Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nervana 2 | 0.0551 | 0.6535 | 0.977 |
Brugia malayi | Protein kinase domain containing protein | 0.0838 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0838 | 1 | 1 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0287 | 0.3353 | 0.3353 |
Trichomonas vaginalis | AGC family protein kinase | 0.0838 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0551 | 0.6535 | 0.977 |
Echinococcus multilocularis | nervana 2 | 0.0551 | 0.6535 | 0.977 |
Brugia malayi | Hr1 repeat family protein | 0.0287 | 0.3353 | 0.3323 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.0045 | 0.0045 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0045 | 0.0045 |
Trichomonas vaginalis | AGC family protein kinase | 0.0838 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0287 | 0.3353 | 0.0111 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0287 | 0.3353 | 0.3353 |
Echinococcus granulosus | nervana 2 | 0.0551 | 0.6535 | 0.977 |
Giardia lamblia | Kinase, AGC PKA | 0.0557 | 0.6609 | 0.5 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0557 | 0.6609 | 0.4899 |
Brugia malayi | protein kinase C II. | 0.0287 | 0.3353 | 0.3323 |
Entamoeba histolytica | protein kinase 2, putative | 0.0557 | 0.6609 | 0.4899 |
Entamoeba histolytica | protein kinase, putative | 0.0838 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0045 | 0.0045 |
Trichomonas vaginalis | AGC family protein kinase | 0.0838 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0838 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0838 | 1 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0551 | 0.6535 | 0.977 |
Echinococcus multilocularis | nervana 2 | 0.0551 | 0.6535 | 0.977 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 0.0045 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0838 | 1 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0557 | 0.6609 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0287 | 0.3353 | 0.0111 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0557 | 0.6609 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0557 | 0.6609 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0838 | 1 | 1 |
Toxoplasma gondii | AGC kinase | 0.0838 | 1 | 0.5 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0287 | 0.3353 | 0.3353 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.3353 | 0.3353 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0551 | 0.6535 | 0.977 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0557 | 0.6609 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0557 | 0.6609 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0838 | 1 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0557 | 0.6609 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0557 | 0.6609 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0287 | 0.3353 | 0.3323 |
Leishmania major | cytochrome p450-like protein | 0.0013 | 0.0045 | 0.5 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0557 | 0.6609 | 1 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0287 | 0.3353 | 0.3353 |
Trichomonas vaginalis | AGC family protein kinase | 0.0838 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0287 | 0.3353 | 0.0111 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0557 | 0.6609 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0838 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0287 | 0.3353 | 0.3323 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0287 | 0.3353 | 0.3353 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0557 | 0.6609 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0838 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0287 | 0.3353 | 0.0111 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0287 | 0.3353 | 0.3353 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0557 | 0.6609 | 0.4899 |
Trypanosoma cruzi | Protein kinase B | 0.0557 | 0.6609 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0557 | 0.6609 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0551 | 0.6535 | 0.977 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.