TDR Targets

Basic information

Technical information

TDR Targets ID: 824842
Name: N-(3-chlorophenyl)-2-[6-ethoxy-3-(4-ethylbenz oyl)-4-oxoquinolin-1-yl]acetamide
MW: 488.962 | Formula: C28H25ClN2O4
H donors: 1 H acceptors: 3 LogP: 5.91 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc2c(c1)c(=O)c(cn2CC(=O)Nc1cccc(c1)Cl)C(=O)c1ccc(cc1)CC
InChi: 1S/C28H25ClN2O4/c1-3-18-8-10-19(11-9-18)27(33)24-16-31(17-26(32)30-21-7-5-6-20(29)14-21)25-13-12-22(35-4-2)15-23(25)28(24)34/h5-16H,3-4,17H2,1-2H3,(H,30,32)
InChiKey: DSGTWUQZWYKJAJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-chlorophenyl)-2-[6-ethoxy-3-(4-ethylbenzoyl)-4-oxo-1-quinolyl]acetamide
N-(3-chlorophenyl)-2-[6-ethoxy-3-[(4-ethylphenyl)-oxomethyl]-4-oxo-1-quinolyl]acetamide
N-(3-chlorophenyl)-2-[6-ethoxy-3-(4-ethylbenzoyl)-4-keto-1-quinolyl]acetamide
N-(3-chlorophenyl)-2-[6-ethoxy-3-(4-ethylphenyl)carbonyl-4-oxo-quinolin-1-yl]ethanamide
C647-1039
NCGC00111201-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0104	0.1151	0.1697
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.3601	0.5274
Trypanosoma cruzi	20S proteasome subunit	0.0255	0.3149	0.3242
Brugia malayi	Proteasome A-type and B-type family protein	0.0104	0.1151	0.1179
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0104	0.1151	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0512	0.052
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0104	0.1151	0.1185
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0412	0.5221	0.7695
Leishmania major	phosphatidylglycerophosphate synthase, putative	0.0022	0.0061	0.0063
Loa Loa (eye worm)	doublecortin family protein	0.0021	0.0054	0.0048
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0255	0.3149	0.4641
Schistosoma mansoni	cpg binding protein	0.0032	0.0199	0.0199
Echinococcus granulosus	cytochrome P450 2K1	0.0065	0.0634	0.0634
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0007
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0255	0.3149	0.3242
Giardia lamblia	Proteasome subunit beta type 1	0.0412	0.5221	0.7678
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0424	0.0424
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0104	0.1151	0.1185
Leishmania major	proteasome beta 3 subunit, putative	0.0104	0.1151	0.1185
Brugia malayi	secreted modular calcium-binding protein 1	0.0041	0.0315	0.0317
Schistosoma mansoni	coup transcription factor	0.0481	0.6141	0.6141
Brugia malayi	hypothetical protein	0.0254	0.3137	0.3226
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3137	0.3226
Onchocerca volvulus	Glucosylceramidase homolog	0.019	0.2285	0.3665
Entamoeba histolytica	phospholipase D active site domain-containing protein	0.0097	0.1054	0.1553
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2777	0.2854
Leishmania major	proteasome beta 2 subunit, putative	0.0104	0.1151	0.1185
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0412	0.5221	0.5221
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0104	0.1151	0.1697
Loa Loa (eye worm)	phospholipase D	0.0022	0.0061	0.0055
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0048	0.0049
Brugia malayi	sodium-independent organic anion transporter family protein	0.006	0.0567	0.0577
Onchocerca volvulus		0.006	0.0567	0.0843
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.006	0.0567	0.0577
Echinococcus granulosus	phospholipase d3	0.0022	0.0061	0.0061
Onchocerca volvulus		0.0029	0.0157	0.0169
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0481	0.6141	0.6321
Leishmania major	cytochrome p450-like protein	0.0065	0.0634	0.0653
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0199	0.0198
Trypanosoma brucei	Emopamil binding protein, putative	0.014	0.163	0.1678
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0481	0.6141	0.6321
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0008	0.0008
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0104	0.1151	0.1637
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0104	0.1151	0.1697
Trichomonas vaginalis	esterase, putative	0.0039	0.0286	0.0353
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0065	0.0634	0.0924
Brugia malayi	proteasome subunit alpha type 3	0.0104	0.1151	0.1179
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0065	0.0634	0.0934
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0104	0.1151	0.1697
Plasmodium falciparum	phosphatidylglycerophosphate synthase	0.0018	0.0018	0.0026
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0104	0.1151	0.1697
Toxoplasma gondii	protease inhibitor PI2	0.0041	0.0315	0.0464
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0065	0.0634	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0315	0.0317
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0104	0.1151	0.1697
Brugia malayi	hypothetical protein	0.004	0.0307	0.0309
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0104	0.1151	0.1687
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0008	0.0008
Toxoplasma gondii	peptidase, T1 family protein	0.0104	0.1151	0.1697
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.2285	0.332
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0104	0.1151	0.1151
Brugia malayi	sodium-independent organic anion transporter family protein	0.006	0.0567	0.0577
Brugia malayi	Cytochrome P450 family protein	0.0065	0.0634	0.0646
Brugia malayi	proteasome subunit alpha type 4	0.0104	0.1151	0.1179
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0104	0.1151	0.1697
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0424	0.0424
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0104	0.1151	0.1151
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0065	0.0634	0.0934
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0286	0.0287
Loa Loa (eye worm)	DR-78	0.0227	0.2777	0.2854
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0337	0.4238	0.4238
Onchocerca volvulus		0.006	0.0567	0.0843
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0227	0.2777	0.2777
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0481	0.6141	0.6321
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0054	0.0054
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0255	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3137	0.3226
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0061	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0766	0.0782
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0227	0.2777	0.4474
Echinococcus multilocularis	phospholipase d3	0.0022	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0481	0.6141	0.6321
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0412	0.5221	0.5376
Giardia lamblia	Proteasome subunit beta type 7 precursor	0.0104	0.1151	0.1637
Brugia malayi	nuclear receptor NHR-67	0.0227	0.2777	0.2854
Schistosoma mansoni	organic anion transporter	0.006	0.0567	0.0567
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0481	0.6141	0.6141
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0104	0.1151	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2777	0.2854
Giardia lamblia	Proteasome subunit beta type 4 precursor	0.0104	0.1151	0.1637
Plasmodium falciparum	proteasome subunit beta type-4	0.0104	0.1151	0.1697
Loa Loa (eye worm)	cytochrome P450 family protein	0.0085	0.0902	0.0922
