Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.0906 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.5436 | 0.8342 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.5436 | 0.8342 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.6337 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.5436 | 0.8342 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.6337 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.5265 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2665 | 0.2385 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.0906 | 0.0125 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.0906 | 0.0258 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.005 | 0.1112 | 0.0473 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.5436 | 0.8342 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.2665 | 0.4188 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.2665 | 0.2035 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1112 | 0.0349 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2665 | 0.2385 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0106 | 0.5265 | 0.5 |
Onchocerca volvulus | 0.017 | 1 | 1 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.5265 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.0906 | 0.0125 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0106 | 0.5265 | 0.5695 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0106 | 0.5265 | 1 |
Brugia malayi | glutathione reductase | 0.0048 | 0.0906 | 0.0125 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0106 | 0.5265 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0106 | 0.5265 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.0906 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.0906 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.005 | 0.1112 | 0.0718 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0048 | 0.0906 | 0.1721 |
Brugia malayi | RNA binding protein | 0.0071 | 0.2665 | 0.2035 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2665 | 0.2385 |
Schistosoma mansoni | DNA polymerase eta | 0.005 | 0.1112 | 0.0409 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.6337 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.0906 | 0.5 |
Schistosoma mansoni | kinase | 0.0054 | 0.1383 | 0.0753 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.2665 | 0.2035 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2665 | 0.2385 |
Trypanosoma brucei | polo-like protein kinase | 0.0106 | 0.5265 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.6337 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.5436 | 0.8342 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0106 | 0.5265 | 0.4859 |
Giardia lamblia | Kinase, PLK | 0.0106 | 0.5265 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.5436 | 0.8342 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.5265 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.0906 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.2665 | 0.2035 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0106 | 0.5265 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.5265 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.0906 | 0.0125 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0106 | 0.5265 | 0.4859 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.005 | 0.1112 | 0.2113 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2665 | 0.2385 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.5265 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.005 | 0.1112 | 0.0718 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.0906 | 0.0258 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0106 | 0.5265 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.0906 | 0.1721 |
Leishmania major | DNA polymerase eta, putative | 0.005 | 0.1112 | 0.2113 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.5265 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.5265 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.2665 | 0.2035 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.2665 | 0.4188 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.005 | 0.1112 | 0.0349 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.2665 | 0.2035 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.