Detailed information for compound 824842

Basic information

Technical information
  • TDR Targets ID: 824842
  • Name: N-(3-chlorophenyl)-2-[6-ethoxy-3-(4-ethylbenz oyl)-4-oxoquinolin-1-yl]acetamide
  • MW: 488.962 | Formula: C28H25ClN2O4
  • H donors: 1 H acceptors: 3 LogP: 5.91 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc2c(c1)c(=O)c(cn2CC(=O)Nc1cccc(c1)Cl)C(=O)c1ccc(cc1)CC
  • InChi: 1S/C28H25ClN2O4/c1-3-18-8-10-19(11-9-18)27(33)24-16-31(17-26(32)30-21-7-5-6-20(29)14-21)25-13-12-22(35-4-2)15-23(25)28(24)34/h5-16H,3-4,17H2,1-2H3,(H,30,32)
  • InChiKey: DSGTWUQZWYKJAJ-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(3-chlorophenyl)-2-[6-ethoxy-3-(4-ethylbenzoyl)-4-oxo-1-quinolyl]acetamide
  • N-(3-chlorophenyl)-2-[6-ethoxy-3-[(4-ethylphenyl)-oxomethyl]-4-oxo-1-quinolyl]acetamide
  • N-(3-chlorophenyl)-2-[6-ethoxy-3-(4-ethylbenzoyl)-4-keto-1-quinolyl]acetamide
  • N-(3-chlorophenyl)-2-[6-ethoxy-3-(4-ethylphenyl)carbonyl-4-oxo-quinolin-1-yl]ethanamide
  • C647-1039
  • NCGC00111201-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0104 0.1151 0.1179
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0227 0.2777 0.2777
Loa Loa (eye worm) hypothetical protein 0.0075 0.0766 0.0782
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0104 0.1151 0.1151
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0286 0.0286
Schistosoma mansoni hypothetical protein 0.0018 0.0007 0.0007
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0018 0.0018 0.5
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0337 0.4238 0.4238
Brugia malayi intermediate filament protein 0.0029 0.0157 0.0154
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0065 0.0634 0.0653
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0008 0.0008
Mycobacterium ulcerans lipase LipD 0.0039 0.0286 0.0421
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0065 0.0634 0.0924
Loa Loa (eye worm) hypothetical protein 0.0227 0.2777 0.2854
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0481 0.6141 0.6321
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.006 0.0567 0.0567
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0054 0.008
Giardia lamblia 20S proteasome alpha subunit 6 0.0104 0.1151 0.1637
Echinococcus multilocularis zinc finger protein 0.0025 0.011 0.011
Plasmodium vivax proteasome subunit beta type-3, putative 0.0104 0.1151 0.1697
Loa Loa (eye worm) cytochrome P450 family protein 0.0085 0.0902 0.0922
Entamoeba histolytica hypothetical protein 0.004 0.0307 0.0452
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0157 0.0154
Brugia malayi CXXC zinc finger family protein 0.0032 0.0199 0.0198
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0104 0.1151 0.1185
Onchocerca volvulus 0.0029 0.0157 0.0169
Brugia malayi Phospholipase D. Active site motif family protein 0.004 0.0305 0.0307
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0104 0.1151 0.1185
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0104 0.1151 0.1151
Schistosoma mansoni lamin 0.0029 0.0157 0.0157
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0315 0.0464
Echinococcus granulosus Solute carrier organic anion transporter family 0.006 0.0567 0.0567
Brugia malayi Nuclear hormone receptor E75 0.0227 0.2777 0.2854
Echinococcus granulosus geminin 0.019 0.2285 0.2285
Echinococcus multilocularis proteasome subunit alpha type 2 0.0104 0.1151 0.1151
Brugia malayi hypothetical protein 0.0254 0.3137 0.3226
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0104 0.1151 0.1697
Echinococcus granulosus neuropeptide receptor A26 0.0518 0.6626 0.6626
Mycobacterium tuberculosis Conserved protein 0.0039 0.0286 0.041
Schistosoma mansoni cpg binding protein 0.0036 0.0254 0.0254
Echinococcus granulosus proteasome subunit beta t family 0.0104 0.1151 0.1151
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0286 0.0287
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0286 0.041
Trypanosoma cruzi cardiolipin synthetase, putative 0.004 0.0305 0.0314
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0048 0.0071
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0104 0.1151 0.1697
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0065 0.0634 0.0924
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0008 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0065 0.0634 0.0924
Schistosoma mansoni hypothetical protein 0.0018 0.0007 0.0007
Trypanosoma cruzi Emopamil binding protein, putative 0.014 0.163 0.1678
Echinococcus multilocularis phospholipase d3 0.0022 0.0061 0.0061
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0104 0.1151 0.1185
Schistosoma mansoni agrin 0.0041 0.0315 0.0315
Echinococcus granulosus cytochrome P450 2K1 0.0065 0.0634 0.0634
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0048 0.0071
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0104 0.1151 0.1387
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0104 0.1151 0.1185
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0104 0.1151 0.1637
Brugia malayi Phospholipase d protein 1 0.0115 0.1298 0.133
Echinococcus granulosus subfamily T1A non peptidase ue 0.0104 0.1151 0.1151
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0065 0.0634 0.0924
Brugia malayi Protein K4 0.0018 0.0018 0.0011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0007 0.0007
Loa Loa (eye worm) cytochrome P450 0.0065 0.0634 0.0646
Onchocerca volvulus 0.0481 0.6141 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0227 0.2777 0.2854
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0104 0.1151 0.1697
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0481 0.6141 0.6321
Onchocerca volvulus 0.006 0.0567 0.0843
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0008 0.0008
Trypanosoma brucei cytochrome P450, putative 0.0085 0.0902 0.0929
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0104 0.1151 0.1637
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0299 0.0372
Trypanosoma cruzi MFS transporter, putative 0.006 0.0567 0.0584
Leishmania major DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0065 0.0634 0.0934
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0157 0.0154
Brugia malayi Inositol-1 0.004 0.0299 0.0301
Brugia malayi nuclear receptor RXR 0.0227 0.2777 0.2854
Trypanosoma cruzi cytochrome P450, putative 0.0085 0.0902 0.0929
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0054 0.0054
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0286 0.041
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0048 0.006
Leishmania major cytochrome p450-like protein 0.0085 0.0902 0.0929
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0255 0.3149 0.3149
Brugia malayi Proteasome A-type and B-type family protein 0.0104 0.1151 0.1179
Toxoplasma gondii proteasome beta subunit 0.0104 0.1151 0.1697
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0158 0.0158
Brugia malayi Cytochrome P450 family protein 0.0085 0.0902 0.0922
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0065 0.0634 0.0934
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0104 0.1151 0.1185
Loa Loa (eye worm) hypothetical protein 0.0384 0.4853 0.4993