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0286	0.0421
Loa Loa (eye worm)	agrin synaptic family protein	0.0041	0.0315	0.0317
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0065	0.0634	0.0924
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0021	0.0046	0.0046
Onchocerca volvulus		0.0041	0.0315	0.0429
Echinococcus granulosus	proteasome subunit alpha type 6	0.0104	0.1151	0.1151
Schistosoma mansoni	hypothetical protein	0.0065	0.0634	0.0634
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0255	0.3149	0.4603
Loa Loa (eye worm)	cytochrome P450 family protein	0.0106	0.1177	0.1205
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0008	0.0008
Chlamydia trachomatis	phospholipase D endonuclease family protein	0.0018	0.0018	0.5
Schistosoma mansoni	inositol monophosphatase	0.004	0.0299	0.0299
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0104	0.1151	0.1151
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0227	0.2777	0.2854
Plasmodium vivax	cardiolipin synthetase, putative	0.0018	0.0018	0.0026
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0104	0.1151	0.1185
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0104	0.1151	0.1179
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.0008	0.0008
Echinococcus granulosus	dnaJ subfamily B	0.0458	0.5835	0.5835
Loa Loa (eye worm)	hypothetical protein	0.006	0.0567	0.0577
Schistosoma mansoni	zinc finger protein	0.0018	0.0018	0.0018
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.053	0.6785	1
Giardia lamblia	Proteasome subunit beta type 9 precursor	0.0104	0.1151	0.1637
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.053	0.6785	0.6986
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0286	0.0353
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0104	0.1151	0.1697
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0104	0.1151	0.1697
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0104	0.1151	0.1185
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0299	0.0308
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0157	0.0157
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.3601	0.5274
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0412	0.5221	0.7695
Onchocerca volvulus	Putative organic anion transporter	0.006	0.0567	0.0843
Brugia malayi	conserved hypotetical protein	0.0227	0.2777	0.2854
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0065	0.0634	0.0924
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0104	0.1151	0.1179
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0227	0.2777	0.4474
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0104	0.1151	0.1637
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0104	0.1151	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0481	0.6141	0.6321
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0065	0.0634	0.0934
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0104	0.1151	0.1185
Loa Loa (eye worm)	inositol-1	0.004	0.0299	0.0301
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0104	0.1151	0.1697
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0104	0.1151	0.1185
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0286	0.0286
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0307	0.0307
Schistosoma mansoni	cytochrome P450	0.0065	0.0634	0.0634
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0412	0.5221	0.5376
Toxoplasma gondii	isocitrate dehydrogenase	0.0018	0.0008	0.0011
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0065	0.0634	0.0934
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0048	0.0048
Echinococcus multilocularis	dnaJ subfamily B	0.0458	0.5835	0.5835
Echinococcus multilocularis	ecdysone induced protein 78C	0.0481	0.6141	0.6141
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0104	0.1151	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0903	0.0923
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0622	0.8007	0.8007
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.053	0.6785	0.6984
Giardia lamblia	Proteasome subunit beta type 3	0.0104	0.1151	0.1637
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0481	0.6141	0.6321
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0481	0.6141	0.6141
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0104	0.1151	0.1179
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0104	0.1151	0.1697
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0104	0.1151	0.1697
Brugia malayi	Cytochrome P450 family protein	0.0085	0.0902	0.0922
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0048	0.0049
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0008	0.0008
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0227	0.2777	0.2777
Echinococcus multilocularis	proteasome (prosome, macropain)	0.053	0.6785	0.6785
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0104	0.1151	0.1697
Echinococcus granulosus	Solute carrier organic anion transporter family	0.006	0.0567	0.0567
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0055	0.0055
Echinococcus granulosus	RUN	0.0021	0.0054	0.0054
Echinococcus multilocularis	phospholipase D1	0.0115	0.1298	0.1298
Brugia malayi	Proteasome subunit alpha type 7-1	0.0104	0.1151	0.1179
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0104	0.1151	0.1151
Schistosoma mansoni	cpg binding protein	0.0036	0.0254	0.0254
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.2285	0.332
Echinococcus granulosus	neuropeptide receptor A26	0.0518	0.6626	0.6626
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0104	0.1151	0.1697
Schistosoma mansoni	organic anion transporter	0.006	0.0567	0.0567
Leishmania major	cytochrome p450-like protein	0.0085	0.0902	0.0929
Brugia malayi	ecdysone receptor	0.0227	0.2777	0.2854
Brugia malayi	Proteasome A-type and B-type family protein	0.0104	0.1151	0.1179
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.0299	0.0299
Echinococcus multilocularis	proteasome subunit beta type 6	0.0104	0.1151	0.1151
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0065	0.0634	0.0934
Chlamydia trachomatis	phospholipase D superfamily protein	0.0018	0.0018	0.5
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0104	0.1151	0.1185
Leishmania major	proteasome beta 2 subunit, putative	0.0255	0.3149	0.3242
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.053	0.6785	0.6986
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0104	0.1151	0.1185
Brugia malayi	Cytochrome P450 family protein	0.0106	0.1177	0.1205
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0104	0.1151	0.1697
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0065	0.0634	0.0934
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0481	0.6141	0.6321
Brugia malayi	Nuclear hormone receptor-like 1	0.0481	0.6141	0.6321
Echinococcus multilocularis	isocitrate dehydrogenase	0.0018	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.006	0.0567	0.0577
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0104	0.1151	0.1185
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0286	0.0287
Echinococcus granulosus	proteasome subunit beta type 7	0.0104	0.1151	0.1151
Loa Loa (eye worm)	hypothetical protein	0.006	0.0567	0.0577
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.053	0.6785	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0481	0.6141	0.6321
