Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, CMGC MAPK | 0.026 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.026 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.026 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.026 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.026 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0175 | 0.5861 | 0.5861 |
Echinococcus granulosus | mitogen activated protein kinase | 0.026 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0175 | 0.5861 | 0.5861 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0175 | 0.5861 | 0.5861 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0175 | 0.5861 | 0.5861 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.026 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.026 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.0175 | 0.5861 | 0.5861 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0175 | 0.5861 | 0.5861 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.026 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.026 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.026 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.026 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0175 | 0.5861 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0175 | 0.5861 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.026 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.026 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.026 | 1 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0175 | 0.5861 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0175 | 0.5861 | 0.5861 |
Brugia malayi | cell division control protein 2 homolog | 0.0175 | 0.5861 | 0.5861 |
Trichomonas vaginalis | CMGC family protein kinase | 0.026 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0175 | 0.5861 | 0.5861 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.026 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0175 | 0.5861 | 0.5861 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0175 | 0.5861 | 0.5861 |
Trichomonas vaginalis | CMGC family protein kinase | 0.026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.5657 | 0.5657 |
Brugia malayi | Protein kinase domain containing protein | 0.0175 | 0.5861 | 0.5861 |
Schistosoma mansoni | serine/threonine protein kinase | 0.026 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0175 | 0.5861 | 0.5861 |
Plasmodium vivax | protein kinase Crk2 | 0.0175 | 0.5861 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0175 | 0.5861 | 0.5861 |
Trypanosoma brucei | protein kinase, putative | 0.026 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0175 | 0.5861 | 0.5861 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.