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0104 0.1151 0.1185
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0104 0.1151 0.1151
Loa Loa (eye worm) hypothetical protein 0.0021 0.0048 0.0042
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0046 0.0046
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0481 0.6141 0.6141
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0127 0.1451 0.1451
Brugia malayi tailless protein 0.0227 0.2777 0.2854
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0048
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0104 0.1151 0.1697
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0104 0.1151 0.1697
Echinococcus granulosus phospholipase d3 0.0022 0.0061 0.0061
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3601 0.5274
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0085 0.0902 0.1329
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0104 0.1151 0.1185
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0104 0.1151 0.1185
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0104 0.1151 0.1697
Brugia malayi hypothetical protein 0.006 0.0567 0.0577
Plasmodium falciparum proteasome subunit beta type-5 0.053 0.6785 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.053 0.6785 0.6986
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0104 0.1151 0.1637
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0104 0.1151 0.1637
Toxoplasma gondii protease inhibitor PI2 0.0041 0.0315 0.0464
Schistosoma mansoni nuclear receptor 0.0227 0.2777 0.2777
Brugia malayi proteasome subunit alpha type 6 0.0104 0.1151 0.1179
Loa Loa (eye worm) hypothetical protein 0.006 0.0567 0.0577
Giardia lamblia 20S proteasome alpha subunit 2 0.0104 0.1151 0.1637
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.053 0.6785 1
Schistosoma mansoni RAR-like nuclear receptor 0.0481 0.6141 0.6141
Echinococcus granulosus agrin 0.0041 0.0315 0.0315
Onchocerca volvulus Protein ultraspiracle homolog 0.0481 0.6141 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0424 0.0424
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.053 0.6785 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0104 0.1151 0.1637
Echinococcus multilocularis lamin 0.0029 0.0157 0.0157
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0676 0.0676
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0315 0.0317
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0065 0.0634 0.0924
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0104 0.1151 0.1185
Loa Loa (eye worm) hypothetical protein 0.0053 0.0479 0.0486
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0104 0.1151 0.1151
Brugia malayi Proteasome subunit alpha type 7-1 0.0104 0.1151 0.1179
Schistosoma mansoni hypothetical protein 0.0018 0.0018 0.0018
Schistosoma mansoni nuclear hormone receptor 0.0227 0.2777 0.2777
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0299 0.0299
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0751 0.9711 1
Echinococcus granulosus cpg binding protein 0.0036 0.0254 0.0254
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0412 0.5221 0.7695
Onchocerca volvulus Glucosylceramidase homolog 0.019 0.2285 0.3665
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0104 0.1151 0.1697
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3601 0.5274
Schistosoma mansoni rab6-interacting 0.0021 0.0054 0.0054
Schistosoma mansoni nuclear hormone receptor 0.0227 0.2777 0.2777
Echinococcus granulosus phospholipase D 0.0102 0.112 0.112
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0104 0.1151 0.1151
Onchocerca volvulus Notchless protein homolog 0.0104 0.1151 0.1802
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0104 0.1151 0.1697
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0286 0.0294
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0104 0.1151 0.1697
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0018 0.0018 0.5
Loa Loa (eye worm) CYP4Cod1 0.0085 0.0902 0.0922
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0104 0.1151 0.1697
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0055
Echinococcus granulosus nuclear receptor nhr 48 0.0227 0.2777 0.2777
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0244 0.0349
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0254 0.3137 0.3137
Schistosoma mansoni polycystin 1-related 0.0021 0.0054 0.0054
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0065 0.0634 0.0934
Schistosoma mansoni hypothetical protein 0.019 0.2285 0.2285
Echinococcus multilocularis dna polymerase eta 0.0021 0.0048 0.0048
Chlamydia trachomatis phospholipase D superfamily protein 0.0018 0.0018 0.5
Loa Loa (eye worm) hypothetical protein 0.0481 0.6141 0.6321
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0255 0.3149 0.4603
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0008 0.0008
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0048 0.0042
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0307 0.0307
Trypanosoma brucei cardiolipin synthetase 0.004 0.0305 0.0314
Echinococcus granulosus phospholipase D1 0.0115 0.1298 0.1298
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0299 0.0308
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0048
Schistosoma mansoni lamin 0.0029 0.0157 0.0157
Brugia malayi Cytochrome P450 family protein 0.0065 0.0634 0.0646
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0481 0.6141 0.6141
Brugia malayi PHD-finger family protein 0.0032 0.0196 0.0194
Loa Loa (eye worm) beta-lactamase 0.0039 0.0286 0.0287
Trypanosoma brucei C-8 sterol isomerase, putative 0.0751 0.9711 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0903 0.0923
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0104 0.1151 0.1185
Loa Loa (eye worm) hypothetical protein 0.0481 0.6141 0.6321
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0104 0.1151 0.1151
Giardia lamblia 20S proteasome alpha subunit 1 0.0104 0.1151 0.1637
Brugia malayi Bromodomain containing protein 0.0092 0.0996 0.1019
Giardia lamblia Proteasome subunit beta type 3 0.0104 0.1151 0.1637
Echinococcus multilocularis dnaJ subfamily B 0.0458 0.5835 0.5835
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0065 0.0634 0.0934
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0065 0.0634 0.0653
Echinococcus multilocularis phospholipase D 0.0102 0.112 0.112
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0286 0.041
Echinococcus granulosus lamin 0.0029 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0029 0.0157 0.0154
Loa Loa (eye worm) PAS-3 protein 0.0104 0.1151 0.1179
Plasmodium vivax proteasome subunit beta type-7, putative 0.0104 0.1151 0.1697
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0104 0.1151 0.1151
Schistosoma mansoni hypothetical protein 0.019 0.2285 0.2285
Brugia malayi proteasome subunit beta type 1 0.0412 0.5221 0.5372
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0227 0.2777 0.2777
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0104 0.1151 0.1185
Onchocerca volvulus 0.0029 0.0157 0.0169
Echinococcus multilocularis neuropeptide s receptor 0.0518 0.6626 0.6626
Loa Loa (eye worm) hypothetical protein 0.0227 0.2777 0.2854