Loa Loa (eye worm)	hypothetical protein	0.0384	0.4853	0.4993
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1936	0.1987
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0041	0.0315	0.0464
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0104	0.1151	0.1697
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0254	0.3137	0.3226
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.006	0.0567	0.0567
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0286	0.0353
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0104	0.1151	0.1637
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0315	0.0317
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0104	0.1151	0.1185
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0104	0.1151	0.1185
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0007	0.0007
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0048	0.0049
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0104	0.1151	0.1185
Brugia malayi	Phospholipase D. Active site motif family protein	0.004	0.0305	0.0307
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0104	0.1151	0.1151
Brugia malayi	hypothetical protein	0.0227	0.2777	0.2854
Schistosoma mansoni	nuclear receptor nhr-48	0.0227	0.2777	0.2777
Trypanosoma brucei	cardiolipin synthetase	0.004	0.0305	0.0314
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0104	0.1151	0.1697
Onchocerca volvulus		0.0039	0.0286	0.0381
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0286	0.0064
Trichomonas vaginalis	glucosylceramidase, putative	0.02	0.242	0.3521
Brugia malayi	Bromodomain containing protein	0.0046	0.0385	0.039
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0481	0.6141	0.6141
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0048	0.0071
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0104	0.1151	0.1637
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0227	0.2777	0.2854
Brugia malayi	prostaglandin transporter	0.006	0.0567	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0055	0.0049
Brugia malayi	Nuclear hormone receptor E75	0.0227	0.2777	0.2854
Loa Loa (eye worm)	hypothetical protein	0.0481	0.6141	0.6321
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Echinococcus granulosus	fetal alzheimer antigen falz	0.0029	0.0158	0.0158
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0286	0.041
Onchocerca volvulus		0.0029	0.0157	0.0169
Loa Loa (eye worm)	steroid hormone receptor	0.0481	0.6141	0.6321
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0041	0.0315	0.0317
Brugia malayi	orphan nuclear receptor NR2E1	0.0227	0.2777	0.2854
Schistosoma mansoni	bromodomain containing protein	0.0078	0.0809	0.0809
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.2285	0.332
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0286	0.041
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0021	0.0046	0.0046
Schistosoma mansoni	hypothetical protein	0.0141	0.1639	0.1639
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0104	0.1151	0.1151
Onchocerca volvulus		0.0032	0.0199	0.0238
Brugia malayi	proteasome subunit alpha type 2	0.0104	0.1151	0.1179
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0104	0.1151	0.1697
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0255	0.3149	0.3149
Schistosoma mansoni	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	0.0018	0.0018	0.0018
Trypanosoma brucei	phosphatidylglycerolphosphate synthase, mitochondrial	0.0018	0.0018	0.0018
Trypanosoma brucei	cardiolipin synthetase, putative	0.004	0.0305	0.0314
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0227	0.2777	0.2777
Loa Loa (eye worm)	hypothetical protein	0.0481	0.6141	0.6321
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0227	0.2777	0.2777
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2777	0.2854
Brugia malayi	nuclear receptor RXR	0.0254	0.3137	0.3226
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0041	0.0315	0.0464
Toxoplasma gondii	proteasome subunit	0.0104	0.1151	0.1697
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0041	0.0315	0.0317
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0018	0.0008	0.0008
Schistosoma mansoni	lipoxygenase	0.0089	0.0946	0.0946
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0048
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0289	0.3601	0.3703
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0021	0.0055	0.0055
Brugia malayi	proteasome subunit alpha type 6	0.0104	0.1151	0.1179
Brugia malayi	Phospholipase d protein 1	0.0115	0.1298	0.133
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0104	0.1151	0.1151
Brugia malayi	Bromodomain containing protein	0.0092	0.0996	0.1019
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0127	0.1451	0.1451
Entamoeba histolytica	hypothetical protein	0.004	0.0307	0.0452
Brugia malayi	Proteasome subunit alpha type 1	0.0104	0.1151	0.1179
Plasmodium vivax	proteasome subunit beta type-5, putative	0.053	0.6785	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.0348	0.0348
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0227	0.2777	0.2777
Schistosoma mansoni	retinoic acid receptor RXR	0.0592	0.7602	0.7602
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0104	0.1151	0.1185
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0141	0.1639	0.1639
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0104	0.1151	0.1697
Schistosoma mansoni	microtubule-associated protein tau	0.0773	1	1
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0065	0.0634	0.0924
Echinococcus granulosus	nuclear receptor nhr 48	0.0227	0.2777	0.2777
Trypanosoma cruzi	DNA polymerase eta, putative	0.0021	0.0048	0.0049
Mycobacterium leprae	probable proteasome (alpha subunit) PrcA	0.0104	0.1151	0.1387
Loa Loa (eye worm)	PAS-3 protein	0.0104	0.1151	0.1179
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.053	0.6785	0.6785
Echinococcus multilocularis	expressed protein	0.0041	0.0315	0.0315
Brugia malayi	tailless protein	0.0227	0.2777	0.2854
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.014	0.163	0.1678
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0065	0.0634	0.0934
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0048	0.0048
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0065	0.0634	0.0934
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0054	0.0054
Brugia malayi	nuclear hormone receptor	0.0481	0.6141	0.6321
Loa Loa (eye worm)	hypothetical protein	0.0028	0.015	0.0147
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0286	0.041
Echinococcus multilocularis	musashi	0.0029	0.0157	0.0157
Leishmania major	proteasome alpha 7 subunit, putative	0.0104	0.1151	0.1185
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0104	0.1151	0.1151
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0021	0.0048	0.0071
Loa Loa (eye worm)	PHD-finger family protein	0.0025	0.0103	0.0099
Toxoplasma gondii	ABC1 family protein	0.0039	0.0286	0.0421
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0255	0.3149	0.4641
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0104	0.1151	0.1185
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0766	0.0782
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0007
Echinococcus granulosus	geminin	0.019	0.2285	0.2285
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0104	0.1151	0.1697
