TDR Targets

Basic information

Technical information

TDR Targets ID: 826144
Name: N-(4-fluoro-2-methylphenyl)-2-(2-oxo-6-pyrrol idin-1-ylsulfonyl-1,3-benzoxazol-3-yl)acetami de
MW: 433.453 | Formula: C20H20FN3O5S
H donors: 1 H acceptors: 4 LogP: 2.33 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cn1c(=O)oc2c1ccc(c2)S(=O)(=O)N1CCCC1)Nc1ccc(cc1C)F
InChi: 1S/C20H20FN3O5S/c1-13-10-14(21)4-6-16(13)22-19(25)12-24-17-7-5-15(11-18(17)29-20(24)26)30(27,28)23-8-2-3-9-23/h4-7,10-11H,2-3,8-9,12H2,1H3,(H,22,25)
InChiKey: FMZZZYRIQOJOQE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-fluoro-2-methyl-phenyl)-2-(2-oxo-6-pyrrolidin-1-ylsulfonyl-1,3-benzoxazol-3-yl)acetamide
N-(4-fluoro-2-methylphenyl)-2-(2-oxo-6-1-pyrrolidinylsulfonyl-1,3-benzoxazol-3-yl)acetamide
N-(4-fluoro-2-methyl-phenyl)-2-(2-keto-6-pyrrolidin-1-ylsulfonyl-1,3-benzoxazol-3-yl)acetamide
N-(4-fluoro-2-methyl-phenyl)-2-(2-oxo-6-pyrrolidin-1-ylsulfonyl-1,3-benzoxazol-3-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Cathepsin B precursor	0.0078	0.025	0.2577
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0181	0.0609	0.2379
Leishmania major	cathepsin L-like protease	0.0331	0.1137	1
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.025	0.2197
Plasmodium vivax	serine-repeat antigen (SERA)	0.0078	0.025	0.2197
Entamoeba histolytica	cysteine protease, putative	0.0078	0.025	0.2197
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Onchocerca volvulus		0.0331	0.1137	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0078	0.025	0.2197
Schistosoma mansoni	Smad4	0.0008	0.0006	0.0022
Leishmania major	cathepsin L-like protease	0.0331	0.1137	1
Brugia malayi	Pre-SET motif family protein	0.003	0.0083	0.0324
Echinococcus multilocularis	calcium uptake protein 1	0.0007	0.0002	0.0002
Loa Loa (eye worm)	cysteine protease	0.0331	0.1137	0.4439
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0052	0.0158	0.0158
Echinococcus multilocularis	cathepsin L	0.0078	0.025	0.025
Brugia malayi	Serotonin receptor	0.0052	0.0158	0.0617
Echinococcus multilocularis	neuropeptides capa receptor	0.0052	0.0158	0.0158
Loa Loa (eye worm)	fibroinase	0.0331	0.1137	0.4439
Giardia lamblia	Cathepsin B precursor	0.0078	0.025	0.2577
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.1137	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.025	0.2197
Echinococcus multilocularis	neuropeptide receptor A26	0.0052	0.0158	0.0158
Brugia malayi	Dopamine receptor protein 1	0.0052	0.0158	0.0617
Onchocerca volvulus	Cathepsin L homolog	0.0078	0.025	0.2197
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Loa Loa (eye worm)	G-protein coupled receptor	0.0052	0.0158	0.0617
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0006	0.0022
Toxoplasma gondii	cathepsin CPC1	0.0078	0.025	0.2197
Echinococcus granulosus	serotonin receptor	0.0052	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Entamoeba histolytica	cysteine protease, putative	0.0078	0.025	0.2197
Echinococcus multilocularis	g-protein coupled receptor	0.0052	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Leishmania major	cysteine peptidase A (CPA)	0.0331	0.1137	1
Schistosoma mansoni	neuropeptide receptor	0.0052	0.0158	0.0617
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0052	0.0158	0.0158
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0331	0.1137	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0052	0.0158	0.0617
Onchocerca volvulus		0.0052	0.0158	0.1391
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0181	0.0609	0.2379
Schistosoma mansoni	adenoreceptor	0.0052	0.0158	0.0617
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0078	0.025	0.0975
Loa Loa (eye worm)	TK/ALK protein kinase	0.0149	0.0498	0.1944
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0083	0.073
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0078	0.025	0.2197
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0006	0.0006
Brugia malayi	Cathepsin L-like precursor	0.0331	0.1137	0.4439
Giardia lamblia	Cathepsin B precursor	0.0282	0.0964	1
Plasmodium falciparum	serine repeat antigen 5	0.0078	0.025	0.2197
Onchocerca volvulus		0.0331	0.1137	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0078	0.025	0.0975
Brugia malayi	G-protein coupled receptor	0.0052	0.0158	0.0617
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0078	0.025	0.0975
Echinococcus granulosus	neuropeptide s receptor	0.0052	0.0158	0.0158
Echinococcus multilocularis	cathepsin L cysteine protease	0.0331	0.1137	0.1137
Loa Loa (eye worm)	hypothetical protein	0.0078	0.025	0.0975
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Entamoeba histolytica	cysteine protease, putative	0.0331	0.1137	1
Toxoplasma gondii	calcium-dependent protein kinase	0.0007	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trypanosoma cruzi	cysteine peptidase, putative	0.0331	0.1137	0.4439
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.1137	1
Entamoeba histolytica	cysteine protease, putative	0.0181	0.0609	0.536