Echinococcus multilocularis cpg binding protein 0.0036 0.0254 0.0254
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0065 0.0634 0.0934
Brugia malayi Cytochrome P450 family protein 0.0085 0.0902 0.0922
Schistosoma mansoni lipoxygenase 0.0089 0.0946 0.0946
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Trypanosoma cruzi cardiolipin synthetase, putative 0.004 0.0305 0.0314
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0104 0.1151 0.1151
Schistosoma mansoni inositol monophosphatase 0.004 0.0299 0.0299
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0104 0.1151 0.1179
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0104 0.1151 0.1697
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0299 0.0372
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0104 0.1151 0.1185
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0065 0.0634 0.0934
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Onchocerca volvulus Bile acid receptor homolog 0.0481 0.6141 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0481 0.6141 0.6141
Mycobacterium leprae Probable lipase LipE 0.0039 0.0286 0.0064
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0104 0.1151 0.1697
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0104 0.1151 0.1697
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0055 0.0055
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3601 0.5274
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0348 0.0348
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0046 0.0046
Brugia malayi hypothetical protein 0.0018 0.0018 0.0011
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0199 0.0198
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0412 0.5221 0.5221
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0278 0.028
Brugia malayi orphan nuclear receptor NR2E1 0.0227 0.2777 0.2854
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0315 0.0317
Mycobacterium leprae Conserved hypothetical protein 0.0065 0.0634 0.0596
Loa Loa (eye worm) hypothetical protein 0.0481 0.6141 0.6321
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0424 0.043
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0481 0.6141 0.6321
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0481 0.6141 0.6141
Leishmania major hypothetical protein, conserved 0.0018 0.0018 0.0018
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0054 0.0054
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0481 0.6141 0.6141
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0065 0.0634 0.0934
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0424 0.043
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0054 0.0054
Giardia lamblia Proteasome subunit beta type 5 precursor 0.053 0.6785 1
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0056 0.005
Echinococcus granulosus Nuclear hormone receptor HR96 0.0227 0.2777 0.2777
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.053 0.6785 0.6984
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0065 0.0634 0.0934
Leishmania major cytochrome p450-like protein 0.0065 0.0634 0.0653
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0104 0.1151 0.1637
Entamoeba histolytica phospholipase D, putative 0.0115 0.1298 0.1913
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0104 0.1151 0.1697
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2285 0.332
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0412 0.5221 0.5221
Plasmodium vivax cardiolipin synthetase, putative 0.0018 0.0018 0.0026
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.053 0.6785 0.6785
Entamoeba histolytica phospholipase D, putative 0.0115 0.1298 0.1913
Brugia malayi steroid hormone receptor 0.0481 0.6141 0.6321
Brugia malayi Nuclear hormone receptor-like 1 0.0254 0.3137 0.3226
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0286 0.0421
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0018 0.0018 0.5
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0065 0.0634 0.0924
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0065 0.0634 0.0924
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0104 0.1151 0.1185
Loa Loa (eye worm) agrin synaptic family protein 0.0041 0.0315 0.0317
Leishmania major cardiolipin synthetase, putative 0.0018 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0254 0.3137 0.3226
Loa Loa (eye worm) hypothetical protein 0.0163 0.1936 0.1987
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0286 0.041
Loa Loa (eye worm) phospholipase D 0.0022 0.0061 0.0055
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0227 0.2777 0.2777
Echinococcus multilocularis RUN 0.0021 0.0054 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0481 0.6141 0.6321
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Toxoplasma gondii cytochrome p450 superfamily protein 0.0065 0.0634 0.0934
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0424 0.0424
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0424 0.0424
Trypanosoma cruzi Emopamil binding protein, putative 0.014 0.163 0.1678
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0048 0.0042
Toxoplasma gondii phospholipase D active site domain-containing protein 0.004 0.0305 0.045
Onchocerca volvulus Putative organic anion transporter 0.006 0.0567 0.0843
Schistosoma mansoni zinc finger protein 0.0227 0.2777 0.2777
Trypanosoma cruzi ISWI complex protein 0.0018 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0071 0.0717 0.0731
Trypanosoma brucei proteasome subunit beta type-5, putative 0.053 0.6785 0.6986
Onchocerca volvulus 0.006 0.0567 0.0843
Echinococcus granulosus proteasome prosome macropain 0.053 0.6785 0.6785
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0299 0.0441
Toxoplasma gondii proteasome subunit alpha type, putative 0.0104 0.1151 0.1697
Toxoplasma gondii peptidase, T1 family protein 0.0104 0.1151 0.1697
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0065 0.0634 0.0934
Schistosoma mansoni hypothetical protein 0.0018 0.0007 0.0007
Echinococcus granulosus FTZ F1 alpha 0.0481 0.6141 0.6141
Schistosoma mansoni retinoic acid receptor RXR 0.0592 0.7602 0.7602
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0104 0.1151 0.1637
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0289 0.3601 0.3703
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.242 0.3521
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0158 0.0158
Loa Loa (eye worm) proteasome subunit beta type 1 0.0412 0.5221 0.5372
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0104 0.1151 0.1697
Schistosoma mansoni follistatin 0.0041 0.0315 0.0315
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0104 0.1151 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0299 0.0441
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0065 0.0634 0.0934
Echinococcus granulosus proteasome subunit beta type 7 0.0104 0.1151 0.1151
Loa Loa (eye worm) hypothetical protein 0.0227 0.2777 0.2854
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3601 0.5274
Loa Loa (eye worm) hypothetical protein 0.006 0.0567 0.0577
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0104 0.1151 0.1185
Brugia malayi nuclear hormone receptor 0.0481 0.6141 0.6321