Echinococcus multilocularis	geminin	0.019	0.2285	0.2285
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0018	0.0018
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0104	0.1151	0.1185
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3137	0.3226
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0104	0.1151	0.1697
Brugia malayi	photoreceptor-specific nuclear receptor	0.0481	0.6141	0.6321
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0048	0.0048
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0286	0.0286
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0104	0.1151	0.1697
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0104	0.1151	0.1151
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0104	0.1151	0.1151
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0065	0.0634	0.0924
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0104	0.1151	0.1185
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0286	0.0421
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0041	0.0315	0.0317
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.004	0.0299	0.2482
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.006	0.0567	0.0567
Schistosoma mansoni	cpg binding protein	0.0036	0.0254	0.0254
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0104	0.1151	0.1185
Trypanosoma cruzi	MFS transporter, putative	0.006	0.0567	0.0584
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0018	0.0008	0.0011
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0227	0.2777	0.2854
Onchocerca volvulus		0.0481	0.6141	1
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0751	0.9711	1
Echinococcus multilocularis		0.0065	0.0634	0.0634
Echinococcus granulosus	thyroid hormone receptor alpha	0.0227	0.2777	0.2777
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0104	0.1151	0.1185
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0481	0.6141	0.6141
Echinococcus multilocularis	dna polymerase eta	0.0021	0.0048	0.0048
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0104	0.1151	0.1151
Brugia malayi	hypothetical protein	0.006	0.0567	0.0577
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0018	0.0018
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0255	0.3149	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0315	0.0317
Echinococcus multilocularis	neuropeptide s receptor	0.0518	0.6626	0.6626
Echinococcus multilocularis	proteasome subunit beta type 7	0.0104	0.1151	0.1151
Onchocerca volvulus		0.006	0.0567	0.0843
Entamoeba histolytica	hypothetical protein	0.004	0.0307	0.0452
Leishmania major	proteasome alpha 1 subunit, putative	0.0104	0.1151	0.1185
Loa Loa (eye worm)	hypothetical protein	0.002	0.0042	0.0035
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0247	0.3046	0.4483
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0157	0.0154
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0104	0.1151	0.1185
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0104	0.1151	0.1185
Schistosoma mansoni	nuclear receptor	0.0227	0.2777	0.2777
Brugia malayi	Steroid receptor seven-up type 2	0.0481	0.6141	0.6321
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0424	0.0424
Brugia malayi	beta-lactamase	0.0039	0.0286	0.0287
Brugia malayi	steroid hormone receptor	0.0481	0.6141	0.6321
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0065	0.0634	0.0924
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.3601	0.5274
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0104	0.1151	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0018	0.0008	0.0008
Schistosoma mansoni	thyroid hormone receptor	0.0622	0.8007	0.8007
Brugia malayi	nuclear receptor NHR-88	0.0227	0.2777	0.2854
Echinococcus granulosus	follistatin	0.0041	0.0315	0.0315
Echinococcus multilocularis	zinc finger protein	0.0025	0.011	0.011
Onchocerca volvulus	Putative phospholipase D	0.0022	0.0061	0.0012
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0227	0.2777	0.2777
Loa Loa (eye worm)	hypothetical protein	0.0481	0.6141	0.6321
Leishmania major	cardiolipin synthetase, putative	0.0018	0.0018	0.0018
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0104	0.1151	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0751	0.9711	1
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0104	0.1151	0.1151
Loa Loa (eye worm)	hypothetical protein	0.006	0.0567	0.0577
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0104	0.1151	0.1637
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0104	0.1151	0.1185
Brugia malayi	nuclear hormone receptor family member odr-7	0.0227	0.2777	0.2854
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0424	0.0424
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0104	0.1151	0.1185
Loa Loa (eye worm)	cytochrome P450	0.0065	0.0634	0.0646
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0104	0.1151	0.1185
Leishmania major	proteasome alpha 7 subunit, putative	0.0104	0.1151	0.1185
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2777	0.2854
Giardia lamblia	20S proteasome alpha subunit 3	0.0104	0.1151	0.1637
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.0008	0.0008
Brugia malayi	proteasome subunit beta type 2	0.0255	0.3149	0.3237
Brugia malayi	beta-lactamase family protein	0.0039	0.0286	0.0287
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0104	0.1151	0.1179
Trypanosoma brucei	cytochrome P450, putative	0.0085	0.0902	0.0929
Brugia malayi	nuclear receptor NHR-88	0.0481	0.6141	0.6321
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Toxoplasma gondii	proteasome beta subunit	0.0104	0.1151	0.1697
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0286	0.0421
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0286	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0315	0.0317
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0065	0.0634	0.0934
Echinococcus multilocularis	cpg binding protein	0.0036	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0386	0.0391
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.0299	0.0299
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0074	0.0752	0.0752
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0104	0.1151	0.1179
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0286	0.0287
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0481	0.6141	0.6141
Trypanosoma brucei	DNA polymerase eta, putative	0.0021	0.0048	0.0049
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0104	0.1151	0.1697
Toxoplasma gondii	transporter, major facilitator family protein	0.006	0.0567	0.0835
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0065	0.0634	0.0924
Leishmania major	cytochrome p450-like protein	0.0065	0.0634	0.0653
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0255	0.3149	0.3237
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0286	0.0287
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0104	0.1151	0.1697
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0104	0.1151	0.1185
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0064	0.0618	0.091
Echinococcus multilocularis	agrin	0.0041	0.0315	0.0315
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0286	0.041
Brugia malayi	hypothetical protein	0.0018	0.0018	0.0011
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0048	0.0048
