Detailed information for compound 825794

Basic information

Technical information
  • TDR Targets ID: 825794
  • Name: 3-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1 ,2,4-oxadiazol-5-yl]-N-(4-propan-2-ylphenyl)p ropanamide
  • MW: 354.446 | Formula: C20H26N4O2
  • H donors: 1 H acceptors: 3 LogP: 2.61 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCC(=CC1)c1noc(n1)CCC(=O)Nc1ccc(cc1)C(C)C
  • InChi: 1S/C20H26N4O2/c1-14(2)15-4-6-17(7-5-15)21-18(25)8-9-19-22-20(23-26-19)16-10-12-24(3)13-11-16/h4-7,10,14H,8-9,11-13H2,1-3H3,(H,21,25)
  • InChiKey: WQYZVTBSTBPBLP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-isopropylphenyl)-3-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1,2,4-oxadiazol-5-yl]propanamide
  • N-(4-isopropylphenyl)-3-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1,2,4-oxadiazol-5-yl]propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major beta tubulin 0.0027 0.007 0.0155
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0126 0.1596 0.9416
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.007 0.0413
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.011 0.1343 0.3005
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0126 0.1596 0.9416
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0024 0.0021 0.0122
Trichomonas vaginalis tubulin gamma chain, putative 0.0027 0.007 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Echinococcus multilocularis nAChR subunit 0.0126 0.1596 0.9416
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0024 0.0021 0.0122
Loa Loa (eye worm) ACC-1 protein 0.0126 0.1596 0.1596
Onchocerca volvulus 0.0126 0.1596 1
Brugia malayi Peroxidasin 0.003 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0126 0.1596 0.1596
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0058 0.0553 0.3262
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Leishmania major beta tubulin 0.0027 0.007 0.0155
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0058 0.0553 0.0553
Brugia malayi Cytochrome P450 family protein 0.0396 0.5725 0.5725
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0126 0.1596 0.1596
Loa Loa (eye worm) acetylcholine receptor protein 0.0058 0.0553 0.0553
Plasmodium vivax tubulin beta chain, putative 0.0027 0.007 1
Onchocerca volvulus 0.0126 0.1596 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0024 0.0021 0.0021
Echinococcus multilocularis glycine receptor subunit beta 0.0126 0.1596 0.9416
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.011 0.1343 0.2777
Echinococcus granulosus peroxidasin 0.003 0.0113 0.0669
Brugia malayi hypothetical protein 0.0058 0.0553 0.0553
Onchocerca volvulus Peroxidase homolog 0.003 0.0113 0.0711
Giardia lamblia Beta tubulin 0.0027 0.007 0.5
Brugia malayi Cation transporter family protein 0.0126 0.1596 0.1596
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0126 0.1596 0.1596
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.011 0.1343 0.3005
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0126 0.1596 0.9416
Brugia malayi Cytochrome P450 family protein 0.011 0.1343 0.1343
Schistosoma mansoni neurotransmitter gated ion channel 0.0068 0.0703 0.4146
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.011 0.1343 0.2777
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.007 0.5
Schistosoma mansoni nAChR subunit 0.0126 0.1596 0.9416
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.011 0.1343 0.2777
Echinococcus multilocularis beta tubulin 0.0027 0.007 0.0413
Echinococcus multilocularis 0.011 0.1343 0.7926
Loa Loa (eye worm) cytochrome P450 family protein 0.0231 0.3204 0.3204
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0126 0.1596 0.1596
Loa Loa (eye worm) hypothetical protein 0.0068 0.0703 0.0703
Brugia malayi SWIRM domain containing protein 0.0024 0.0021 0.0021
Brugia malayi Animal haem peroxidase family protein 0.003 0.0113 0.0113
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.011 0.1343 0.2777
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0024 0.0021 0.0122
Onchocerca volvulus Putative nachr subunit 0.0126 0.1596 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.011 0.1343 0.2777
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0058 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0311 0.4422 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0126 0.1596 0.9416
Brugia malayi Blistered cuticle protein 3 0.003 0.0113 0.0113
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.011 0.1343 0.2777
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.007 0.0413
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0126 0.1596 0.9416