Brugia malayi Steroid receptor seven-up type 2 0.0481 0.6141 0.6321
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0481 0.6141 0.6321
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0011
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0157 0.0154
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0104 0.1151 0.1637
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0227 0.2777 0.2777
Echinococcus multilocularis musashi 0.0029 0.0157 0.0157
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0104 0.1151 0.1151
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0104 0.1151 0.1185
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0104 0.1151 0.1185
Loa Loa (eye worm) hypothetical protein 0.0097 0.1054 0.1078
Chlamydia trachomatis phospholipase D superfamily protein 0.0018 0.0018 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0049
Echinococcus granulosus zinc finger protein 0.0025 0.011 0.011
Schistosoma mansoni bromodomain containing protein 0.0078 0.0809 0.0809
Giardia lamblia Proteasome subunit beta type 2 0.0255 0.3149 0.4603
Echinococcus multilocularis neuropeptide receptor A26 0.0518 0.6626 0.6626
Loa Loa (eye worm) hypothetical protein 0.0041 0.0315 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0481 0.6141 0.6321
Echinococcus multilocularis proteasome (prosome, macropain) 0.053 0.6785 0.6785
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0104 0.1151 0.1697
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0104 0.1151 0.1185
Loa Loa (eye worm) hypothetical protein 0.0481 0.6141 0.6321
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0104 0.1151 0.1697
Loa Loa (eye worm) hypothetical protein 0.0254 0.3137 0.3226
Plasmodium vivax proteasome subunit beta type-4, putative 0.0104 0.1151 0.1697
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0254 0.3137 0.3137
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0104 0.1151 0.1185
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0481 0.6141 0.6321
Brugia malayi Proteasome A-type and B-type family protein 0.0104 0.1151 0.1179
Leishmania major proteasome beta 5 subunit, putative 0.053 0.6785 0.6986
Toxoplasma gondii heat shock protein hslv, putative 0.0104 0.1151 0.1697
Brugia malayi Nuclear hormone receptor-like 1 0.0254 0.3137 0.3226
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0065 0.0634 0.0934
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0104 0.1151 0.1185
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0104 0.1151 0.1697
Loa Loa (eye worm) hypothetical protein 0.0254 0.3137 0.3226
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0048 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0481 0.6141 0.6321
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0104 0.1151 0.1697
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0104 0.1151 0.1179
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0751 0.9711 1
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2285 0.332
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0227 0.2777 0.2777
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0104 0.1151 0.1697
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0104 0.1151 0.1151
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0104 0.1151 0.1179
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0412 0.5221 0.7695
Loa Loa (eye worm) hypothetical protein 0.006 0.0567 0.0577
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0065 0.0634 0.0924
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0104 0.1151 0.1151
Plasmodium vivax proteasome subunit beta type-2, putative 0.0255 0.3149 0.4641
Echinococcus granulosus dnaJ subfamily B 0.0458 0.5835 0.5835
Schistosoma mansoni loxhd1 0.0021 0.0054 0.0054
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0104 0.1151 0.1697
Loa Loa (eye worm) hypothetical protein 0.0227 0.2777 0.2854
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0141 0.1639 0.1639
Brugia malayi nuclear receptor NHR-67 0.0227 0.2777 0.2854
Schistosoma mansoni lipoxygenase 0.0127 0.1451 0.1451
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Echinococcus multilocularis ecdysone induced protein 78C 0.0481 0.6141 0.6141
Onchocerca volvulus 0.006 0.0567 0.0843
Brugia malayi Phospholipase D. Active site motif family protein 0.0022 0.0061 0.0055
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0104 0.1151 0.1185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0424 0.0424
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.242 0.3521
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0048 0.0049
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0104 0.1151 0.1697
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0618 0.091
Leishmania major DNA polymerase eta, putative 0.0021 0.0048 0.0049
Trypanosoma cruzi cytochrome P450, putative 0.0085 0.0902 0.0929
Echinococcus multilocularis thyroid hormone receptor alpha 0.0622 0.8007 0.8007
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0065 0.0634 0.0924
Schistosoma mansoni hypothetical protein 0.0458 0.5835 0.5835
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0227 0.2777 0.2777
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0065 0.0634 0.0924
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0315 0.0317
Loa Loa (eye worm) hypothetical protein 0.0049 0.0424 0.043
Loa Loa (eye worm) hypothetical protein 0.0254 0.3137 0.3226
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0065 0.0634 0.0924
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0141 0.1639 0.1639
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0104 0.1151 0.1697
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0104 0.1151 0.1697
Brugia malayi nuclear receptor RXR 0.0254 0.3137 0.3226
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0104 0.1151 0.1185
Schistosoma mansoni hypothetical protein 0.0025 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0227 0.2777 0.2854
Giardia lamblia 20S proteasome alpha subunit 4 0.0104 0.1151 0.1637
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0481 0.6141 0.6321
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0286 0.041
Schistosoma mansoni cpg binding protein 0.0032 0.0199 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0481 0.6141 0.6321
Brugia malayi prostaglandin transporter 0.006 0.0567 0.0577
Loa Loa (eye worm) hypothetical protein 0.006 0.0567 0.0577
Leishmania major hypothetical protein, conserved 0.014 0.163 0.1678
Brugia malayi nuclear hormone receptor 0.0227 0.2777 0.2854
Loa Loa (eye worm) hypothetical protein 0.0254 0.3137 0.3226
Leishmania major cytochrome p450-like protein 0.0065 0.0634 0.0653
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0255 0.3149 0.4641
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0104 0.1151 0.1151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0481 0.6141 0.6321
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0412 0.5221 0.5376
Brugia malayi hypothetical protein 0.0021 0.0054 0.0048
Giardia lamblia 20S proteasome alpha subunit 7 0.0104 0.1151 0.1637
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0104 0.1151 0.1637