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0052	0.0158	0.0158
Brugia malayi	cathepsin F-like cysteine proteinase	0.0103	0.0337	0.1316
Brugia malayi	follicle stimulating hormone receptor	0.0052	0.0158	0.0617
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Brugia malayi	Papain family cysteine protease containing protein	0.0078	0.025	0.0975
Giardia lamblia	Hypothetical protein	0.0078	0.025	0.2577
Echinococcus multilocularis	neuropeptides capa receptor	0.0052	0.0158	0.0158
Brugia malayi	Cathepsin L-like precursor	0.0331	0.1137	0.4439
Plasmodium falciparum	serine repeat antigen 6	0.0078	0.025	0.2197
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0078	0.025	0.2197
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0083	0.0324
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0006	0.0022
Trypanosoma cruzi	major cysteine proteinase, putative	0.0078	0.025	0.0975
Entamoeba histolytica	cysteine protease, putative	0.0078	0.025	0.2197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0078	0.025	0.0975
Echinococcus granulosus	neuropeptide Y receptor	0.0052	0.0158	0.0158
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0181	0.0609	0.536
Giardia lamblia	Cathepsin L precursor	0.0078	0.025	0.2577
Onchocerca volvulus		0.0331	0.1137	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0331	0.1137	0.4439
Brugia malayi	cathepsin L precursor	0.0078	0.025	0.0975
Onchocerca volvulus		0.0052	0.0158	0.1391
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.008	0.0258	0.0258
Entamoeba histolytica	cysteine protease, putative	0.0181	0.0609	0.536
Schistosoma mansoni	cathepsin C	0.0078	0.025	0.0975
Giardia lamblia	Cysteine protease	0.0078	0.025	0.2577
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0052	0.0158	0.0617
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0049	0.0148	0.1305
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0078	0.025	0.2577
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0078	0.025	0.0975
Echinococcus granulosus	7tm_1 domain containing protein	0.0052	0.0158	0.0158
Echinococcus granulosus	orexin receptor type 2	0.0052	0.0158	0.0158
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.025	0.2197
Echinococcus granulosus	neuropeptide receptor	0.0052	0.0158	0.0158
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0006	0.0006
Plasmodium vivax	vivapain-3	0.0181	0.0609	0.536
Schistosoma mansoni	biogenic amine receptor	0.0052	0.0158	0.0617
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0052	0.0158	0.1391
Echinococcus granulosus	neuropeptides capa receptor	0.0052	0.0158	0.0158
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.1137	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Brugia malayi	fibroinase precursor	0.0078	0.025	0.0975
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0136	0.0136
Echinococcus multilocularis	neuropeptide receptor	0.0052	0.0158	0.0158
Echinococcus granulosus	calpain A	0.0007	0.0002	0.0002
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.025	0.2197
Echinococcus granulosus	fmrfamide receptor	0.0052	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0228	0.0777	0.3035
Schistosoma mansoni	hypothetical protein	0.0052	0.0158	0.0617
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0213
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.2863	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0052	0.0158	0.0617
Brugia malayi	Cathepsin L-like precursor	0.0331	0.1137	0.4439
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0078	0.025	0.2197
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0078	0.025	0.2197
Schistosoma mansoni	hypothetical protein	0.0018	0.0039	0.0154
Echinococcus granulosus	MAM	0.0018	0.0039	0.0039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.025	0.2197
Echinococcus multilocularis	serotonin receptor	0.0052	0.0158	0.0158
Giardia lamblia	Cathepsin L-like protease	0.0078	0.025	0.2577
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0052	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Giardia lamblia	Cathepsin B precursor	0.0282	0.0964	1
Leishmania major	cathepsin L-like protease	0.0331	0.1137	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.1137	1
Echinococcus granulosus	EF hand domain containing family member A2	0.0007	0.0002	0.0002
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0052	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Brugia malayi	Matrixin family protein	0.0022	0.0055	0.0213
Onchocerca volvulus		0.0052	0.0158	0.1391
Echinococcus granulosus	neuropeptide receptor	0.0052	0.0158	0.0158
Echinococcus granulosus	biogenic amine 5HT receptor	0.0052	0.0158	0.0158
Brugia malayi	cathepsin L-like precursor	0.0228	0.0777	0.3035
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.1137	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0078	0.025	0.2197
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0052	0.0158	0.0617
Entamoeba histolytica	cysteine proteinase, putative	0.0181	0.0609	0.536