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.011 0.1343 0.2777
Onchocerca volvulus 0.0058 0.0553 0.3464
Giardia lamblia Beta tubulin 0.0027 0.007 0.5
Mycobacterium leprae putative cytochrome p450 0.011 0.1343 1
Loa Loa (eye worm) beta-tubulin 0.0027 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0126 0.1596 0.1596
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0126 0.1596 0.9416
Leishmania major cytochrome p450-like protein 0.0231 0.3204 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0703 0.0703
Onchocerca volvulus 0.0058 0.0553 0.3464
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0126 0.1596 0.9416
Schistosoma mansoni nAChR subunit 0.0126 0.1596 0.9416
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Onchocerca volvulus 0.0024 0.0021 0.0129
Leishmania major cytochrome p450-like protein 0.011 0.1343 0.4155
Loa Loa (eye worm) BEN-1 protein 0.0027 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Echinococcus granulosus beta tubulin 0.0027 0.007 0.0413
Brugia malayi Animal haem peroxidase family protein 0.003 0.0113 0.0113
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0126 0.1596 0.9416
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.011 0.1343 0.2777
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0021 0.2946
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Echinococcus granulosus glycine receptor subunit alpha 1 0.0126 0.1596 0.9416
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.011 0.1343 0.3005
Echinococcus granulosus beta tubulin 0.0027 0.007 0.0413
Onchocerca volvulus Peroxidasin homolog 0.003 0.0113 0.0711
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0126 0.1596 0.1596
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0126 0.1596 0.9416
Toxoplasma gondii beta-1 tubulin, putative 0.0027 0.007 0.0373
Schistosoma mansoni nAChR subunit 0.0126 0.1596 0.9416
Brugia malayi hypothetical protein 0.0024 0.0021 0.0021
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.011 0.1343 0.3005
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0126 0.1596 0.9416
Loa Loa (eye worm) hypothetical protein 0.0068 0.0703 0.0703
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0113 0.0113
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0068 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Leishmania major beta tubulin 0.0027 0.007 0.0155
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0126 0.1596 0.1596
Onchocerca volvulus 0.0068 0.0703 0.4404
Loa Loa (eye worm) hypothetical protein 0.0122 0.1521 0.1521
Brugia malayi beta-tubulin, identical 0.0027 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.011 0.1343 0.3005
Plasmodium falciparum tubulin beta chain 0.0027 0.007 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.011 0.1343 0.3005
Leishmania major beta tubulin 0.0027 0.007 0.0155
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Echinococcus granulosus nAChR subunit 0.0068 0.0703 0.4146
Leishmania major beta tubulin 0.0027 0.007 0.0155
Schistosoma mansoni peroxidasin 0.003 0.0113 0.0669
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0133 0.1695 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0021 0.2946
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0113 0.0113
Loa Loa (eye worm) BEN-1 protein 0.0027 0.007 0.007
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.011 0.1343 0.4062
Onchocerca volvulus Peroxidase homolog 0.003 0.0113 0.0711
Loa Loa (eye worm) hypothetical protein 0.0675 1 1
Brugia malayi hypothetical protein 0.0058 0.0553 0.0553
Schistosoma mansoni lipoxygenase 0.0133 0.1695 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0703 0.0703
Toxoplasma gondii beta tubulin 0.0027 0.007 0.0373
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.011 0.1343 0.3005
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0126 0.1596 0.1596
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.011 0.1343 0.3005
Brugia malayi Cation transporter family protein 0.0126 0.1596 0.1596
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.007 0.0413
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.007 0.0413
Onchocerca volvulus Dual oxidase homolog 0.003 0.0113 0.0711
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0058 0.0553 0.0553
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0027 0.007 0.0413
Leishmania major beta tubulin 0.0027 0.007 0.0155
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Onchocerca volvulus 0.0126 0.1596 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Brugia malayi cytochrome P450 0.011 0.1343 0.1343
