0086 0.0404
Echinococcus granulosus Rac GTPase activating protein 1 0.0042 0.0176 0.0854
Entamoeba histolytica hypothetical protein 0.0037 0.0147 0.3277
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0013 0.019
Entamoeba histolytica hypothetical protein 0.0012 0.0013 0.0293
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0013 0.004
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0028 0.0099 0.047
Onchocerca volvulus 0.0079 0.0368 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0005 0.0001
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0095 0.0452 1
Brugia malayi diacylglycerol kinase 0.0042 0.0176 0.1036
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.006 0.0269 0.1319
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.006 0.0269 0.1637
Schistosoma mansoni ATPase 0.0028 0.0099 0.047
Brugia malayi topoisomerase 0.001 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.008
Schistosoma mansoni notch 0.0025 0.0086 0.0404
Schistosoma mansoni serine/threonine kinase 0.006 0.0269 0.1319
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0013 0.0042
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0005 0.0028
Entamoeba histolytica hypothetical protein 0.001 0.0005 0.0104
Loa Loa (eye worm) hypothetical protein 0.0026 0.0089 0.0539
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0005 0.0002
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.0021 0.008
Loa Loa (eye worm) E1-E2 ATPase 0.001 0.0006 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0013 0.019
Loa Loa (eye worm) AGC/PKN protein kinase 0.006 0.0269 0.1637
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0029
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0005 0.0008
Trichomonas vaginalis C-MYB, putative 0.0094 0.045 0.9947
Schistosoma mansoni DNA helicase recq5 0.001 0.0005 0.0002
Leishmania major P-type ATPase, putative 0.0013 0.0021 0.1544
Loa Loa (eye worm) hypothetical protein 0.0042 0.0176 0.107
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0044 0.0183 0.0889
Echinococcus multilocularis chromobox protein 1 0.0072 0.0332 0.1631
Brugia malayi EGF-like domain containing protein 0.0025 0.0086 0.0505
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0021 0.0466
Loa Loa (eye worm) hypothetical protein 0.0042 0.0176 0.107
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0013 0.008
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0019 0.0054 0.0316
Schistosoma mansoni serine/threonine protein kinase 0.0388 0.2008 1
Brugia malayi Calcium binding EGF domain containing protein 0.0025 0.0086 0.0505
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0111 0.0541 0.329
Brugia malayi Na,K-ATPase alpha subunit 0.0016 0.0038 0.0224
Brugia malayi Membrane calcium atpase protein 3 0.0013 0.0021 0.0122
Onchocerca volvulus 0.0025 0.0086 0.2229
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0013 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0013 0.019
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0147 0.0713
Brugia malayi Calcium binding EGF domain containing protein 0.0025 0.0086 0.0505
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0013 0.0042
Plasmodium falciparum calcium-transporting ATPase 0.0025 0.0082 0.8153
Schistosoma mansoni atypical protein kinase C 0.0102 0.0494 0.2442
Brugia malayi EGF-like domain containing protein 0.0025 0.0086 0.0505
Brugia malayi Variant SH3 domain containing protein 0.0042 0.0176 0.1036
Onchocerca volvulus Neurogenic locus notch homolog 0.0026 0.0087 0.2264
Echinococcus multilocularis slit 2 protein 0.0025 0.0086 0.0404
Echinococcus multilocularis serine:threonine protein kinase N2 0.006 0.0269 0.1319
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0005 0.003
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.018 0.4838
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0016 0.0038 0.3541
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0025 0.0082 0.0384
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0013 0.0021 0.008
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0013 0.0078
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0021 0.1577
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0094 0.045 1
Entamoeba histolytica protein kinase, putative 0.001 0.0004 0.01
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0013 0.0042
Onchocerca volvulus 0.0042 0.0176 0.4711
Trichomonas vaginalis AGC family protein kinase 0.006 0.0269 0.5904
Echinococcus granulosus Chromobox protein 3 0.0012 0.0013 0.0042
Brugia malayi C1-like domain containing protein 0.0044 0.0183 0.1077
Brugia malayi GCC2 and GCC3 family protein 0.0025 0.0086 0.0505