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.025	0.0975
Toxoplasma gondii	calmodulin CAM1	0.0007	0.0002	0.0014
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.1137	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.0158	0.0617
Giardia lamblia	Hypothetical protein	0.0078	0.025	0.2577
Onchocerca volvulus	Cathepsin L homolog	0.0331	0.1137	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0052	0.0158	0.0617
Brugia malayi	hypothetical protein	0.0052	0.0158	0.0617
Entamoeba histolytica	hypothetical protein, conserved	0.0007	0.0002	0.0014
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0136	0.0136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.003	0.0083	0.0324
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0136	0.0532
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Entamoeba histolytica	cysteine protease, putative	0.0181	0.0609	0.536
Trypanosoma cruzi	cysteine proteinase, putative	0.0181	0.0609	0.2379
Echinococcus multilocularis	G protein coupled receptor 139	0.0052	0.0158	0.0158
Brugia malayi	neuropeptide F receptor	0.0052	0.0158	0.0617
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0006	0.0022
Schistosoma mansoni	hypothetical protein	0.0018	0.0039	0.0154
Schistosoma mansoni	reticulocalbin	0.0007	0.0002	0.0006
Schistosoma mansoni	neuropeptide receptor	0.0052	0.0158	0.0617
Brugia malayi	hypothetical protein	0.0052	0.0158	0.0617
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0136	0.0136
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trichomonas vaginalis	set domain proteins, putative	0.0239	0.0815	0.717
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0052	0.0158	0.0617
Echinococcus granulosus	calbindin 32	0.0007	0.0002	0.0002
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0039	0.0154
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0052	0.0158	0.0158
Loa Loa (eye worm)	TYRA-2 protein	0.0052	0.0158	0.0617
Brugia malayi	G-protein coupled receptor	0.0052	0.0158	0.0617
Echinococcus multilocularis	neuropeptide Y receptor	0.0052	0.0158	0.0158
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0078	0.025	0.2197
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.0158	0.0617
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0027	0.0071	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0331	0.1137	1
Brugia malayi	hypothetical protein	0.0052	0.0158	0.0617
Loa Loa (eye worm)	neuropeptide F receptor	0.0052	0.0158	0.0617
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0078	0.025	0.0975
Schistosoma mansoni	amine GPCR	0.0052	0.0158	0.0617
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0078	0.025	0.2197
Echinococcus granulosus	g protein coupled receptor	0.0052	0.0158	0.0158
Entamoeba histolytica	cysteine protease, putative	0.0181	0.0609	0.536
Trichomonas vaginalis	calcineurin B subunit, putative	0.0007	0.0002	0.0014
Echinococcus granulosus	g-protein coupled receptor	0.0052	0.0158	0.0158
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0078	0.025	0.0975
Giardia lamblia	Cathepsin B precursor	0.0078	0.025	0.2577
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0083	0.0083
Giardia lamblia	Encystation-specific protease	0.0078	0.025	0.2577
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Schistosoma mansoni	growth hormone secretagogue receptor	0.0052	0.0158	0.0617
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0738	0.2561	1
Entamoeba histolytica	cysteine protease, putative	0.0181	0.0609	0.536
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0052	0.0158	0.0158
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Schistosoma mansoni	cathepsin F (C01 family)	0.0331	0.1137	0.4439
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.1137	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0282	0.0964	0.3766
Schistosoma mansoni	neuropeptide receptor	0.0052	0.0158	0.0617
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0103	0.0337	0.1316
Plasmodium vivax	unspecified product	0.0181	0.0609	0.536
Entamoeba histolytica	cysteine proteinase 1, putative	0.0181	0.0609	0.536
Echinococcus granulosus	survival motor neuron protein 1	0.0235	0.0801	0.0801
Brugia malayi	putative neuropeptide receptor NPR1	0.0052	0.0158	0.0617
Onchocerca volvulus		0.0052	0.0158	0.1391
Brugia malayi	Cathepsin L-like precursor	0.0103	0.0337	0.1316
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.1137	1
Schistosoma mansoni	amine GPCR	0.0052	0.0158	0.0617
Plasmodium vivax	SET domain protein, putative	0.003	0.0083	0.073
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0052	0.0158	0.0617
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.025	0.2197
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0078	0.025	0.2197
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0052	0.0158	0.0617
Echinococcus granulosus	g protein coupled receptor	0.0052	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0078	0.025	0.0975
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0079	0.0079