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.011 0.1343 0.2777
Brugia malayi Animal haem peroxidase family protein 0.003 0.0113 0.0113
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0126 0.1596 0.1596
Brugia malayi Cytochrome P450 family protein 0.0231 0.3204 0.3204
Schistosoma mansoni hypothetical protein 0.011 0.1343 0.7926
Brugia malayi hypothetical protein 0.0058 0.0553 0.0553
Schistosoma mansoni nAChR subunit 0.0126 0.1596 0.9416
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0058 0.0553 0.3262
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0126 0.1596 0.9416
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.011 0.1343 0.2777
Echinococcus granulosus glycine receptor subunit alpha 1 0.0126 0.1596 0.9416
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0335 0.4783 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0126 0.1596 0.9416
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0058 0.0553 0.3262
Loa Loa (eye worm) hypothetical protein 0.0068 0.0703 0.0703
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.011 0.1343 0.2777
Loa Loa (eye worm) GABA receptor subunit 0.0068 0.0703 0.0703
Leishmania major beta tubulin 0.0027 0.007 0.0155
Leishmania major beta tubulin 0.0027 0.007 0.0155
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0231 0.3204 0.6685
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0068 0.0703 0.4146
Loa Loa (eye worm) hypothetical protein 0.0068 0.0703 0.0703
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.011 0.1343 0.3005
Echinococcus multilocularis beta tubulin 0.0027 0.007 0.0413
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0068 0.0703 0.0703
Loa Loa (eye worm) tubulin beta chain 0.0027 0.007 0.007
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.011 0.1343 0.3005
Loa Loa (eye worm) cytochrome P450 family protein 0.0396 0.5725 0.5725
Schistosoma mansoni lipoxygenase 0.0093 0.1082 0.6387
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0068 0.0703 0.4146
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0126 0.1596 0.9416
Echinococcus granulosus lysine specific histone demethylase 1A 0.0024 0.0021 0.0122
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.011 0.1343 0.4155
Onchocerca volvulus 0.0126 0.1596 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.007 0.0413
Brugia malayi excitatory GABA receptor EXP-1A 0.0126 0.1596 0.1596
Loa Loa (eye worm) tubulin beta-1 chain 0.0027 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0126 0.1596 0.1596
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0058 0.0553 0.0553
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0126 0.1596 0.1596
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0126 0.1596 0.1596
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.011 0.1343 0.3005
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.011 0.1343 0.3005
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.011 0.1343 0.2777
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.007 0.5
Schistosoma mansoni nAChR subunit 0.0126 0.1596 0.9416
Schistosoma mansoni tubulin subunit beta 0.0027 0.007 0.0413
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0126 0.1596 0.9416
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Onchocerca volvulus 0.0126 0.1596 1
Echinococcus granulosus cytochrome P450 2K1 0.011 0.1343 0.7926
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0113 0.0113
Leishmania major beta tubulin 0.0027 0.007 0.0155
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.011 0.1343 0.2777
Toxoplasma gondii cytochrome p450 superfamily protein 0.011 0.1343 1
Giardia lamblia Beta tubulin 0.0027 0.007 0.5
Onchocerca volvulus 0.0126 0.1596 1
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.007 0.0413
Loa Loa (eye worm) CYP4Cod1 0.0231 0.3204 0.3204
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.011 0.1343 0.3005
Entamoeba histolytica hypothetical protein 0.0068 0.0703 1
Echinococcus multilocularis tubulin beta 1 chain 0.0027 0.007 0.0413
Trypanosoma cruzi beta tubulin, putative 0.0027 0.007 0.0155
Loa Loa (eye worm) hypothetical protein 0.0068 0.0703 0.0703
Leishmania major beta tubulin 0.0027 0.007 0.0155
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Onchocerca volvulus 0.003 0.0113 0.0711
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Echinococcus multilocularis glycine receptor subunit beta 0.0126 0.1596 0.9416
Schistosoma mansoni nAChR subunit 0.0058 0.0553 0.3262
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0021 0.2946
Echinococcus granulosus lysine specific histone demethylase 1A 0.0024 0.0021 0.0122