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0013 0.0042
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0016 0.0038 0.3424
Loa Loa (eye worm) hypothetical protein 0.0124 0.0611 0.3719
Echinococcus granulosus notch 0.0025 0.0086 0.0404
Schistosoma mansoni hypothetical protein 0.0175 0.0877 0.4352
Schistosoma mansoni hypothetical protein 0.0025 0.0086 0.0404
Trypanosoma brucei P-type H+-ATPase, putative 0.001 0.0006 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0269 0.1319
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0013 0.0903
Schistosoma mansoni septate junction protein 0.0025 0.0086 0.0404
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0021 0.0357
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0016 0.0038 0.3541
Brugia malayi RhoGEF domain containing protein 0.0042 0.0176 0.1036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0719
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0368 0.2169
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0016 0.0038 0.0846
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0089 0.8904
Trichomonas vaginalis AGC family protein kinase 0.006 0.0269 0.5904
Brugia malayi Protein cec-1. 0.0012 0.0013 0.0078
Giardia lamblia High cysteine protein 0.0025 0.0086 0.1809
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.004
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0013 0.0042
Brugia malayi notch-like transmembrane receptor 0.0025 0.0086 0.0505
Schistosoma mansoni slit 0.0025 0.0086 0.0404
Entamoeba histolytica protein kinase, putative 0.006 0.0269 0.5978
Schistosoma mansoni diacylglycerol kinase theta 0.0042 0.0176 0.0854
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0013 0.0903
Onchocerca volvulus 0.0012 0.0013 0.0234
Brugia malayi EGF-like domain containing protein 0.0025 0.0086 0.0505
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0011 0.001 0.0061
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.008
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Schistosoma mansoni DNA helicase recq1 0.001 0.0005 0.0002
Echinococcus granulosus protein kinase c eta type 0.0042 0.0176 0.0854
Trichomonas vaginalis pc-MYB2, putative 0.0094 0.045 0.9947
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0013 0.0042
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0102 0.2173
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.0099 0.2105
Loa Loa (eye worm) helicase 0.0012 0.0013 0.008
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0094 0.045 0.9947
Trichomonas vaginalis AGC family protein kinase 0.006 0.0269 0.5904
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0176 0.0854
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0094 0.045 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0013 0.019
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0013 0.0021 0.0604
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0013 0.0078
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0183 0.0889
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0059 0.0262 0.5751
Echinococcus granulosus delta-like protein 1 0.0025 0.0086 0.0404
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0028 0.0099 0.0339
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0082 0.1728
Schistosoma mansoni notch 0.0026 0.0087 0.0411
Trichomonas vaginalis AGC family protein kinase 0.006 0.0269 0.5904
Schistosoma mansoni protein kinase C mu 0.0044 0.0183 0.0889
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0021 0.1727
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0534 0.2784 0.388
Loa Loa (eye worm) hypothetical protein 0.0042 0.0176 0.107
Trichomonas vaginalis AGC family protein kinase 0.006 0.0269 0.5904
Schistosoma mansoni hypothetical protein 0.0025 0.0086 0.0404
Echinococcus granulosus unc 13 munc13 0.0051 0.0223 0.1087
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0016 0.0038 0.012
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0005 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0013 0.019
Echinococcus granulosus calcium transporting atpase 0.0025 0.0082 0.0384
Toxoplasma gondii P-type ATPase4, putative 0.0016 0.0038 0.012
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0025 0.0086 0.2229
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0013 0.019
Loa Loa (eye worm) hypothetical protein 0.0319 0.1643 1
Brugia malayi Peroxidasin 0.0079 0.0368 0.2169
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Echinococcus granulosus RNA directed DNA polymerase 0.0277 0.1418 0.7056
Brugia malayi EGF-like domain containing protein 0.0025 0.0086 0.0505
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0011 0.001 0.0005
