Detailed information for compound 82559

Basic information

Technical information
  • TDR Targets ID: 82559
  • Name: 3-[3,5-difluoro-4-methyl-6-(4-methyl-4-phenyl piperidin-1-yl)pyridin-2-yl]oxybenzenecarboxi midamide
  • MW: 436.497 | Formula: C25H26F2N4O
  • H donors: 1 H acceptors: 1 LogP: 5.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1c(nc(c(c1C)F)Oc1cccc(c1)C(=N)N)N1CCC(CC1)(C)c1ccccc1
  • InChi: 1S/C25H26F2N4O/c1-16-20(26)23(31-13-11-25(2,12-14-31)18-8-4-3-5-9-18)30-24(21(16)27)32-19-10-6-7-17(15-19)22(28)29/h3-10,15H,11-14H2,1-2H3,(H3,28,29)
  • InChiKey: QGIPJVHEMNUPHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[3,5-difluoro-4-methyl-6-(4-methyl-4-phenyl-1-piperidyl)-2-pyridyl]oxy]benzamidine
  • 3-[[3,5-difluoro-4-methyl-6-(4-methyl-4-phenyl-1-piperidinyl)-2-pyridyl]oxy]benzamidine
  • 3-[3,5-difluoro-4-methyl-6-(4-methyl-4-phenyl-piperidin-1-yl)pyridin-2-yl]oxybenzenecarboximidamide
  • 3-[[3,5-difluoro-4-methyl-6-(4-methyl-4-phenyl-piperidino)-2-pyridyl]oxy]benzamidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lamin dm0 0.0028 0.0444 0.0443
Loa Loa (eye worm) hypothetical protein 0.0335 0.8078 0.8734
Echinococcus multilocularis geminin 0.0179 0.4191 0.4191
Echinococcus multilocularis receptor type guanylyl cyclase 0.003 0.0485 0.0485
Echinococcus multilocularis tyrosine kinase 0.003 0.0485 0.0485
Echinococcus granulosus expressed protein 0.0394 0.9551 0.9551
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.6526 1
Schistosoma mansoni lamin 0.0028 0.0444 0.0998
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0114 0.0123
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0238 0.0238
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0256 0.4316
Schistosoma mansoni glutamate receptor kainate 0.0159 0.3693 0.831
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0507 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0519 0.1169
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0189 0.4444 0.4444
Brugia malayi metabotropic glutamate receptor type 2 0.003 0.0485 0.0525
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0238 0.0238
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0273 0.6526 0.7056
Brugia malayi PXA domain containing protein 0.002 0.0238 0.0258
Schistosoma mansoni glutamate receptor NMDA 0.0159 0.3693 0.831
Loa Loa (eye worm) hypothetical protein 0.0013 0.0064 0.0069
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0059 0.1199 0.1199
Schistosoma mansoni hypothetical protein 0.0133 0.3045 0.6852
Entamoeba histolytica hypothetical protein 0.002 0.0238 0.092
Schistosoma mansoni rab6-interacting 0.0021 0.0253 0.0569
Loa Loa (eye worm) hypothetical protein 0.003 0.0485 0.0525
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0491 0.049
Echinococcus granulosus glutamate receptor 4 0.0223 0.529 0.529
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0058 0.0218
Loa Loa (eye worm) hypothetical protein 0.0016 0.0136 0.0147
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0256 0.0255
Schistosoma mansoni lipoxygenase 0.0058 0.1186 0.2669
Echinococcus granulosus axis inhibition protein axin 0.002 0.0238 0.0238
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0507 0.8557
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0077 0.0076
Schistosoma mansoni glutamate receptor AMPA 0.0159 0.3693 0.831
Onchocerca volvulus 0.0028 0.0444 0.0744
Brugia malayi Cytochrome P450 family protein 0.0013 0.0058 0.0062
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.2593 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0256 0.0027
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0136 0.2293
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0256 0.0255
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0256 0.0027
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.003 0.0485 0.0525
Echinococcus granulosus metabotropic glutamate receptor 5 0.003 0.0485 0.0485
Leishmania major cytochrome p450-like protein 0.0013 0.0058 0.0218
Onchocerca volvulus 0.003 0.0485 0.0814
Brugia malayi Pre-SET motif family protein 0.022 0.5208 0.5631
Brugia malayi Metabotropic glutamate receptor precursor. 0.003 0.0485 0.0525
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.4431 0.6667
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.003 0.0485 0.0525
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0238 0.0258
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0256 0.0106
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0238 0.0258
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0238 0.0258
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0592 0.2279
Echinococcus granulosus RUN 0.0021 0.0253 0.0253
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.4191 0.6286
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0613 0.0662
Echinococcus granulosus Tolloid protein 1 0.0016 0.0136 0.0136