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Schistosoma mansoni nAChR subunit 0.0126 0.1596 0.9416
Trypanosoma brucei cytochrome P450, putative 0.0231 0.3204 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0126 0.1596 0.9416
Schistosoma mansoni peroxidasin 0.003 0.0113 0.0669
Echinococcus multilocularis peroxidasin 0.003 0.0113 0.0669
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.007 0.0413
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0126 0.1596 0.9416
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.011 0.1343 0.2777
Echinococcus granulosus nAChR subunit 0.0126 0.1596 0.9416
Onchocerca volvulus 0.0068 0.0703 0.4404
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0126 0.1596 0.9416
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.007 0.0413
Brugia malayi hypothetical protein 0.0058 0.0553 0.0553
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0126 0.1596 0.1596
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.011 0.1343 0.3005
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.011 0.1343 0.3005
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Echinococcus multilocularis protoporphyrinogen oxidase 0.0024 0.0021 0.0122
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.007 0.0413
Onchocerca volvulus Peroxidasin homolog 0.003 0.0113 0.0711
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Loa Loa (eye worm) hypothetical protein 0.0068 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.011 0.1343 0.2777
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0126 0.1596 0.9416
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0126 0.1596 0.9416
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Echinococcus granulosus tubulin subunit beta 0.0027 0.007 0.0413
Trypanosoma cruzi cytochrome P450, putative 0.0231 0.3204 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0024 0.0021 0.2946
Onchocerca volvulus 0.003 0.0113 0.0711
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0024 0.0021 0.2946
Echinococcus multilocularis 0.0024 0.0021 0.0122
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Echinococcus granulosus glycine receptor subunit beta 0.0126 0.1596 0.9416
Loa Loa (eye worm) hypothetical protein 0.0617 0.9107 0.9107
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Trypanosoma cruzi cytochrome P450, putative 0.0231 0.3204 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0058 0.0553 0.0553
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.011 0.1343 0.2777
Brugia malayi Cation transporter family protein 0.0126 0.1596 0.1596
Loa Loa (eye worm) ACC-1 protein 0.0126 0.1596 0.1596
Brugia malayi Tubulin beta-1 chain 0.0027 0.007 0.007
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.011 0.1343 0.2777
Schistosoma mansoni tubulin subunit beta 0.0027 0.007 0.0413
Schistosoma mansoni tubulin subunit beta 0.0027 0.007 0.0413
Schistosoma mansoni nAChR subunit 0.0126 0.1596 0.9416
Trichomonas vaginalis tubulin, putative 0.0027 0.007 0.5
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0126 0.1596 0.1596
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Schistosoma mansoni neurotransmitter gated ion channel 0.0058 0.0553 0.3262
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.007 0.0413
Leishmania major beta tubulin 0.0027 0.007 0.0155
Onchocerca volvulus 0.0058 0.0553 0.3464
Loa Loa (eye worm) cytochrome P450 0.011 0.1343 0.1343
Onchocerca volvulus Chorion peroxidase homolog 0.003 0.0113 0.0711
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Schistosoma mansoni neurotransmitter gated ion channel 0.0058 0.0553 0.3262
Schistosoma mansoni tubulin subunit beta 0.0027 0.007 0.0413
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.011 0.1343 0.2777
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.011 0.1343 0.2777
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0058 0.0553 0.0553
Chlamydia trachomatis protoporphyrinogen oxidase 0.0024 0.0021 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Leishmania major beta tubulin 0.0027 0.007 0.0155
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0126 0.1596 0.9416
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.011 0.1343 0.3005
Loa Loa (eye worm) blistered cuticle protein 3 0.003 0.0113 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.011 0.1343 0.3005
Leishmania major beta tubulin 0.0027 0.007 0.0155
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0126 0.1596 0.1596
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0058 0.0553 0.3262
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Leishmania major beta tubulin 0.0027 0.007 0.0155