Brugia malayi	Papain family cysteine protease containing protein	0.0331	0.1137	0.4439
Echinococcus granulosus	cysteine protease	0.0181	0.0609	0.0609
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0738	0.2561	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.025	0.2197
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0078	0.025	0.2197
Echinococcus granulosus	neuropeptides capa receptor	0.0052	0.0158	0.0158
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0052	0.0158	0.0158
Brugia malayi	Cathepsin L-like precursor	0.0228	0.0777	0.3035
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0052	0.0158	0.0617
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.0392	0.1529
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0078	0.025	0.2197
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0804	0.2791	0.2791
Giardia lamblia	Cathepsin L precursor	0.0078	0.025	0.2577
Entamoeba histolytica	cysteine protease, putative	0.0078	0.025	0.2197
Plasmodium vivax	vivapain-1	0.0181	0.0609	0.536
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0078	0.025	0.2197
Echinococcus granulosus	neuropeptide receptor A26	0.0052	0.0158	0.0158
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0228	0.0777	0.3035
Brugia malayi	Dopamine receptor	0.0052	0.0158	0.0617
Loa Loa (eye worm)	programmed cell death protein 6	0.0007	0.0002	0.0006
Schistosoma mansoni	neuropeptide F-like receptor	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0337	0.1316
Mycobacterium leprae	PROBABLE HYDROLASE	0.0027	0.0071	0.5
Giardia lamblia	Cathepsin L precursor	0.0078	0.025	0.2577
Giardia lamblia	Cathepsin L-like protease	0.0078	0.025	0.2577
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0083	0.0324
Entamoeba histolytica	cysteine proteinase, putative	0.0331	0.1137	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0015	0.006
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0052	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.013	0.0432	0.1686
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0078	0.025	0.2197
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0052	0.0158	0.0617
Echinococcus multilocularis	g protein coupled receptor	0.0052	0.0158	0.0158
Echinococcus multilocularis	orexin receptor type 2	0.0052	0.0158	0.0158
Brugia malayi	Matrixin family protein	0.0022	0.0055	0.0213
Echinococcus multilocularis	plexin a4	0.0013	0.0022	0.0022
Echinococcus multilocularis	cathepsin b	0.0738	0.2561	0.2561
Trypanosoma cruzi	cysteine peptidase, putative	0.0331	0.1137	0.4439
Giardia lamblia	Cathepsin L precursor	0.0078	0.025	0.2577
Schistosoma mansoni	hypothetical protein	0.0031	0.0087	0.0339
Trypanosoma cruzi	cruzipain precursor, putative	0.0331	0.1137	0.4439
Schistosoma mansoni	cathepsin F (C01 family)	0.0228	0.0777	0.3035
Schistosoma mansoni	neuropeptide f receptor 76f	0.0052	0.0158	0.0617
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0006	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Brugia malayi	plexin A	0.0013	0.0022	0.0087
Echinococcus multilocularis	Smad4	0.0008	0.0006	0.0006
Brugia malayi	hypothetical protein	0.0235	0.0801	0.3129
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0078	0.025	0.0975
Echinococcus multilocularis	dro:myosuppressin receptor	0.0052	0.0158	0.0158
Brugia malayi	hypothetical protein	0.0052	0.0158	0.0617
Echinococcus multilocularis	cathepsin b	0.0738	0.2561	0.2561
Echinococcus granulosus	cathepsin l1	0.0331	0.1137	0.1137
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0282	0.0964	0.3766
Trypanosoma brucei	calmodulin, putative	0.0007	0.0002	0.0014
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0078	0.025	0.0975
Echinococcus multilocularis	g protein coupled receptor	0.0052	0.0158	0.0158
Entamoeba histolytica	cysteine proteinase 2	0.0181	0.0609	0.536
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0052	0.0158	0.0158
Brugia malayi	Smad1	0.0008	0.0006	0.0022
Brugia malayi	MH2 domain containing protein	0.0008	0.0006	0.0022
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0145	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0331	0.1137	0.4439
Echinococcus multilocularis	EF hand domain containing family member A2	0.0007	0.0002	0.0002
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0052	0.0158	0.0158
Onchocerca volvulus		0.0052	0.0158	0.1391
Brugia malayi	hypothetical protein	0.0052	0.0158	0.0617
Schistosoma mansoni	histamine h1 receptor	0.0052	0.0158	0.0617
Entamoeba histolytica	cysteine protease, putative	0.0181	0.0609	0.536
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0052	0.0158	0.0158
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0052	0.0158	0.0158
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.1137	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0052	0.0158	0.0617
Brugia malayi	G protein-coupled receptor F59B2.13	0.0052	0.0158	0.0617
Schistosoma mansoni	plexin	0.0011	0.0015	0.006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0071	0.0279
Brugia malayi	Cathepsin L-like precursor	0.0331	0.1137	0.4439
