Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0025 | 0.0147 | 0.0147 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3315 | 0.5019 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.074 | 0.9357 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.079 | 1 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.079 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0025 | 0.0147 | 0.0141 |
Echinococcus granulosus | intermediate filament protein | 0.0025 | 0.0147 | 0.02 |
Trichomonas vaginalis | AGC family protein kinase | 0.079 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.2608 | 0.2608 |
Trypanosoma cruzi | Protein kinase B | 0.0525 | 0.659 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0216 | 0.2608 | 0.2776 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0519 | 0.6515 | 0.6957 |
Trichomonas vaginalis | AGC family protein kinase | 0.0271 | 0.3315 | 0.0111 |
Entamoeba histolytica | protein kinase, putative | 0.079 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0025 | 0.0147 | 0.0147 |
Trichomonas vaginalis | AGC family protein kinase | 0.0271 | 0.3315 | 0.0111 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0271 | 0.3315 | 0.5019 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0519 | 0.6515 | 0.6957 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0271 | 0.3315 | 0.3315 |
Trichomonas vaginalis | AGC family protein kinase | 0.0271 | 0.3315 | 0.0111 |
Brugia malayi | protein kinase C II. | 0.0271 | 0.3315 | 0.3315 |
Leishmania major | hypothetical protein, conserved | 0.0023 | 0.0126 | 1 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0271 | 0.3315 | 0.5019 |
Echinococcus granulosus | geminin | 0.0155 | 0.1821 | 0.2746 |
Trichomonas vaginalis | AGC family protein kinase | 0.079 | 1 | 1 |
Echinococcus granulosus | NDR protein kinase | 0.0271 | 0.3315 | 0.5019 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0525 | 0.659 | 1 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0271 | 0.3315 | 0.3315 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.3315 | 0.3315 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0525 | 0.659 | 1 |
Schistosoma mansoni | lamin | 0.0025 | 0.0147 | 0.02 |
Echinococcus multilocularis | protein kinase c iota type | 0.0271 | 0.3315 | 0.3532 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0271 | 0.3315 | 0.3315 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0271 | 0.3315 | 0.3532 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0271 | 0.3315 | 0.3532 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0271 | 0.3315 | 0.3532 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0525 | 0.659 | 0.7038 |
Echinococcus multilocularis | nervana 2 | 0.0519 | 0.6515 | 0.6957 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.1821 | 0.2746 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3315 | 0.5019 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0397 | 0.058 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0271 | 0.3315 | 0.3532 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0271 | 0.3315 | 0.5019 |
Trichomonas vaginalis | AGC family protein kinase | 0.079 | 1 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0271 | 0.3315 | 0.5019 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1606 | 0.1606 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0231 | 0.0327 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3315 | 0.5019 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0141 | 0.0141 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0023 | 0.0126 | 0.0168 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0525 | 0.659 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0031 | 0.0231 | 0.0231 |
Entamoeba histolytica | protein kinase, putative | 0.079 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.079 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.079 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.079 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3315 | 0.5019 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0525 | 0.659 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0525 | 0.659 | 0.6502 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0126 | 0.0168 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3315 | 0.5019 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0033 | 0.0253 | 0.0361 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0525 | 0.659 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0014 | 0.0016 | 0.0016 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0271 | 0.3315 | 0.3532 |
Echinococcus granulosus | lamin dm0 | 0.0025 | 0.0147 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0147 | 0.0147 |
Echinococcus multilocularis | nervana 2 | 0.0519 | 0.6515 | 0.6957 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0525 | 0.659 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0025 | 0.0147 | 0.0147 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0271 | 0.3315 | 0.3532 |