Echinococcus multilocularis neurogenic locus notch protein 0.0025 0.0086 0.0404
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0044 0.0183 0.1112
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0094 0.045 0.9947
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0368 0.2169
Echinococcus multilocularis chromobox protein 1 0.0072 0.0332 0.1631
Brugia malayi Protein kinase domain containing protein 0.0044 0.0183 0.1077
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0013 0.0903
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0016 0.0038 0.3424
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.006 0.0269 0.1319
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0025 0.0086 0.0505
Trichomonas vaginalis hypothetical protein 0.0012 0.0013 0.019
Onchocerca volvulus 0.0016 0.0038 0.0919
Trichomonas vaginalis C-MYB, putative 0.0094 0.045 0.9947
Onchocerca volvulus Chorion peroxidase homolog 0.0079 0.0368 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0013 0.0903
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0602
Brugia malayi Muscle positioning protein 4 0.0025 0.0086 0.0505
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0013 0.0042
Brugia malayi hypothetical protein 0.0012 0.0014 0.0085
Echinococcus granulosus protein kinase c iota type 0.0102 0.0494 0.2442
Loa Loa (eye worm) hypothetical protein 0.0042 0.0176 0.107
Trichomonas vaginalis AGC family protein kinase 0.006 0.0269 0.5904
Schistosoma mansoni notch 0.0025 0.0086 0.0404
Loa Loa (eye worm) hypothetical protein 0.0042 0.0176 0.107
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0013 0.0021 0.008
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0028 0.0099 0.047
Schistosoma mansoni rac gtpase activating protein 0.0042 0.0176 0.0854
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0013 0.0031
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0095 0.0452 0.1611
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Echinococcus multilocularis chromobox protein 2 0.0012 0.0013 0.0042
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Schistosoma mansoni chromobox protein 0.0072 0.0332 0.1631
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0013 0.019
Schistosoma mansoni chromobox protein 0.0012 0.0013 0.0042
Brugia malayi SET domain containing protein 0.0012 0.0013 0.0078
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1895 1 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0016 0.0038 0.1262
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0044 0.0183 0.0889
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0005 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0013 0.019
Echinococcus multilocularis RNA directed DNA polymerase 0.0277 0.1418 0.7056
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0005 0.0104
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0147 0.0713
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.008
Brugia malayi RhoGAP domain containing protein 0.0042 0.0176 0.1036
Trypanosoma brucei rac serine-threonine kinase, putative 0.006 0.0269 1
Brugia malayi chromobox protein homolog 3 0.004 0.0164 0.0968
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0016 0.0038 0.0745
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0088
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0013 0.0042
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.0099 0.2105
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Echinococcus multilocularis unc 13 (munc13) 0.0051 0.0223 0.1087
Brugia malayi Heterochromatin protein 1 0.0072 0.0332 0.1954
Brugia malayi Protein kinase c protein 2 0.0329 0.1697 1
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0028 0.0099 1
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.0021 0.008
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0042 0.0176 0.107
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0277 0.1418 0.7056
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0044 0.0183 0.1112
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0013 0.019
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0013 0.0042
Echinococcus multilocularis serine threonine protein kinase 0.0345 0.1783 0.8877
Echinococcus multilocularis peroxidasin 0.0079 0.0368 0.1814
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.008
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0013 0.0078
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0269 0.1319
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0541 0.2675
Schistosoma mansoni notch 0.0025 0.0086 0.0404
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0013 0.0021 0.0057