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0078	0.025	0.0975
Brugia malayi	Protein kinase domain containing protein	0.0149	0.0498	0.1945
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.1137	1
Onchocerca volvulus	Cathepsin L homolog	0.0331	0.1137	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0078	0.025	0.2197
Onchocerca volvulus		0.0052	0.0158	0.1391
Giardia lamblia	Cysteine protease	0.0078	0.025	0.2577
Schistosoma mansoni	opsin-like receptor	0.0052	0.0158	0.0617
Echinococcus granulosus	allatostatin A receptor	0.0052	0.0158	0.0158
Entamoeba histolytica	cysteine protease, putative	0.0181	0.0609	0.536
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0331	0.1137	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Echinococcus granulosus	smad	0.0008	0.0006	0.0006
Echinococcus granulosus	somatostatin receptor	0.0052	0.0158	0.0158
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.0158	0.0617
Onchocerca volvulus		0.0052	0.0158	0.1391
Echinococcus multilocularis	neuropeptide receptor	0.0052	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0213
Echinococcus multilocularis	somatostatin receptor	0.0052	0.0158	0.0158
Schistosoma mansoni	opsin-like receptor	0.0052	0.0158	0.0617
Onchocerca volvulus	Matrilysin homolog	0.0049	0.0148	0.1305
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0331	0.1137	0.4439
Onchocerca volvulus		0.0052	0.0158	0.1391
Brugia malayi	RE15519p	0.0052	0.0158	0.0617
Entamoeba histolytica	cysteine protease, putative	0.0181	0.0609	0.536
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0078	0.025	0.0975
Brugia malayi	AKH receptor	0.0052	0.0158	0.0617
Brugia malayi	Papain family cysteine protease containing protein	0.0181	0.0609	0.2379
Echinococcus multilocularis	calpain A	0.0007	0.0002	0.0002
Echinococcus multilocularis	sex peptide receptor	0.0052	0.0158	0.0158
Echinococcus multilocularis	allatostatin A receptor	0.0052	0.0158	0.0158
Onchocerca volvulus		0.0018	0.0039	0.0346
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0078	0.025	0.0975
Mycobacterium ulcerans	hydrolase	0.0027	0.0071	0.5
Onchocerca volvulus		0.0052	0.0158	0.1391
Trypanosoma cruzi	cruzipain precursor, putative	0.0103	0.0337	0.1316
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0331	0.1137	0.1137
Giardia lamblia	Cathepsin B precursor	0.0078	0.025	0.2577
Echinococcus multilocularis	neuropeptide Y receptor	0.0052	0.0158	0.0158
Brugia malayi	MH2 domain containing protein	0.0008	0.0006	0.0022
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.1137	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0052	0.0158	0.0158
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0136	0.0532
Entamoeba histolytica	cysteine proteinase, putative	0.0181	0.0609	0.536
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.1137	1
Leishmania major	cathepsin L-like protease	0.0331	0.1137	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0052	0.0158	0.0158
Brugia malayi	larval opioid receptor	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0078	0.025	0.0975
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0052	0.0158	0.0617
Echinococcus granulosus	cathepsin b	0.0738	0.2561	0.2561
Schistosoma mansoni	cathepsin s	0.0103	0.0337	0.1316
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0052	0.0158	0.0617
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0181	0.0609	0.536
Onchocerca volvulus		0.0022	0.0055	0.048
Brugia malayi	Melatonin receptor type 1A	0.0052	0.0158	0.0617
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0181	0.0609	0.536
Echinococcus multilocularis	fmrfamide receptor	0.0052	0.0158	0.0158
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0052	0.0158	0.0158
Echinococcus granulosus	dro:myosuppressin receptor	0.0052	0.0158	0.0158
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0331	0.1137	0.1137
Plasmodium vivax	vivapain-2	0.0331	0.1137	1
Loa Loa (eye worm)	matrix metalloproteinase	0.0022	0.0055	0.0213
Echinococcus granulosus	calumenin	0.0007	0.0002	0.0002
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.0392	0.1529
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0331	0.1137	0.1137
Onchocerca volvulus		0.0052	0.0158	0.1391
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0078	0.025	0.0975
Leishmania major	cathepsin L-like protease	0.0331	0.1137	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0052	0.0158	0.0158
Echinococcus granulosus	sex peptide receptor	0.0052	0.0158	0.0158
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0052	0.0158	0.0158
Brugia malayi	hypothetical protein	0.0018	0.0039	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0052	0.0158	0.0158
Onchocerca volvulus		0.0052	0.0158	0.1391
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.025	0.2197
Onchocerca volvulus		0.0331	0.1137	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0052	0.0158	0.0617
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0078	0.025	0.2577