Giardia lamblia | Kinase, AGC PKA | 0.0525 | 0.659 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0271 | 0.3315 | 0.3532 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0023 | 0.0126 | 0.0111 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0044 | 0.0397 | 0.0397 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0271 | 0.3315 | 0.5019 |
Schistosoma mansoni | survival motor neuron protein | 0.0044 | 0.0397 | 0.058 |
Brugia malayi | Hr1 repeat family protein | 0.0271 | 0.3315 | 0.3315 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0271 | 0.3315 | 0.3532 |
Schistosoma mansoni | atypical protein kinase C | 0.0271 | 0.3315 | 0.5019 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0033 | 0.0253 | 0.0254 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0046 | 0.0416 | 0.0416 |
Trichomonas vaginalis | AGC family protein kinase | 0.079 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0271 | 0.3315 | 0.3315 |
Echinococcus granulosus | protein kinase C gamma type | 0.0271 | 0.3315 | 0.5019 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0126 | 0.0168 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0033 | 0.0253 | 0.0361 |
Trichomonas vaginalis | AGC family protein kinase | 0.0271 | 0.3315 | 0.0111 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0525 | 0.659 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0014 | 0.0016 | 0.0016 |
Echinococcus granulosus | nervana 2 | 0.0519 | 0.6515 | 0.9886 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0014 | 0.0016 | 0.5 |
Echinococcus granulosus | lamin | 0.0025 | 0.0147 | 0.02 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0014 | 0.0016 | 0.0016 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0525 | 0.659 | 0.6502 |
Brugia malayi | Protein kinase domain containing protein | 0.0271 | 0.3315 | 0.3315 |
Echinococcus granulosus | nervana 2 | 0.0519 | 0.6515 | 0.9886 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0271 | 0.3315 | 0.5019 |
Entamoeba histolytica | protein kinase 2, putative | 0.0525 | 0.659 | 0.6502 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0416 | 0.0416 |
Brugia malayi | intermediate filament protein | 0.0025 | 0.0147 | 0.0147 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.079 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0025 | 0.0147 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0126 | 0.0126 |
Echinococcus multilocularis | geminin | 0.0155 | 0.1821 | 0.1933 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0126 | 0.0168 |
Entamoeba histolytica | protein kinase, putative | 0.0271 | 0.3315 | 0.3142 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0021 | 0.0021 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0014 | 0.0016 | 0.0016 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0253 | 0.0361 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0525 | 0.659 | 0.7038 |
Echinococcus multilocularis | lamin dm0 | 0.0025 | 0.0147 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0016 | 0.0016 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.1821 | 0.2746 |
Brugia malayi | hypothetical protein | 0.0216 | 0.2608 | 0.2608 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0046 | 0.0416 | 0.0416 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0271 | 0.3315 | 0.3315 |
Brugia malayi | Protein kinase domain containing protein | 0.0271 | 0.3315 | 0.3315 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0014 | 0.0016 | 0.0016 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0519 | 0.6515 | 0.9886 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0126 | 0.0126 |
Trichomonas vaginalis | AGC family protein kinase | 0.079 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0025 | 0.0147 | 0.02 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0271 | 0.3315 | 0.3315 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0253 | 0.0253 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0014 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0046 | 0.0416 | 0.0416 |
Onchocerca volvulus | 0.0044 | 0.0397 | 0.1713 | |
Schistosoma mansoni | lamin | 0.0025 | 0.0147 | 0.02 |
Brugia malayi | hypothetical protein | 0.0138 | 0.1606 | 0.1606 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0231 | 0.0231 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0216 | 0.2608 | 0.3944 |
Onchocerca volvulus | 0.0138 | 0.1606 | 1 | |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0271 | 0.3315 | 0.3532 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0525 | 0.659 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.0271 | 0.3315 | 0.5019 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0525 | 0.659 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3315 | 0.5019 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0023 | 0.0126 | 0.0111 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0271 | 0.3315 | 0.5019 |
Toxoplasma gondii | AGC kinase | 0.079 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0126 | 0.0168 |
Echinococcus granulosus | protein kinase c iota type | 0.0271 | 0.3315 | 0.5019 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0519 | 0.6515 | 0.9886 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.