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0255 0.3149 0.3242
Echinococcus granulosus intermediate filament protein 0.0029 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0227 0.2777 0.2854
Mycobacterium tuberculosis Conserved protein 0.0039 0.0286 0.041
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0227 0.2777 0.2854
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0104 0.1151 0.1697
Leishmania major proteasome alpha 3 subunit, putative 0.0104 0.1151 0.1185
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0104 0.1151 0.1179
Plasmodium falciparum proteasome subunit beta type-4 0.0104 0.1151 0.1697
Loa Loa (eye worm) hypothetical protein 0.0097 0.1054 0.1078
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0065 0.0634 0.0924
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0481 0.6141 0.6141
Onchocerca volvulus 0.0039 0.0286 0.0381
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0481 0.6141 0.6141
Echinococcus granulosus proteasome subunit beta type 6 0.0104 0.1151 0.1151
Brugia malayi proteasome subunit beta type 2 0.0255 0.3149 0.3237
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0104 0.1151 0.1151
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0286 0.0286
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0065 0.0634 0.0924
Loa Loa (eye worm) hypothetical protein 0.0481 0.6141 0.6321
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0104 0.1151 0.1185
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0104 0.1151 0.1697
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0104 0.1151 0.1687
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0103 0.0099
Schistosoma mansoni nuclear receptor 0.0227 0.2777 0.2777
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0104 0.1151 0.1697
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0752 0.0752
Schistosoma mansoni zinc finger protein 0.0018 0.0018 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2285 0.332
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0481 0.6141 0.6141
Loa Loa (eye worm) hypothetical protein 0.0056 0.0512 0.052
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0048 0.0049
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0481 0.6141 1
Schistosoma mansoni cytochrome P450 0.0065 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0227 0.2777 0.2854
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0254 0.3137 0.3137
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0104 0.1151 0.1185
Schistosoma mansoni nuclear receptor nhr-48 0.0227 0.2777 0.2777
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0286 0.0353
Schistosoma mansoni inositol monophosphatase 0.004 0.0299 0.0299
Brugia malayi hypothetical protein 0.004 0.0307 0.0309
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0104 0.1151 0.1697
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0104 0.1151 0.1697
Mycobacterium tuberculosis Conserved protein 0.0039 0.0286 0.041
Schistosoma mansoni rab6-interacting 0.0021 0.0054 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0227 0.2777 0.2777
Trypanosoma brucei Emopamil binding protein, putative 0.014 0.163 0.1678
Loa Loa (eye worm) hypothetical protein 0.0227 0.2777 0.2854
Loa Loa (eye worm) proteasome subunit beta type 2 0.0255 0.3149 0.3237
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0104 0.1151 0.1697
Schistosoma mansoni hypothetical protein 0.0018 0.0007 0.0007
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0104 0.1151 0.1185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0424 0.0424
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0065 0.0634 0.0924
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0104 0.1151 0.1151
Loa Loa (eye worm) hypothetical protein 0.0041 0.0315 0.0317
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0255 0.3149 0.3242
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0065 0.0634 0.0934
Onchocerca volvulus 0.0039 0.0286 0.0381
Onchocerca volvulus 0.0071 0.0717 0.1089
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0054 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0286 0.0294
Onchocerca volvulus 0.0032 0.0199 0.0238
Leishmania major proteasome beta-1 subunit, putative 0.0104 0.1151 0.1185
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0048 0.0048
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0104 0.1151 0.1185
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0481 0.6141 0.6321
Trypanosoma brucei phosphatidylglycerolphosphate synthase, mitochondrial 0.0018 0.0018 0.0018
Echinococcus multilocularis proteasome subunit beta type 7 0.0104 0.1151 0.1151
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0315 0.0317
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0104 0.1151 0.1637
Toxoplasma gondii proteasome subunit beta type, putative 0.053 0.6785 1
Echinococcus multilocularis FTZ F1 alpha 0.0481 0.6141 0.6141
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0481 0.6141 0.6141
Brugia malayi nuclear hormone receptor family member nhr-6 0.0227 0.2777 0.2854
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0104 0.1151 0.1151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0481 0.6141 0.6321
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0104 0.1151 0.1151
Loa Loa (eye worm) steroid hormone receptor 0.0481 0.6141 0.6321
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0104 0.1151 0.1185
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0255 0.3149 0.3149
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0048 0.0049
Loa Loa (eye worm) hypothetical protein 0.006 0.0567 0.0577
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0512 0.052
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0299 0.0372
Mycobacterium ulcerans beta-lactamase 0.0039 0.0286 0.0421
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0104 0.1151 0.1637
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0287
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0104 0.1151 0.1637
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0287
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0481 0.6141 0.6141
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0104 0.1151 0.1185
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0104 0.1151 0.1151
Leishmania major proteasome alpha 1 subunit, putative 0.0104 0.1151 0.1185
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0048 0.0071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0287
Schistosoma mansoni phospholipase D 0.0115 0.1298 0.1298
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0227 0.2777 0.2854
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0104 0.1151 0.1151
Loa Loa (eye worm) hypothetical protein 0.0041 0.0315 0.0317
Giardia lamblia Proteasome subunit beta type 1 0.0412 0.5221 0.7678
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0104 0.1151 0.1179
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0412 0.5221 0.5376
Mycobacterium ulcerans proteasome PrcB 0.053 0.6785 1
Schistosoma mansoni thyroid hormone receptor 0.0622 0.8007 0.8007
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0104 0.1151 0.1637
Brugia malayi ecdysone receptor 0.0227 0.2777 0.2854