Brugia malayi	cathepsin B-like cysteine proteinase	0.0738	0.2561	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.0158	0.0617
Brugia malayi	Dopamine receptor protein 2	0.0052	0.0158	0.0617
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.1137	1
Loa Loa (eye worm)	matrixin family protein	0.0053	0.0164	0.064
Plasmodium falciparum	serine repeat antigen 2	0.0078	0.025	0.2197
Leishmania major	cathepsin L-like protease	0.0331	0.1137	1
Toxoplasma gondii	cathepsin B	0.0282	0.0964	0.8484
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0078	0.025	0.0975
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0136	0.0532
Echinococcus multilocularis	neuropeptide s receptor	0.0052	0.0158	0.0158
Echinococcus multilocularis	cysteine protease	0.0331	0.1137	0.1137
Onchocerca volvulus		0.0331	0.1137	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0136	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0738	0.2561	1
Brugia malayi	Serotonin receptor	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0228	0.0777	0.3035
Echinococcus granulosus	cathepsin L	0.0181	0.0609	0.0609
Brugia malayi	GnHR receptor homolog	0.0052	0.0158	0.0617
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0078	0.025	0.2197
Echinococcus multilocularis	survival motor neuron protein 1	0.0235	0.0801	0.0801
Brugia malayi	Matrixin family protein	0.0053	0.0164	0.064
Echinococcus granulosus	cathepsin b	0.0738	0.2561	0.2561
Loa Loa (eye worm)	hypothetical protein	0.0078	0.025	0.0975
Entamoeba histolytica	cysteine protease, putative	0.0078	0.025	0.2197
Brugia malayi	hypothetical protein	0.0052	0.0158	0.0617
Trypanosoma cruzi	cysteine peptidase, putative	0.0331	0.1137	0.4439
Loa Loa (eye worm)	hypothetical protein	0.0228	0.0777	0.3035
Echinococcus granulosus	g protein coupled receptor	0.0052	0.0158	0.0158
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0331	0.1137	0.1137
Entamoeba histolytica	cysteine protease, putative	0.0181	0.0609	0.536
Echinococcus multilocularis	smad	0.0008	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Onchocerca volvulus		0.0331	0.1137	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Onchocerca volvulus		0.0007	0.0002	0.0014
Trypanosoma cruzi	cysteine peptidase, putative	0.0331	0.1137	0.4439
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0039	0.0154
Trypanosoma cruzi	cysteine protease, putative	0.0181	0.0609	0.2379
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0078	0.025	0.2197
Brugia malayi	hypothetical protein	0.0052	0.0158	0.0617
Schistosoma mansoni	myosin xvIII	0.0052	0.0158	0.0617
Entamoeba histolytica	grainin, putative	0.0007	0.0002	0.0014
Brugia malayi	MH1 domain containing protein	0.0008	0.0006	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0006	0.0006
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0136	0.0532
Onchocerca volvulus		0.0228	0.0777	0.6836
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Onchocerca volvulus		0.0018	0.0039	0.0346
Schistosoma mansoni	neuropeptide F-like receptor	0.0052	0.0158	0.0617
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0078	0.025	0.2577
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Plasmodium falciparum	serine repeat antigen 4	0.0078	0.025	0.2197
Loa Loa (eye worm)	plexin A	0.0013	0.0022	0.0087
Loa Loa (eye worm)	melatonin receptor type 1A	0.0052	0.0158	0.0617
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.0158	0.0617
Entamoeba histolytica	cysteine proteinase, putative	0.0228	0.0777	0.6836
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.1137	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0331	0.1137	1
Entamoeba histolytica	cysteine protease, putative	0.0181	0.0609	0.536
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0078	0.025	0.2577
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0738	0.2561	1
Onchocerca volvulus		0.0052	0.0158	0.1391
Trypanosoma cruzi	major cysteine proteinase, putative	0.0078	0.025	0.0975
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0181	0.0609	0.536
Echinococcus granulosus	cathepsin L	0.0078	0.025	0.025
Schistosoma mansoni	amine GPCR	0.0052	0.0158	0.0617
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0052	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0039	0.0154
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0078	0.025	0.2197
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0052	0.0158	0.0158
Onchocerca volvulus		0.0011	0.0015	0.0135
Brugia malayi	G protein-coupled receptor	0.0052	0.0158	0.0617
Loa Loa (eye worm)	G-protein coupled receptor	0.0052	0.0158	0.0617
Toxoplasma gondii	cathepsin CPL	0.0331	0.1137	1
Onchocerca volvulus		0.0052	0.0158	0.1391
Schistosoma mansoni	hypothetical protein	0.0052	0.0158	0.0617
Brugia malayi	ORL1-like opioid receptor	0.0052	0.0158	0.0617
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0052	0.0158	0.0158
Onchocerca volvulus		0.0078	0.025	0.2197
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0078	0.025	0.2197
Giardia lamblia	Cathepsin B precursor	0.0078	0.025	0.2577
Plasmodium falciparum	serine repeat antigen 3	0.0078	0.025	0.2197