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0126 0.1596 0.1596
Toxoplasma gondii beta-tubulin, putative 0.0027 0.007 0.0373
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.007 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Schistosoma mansoni tubulin subunit beta 0.0027 0.007 0.0413
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0126 0.1596 0.1596
Trichomonas vaginalis tubulin alpha chain, putative 0.0027 0.007 0.5
Schistosoma mansoni cytochrome P450 0.011 0.1343 0.7926
Echinococcus granulosus glycine receptor subunit beta 0.0126 0.1596 0.9416
Schistosoma mansoni acetylcholine receptor subunit beta 0.0058 0.0553 0.3262
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0126 0.1596 0.9416
Schistosoma mansoni nAChR subunit 0.0058 0.0553 0.3262
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Schistosoma mansoni amine oxidase 0.0024 0.0021 0.0122
Leishmania major beta tubulin 0.0027 0.007 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.011 0.1343 0.3005
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.011 0.1343 0.4155
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0068 0.0703 0.0703
Schistosoma mansoni acetylcholine receptor-related 0.0058 0.0553 0.3262
Leishmania major beta tubulin 0.0027 0.007 0.0155
Brugia malayi Animal haem peroxidase family protein 0.003 0.0113 0.0113
Leishmania major beta tubulin 0.0027 0.007 0.0155
Brugia malayi Animal haem peroxidase family protein 0.003 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Leishmania major lanosterol 14-alpha-demethylase, putative 0.011 0.1343 0.4155
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Echinococcus granulosus tubulin beta 1 chain 0.0027 0.007 0.0413
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0068 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Echinococcus multilocularis nAChR subunit 0.0068 0.0703 0.4146
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0024 0.0021 0.2946
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0058 0.0553 0.3262
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0126 0.1596 0.1596
Loa Loa (eye worm) tubulin beta-4 chain 0.0027 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0126 0.1596 0.1596
Loa Loa (eye worm) hypothetical protein 0.0058 0.0553 0.0553
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0126 0.1596 0.9416
Onchocerca volvulus 0.003 0.0113 0.0711
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0126 0.1596 0.1596
Plasmodium falciparum protoporphyrinogen oxidase 0.0024 0.0021 0.2946
Leishmania major beta tubulin 0.0027 0.007 0.0155
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0021
Mycobacterium leprae Conserved hypothetical protein 0.011 0.1343 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0231 0.3204 0.3204
Leishmania major cytochrome p450-like protein 0.011 0.1343 0.4155
Brugia malayi hypothetical protein 0.003 0.0113 0.0113
Echinococcus multilocularis tubulin subunit beta 0.0027 0.007 0.0413
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0126 0.1596 0.1596
Loa Loa (eye worm) LGC-31 protein 0.0126 0.1596 0.1596
Trypanosoma cruzi cytochrome p450-like protein, putative 0.011 0.1343 0.4155
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Schistosoma mansoni tubulin subunit beta 0.0027 0.007 0.0413
Loa Loa (eye worm) hypothetical protein 0.0126 0.1596 0.1596
Schistosoma mansoni amine oxidase 0.0024 0.0021 0.0122
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0126 0.1596 0.9416
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0058 0.0553 0.0553
Echinococcus granulosus tubulin beta 4A class IVa 0.0027 0.007 0.0413
Loa Loa (eye worm) tubulin beta-2A chain 0.0027 0.007 0.007
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0058 0.0553 0.0553
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0335 0.4783 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0133 0.1695 1
Brugia malayi hypothetical protein 0.0058 0.0553 0.0553
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.011 0.1343 0.2777
Brugia malayi Cytochrome P450 family protein 0.0231 0.3204 0.3204
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0126 0.1596 0.9416
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.011 0.1343 0.3005
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.011 0.1343 0.3005
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0113
Echinococcus granulosus glycine receptor subunit alpha 1 0.0126 0.1596 0.9416

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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