Schistosoma mansoni regulator of G protein signaling 0.002 0.0238 0.0536
Onchocerca volvulus 0.0032 0.0519 0.0871
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0189 0.4444 0.4444
Loa Loa (eye worm) hypothetical protein 0.0013 0.0064 0.0069
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0114 0.0123
Brugia malayi hypothetical protein 0.0021 0.0253 0.0273
Brugia malayi phosphofructokinase 0.0115 0.2593 0.2804
Loa Loa (eye worm) hypothetical protein 0.002 0.0238 0.0258
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2593 0.3745
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0136 0.0147
Schistosoma mansoni regulator of G protein signaling 0.002 0.0238 0.0536
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0253 0.0253
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0059 0.1199 0.1199
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0058 0.0062
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0136 0.0147
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0238 0.0536
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0256 0.0276
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0058 0.0218
Loa Loa (eye worm) hypothetical protein 0.002 0.0238 0.0258
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0507 0.9754
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0592 0.2279
Echinococcus granulosus receptor type guanylyl cyclase 0.003 0.0485 0.0485
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0256 0.0986
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0519 0.1169
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0507 0.0426
Echinococcus granulosus glutamate NMDA receptor subunit 0.0159 0.3693 0.3693
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0444 0.0479
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0136 0.0136
Trichomonas vaginalis set domain proteins, putative 0.025 0.5964 0.9106
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0273
Loa Loa (eye worm) hypothetical protein 0.0014 0.0077 0.0083
Loa Loa (eye worm) hypothetical protein 0.0016 0.0136 0.0147
Loa Loa (eye worm) hypothetical protein 0.0021 0.0253 0.0273
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0238 0.0258
Schistosoma mansoni loxhd1 0.0021 0.0253 0.0569
Brugia malayi metabotropic GABA-B receptor subtype 2 0.003 0.0485 0.0525
Schistosoma mansoni regulator of G protein signaling 0.002 0.0238 0.0536
Schistosoma mansoni lamin 0.0028 0.0444 0.0998
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.1186 0.1186
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0238 0.0536
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0592 0.2283
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0273 0.6526 0.7056
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0507 1
Schistosoma mansoni protein kinase 0.003 0.0485 0.1092
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0282 0.6755 0.6755
Loa Loa (eye worm) hypothetical protein 0.002 0.0238 0.0258
Brugia malayi hypothetical protein 0.0129 0.2936 0.3174
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.4431 0.6667
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0238 0.0238
Entamoeba histolytica hypothetical protein 0.002 0.0238 0.092
Echinococcus multilocularis glutamate receptor 2 0.0412 1 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0256 0.0276
Loa Loa (eye worm) glutamate receptor 2 0.0159 0.3693 0.3993
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0444 0.0479
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.2593 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0507 0.0426
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0444 0.0479
Echinococcus multilocularis nmda type glutamate receptor 0.003 0.0485 0.0485
Schistosoma mansoni thyroid hormone receptor 0.0144 0.3311 0.7451
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.4191 0.6286
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.6526 1
Echinococcus granulosus bloom syndrome protein 0.0021 0.0256 0.0255
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2593 0.3745
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0077 0.0076
Echinococcus granulosus axis inhibition protein axin 0.002 0.0238 0.0238
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0059 0.1199 0.1199
Echinococcus multilocularis lamin 0.0028 0.0444 0.0443
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0519 0.0519
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0059 0.1199 0.1199
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0256 0.0255
Brugia malayi PXA domain containing protein 0.002 0.0238 0.0258
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0507 0.0426
Schistosoma mansoni DNA helicase recq1 0.0021 0.0256 0.0575
Trichomonas vaginalis rotamase, putative 0.0035 0.0613 0.0595
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0058 0.0062