Brugia malayi	cathepsin F-like cysteine proteinase	0.0078	0.025	0.0975
Plasmodium vivax	hypothetical protein, conserved	0.0007	0.0002	0.0014
Plasmodium vivax	unspecified product	0.0103	0.0337	0.2965
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0078	0.025	0.0975
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0078	0.025	0.2197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Schistosoma mansoni	neuropeptide receptor	0.0052	0.0158	0.0617
Echinococcus granulosus	neuropeptide Y receptor	0.0052	0.0158	0.0158
Schistosoma mansoni	amine GPCR	0.0052	0.0158	0.0617
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0282	0.0964	0.8484
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0006	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0181	0.0609	0.2379
Schistosoma mansoni	cathepsin B (C01 family)	0.0078	0.025	0.0975
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0078	0.025	0.2197
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0083	0.0083
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0006	0.0022
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0083	0.0324
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.025	0.2197
Echinococcus multilocularis	cathepsin L	0.0181	0.0609	0.0609
Schistosoma mansoni	biogenic amine receptor	0.0052	0.0158	0.0617
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0078	0.025	0.2197
Brugia malayi	putative neuropeptide receptor	0.0052	0.0158	0.0617
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0052	0.0158	0.0617
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0052	0.0158	0.0617
Brugia malayi	Matrixin family protein	0.0022	0.0055	0.0213
Plasmodium falciparum	serine repeat antigen 1	0.0078	0.025	0.2197
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0078	0.025	0.2197
Brugia malayi	Cathepsin L-like precursor	0.0331	0.1137	0.4439
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Loa Loa (eye worm)	Smad1	0.0008	0.0006	0.0022
Echinococcus granulosus	plexin a4	0.0013	0.0022	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.0158	0.0617
Echinococcus granulosus	G protein coupled receptor 139	0.0052	0.0158	0.0158
Echinococcus multilocularis	serotonin receptor	0.0052	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Plasmodium vivax	serine-repeat antigen (SERA)	0.0078	0.025	0.2197
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0078	0.025	0.2197
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0078	0.025	0.0975
Entamoeba histolytica	cysteine proteinase, putative	0.0181	0.0609	0.536
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0078	0.025	0.2197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0777	0.6836
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Schistosoma mansoni	hypothetical protein	0.0048	0.0145	0.0568
Brugia malayi	Pre-SET motif family protein	0.021	0.0713	0.2786
Leishmania major	hypothetical protein, conserved	0.0007	0.0002	0.0014
Brugia malayi	Plexin repeat family protein	0.0011	0.0015	0.006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0078	0.025	0.2197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Entamoeba histolytica	cysteine proteinase, putative	0.0181	0.0609	0.536
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Schistosoma mansoni	opsin-like receptor	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0337	0.1316
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0337	0.1316
Brugia malayi	Papain family cysteine protease containing protein	0.0181	0.0609	0.2379
Brugia malayi	MH2 domain containing protein	0.0118	0.0392	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Onchocerca volvulus	Matrilysin homolog	0.0022	0.0055	0.048
Echinococcus granulosus	tm gpcr rhodopsin	0.0052	0.0158	0.0158
Giardia lamblia	Cathepsin L precursor	0.0078	0.025	0.2577
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0078	0.025	0.2197
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0052	0.0158	0.0617
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0007	0.0002	0.0006
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0052	0.0158	0.0617
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0078	0.025	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trypanosoma cruzi	cysteine peptidase, putative	0.0103	0.0337	0.1316
Echinococcus multilocularis	calbindin 32	0.0007	0.0002	0.0002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.0158	0.0617
Brugia malayi	Hemopexin family protein	0.0031	0.0087	0.0339
Echinococcus multilocularis	fmrfamide receptor	0.0052	0.0158	0.0158
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0282	0.0964	0.8484
Schistosoma mansoni	amine GPCR	0.0052	0.0158	0.0617
Schistosoma mansoni	cathepsin F (C01 family)	0.0331	0.1137	0.4439
Toxoplasma gondii	cathepsin CPC2	0.0078	0.025	0.2197
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0052	0.0158	0.0617
Echinococcus granulosus	7TM GPCR rhodopsin	0.0052	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0181	0.0609	0.536