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.2285	0.332
Echinococcus granulosus	lamin	0.0029	0.0157	0.0157
Schistosoma mansoni	phospholipase D	0.0115	0.1298	0.1298
Schistosoma mansoni	lamin	0.0029	0.0157	0.0157
Schistosoma mansoni	hypothetical protein	0.004	0.0307	0.0307
Giardia lamblia	20S proteasome alpha subunit 5	0.0104	0.1151	0.1637
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0104	0.1151	0.1185
Brugia malayi	hypothetical protein	0.0021	0.0054	0.0048
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0041	0.0315	0.0317
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0104	0.1151	0.1637
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0065	0.0634	0.0934
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0104	0.1151	0.1697
Loa Loa (eye worm)	bromodomain containing protein	0.0021	0.0056	0.005
Entamoeba histolytica	hypothetical protein	0.004	0.0307	0.0452
Leishmania major	proteasome beta 7 subunit, putative	0.0104	0.1151	0.1185
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0412	0.5221	0.5221
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0048	0.0042
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0104	0.1151	0.1637
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0048	0.0071
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0065	0.0634	0.0934
Brugia malayi	nuclear receptor RXR	0.0227	0.2777	0.2854
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0227	0.2777	0.2777
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0065	0.0634	0.0924
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0055	0.0055
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0065	0.0634	0.0924
Giardia lamblia	20S proteasome alpha subunit 2	0.0104	0.1151	0.1637
Toxoplasma gondii	heat shock protein hslv, putative	0.0104	0.1151	0.1697
Chlamydia trachomatis	phospholipase D endonuclease family protein	0.0018	0.0018	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0481	0.6141	0.6321
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.053	0.6785	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.0676	0.0676
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0048	0.0042
Leishmania major	hypothetical protein, conserved	0.0018	0.0018	0.0018
Schistosoma mansoni	nuclear hormone receptor	0.0227	0.2777	0.2777
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0424	0.0424
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0278	0.028
Schistosoma mansoni	zinc finger protein	0.0227	0.2777	0.2777
Echinococcus granulosus	Proteasome subunit alpha beta	0.0104	0.1151	0.1151
Brugia malayi	Nuclear hormone receptor-like 1	0.0254	0.3137	0.3226
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0104	0.1151	0.1151
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0481	0.6141	0.6321
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0104	0.1151	0.1697
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0104	0.1151	0.1151
Schistosoma mansoni	hypothetical protein	0.0458	0.5835	0.5835
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2777	0.2854
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0065	0.0634	0.0924
Trichomonas vaginalis	glucosylceramidase, putative	0.02	0.242	0.3521
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0065	0.0634	0.0924
Brugia malayi	SPARC precursor	0.0041	0.0315	0.0317
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.3601	0.5274
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0104	0.1151	0.1179
Brugia malayi	PHD-finger family protein	0.0032	0.0196	0.0194
Schistosoma mansoni	loxhd1	0.0021	0.0054	0.0054
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0289	0.3601	0.3703
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0065	0.0634	0.0934
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0085	0.0902	0.1329
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0104	0.1151	0.1697
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0481	0.6141	0.6321
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0041	0.0315	0.0464
Echinococcus granulosus	GPCR family 2	0.0018	0.0007	0.0007
Leishmania major	hypothetical protein, conserved	0.014	0.163	0.1678
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2777	0.2854
Schistosoma mansoni	nuclear hormone receptor	0.0481	0.6141	0.6141
Echinococcus granulosus	phospholipase D1	0.0115	0.1298	0.1298
Echinococcus granulosus	proteasome subunit beta t family	0.0104	0.1151	0.1151
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0481	0.6141	0.6321
Brugia malayi	proteasome subunit beta type 1	0.0412	0.5221	0.5372
Plasmodium falciparum	LCCL domain-containing protein	0.0021	0.0054	0.008
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0481	0.6141	0.6141
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.2285	0.332
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0104	0.1151	0.1151
Schistosoma mansoni	nuclear receptor	0.0227	0.2777	0.2777
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0227	0.2777	0.2777
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0104	0.1151	0.1697
Brugia malayi	Protein K4	0.0018	0.0018	0.0011
Trypanosoma cruzi	cytochrome P450, putative	0.0085	0.0902	0.0929
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0481	0.6141	0.6321
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.053	0.6785	0.6986
Trichomonas vaginalis	inositol monophosphatase, putative	0.004	0.0299	0.0372
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0104	0.1151	0.1697
Echinococcus granulosus	histone lysine methyltransferase setb	0.0021	0.0055	0.0055
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0065	0.0634	0.0934
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0286	0.0287
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0104	0.1151	0.1151
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0007
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0286	0.0294
Trypanosoma cruzi	Emopamil binding protein, putative	0.014	0.163	0.1678
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0481	0.6141	0.6141
Brugia malayi	Nuclear hormone receptor E75	0.0227	0.2777	0.2854
Echinococcus multilocularis	phospholipase D	0.0102	0.112	0.112
Plasmodium vivax	multidomain scavenger receptor, putative	0.0021	0.0054	0.008
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0018	0.0008	0.0011
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0481	0.6141	0.6321
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0104	0.1151	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0278	0.028
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0286	0.041
Brugia malayi	nuclear hormone receptor	0.0227	0.2777	0.2854
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0104	0.1151	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0717	0.0731
Mycobacterium leprae	putative cytochrome p450	0.0065	0.0634	0.0596
Onchocerca volvulus		0.006	0.0567	0.0843
Mycobacterium ulcerans	lipase LipD	0.0039	0.0286	0.0421
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0021	0.0046	0.0046
Entamoeba histolytica	phospholipase D, putative	0.0115	0.1298	0.1913
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0286	0.0287
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.0299	0.0441
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0065	0.0634	0.0924
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0157	0.0154