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.2593 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0238 0.0258
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0238 0.0536
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.2593 0.5835
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0519 0.0519
Brugia malayi Receptor family ligand binding region containing protein 0.003 0.0485 0.0525
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0159 0.3693 0.3693
Echinococcus granulosus geminin 0.0179 0.4191 0.4191
Brugia malayi Cytochrome P450 family protein 0.0013 0.0058 0.0062
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0001 0.0024
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0256 0.0255
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.3045 0.3045
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.4191 0.6286
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.2593 1
Echinococcus multilocularis NMDA receptor 0.0059 0.1199 0.1199
Loa Loa (eye worm) hypothetical protein 0.0021 0.0256 0.0276
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0256 0.0981
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0238 0.0258
Brugia malayi hypothetical protein 0.002 0.0238 0.0258
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.4191 0.6286
Echinococcus granulosus glutamate receptor 2 0.0354 0.8535 0.8535
Loa Loa (eye worm) hypothetical protein 0.0016 0.0136 0.0147
Onchocerca volvulus 0.003 0.0485 0.0814
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0507 0.8557
Echinococcus multilocularis glutamate receptor 2 0.0382 0.9249 0.9249
Loa Loa (eye worm) hypothetical protein 0.0016 0.0136 0.0147
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.2593 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0238 0.0258
Echinococcus granulosus lamin 0.0028 0.0444 0.0443
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0238 0.0536
Brugia malayi Guanylyl cyclase protein 23 0.003 0.0485 0.0525
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0238 0.0536
Schistosoma mansoni metabotropic glutamate receptor 0.003 0.0485 0.1092
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0238 0.0238
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0507 0.0426
Loa Loa (eye worm) RecQ helicase 0.0021 0.0256 0.0276
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0613 0.0662
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0256 0.0276
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0189 0.4444 0.4444
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0519 0.8773
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0189 0.4444 0.4444
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0136 0.0305
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0238 0.0238
Echinococcus multilocularis fibrillin 1 0.0016 0.0136 0.0136
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.2593 0.2593
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.2593 0.5
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0238 0.0238
Schistosoma mansoni ATP-binding cassette transporter 0.0159 0.3693 0.831
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.2593 0.2804
Plasmodium vivax SET domain protein, putative 0.0032 0.0519 1
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0238 0.0238
Trichomonas vaginalis rotamase, putative 0.0034 0.0592 0.0562
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0223 0.529 0.572
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0238 0.0238
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0136 0.0147
Schistosoma mansoni tyrosine kinase 0.003 0.0485 0.1092
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.003 0.0485 0.0525
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0485 0.0525
Schistosoma mansoni axis inhibition protein axin 0.002 0.0238 0.0536
Entamoeba histolytica hypothetical protein 0.003 0.0485 0.1872
Brugia malayi 6-phosphofructokinase 0.0115 0.2593 0.2804
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0412 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0485 0.0525
Brugia malayi Pre-SET motif family protein 0.0032 0.0519 0.0561
Brugia malayi Fibulin-1 precursor 0.0016 0.0136 0.0147
Loa Loa (eye worm) hypothetical protein 0.003 0.0485 0.0525
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.3045 0.3045
Loa Loa (eye worm) hypothetical protein 0.003 0.0485 0.0525
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0256 0.0981
Onchocerca volvulus 0.025 0.5964 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.003 0.0485 0.0485
Echinococcus multilocularis glutamate receptor 2 0.0354 0.8535 0.8535
Echinococcus granulosus glutamate receptor 1 0.0223 0.529 0.529
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.2593 1
Echinococcus granulosus atrial natriuretic peptide receptor 0.003 0.0485 0.0485
Schistosoma mansoni tyrosine kinase 0.003 0.0485 0.1092
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0238 0.0258