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0286 0.0286
Brugia malayi hypothetical protein 0.0227 0.2777 0.2854
Schistosoma mansoni DNA polymerase eta 0.0021 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0046 0.0386 0.0391
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0065 0.0634 0.0934
Echinococcus granulosus proteasome subunit alpha type 2 0.0104 0.1151 0.1151
Brugia malayi beta-lactamase family protein 0.0039 0.0286 0.0287
Onchocerca volvulus Putative phospholipase D 0.0022 0.0061 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0481 0.6141 0.6321
Loa Loa (eye worm) hypothetical protein 0.0028 0.015 0.0147
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0054 0.0054
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0412 0.5221 0.7695
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0286 0.0353
Leishmania major proteasome beta 2 subunit, putative 0.0104 0.1151 0.1185
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0065 0.0634 0.0924
Loa Loa (eye worm) hypothetical protein 0.0751 0.9711 1
Echinococcus granulosus proteasome subunit alpha type 6 0.0104 0.1151 0.1151
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0104 0.1151 0.1185
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0008 0.0008
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0104 0.1151 0.1151
Brugia malayi hypothetical protein 0.006 0.0567 0.0577
Brugia malayi beta-lactamase 0.0039 0.0286 0.0287
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0286 0.0286
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.006 0.0567 0.0577
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0065 0.0634 0.0934
Loa Loa (eye worm) inositol-1 0.004 0.0299 0.0301
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0104 0.1151 0.1185
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0481 0.6141 0.6141
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2285 0.332
Mycobacterium leprae proteasome (beta subunit) PrcB 0.053 0.6785 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0481 0.6141 0.6141
Echinococcus multilocularis 0.0065 0.0634 0.0634
Giardia lamblia 20S proteasome alpha subunit 5 0.0104 0.1151 0.1637
Loa Loa (eye worm) hypothetical protein 0.0227 0.2777 0.2854
Onchocerca volvulus 0.0227 0.2777 0.4474
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0008 0.0011
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0299 0.0299
Brugia malayi ecdysteroid receptor 0.0481 0.6141 0.6321
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0424 0.0424
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0104 0.1151 0.1697
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0286 0.0353
Brugia malayi proteasome subunit alpha type 1 0.0104 0.1151 0.1179
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0104 0.1151 0.1151
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0286 0.0287
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0048 0.0048
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0127 0.1451 0.1451
Loa Loa (eye worm) nuclear receptor NHR-67 0.0227 0.2777 0.2854
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0412 0.5221 0.7678
Echinococcus multilocularis proteasome subunit alpha type 6 0.0104 0.1151 0.1151
Leishmania major proteasome beta 7 subunit, putative 0.0104 0.1151 0.1185
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3601 0.5274
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0299 0.0308
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0104 0.1151 0.1637
Brugia malayi Nuclear hormone receptor E75 0.0227 0.2777 0.2854
Entamoeba histolytica hypothetical protein 0.004 0.0307 0.0452
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0104 0.1151 0.1697
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0104 0.1151 0.1185
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0018 0.0018 0.5
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0299 0.0308
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0008 0.0008
Plasmodium vivax proteasome subunit beta type-6, putative 0.0104 0.1151 0.1697
Echinococcus granulosus GPCR family 2 0.0018 0.0007 0.0007
Echinococcus granulosus RUN 0.0021 0.0054 0.0054
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0065 0.0634 0.0924
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0104 0.1151 0.1185
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0008 0.0008
Onchocerca volvulus 0.006 0.0567 0.0843
Leishmania major proteasome beta 3 subunit, putative 0.0104 0.1151 0.1185
Brugia malayi beta-lactamase family protein 0.0039 0.0286 0.0287
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.053 0.6785 0.6986
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0299 0.2482
Loa Loa (eye worm) cytochrome P450 family protein 0.0106 0.1177 0.1205
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0065 0.0634 0.0934
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0055 0.0055
Brugia malayi secreted modular calcium-binding protein 1 0.0041 0.0315 0.0317
Loa Loa (eye worm) cytochrome P450 family protein 0.0085 0.0902 0.0922
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0481 0.6141 0.6141
Brugia malayi Proteasome subunit alpha type 1 0.0104 0.1151 0.1179
Schistosoma mansoni microtubule-associated protein tau 0.0773 1 1
Trypanosoma brucei ISWI complex protein 0.0018 0.0018 0.0018
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0104 0.1151 0.1185
Mycobacterium ulcerans hypothetical protein 0.0039 0.0286 0.0421
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Plasmodium falciparum phosphatidylglycerophosphate synthase 0.0018 0.0018 0.0026
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0104 0.1151 0.1179
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0054 0.0054
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0104 0.1151 0.1697
Loa Loa (eye worm) hypothetical protein 0.0254 0.3137 0.3226
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Brugia malayi Nuclear hormone receptor-like 1 0.0481 0.6141 0.6321
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0286 0.0421
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0481 0.6141 0.6141
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0512 0.052
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0255 0.3149 0.4603
Toxoplasma gondii proteasome subunit alpha1, putative 0.0104 0.1151 0.1697
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0481 0.6141 0.6321
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0104 0.1151 0.1697
Entamoeba histolytica phospholipase D active site domain-containing protein 0.0097 0.1054 0.1553
Brugia malayi SPARC precursor 0.0041 0.0315 0.0317
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0227 0.2777 0.2854
Loa Loa (eye worm) hypothetical protein 0.0481 0.6141 0.6321
Echinococcus granulosus lamin dm0 0.0029 0.0157 0.0157
Trypanosoma cruzi ISWI complex protein 0.0018 0.0018 0.0018
Echinococcus granulosus Proteasome subunit alpha type 7 0.0104 0.1151 0.1151
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0286 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0104 0.1151 0.1151
Loa Loa (eye worm) proteasome subunit beta type 3 0.0104 0.1151 0.1179