Trypanosoma brucei	proteasome alpha 7 subunit	0.0104	0.1151	0.1185
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.004	0.0299	0.0441
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0007	0.0007
Brugia malayi	proteasome subunit alpha type 1	0.0104	0.1151	0.1179
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0065	0.0634	0.0653
Echinococcus granulosus	FTZ F1 alpha	0.0481	0.6141	0.6141
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0286	0.0421
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0751	0.9711	1
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0412	0.5221	0.7695
Brugia malayi	Nuclear hormone receptor-like 1	0.0254	0.3137	0.3226
Echinococcus granulosus	ecdysone induced protein 78C	0.0481	0.6141	0.6141
Echinococcus granulosus	proteasome subunit alpha type 2	0.0104	0.1151	0.1151
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0104	0.1151	0.1697
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0424	0.0424
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0307	0.0307
Giardia lamblia	20S proteasome alpha subunit 4	0.0104	0.1151	0.1637
Brugia malayi	Doublecortin family protein	0.0021	0.0054	0.0048
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0104	0.1151	0.1179
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.014	0.163	0.1678
Leishmania major	proteasome beta-1 subunit, putative	0.0104	0.1151	0.1185
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0286	0.0294
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0227	0.2777	0.2777
Onchocerca volvulus	Notchless protein homolog	0.0104	0.1151	0.1802
Trypanosoma brucei	unspecified product	0.0021	0.0048	0.0049
Trypanosoma cruzi	Emopamil binding protein, putative	0.014	0.163	0.1678
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0104	0.1151	0.1185
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0255	0.3149	0.4641
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0104	0.1151	0.1185
Echinococcus multilocularis	neuropeptide receptor A26	0.0518	0.6626	0.6626
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0104	0.1151	0.1179
Schistosoma mansoni	RAR-like nuclear receptor	0.0481	0.6141	0.6141
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0424	0.043
Echinococcus granulosus	proteasome prosome macropain	0.053	0.6785	0.6785
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0481	0.6141	0.6321
Echinococcus granulosus	proteasome subunit beta type 6	0.0104	0.1151	0.1151
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0286	0.0287
Onchocerca volvulus		0.0039	0.0286	0.0381
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0048	0.0048
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0512	0.052
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0481	0.6141	0.6141
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0481	0.6141	0.6141
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0104	0.1151	0.1185
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0029	0.0158	0.0158
Toxoplasma gondii	phospholipase D active site domain-containing protein	0.004	0.0305	0.045
Giardia lamblia	20S proteasome alpha subunit 7	0.0104	0.1151	0.1637
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0104	0.1151	0.1697
Echinococcus granulosus	neuropeptide s receptor	0.0518	0.6626	0.6626
Onchocerca volvulus	Protein ultraspiracle homolog	0.0481	0.6141	1
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0008	0.0008
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0041	0.0315	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1054	0.1078
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0412	0.5221	0.5221
Echinococcus multilocularis	nuclear receptor nhr 48	0.0227	0.2777	0.2777
Loa Loa (eye worm)	hypothetical protein	0.0481	0.6141	0.6321
Schistosoma mansoni	rab6-interacting	0.0021	0.0054	0.0054
Mycobacterium ulcerans	proteasome PrcA	0.0104	0.1151	0.1697
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0104	0.1151	0.1185
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0104	0.1151	0.1151
Echinococcus multilocularis	lamin	0.0029	0.0157	0.0157
Brugia malayi	Cytochrome P450 family protein	0.0085	0.0902	0.0922
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0481	0.6141	0.6141
Loa Loa (eye worm)	hypothetical protein	0.0481	0.6141	0.6321
Onchocerca volvulus	Bile acid receptor homolog	0.0481	0.6141	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0157	0.0154
Schistosoma mansoni	thyroid hormone receptor	0.0622	0.8007	0.8007
Echinococcus multilocularis	microtubule associated protein 2	0.0773	1	1
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0104	0.1151	0.1697
Schistosoma mansoni	hypothetical protein	0.0018	0.0018	0.0018
Onchocerca volvulus		0.0227	0.2777	0.4474
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0048	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0667	0.068
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0412	0.5221	0.7695
Echinococcus granulosus	zinc finger protein	0.0025	0.011	0.011
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0481	0.6141	0.6321
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0286	0.041
Echinococcus granulosus	agrin	0.0041	0.0315	0.0315
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0286	0.0286
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0286	0.041
Trypanosoma brucei	ISWI complex protein	0.0018	0.0018	0.0018
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0255	0.3149	0.4641
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0104	0.1151	0.1151
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0065	0.0634	0.0934
Loa Loa (eye worm)	hypothetical protein	0.006	0.0567	0.0577
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0481	0.6141	0.6141
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0141	0.1639	0.1639
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2777	0.2854
Plasmodium vivax	phosphatidylglycerophosphate synthase, putative	0.0018	0.0018	0.0026
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0255	0.3149	0.4603
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0065	0.0634	0.0934
Onchocerca volvulus		0.0071	0.0717	0.1089
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0104	0.1151	0.1697
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0065	0.0634	0.0653
Brugia malayi	sodium-independent organic anion transporter family protein	0.006	0.0567	0.0577
Echinococcus multilocularis	lamin dm0	0.0029	0.0157	0.0157
Brugia malayi	hypothetical protein	0.0254	0.3137	0.3226
Schistosoma mansoni	hypothetical protein	0.0021	0.0054	0.0054
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0104	0.1151	0.1697
Onchocerca volvulus	Putative organic anion transporter	0.006	0.0567	0.0843
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0104	0.1151	0.1185
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0104	0.1151	0.1185
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0481	0.6141	0.6321
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0036	0.0244	0.0349
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0007	0.0007
Chlamydia trachomatis	phospholipase D superfamily protein	0.0018	0.0018	0.5
Onchocerca volvulus		0.014	0.163	0.2589
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3137	0.3226