Echinococcus granulosus tyrosine kinase 0.003 0.0485 0.0485
Echinococcus granulosus glutamate receptor subunit protein glur 0.0282 0.6755 0.6755
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0238 0.0238
Schistosoma mansoni intermediate filament proteins 0.0028 0.0444 0.0998
Onchocerca volvulus Glucosylceramidase homolog 0.0179 0.4191 0.7027
Echinococcus granulosus metabotropic glutamate receptor 2 0.003 0.0485 0.0485
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0507 0.0426
Brugia malayi Glutamate receptor 2 precursor 0.0382 0.9249 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.2593 1
Brugia malayi hypothetical protein 0.0021 0.0253 0.0273
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0238 0.0258
Loa Loa (eye worm) phosphofructokinase 0.0115 0.2593 0.2804
Echinococcus multilocularis expressed protein 0.0035 0.0613 0.0613
Echinococcus multilocularis nmda type glutamate receptor 0.0084 0.1825 0.1825
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0238 0.0238
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0253 0.0253
Echinococcus multilocularis metabotropic glutamate receptor 2 0.003 0.0485 0.0485
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0507 0.8557
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0519 0.1169
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.5208 0.5631
Echinococcus granulosus expressed protein 0.0035 0.0613 0.0613
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0592 0.2279
Echinococcus granulosus nmda type glutamate receptor 0.003 0.0485 0.0485
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.6526 1
Schistosoma mansoni axis inhibition protein axin 0.002 0.0238 0.0536
Echinococcus multilocularis musashi 0.0028 0.0444 0.0443
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0253 0.0253
Schistosoma mansoni egf-like domain protein 0.0016 0.0136 0.0305
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0032 0.0519 0.0561
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0238 0.0238
Brugia malayi hypothetical protein 0.003 0.0485 0.0525
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.1186 0.1186
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0238 0.0258
Schistosoma mansoni lipoxygenase 0.0021 0.0253 0.0569
Schistosoma mansoni regulator of G protein signaling 0.002 0.0238 0.0536
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0507 0.0426
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0256 0.0981
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0412 1 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0592 0.2279
Echinococcus granulosus intermediate filament protein 0.0028 0.0444 0.0443
Schistosoma mansoni polycystin 1-related 0.0021 0.0253 0.0569
Loa Loa (eye worm) hypothetical protein 0.0016 0.0136 0.0147
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0253 0.4868
Loa Loa (eye worm) hypothetical protein 0.002 0.0238 0.0258
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.6526 1
Schistosoma mansoni DNA helicase recq5 0.0021 0.0256 0.0575
Onchocerca volvulus 0.0021 0.0253 0.0424
Entamoeba histolytica hypothetical protein 0.002 0.0238 0.092
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0256 0.0255
Loa Loa (eye worm) hypothetical protein 0.0223 0.529 0.572
Brugia malayi Receptor family ligand binding region containing protein 0.003 0.0485 0.0525
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0485 0.0525
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0613 0.0595
Loa Loa (eye worm) glutamate receptor 0.003 0.0485 0.0525
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0189 0.4444 0.4444
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0256 0.0027
Schistosoma mansoni rotamase 0.0035 0.0613 0.1379
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.003 0.0485 0.0525
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0507 0.1954
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2593 0.3745
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.3311 0.3311
Schistosoma mansoni regulator of G protein signaling 0.002 0.0238 0.0536
Leishmania major extracellular receptor, putative 0.003 0.0485 0.1867
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0136 0.2293
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0058 0.0218
Echinococcus multilocularis glutamate receptor 4 0.0223 0.529 0.529
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0238 0.0238
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0058 0.0062
Schistosoma mansoni hypothetical protein 0.0179 0.4191 0.943
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0025 0.036 0.1193
Brugia malayi intermediate filament protein 0.0028 0.0444 0.0479
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.4191 0.6286
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0592 1
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0136 0.0147