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0008 0.0011
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0008 0.0008
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0104 0.1151 0.1697
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0481 0.6141 0.6141
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0481 0.6141 0.6321
Onchocerca volvulus 0.0227 0.2777 0.4474
Echinococcus multilocularis phospholipase D1 0.0115 0.1298 0.1298
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0041 0.0315 0.0317
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2285 0.332
Loa Loa (eye worm) hypothetical protein 0.0068 0.0667 0.068
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.3046 0.4483
Plasmodium vivax proteasome subunit beta type-5, putative 0.053 0.6785 1
Brugia malayi hypothetical protein 0.0254 0.3137 0.3226
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0048 0.0049
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0104 0.1151 0.1185
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.3601 0.5274
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0035
Loa Loa (eye worm) hypothetical protein 0.0227 0.2777 0.2854
Schistosoma mansoni cpg binding protein 0.0036 0.0254 0.0254
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0104 0.1151 0.1151
Onchocerca volvulus 0.014 0.163 0.2589
Loa Loa (eye worm) DR-78 0.0227 0.2777 0.2854
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0481 0.6141 0.6141
Brugia malayi cytochrome P450 0.0065 0.0634 0.0646
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2285 0.332
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0104 0.1151 0.1697
Trypanosoma cruzi 20S proteasome subunit 0.0255 0.3149 0.3242
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0048 0.006
Echinococcus granulosus organic anion transporting polypeptide 30B 0.006 0.0567 0.0567
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0104 0.1151 0.1151
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0299 0.0441
Leishmania major phosphatidylglycerophosphate synthase, putative 0.0022 0.0061 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0481 0.6141 0.6321
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0104 0.1151 0.1697
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0104 0.1151 0.1637
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0481 0.6141 0.6321
Trypanosoma brucei proteasome alpha 7 subunit 0.0104 0.1151 0.1185
Echinococcus multilocularis lamin dm0 0.0029 0.0157 0.0157
Brugia malayi nuclear receptor NHR-88 0.0481 0.6141 0.6321
Echinococcus granulosus dna polymerase eta 0.0021 0.0048 0.0048
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0104 0.1151 0.1151
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0046 0.0046
Leishmania major proteasome beta 2 subunit, putative 0.0255 0.3149 0.3242
Loa Loa (eye worm) hypothetical protein 0.0038 0.0278 0.028
Brugia malayi proteasome subunit alpha type 4 0.0104 0.1151 0.1179
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0065 0.0634 0.0934
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0286 0.0353
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0065 0.0634 0.0924
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0286 0.041
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.014 0.163 0.1678
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0048 0.0042
Brugia malayi nuclear receptor NHR-88 0.0227 0.2777 0.2854
Brugia malayi GYF domain containing protein 0.0071 0.0717 0.0731
Trypanosoma brucei proteasome beta 6 subunit 0.0412 0.5221 0.5376
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0065 0.0634 0.0934
Loa Loa (eye worm) hypothetical protein 0.0227 0.2777 0.2854
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0104 0.1151 0.1179
Brugia malayi conserved hypotetical protein 0.0227 0.2777 0.2854
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0286 0.0294
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0065 0.0634 0.0924
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0104 0.1151 0.1697
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0412 0.5221 0.5221
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0104 0.1151 0.1151
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0104 0.1151 0.1185
Leishmania major C-8 sterol isomerase-like protein 0.0751 0.9711 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0315 0.0464
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0289 0.3601 0.3703
Schistosoma mansoni CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 0.0018 0.0018 0.0018
Brugia malayi hypothetical protein 0.0227 0.2777 0.2854
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.014 0.163 0.1678
Onchocerca volvulus Putative organic anion transporter 0.006 0.0567 0.0843
Schistosoma mansoni intermediate filament proteins 0.0029 0.0157 0.0157
Schistosoma mansoni zinc finger protein 0.0025 0.011 0.011
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0104 0.1151 0.1697
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0104 0.1151 0.1151
Echinococcus multilocularis microtubule associated protein 2 0.0773 1 1
Leishmania major proteasome alpha 7 subunit, putative 0.0104 0.1151 0.1185
Toxoplasma gondii proteasome subunit 0.0104 0.1151 0.1697
Echinococcus granulosus dna polymerase kappa 0.0021 0.0048 0.0048
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0008 0.0008
Plasmodium falciparum mitochondrial cardiolipin synthase, putative 0.0018 0.0018 0.0026
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0255 0.3149 0.4641
Trypanosoma brucei unspecified product 0.0021 0.0048 0.0049
Brugia malayi sodium-independent organic anion transporter family protein 0.006 0.0567 0.0577
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0065 0.0634 0.0653
Echinococcus granulosus Nuclear hormone receptor HR96 0.0227 0.2777 0.2777
Brugia malayi Bromodomain containing protein 0.0046 0.0385 0.039
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0041 0.0315 0.0317
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0481 0.6141 0.6141
Onchocerca volvulus Putative organic anion transporter 0.006 0.0567 0.0843
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0008 0.0008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0481 0.6141 0.6141
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0752 0.0752
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0227 0.2777 0.4474
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0104 0.1151 0.1185
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0065 0.0634 0.0924
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0315 0.0464
Schistosoma mansoni hypothetical protein 0.0038 0.0278 0.0278
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0054 0.0054
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0048 0.0048
Brugia malayi photoreceptor-specific nuclear receptor 0.0481 0.6141 0.6321
Brugia malayi hypothetical protein 0.0021 0.0054 0.0048
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0227 0.2777 0.4474
Echinococcus granulosus follistatin 0.0041 0.0315 0.0315
Echinococcus multilocularis Solute carrier organic anion transporter family 0.006 0.0567 0.0567