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0065	0.0634	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2777	0.2854
Chlamydia trachomatis	phospholipase D endonuclease family protein	0.0018	0.0018	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0065	0.0634	0.0924
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0481	0.6141	0.6141
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0008	0.0008
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0021	0.0046	0.0046
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0255	0.3149	0.3149
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.053	0.6785	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0127	0.1451	0.1451
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0481	0.6141	0.6141
Leishmania major	proteasome alpha 2 subunit, putative	0.0104	0.1151	0.1185
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0481	0.6141	0.6141
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0227	0.2777	0.2854
Echinococcus granulosus	Polycystic kidney disease protein	0.0021	0.0054	0.0054
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0104	0.1151	0.1151
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.0348	0.0348
Plasmodium falciparum	proteasome subunit beta type-5	0.053	0.6785	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0481	0.6141	0.6141
Trypanosoma brucei	proteasome beta 6 subunit	0.0412	0.5221	0.5376
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0104	0.1151	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0286	0.0287
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0424	0.043
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0286	0.041
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0065	0.0634	0.0934
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0307	0.0307
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0041	0.0315	0.0317
Echinococcus multilocularis	RUN	0.0021	0.0054	0.0054
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0065	0.0634	0.0924
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0104	0.1151	0.1697
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0104	0.1151	0.1697
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.3601	0.5274
Loa Loa (eye worm)	hypothetical protein	0.006	0.0567	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2777	0.2854
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0104	0.1151	0.1151
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0104	0.1151	0.1697
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0104	0.1151	0.1697
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0412	0.5221	0.5376
Brugia malayi	beta-lactamase family protein	0.0039	0.0286	0.0287
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0481	0.6141	0.6141
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0104	0.1151	0.1179
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2777	0.2854
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0412	0.5221	0.7678
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0286	0.041
Brugia malayi	proteasome subunit beta type 3	0.0104	0.1151	0.1179
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0104	0.1151	0.1185
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1054	0.1078
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0018	0.0008	0.0008
Trypanosoma cruzi	cardiolipin synthetase, putative	0.004	0.0305	0.0314
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0481	0.6141	0.6321
Schistosoma mansoni	rab6-interacting	0.0021	0.0054	0.0054
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0104	0.1151	0.1637
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0286	0.0421
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Loa Loa (eye worm)	hypothetical protein	0.006	0.0567	0.0577
Schistosoma mansoni	lamin	0.0029	0.0157	0.0157
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0104	0.1151	0.1697
Brugia malayi	ecdysteroid receptor	0.0481	0.6141	0.6321
Brugia malayi	20S proteasome alpha5 subunit	0.0104	0.1151	0.1179
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0074	0.0752	0.0752
Leishmania major	hypothetical protein, conserved	0.0039	0.0286	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0479	0.0486
Brugia malayi	hypothetical protein	0.006	0.0567	0.0577
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0065	0.0634	0.0924
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0007	0.0007
Echinococcus granulosus	dna polymerase eta	0.0021	0.0048	0.0048
Schistosoma mansoni	DNA polymerase eta	0.0021	0.0048	0.0048
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0412	0.5221	0.5372
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0592	0.7602	0.7602
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0104	0.1151	0.1185
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0286	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2777	0.2854
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0104	0.1151	0.1151
Brugia malayi	intermediate filament protein	0.0029	0.0157	0.0154
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0286	0.0064
Brugia malayi	GYF domain containing protein	0.0071	0.0717	0.0731
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0299	0.0308
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0481	0.6141	0.6321
Leishmania major	proteasome alpha 3 subunit, putative	0.0104	0.1151	0.1185
Schistosoma mansoni	hypothetical protein	0.0038	0.0278	0.0278
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0286	0.041
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.014	0.163	0.1678
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0065	0.0634	0.0934
Schistosoma mansoni	hypothetical protein	0.019	0.2285	0.2285
Brugia malayi	hypothetical protein	0.0021	0.0054	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2777	0.2854
Brugia malayi	Proteasome A-type and B-type family protein	0.053	0.6785	0.6984
Echinococcus granulosus	lamin dm0	0.0029	0.0157	0.0157
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0104	0.1151	0.1179
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0065	0.0634	0.0934
Giardia lamblia	20S proteasome alpha subunit 1	0.0104	0.1151	0.1637
Giardia lamblia	20S proteasome alpha subunit 6	0.0104	0.1151	0.1637
Plasmodium falciparum	mitochondrial cardiolipin synthase, putative	0.0018	0.0018	0.0026
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Schistosoma mansoni	nuclear hormone receptor	0.0227	0.2777	0.2777
Loa Loa (eye worm)	hypothetical protein	0.0481	0.6141	0.6321
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0104	0.1151	0.1185
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0512	0.052
Schistosoma mansoni	lipoxygenase	0.0127	0.1451	0.1451
Leishmania major	proteasome alpha 1 subunit, putative	0.0104	0.1151	0.1185
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0481	0.6141	0.6141
Echinococcus multilocularis	follistatin	0.0041	0.0315	0.0315
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0481	0.6141	0.6321
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.2285	0.332
Echinococcus granulosus	cpg binding protein	0.0036	0.0254	0.0254
Leishmania major	C-8 sterol isomerase-like protein	0.0751	0.9711	1
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0065	0.0634	0.0924
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0104	0.1151	0.1185