Echinococcus multilocularis RUN 0.0021 0.0253 0.0253
Schistosoma mansoni rab6-interacting 0.0021 0.0253 0.0569
Echinococcus multilocularis laminin 0.0016 0.0136 0.0136
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.2593 0.2593
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0485 0.0525
Echinococcus multilocularis lamin dm0 0.0028 0.0444 0.0443
Schistosoma mansoni glutamate receptor kainate 0.0159 0.3693 0.831
Loa Loa (eye worm) glutamate receptor 1 0.0382 0.9249 1
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.2593 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0485 0.0525
Schistosoma mansoni glutamate receptor AMPA 0.0159 0.3693 0.831
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0238 0.0238
Brugia malayi Glutamate receptor 1 precursor 0.0382 0.9249 1
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.6526 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0431 0.0465
Echinococcus granulosus laminin 0.0016 0.0136 0.0136
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0238 0.0536
Schistosoma mansoni metabotropic glutamate receptor 0.003 0.0485 0.1092
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0507 1
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.4191 0.6286
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0256 0.0276
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0507 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0507 0.0426
Echinococcus multilocularis atrial natriuretic peptide receptor 0.003 0.0485 0.0485
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.6526 1
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0059 0.1199 0.1199
Loa Loa (eye worm) hypothetical protein 0.0028 0.0444 0.0479
Loa Loa (eye worm) hypothetical protein 0.003 0.0485 0.0525
Brugia malayi hypothetical protein 0.002 0.0238 0.0258
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.2593 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0485 0.0525
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.2593 0.5835
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0507 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0256 0.4316
Trypanosoma cruzi extracellular receptor, putative 0.003 0.0485 0.1867
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0238 0.0238
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.003 0.0485 0.0525
Schistosoma mansoni glutamate receptor kainate 0.0159 0.3693 0.831
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0238 0.0258
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0507 0.0656
Schistosoma mansoni hypothetical protein 0.0021 0.0253 0.0569
Schistosoma mansoni glutamate receptor NMDA 0.0189 0.4444 1
Onchocerca volvulus 0.0021 0.0253 0.0424
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0189 0.4444 0.4444
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0084 0.1825 0.1825
Loa Loa (eye worm) hypothetical protein 0.002 0.0238 0.0258
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.2593 0.2804
Schistosoma mansoni hypothetical protein 0.0059 0.1199 0.2698
Onchocerca volvulus Arrow homolog 0.0016 0.0136 0.0227
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0507 0.9754
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0253 0.0253
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.003 0.0485 0.0814
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2593 0.3745
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0256 0.0106
Schistosoma mansoni thyroid hormone receptor 0.0144 0.3311 0.7451
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.4191 0.6286
Brugia malayi Doublecortin family protein 0.0021 0.0253 0.0273
Echinococcus granulosus nmda type glutamate receptor 0.0084 0.1825 0.1825
Brugia malayi 6-phosphofructokinase 0.0115 0.2593 0.2804
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0238 0.0536
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0253 0.0273
Echinococcus multilocularis expressed protein 0.0394 0.9551 0.9551
Onchocerca volvulus 0.0028 0.0444 0.0744
Loa Loa (eye worm) hypothetical protein 0.0223 0.529 0.572
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0519 0.1169
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0011 0.0001 0.5
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0136 0.0147
Loa Loa (eye worm) RGS-3 protein 0.002 0.0238 0.0258
Schistosoma mansoni hypothetical protein 0.0179 0.4191 0.943
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0238 0.0238
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0253 0.0253

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 560 nM Binding affinity of the compound was evaluated against Coagulation factor X ChEMBL. 9873451
Ki (binding) = 560 nM Binding affinity of the compound was evaluated against Coagulation factor X ChEMBL. 9873451

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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