Detailed information for compound 825335

Basic information

Technical information
  • TDR Targets ID: 825335
  • Name: ethyl 4-(3-fluorophenyl)-6-[(4-fluorophenyl)s ulfonylmethyl]-2-oxo-3,4-dihydro-1H-pyrimidin e-5-carboxylate
  • MW: 436.429 | Formula: C20H18F2N2O5S
  • H donors: 2 H acceptors: 4 LogP: 1.95 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(NC(=O)NC1c1cccc(c1)F)CS(=O)(=O)c1ccc(cc1)F
  • InChi: 1S/C20H18F2N2O5S/c1-2-29-19(25)17-16(11-30(27,28)15-8-6-13(21)7-9-15)23-20(26)24-18(17)12-4-3-5-14(22)10-12/h3-10,18H,2,11H2,1H3,(H2,23,24,26)
  • InChiKey: SMJFUVHXDSWWOR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(3-fluorophenyl)-6-[(4-fluorophenyl)sulfonylmethyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester
  • 4-(3-fluorophenyl)-6-[(4-fluorophenyl)sulfonylmethyl]-2-keto-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0105 1 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0105 1 1
Echinococcus granulosus caax prenyl protease 1 0.0067 0.3711 0.3711
Toxoplasma gondii transporter, cation channel family protein 0.0105 1 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0105 1 1
Schistosoma mansoni vesicular amine transporter 0.0105 1 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0105 1 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0105 1 1
Echinococcus granulosus voltage dependent calcium channel 0.0105 1 1
Echinococcus granulosus potassium large conductance calcium activated 0.0105 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0105 1 1
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0105 1 1
Echinococcus granulosus hypothetical protein 0.0105 1 1
Echinococcus granulosus two pore calcium channel protein 1 0.0105 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0105 1 1
Toxoplasma gondii hypothetical protein 0.0105 1 1
Loa Loa (eye worm) ryanodine receptor 0.0105 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0105 1 1
Schistosoma mansoni voltage-gated ion channel 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Schistosoma mansoni voltage-dependent calcium channel 0.0105 1 1
Echinococcus multilocularis shaker cognate 0.0105 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0105 1 1
Echinococcus granulosus sodium leak channel non selective protein 0.0105 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 1 1
Schistosoma mansoni farnesylated-protein converting enzyme 1 (M48 family) 0.0067 0.3711 0.3711
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0105 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0105 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0105 1 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Schistosoma mansoni ryanodine receptor related 0.0105 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0105 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0105 1 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0105 1 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0105 1 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0105 1 1
Onchocerca volvulus 0.0105 1 1
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0105 1 1
Schistosoma mansoni transient receptor potential channel 0.0105 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0105 1 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.8134 0.8134
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0105 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0105 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0105 1 1
Echinococcus granulosus two pore calcium channel protein 2 0.0105 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.8134 0.8134
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0105 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0105 1 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0105 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 1 1
Brugia malayi hypothetical protein 0.0105 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Echinococcus multilocularis two pore calcium channel protein 1 0.0105 1 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0105 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0105 1 1
Schistosoma mansoni transient receptor potential channel 0.0105 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0105 1 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0105 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0105 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0105 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0105 1 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0105 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0105 1 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0105 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0105 1 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0105 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0105 1 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0105 1 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Entamoeba histolytica CAAX prenyl protease, putative 0.0067 0.3711 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0105 1 1
Echinococcus multilocularis two pore calcium channel protein 2 0.0105 1 1
Loa Loa (eye worm) peptidase family M48 containing protein 0.0067 0.3711 0.3711
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Echinococcus granulosus voltage dependent calcium channel 0.0105 1 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0105 1 1
Echinococcus granulosus voltage gated potassium channel 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0105 1 1
Echinococcus granulosus transient receptor potential gamma protein 0.0105 1 1
Leishmania major hypothetical protein, unknown function 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0105 1 1
Echinococcus granulosus ryanodine receptor 44f 0.0105 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0105 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0105 1 1
Leishmania major hypothetical protein, conserved 0.0105 1 1
Brugia malayi Transient-receptor-potential like protein 0.0105 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0105 1 1
Echinococcus granulosus shaker cognate 0.0105 1 1
Brugia malayi cation channel family protein 0.0105 1 1
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0105 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0105 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0105 1 1
Brugia malayi Trypsin family protein 0.0094 0.8134 0.8134
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0105 1 1
Echinococcus multilocularis sodium leak channel non selective protein 0.0105 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0105 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0105 1 1
Schistosoma mansoni hypothetical protein 0.0105 1 1
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0105 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.8134 0.8134
Echinococcus granulosus transient receptor potential cation channel 0.0105 1 1
Schistosoma mansoni voltage-gated cation channel 0.0105 1 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0105 1 1
Echinococcus multilocularis conserved hypothetical protein 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0105 1 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0105 1 1
Toxoplasma gondii transporter, cation channel family protein 0.0105 1 1
Brugia malayi voltage-dependent calcium channel 0.0105 1 1
Echinococcus multilocularis potassium large conductance calcium activated 0.0105 1 1
Echinococcus multilocularis sodium channel protein 0.0105 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0105 1 1
Echinococcus granulosus sodium channel protein 0.0105 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0105 1 1
Echinococcus multilocularis voltage dependent calcium channel 0.0105 1 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0105 1 1
Echinococcus multilocularis voltage dependent calcium channel 0.0105 1 1
Echinococcus multilocularis caax prenyl protease 1 0.0067 0.3711 0.3711
Echinococcus multilocularis transfer RNA-Gly 0.0105 1 1
Echinococcus granulosus voltage gated potassium channel 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0105 1 1
Loa Loa (eye worm) voltage-gated calcium channel 0.0105 1 1
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0105 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Echinococcus granulosus voltage gated hydrogen channel 1 0.0105 1 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0105 1 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0105 1 1
Brugia malayi olfactory channel protein osm-9 0.0105 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0105 1 1
Brugia malayi cation channel family protein 0.0105 1 1
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0105 1 1
Echinococcus granulosus calcium activated potassium channel 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0105 1 1
Toxoplasma gondii hypothetical protein 0.0105 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0105 1 1
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.8134 0.8134
Brugia malayi Peptidase family M48 containing protein 0.0067 0.3711 0.3711
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0105 1 1
Schistosoma mansoni 60S ribosomal protein L21 0.0105 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0105 1 1
Schistosoma mansoni calcium-activated potassium channel 0.0105 1 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0105 1 1
Toxoplasma gondii transporter, cation channel family protein 0.0105 1 1
Echinococcus multilocularis calcium activated potassium channel 0.0105 1 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0105 1 1
Echinococcus multilocularis ryanodine receptor 44f 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0105 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0105 1 1
Schistosoma mansoni two-pore calcium channel 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Loa Loa (eye worm) calcium channel 0.0105 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0105 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0105 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0105 1 1
Schistosoma mansoni transient receptor potential channel 4 0.0105 1 1
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0105 1 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Onchocerca volvulus 0.0094 0.8134 0.3557
Echinococcus multilocularis potassium voltage gated channel protein 0.0105 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0105 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0105 1 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0105 1 1
Echinococcus granulosus TRP transient receptor potential channel 0.0105 1 1
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0105 1 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0105 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0105 1 1
Schistosoma mansoni transient receptor potential channel 0.0105 1 1
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0105 1 1
Loa Loa (eye worm) ion channel NompC 0.0105 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0105 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 1 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0105 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0105 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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