Loa Loa (eye worm)	cytochrome P450 family protein	0.0085	0.0902	0.0922
Chlamydia trachomatis	phospholipase D endonuclease family protein	0.0018	0.0018	0.5
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0104	0.1151	0.1185
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0104	0.1151	0.1637
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0104	0.1151	0.1697
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0227	0.2777	0.4474
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0254	0.3137	0.3137
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0299	0.0308
Brugia malayi	Inositol-1	0.004	0.0299	0.0301
Loa Loa (eye worm)	CYP4Cod1	0.0085	0.0902	0.0922
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0065	0.0634	0.0653
Schistosoma mansoni	hypothetical protein	0.019	0.2285	0.2285
Schistosoma mansoni	inositol monophosphatase	0.004	0.0299	0.0299
Entamoeba histolytica	hypothetical protein	0.004	0.0307	0.0452
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0104	0.1151	0.1637
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0254	0.3137	0.3137
Mycobacterium ulcerans	proteasome PrcB	0.053	0.6785	1
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0104	0.1151	0.1151
Echinococcus multilocularis	FTZ F1 alpha	0.0481	0.6141	0.6141
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0481	0.6141	0.6321
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0104	0.1151	0.1637
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0512	0.052
Schistosoma mansoni	agrin	0.0041	0.0315	0.0315
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0104	0.1151	0.1151
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0065	0.0634	0.0934
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0048	0.0049
Trypanosoma brucei	proteasome beta 7 subunit	0.0104	0.1151	0.1185
Schistosoma mansoni	follistatin	0.0041	0.0315	0.0315
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0048	0.0048
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0481	0.6141	0.6141
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0048	0.006
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0065	0.0634	0.0934
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Leishmania major	DNA polymerase eta, putative	0.0021	0.0048	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2777	0.2854
Schistosoma mansoni	zinc finger protein	0.0025	0.011	0.011
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0255	0.3149	0.3242
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0104	0.1151	0.1637
Mycobacterium leprae	Conserved hypothetical protein	0.0065	0.0634	0.0596
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0065	0.0634	0.0924
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0481	0.6141	1
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0104	0.1151	0.1151
Echinococcus multilocularis	Polycystic kidney disease protein	0.0021	0.0054	0.0054
Giardia lamblia	Proteasome subunit beta type 2	0.0255	0.3149	0.4603
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0048	0.0049
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0104	0.1151	0.1697
Onchocerca volvulus	Putative organic anion transporter	0.006	0.0567	0.0843
Brugia malayi	hypothetical protein	0.0227	0.2777	0.2854
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0018	0.0011
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.053	0.6785	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0424	0.043
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0065	0.0634	0.0924
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0254	0.3137	0.3137
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0104	0.1151	0.1151
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0104	0.1151	0.1151
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0048	0.006
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0054	0.0054
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0286	0.0294
Leishmania major	proteasome beta 5 subunit, putative	0.053	0.6785	0.6986
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0481	0.6141	0.6141
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0048
Trichomonas vaginalis	glucosylceramidase, putative	0.019	0.2285	0.332
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0104	0.1151	0.1185
Toxoplasma gondii	proteasome subunit beta type, putative	0.053	0.6785	1
Brugia malayi	Phospholipase D. Active site motif family protein	0.0022	0.0061	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3137	0.3226
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0104	0.1151	0.1185
Trichomonas vaginalis	glucosylceramidase, putative	0.0289	0.3601	0.5274
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0007
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0029	0.0158	0.0158
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0424	0.0424
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.004	0.0299	0.0441
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0254	0.3137	0.3137
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0299	0.0308
Trypanosoma cruzi	cytochrome P450, putative	0.0085	0.0902	0.0929
Toxoplasma gondii	isocitrate dehydrogenase	0.0018	0.0008	0.0011
Onchocerca volvulus		0.0039	0.0286	0.0381
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0065	0.0634	0.0653
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0299	0.0372
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.006	0.0567	0.0567
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0104	0.1151	0.1151
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0227	0.2777	0.2777
Schistosoma mansoni	hypothetical protein	0.0025	0.0103	0.0103
Schistosoma mansoni	polycystin 1-related	0.0021	0.0054	0.0054
Brugia malayi	Proteasome A-type and B-type family protein	0.0104	0.1151	0.1179
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0286	0.0353
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0299	0.0372
Trypanosoma cruzi	cardiolipin synthetase, putative	0.004	0.0305	0.0314
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0199	0.0198
Brugia malayi	cytochrome P450	0.0065	0.0634	0.0646
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0065	0.0634	0.0924
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0104	0.1151	0.1697
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0157	0.0154
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0286	0.0353
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0048	0.0042
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0751	0.9711	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0227	0.2777	0.2854
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0104	0.1151	0.1185
Entamoeba histolytica	phospholipase D, putative	0.0115	0.1298	0.1913
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0286	0.0286
Onchocerca volvulus		0.006	0.0567	0.0843
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0481	0.6141	0.6321
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0065	0.0634	0.0924
Echinococcus granulosus	phospholipase D	0.0102	0.112	0.112
Echinococcus granulosus	intermediate filament protein	0.0029	0.0157	0.0157

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (binding)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1433917
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 824842