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0048 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0055 0.0055
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0307 0.0307
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0286 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0481 0.6141 0.6321
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0007 0.0007
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0065 0.0634 0.0653
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0041 0.0315 0.0464
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0065 0.0634 0.0934
Brugia malayi Cytochrome P450 family protein 0.0106 0.1177 0.1205
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0104 0.1151 0.1697
Brugia malayi nuclear hormone receptor family member odr-7 0.0227 0.2777 0.2854
Brugia malayi Doublecortin family protein 0.0021 0.0054 0.0048
Onchocerca volvulus 0.0041 0.0315 0.0429
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.014 0.163 0.1678
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0286 0.0421
Mycobacterium leprae putative cytochrome p450 0.0065 0.0634 0.0596
Echinococcus granulosus Proteasome subunit alpha beta 0.0104 0.1151 0.1151
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0065 0.0634 0.0924
Giardia lamblia 20S proteasome alpha subunit 3 0.0104 0.1151 0.1637
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0104 0.1151 0.1151
Leishmania major proteasome alpha 2 subunit, putative 0.0104 0.1151 0.1185
Schistosoma mansoni coup transcription factor 0.0481 0.6141 0.6141
Schistosoma mansoni thyroid hormone receptor 0.0622 0.8007 0.8007
Echinococcus multilocularis agrin 0.0041 0.0315 0.0315
Echinococcus multilocularis nuclear receptor nhr 48 0.0227 0.2777 0.2777
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0008 0.0008
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0046 0.0046
Leishmania major proteasome alpha 7 subunit, putative 0.0104 0.1151 0.1185
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0104 0.1151 0.1179
Schistosoma mansoni nuclear hormone receptor 0.0481 0.6141 0.6141
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0254 0.3137 0.3137
Brugia malayi proteasome subunit alpha type 2 0.0104 0.1151 0.1179
Entamoeba histolytica hypothetical protein 0.004 0.0307 0.0452
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0104 0.1151 0.1185
Brugia malayi 20S proteasome alpha5 subunit 0.0104 0.1151 0.1179
Brugia malayi Proteasome A-type and B-type family protein 0.053 0.6785 0.6984
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0054 0.008
Echinococcus granulosus neuropeptide s receptor 0.0518 0.6626 0.6626
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0512 0.052
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0104 0.1151 0.1185
Schistosoma mansoni hypothetical protein 0.0065 0.0634 0.0634
Echinococcus multilocularis geminin 0.019 0.2285 0.2285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0481 0.6141 0.6321
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0141 0.1639 0.1639
Loa Loa (eye worm) hypothetical protein 0.0481 0.6141 0.6321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0481 0.6141 0.6141
Echinococcus multilocularis follistatin 0.0041 0.0315 0.0315
Onchocerca volvulus 0.0039 0.0286 0.0381
Schistosoma mansoni organic anion transporter 0.006 0.0567 0.0567
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0592 0.7602 0.7602
Trypanosoma brucei proteasome beta 7 subunit 0.0104 0.1151 0.1185
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Schistosoma mansoni hypothetical protein 0.004 0.0307 0.0307
Leishmania major proteasome alpha 1 subunit, putative 0.0104 0.1151 0.1185
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.053 0.6785 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0104 0.1151 0.1185
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0104 0.1151 0.1185
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0227 0.2777 0.2777
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0299 0.0308
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0065 0.0634 0.0934
Trichomonas vaginalis esterase, putative 0.0039 0.0286 0.0353
Echinococcus granulosus thyroid hormone receptor alpha 0.0227 0.2777 0.2777
Plasmodium vivax proteasome subunit beta type-1, putative 0.0412 0.5221 0.7695
Schistosoma mansoni hypothetical protein 0.0021 0.0054 0.0054
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2285 0.332
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0287
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0158 0.0158
Toxoplasma gondii transporter, major facilitator family protein 0.006 0.0567 0.0835
Toxoplasma gondii ABC1 family protein 0.0039 0.0286 0.0421
Brugia malayi Proteasome A-type and B-type family protein 0.0104 0.1151 0.1179
Schistosoma mansoni organic anion transporter 0.006 0.0567 0.0567
Plasmodium vivax phosphatidylglycerophosphate synthase, putative 0.0018 0.0018 0.0026
Echinococcus multilocularis expressed protein 0.0041 0.0315 0.0315
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0048 0.0048
Echinococcus granulosus ecdysone induced protein 78C 0.0481 0.6141 0.6141
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0048 0.0049
Onchocerca volvulus 0.006 0.0567 0.0843
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0287
Brugia malayi proteasome subunit alpha type 3 0.0104 0.1151 0.1179
Brugia malayi sodium-independent organic anion transporter family protein 0.006 0.0567 0.0577
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0065 0.0634 0.0653
Entamoeba histolytica hypothetical protein 0.004 0.0307 0.0452
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0412 0.5221 0.5376
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0048 0.0048
Echinococcus multilocularis proteasome subunit beta type 6 0.0104 0.1151 0.1151
Loa Loa (eye worm) hypothetical protein 0.006 0.0567 0.0577
Trypanosoma brucei cardiolipin synthetase, putative 0.004 0.0305 0.0314
Loa Loa (eye worm) sodium-independent organic anion transporter 0.006 0.0567 0.0577
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0424 0.0424
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0255 0.3149 0.3149
Loa Loa (eye worm) hypothetical protein 0.0075 0.0766 0.0782
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0307 0.0307
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0286 0.041
Brugia malayi proteasome subunit beta type 3 0.0104 0.1151 0.1179
Brugia malayi sodium-independent organic anion transporter family protein 0.006 0.0567 0.0577
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0065 0.0634 0.0934
Leishmania major hypothetical protein, conserved 0.0039 0.0286 0.0294
Loa Loa (eye worm) nuclear hormone receptor 0.0227 0.2777 0.2854
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0007 0.0007
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0255 0.3149 0.4641
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0255 0.3149 0.3149
Mycobacterium ulcerans proteasome PrcA 0.0104 0.1151 0.1697
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0481 0.6141 0.6321

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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