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.008
Echinococcus multilocularis N chimaerin 0.0042 0.0176 0.0854
Echinococcus multilocularis protein jagged 1 0.0025 0.0086 0.0404
Onchocerca volvulus 0.0025 0.0086 0.2229
Onchocerca volvulus Peroxidase homolog 0.0079 0.0368 1
Schistosoma mansoni hypothetical protein 0.0025 0.0086 0.0404
Giardia lamblia Myb 1-like protein 0.0095 0.0452 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0029
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0094 0.045 0.9947
Loa Loa (eye worm) hypothetical protein 0.0042 0.0176 0.107
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.006 0.0269 0.1319
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0025 0.0082 0.048
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0013 0.0293
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0054 0.0248
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0016 0.0038 0.1262
Entamoeba histolytica protein kinase, putative 0.006 0.0269 0.5978
Echinococcus granulosus chromobox protein 1 0.0072 0.0332 0.1631
Echinococcus multilocularis myotubularin protein 13 0.0042 0.0176 0.0854
Schistosoma mansoni serine/threonine protein kinase 0.0388 0.2008 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0094 0.045 0.9947
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0013 0.019
Schistosoma mansoni hypothetical protein 0.0175 0.0877 0.4352
Trypanosoma brucei calcium-translocating P-type ATPase 0.0025 0.0082 0.2907
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0082 0.0384
Toxoplasma gondii P-type ATPase PMA1 0.001 0.0006 0.0006
Onchocerca volvulus 0.0012 0.0013 0.0234
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0011 0.001 0.0008
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0016 0.0038 0.0846
Toxoplasma gondii diacylglycerol kinase, putative 0.0042 0.0176 0.0616
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0029
Toxoplasma gondii EGF family domain-containing protein 0.0025 0.0086 0.0291
Trypanosoma cruzi P-type H+-ATPase, putative 0.001 0.0006 0.0178
Brugia malayi hypothetical protein 0.0079 0.0368 0.2169
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0164 0.4392
Onchocerca volvulus 0.0032 0.0118 0.3123
Echinococcus multilocularis protein kinase c eta type 0.0042 0.0176 0.0854
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0332 0.73
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0082 0.0386
Loa Loa (eye worm) hypothetical protein 0.0042 0.0176 0.107
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0013 0.019
Onchocerca volvulus Putative cubilin 0.0025 0.0086 0.2229
Brugia malayi Protein kinase domain containing protein 0.006 0.0269 0.1586
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0089 0.8904
Echinococcus granulosus fibropellin Ia 0.0025 0.0086 0.0404
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.006 0.0269 0.1637
Brugia malayi DKFZp564C0469 protein 0.001 0.0005 0.0028
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1361 0.7167 1
Schistosoma mansoni protein kinase C mu 0.0042 0.0176 0.0854
Echinococcus granulosus protein jagged 1 0.0025 0.0086 0.0404
Echinococcus granulosus raf serine:threonine protein kinase 0.0042 0.0176 0.0854
Schistosoma mansoni peroxidasin 0.0079 0.0368 0.1814
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0016 0.0038 0.0232
Schistosoma mansoni hypothetical protein 0.0025 0.0086 0.0404
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0038 0.0745
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0051 0.0223 0.1087
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0016 0.0038 0.0167
Schistosoma mansoni hypothetical protein 0.0025 0.0086 0.0404
Echinococcus multilocularis serine:threonine protein kinase N2 0.006 0.0269 0.1319
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0011 0.001 0.006
Loa Loa (eye worm) blistered cuticle protein 3 0.0079 0.0368 0.224
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0021 0.0616
Echinococcus granulosus protein kinase c epsilon type 0.0111 0.0541 0.2675
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0094 0.045 0.9947
Schistosoma mansoni notch 0.0025 0.0086 0.0404
Echinococcus granulosus neurogenic locus notch protein 4 0.0025 0.0086 0.0404
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0038 0.0745
Loa Loa (eye worm) hypothetical protein 0.0051 0.0223 0.1354
Schistosoma mansoni protein kinase C 0.0051 0.0223 0.1087
Echinococcus granulosus Na:K ATPase alpha subunit 0.0013 0.0021 0.008
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.224
Echinococcus granulosus Protein kinase C brain isozyme 0.0388 0.2008 1
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0013 0.0021 0.0357
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0013 0.0903
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0368 0.2169
Loa Loa (eye worm) RecQ helicase 0.0025 0.0082 0.0499
Echinococcus granulosus protein jagged 2 0.0025 0.0086 0.0404
Echinococcus granulosus slit 2 protein 0.0025 0.0086 0.0404
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0044 0.0183 0.1077
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0089 0.3175
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0368 0.2169
Echinococcus granulosus neurogenic locus notch protein 0.0025 0.0086 0.0404
Loa Loa (eye worm) AGC/NDR protein kinase 0.006 0.0269 0.1637
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0013 0.019
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0368 0.224
Echinococcus granulosus neurogenic locus notch protein 0.0025 0.0086 0.0404
Brugia malayi CHD4 protein 0.0012 0.0013 0.0078
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0016 0.0038 0.0745
Echinococcus granulosus Diacylglycerol kinase theta 0.0042 0.0176 0.0854
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0242
Schistosoma mansoni laminin gamma-3 chain 0.0025 0.0086 0.0404
Entamoeba histolytica diacylglycerol kinase, putative 0.0042 0.0176 0.3907
Onchocerca volvulus Slit protein homolog 0.0025 0.0086 0.2229
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.006 0.0269 0.1319
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0269 0.1319
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0013 0.019
Brugia malayi Protein kinase domain containing protein 0.006 0.0269 0.1586
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0368 0.224
Onchocerca volvulus 0.0025 0.0086 0.2229
Trichomonas vaginalis AGC family protein kinase 0.006 0.0269 0.5904
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Entamoeba histolytica hypothetical protein 0.0037 0.0147 0.3277
Trichomonas vaginalis chromobox protein, putative 0.0043 0.018 0.3926
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0332 0.2017
Trypanosoma cruzi P-type H+-ATPase, putative 0.001 0.0006 0.0178
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0029
Entamoeba histolytica hypothetical protein 0.0042 0.0176 0.3907
Echinococcus multilocularis calcium transporting atpase 0.0025 0.0082 0.0384
Echinococcus multilocularis protein kinase c iota type 0.0102 0.0494 0.2442
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0025 0.0086 0.0404
Loa Loa (eye worm) hypothetical protein 0.004 0.0164 0.1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0521
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.006 0.0269 0.1319
Brugia malayi Cadherin domain containing protein 0.0025 0.0086 0.0505
Toxoplasma gondii AGC kinase 0.006 0.0269 0.0951
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0013 0.0042
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0042 0.0176 0.107
Echinococcus granulosus chromobox protein 2 0.0012 0.0013 0.0042
Brugia malayi hypothetical protein 0.001 0.0005 0.0028
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0534 0.2784 0.278
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0013 0.019
Schistosoma mansoni chromobox protein 0.0072 0.0332 0.1631

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 2.1 ug ml-1 The compound was tested in vitro for antifungal activity against 10 yeasts. ChEMBL. 9599236
MIC (functional) = 80 ug ml-1 The compound was tested in vitro for antifungal activity against 6 filamentous fungi. ChEMBL. 9599236
Protection (functional) = 10 % In vivo antifungal activity against murine candidosis model after peroral administration with 0.5 mg/kg at various time intervals.(percent protection for 100% mortality with fluconazole-treated group.) ChEMBL. 9599236
Protection (functional) = 10 % In vivo antifungal activity against murine candidosis model after peroral administration with 0.5 mg/kg at various time intervals.(percent protection for 100% mortality with fluconazole-treated group.) ChEMBL. 9599236
Protection (functional) = 80 % In vivo antifungal activity against murine candidosis model after peroral administration with 0.5 mg/kg at various time intervals.(percent protection for 100% mortality with untreated group) ChEMBL. 9599236
Protection (functional) = 80 % In vivo antifungal activity against murine candidosis model after peroral administration with 0.5 mg/kg at various time intervals.(percent protection for 100% mortality with untreated group) ChEMBL. 9599236

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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