Onchocerca volvulus		0.0031	0.0087	0.0763
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.1137	1
Brugia malayi	hypothetical protein	0.0052	0.0158	0.0617
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.021	0.0713	0.2786
Schistosoma mansoni	smad	0.0008	0.0006	0.0022
Echinococcus multilocularis	calumenin	0.0007	0.0002	0.0002
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0083	0.0083
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.0158	0.0617
Trichomonas vaginalis	calmodulin, putative	0.0007	0.0002	0.0014
Onchocerca volvulus		0.0048	0.0145	0.128
Schistosoma mansoni	hypothetical protein	0.0052	0.0158	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0055	0.0213
Giardia lamblia	Cysteine protease	0.0078	0.025	0.2577
Trypanosoma cruzi	cysteine proteinase, putative	0.0181	0.0609	0.2379
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.1137	1
Loa Loa (eye worm)	hypothetical protein	0.0738	0.2561	1
Entamoeba histolytica	cysteine protease, putative	0.0181	0.0609	0.536
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0331	0.1137	1
Echinococcus granulosus	hypothetical protein	0.0052	0.0158	0.0158
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0181	0.0609	0.2379
Brugia malayi	Cathepsin L-like precursor	0.0228	0.0777	0.3035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.0777	0.6836
Echinococcus granulosus	biogenic amine 5HT receptor	0.0052	0.0158	0.0158
Echinococcus granulosus	tm gpcr rhodopsin	0.0052	0.0158	0.0158
Entamoeba histolytica	cysteine protease, putative	0.0181	0.0609	0.536
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0083	0.0324
Brugia malayi	EF hand family protein	0.0007	0.0002	0.0006
Entamoeba histolytica	cysteine protease, putative	0.0181	0.0609	0.536
Echinococcus granulosus	calcium uptake protein 1	0.0007	0.0002	0.0002
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0228	0.0777	0.3035
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0027	0.0071	0.0279
Onchocerca volvulus		0.003	0.0083	0.073
Brugia malayi	MH1 domain containing protein	0.0008	0.0006	0.0022
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0052	0.0158	0.0617
Brugia malayi	hypothetical protein	0.0052	0.0158	0.0617
Echinococcus granulosus	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Onchocerca volvulus		0.0052	0.0158	0.1391
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0282	0.0964	0.8484
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.1137	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0181	0.0609	0.0609
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0331	0.1137	1
Brugia malayi	hypothetical protein	0.0052	0.0158	0.0617
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0052	0.0158	0.0158
Brugia malayi	sulfakinin receptor protein	0.0052	0.0158	0.0617
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0052	0.0158	0.0617
Echinococcus multilocularis	cathepsin L cysteine protease	0.0331	0.1137	0.1137
Leishmania major	cathepsin L-like protease	0.0331	0.1137	1
Onchocerca volvulus		0.0331	0.1137	1
Echinococcus multilocularis	g protein coupled receptor	0.0052	0.0158	0.0158
Plasmodium falciparum	serine repeat antigen 8	0.0078	0.025	0.2197
Onchocerca volvulus	Cathepsin F homolog	0.0331	0.1137	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Brugia malayi	Papain family cysteine protease containing protein	0.0078	0.025	0.0975
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.1137	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0052	0.0158	0.0158
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.008	0.0258	0.0258
Loa Loa (eye worm)	matrixin family protein	0.0049	0.0148	0.0579
Brugia malayi	neuropeptide F receptor	0.0052	0.0158	0.0617
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0052	0.0158	0.0617
Onchocerca volvulus		0.0052	0.0158	0.1391
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0145	0.0568
Giardia lamblia	Cathepsin L precursor	0.0078	0.025	0.2577
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0331	0.1137	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0738	0.2561	1
Brugia malayi	Cathepsin L-like precursor	0.0331	0.1137	0.4439
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0103	0.0337	0.1316
Loa Loa (eye worm)	cathepsin B	0.0282	0.0964	0.3766
Echinococcus granulosus	cathepsin l1	0.0228	0.0777	0.0777
Leishmania major	cathepsin L-like protease	0.0331	0.1137	1
Plasmodium falciparum	serine repeat antigen 9	0.0078	0.025	0.2197
Entamoeba histolytica	hypothetical protein	0.0078	0.025	0.2197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0331	0.1137	1
Schistosoma mansoni	hypothetical protein	0.0052	0.0158	0.0617
Brugia malayi	Matrixin family protein	0.0022	0.0055	0.0213
Plasmodium falciparum	serine repeat antigen 7	0.0078	0.025	0.2197
Brugia malayi	cathepsin L-like cysteine proteinase	0.0078	0.025	0.0975
Onchocerca volvulus		0.0052	0.0158	0.1391
Echinococcus multilocularis	cysteine protease	0.0331	0.1137	0.1137
Schistosoma mansoni	biogenic amine receptor	0.0052	0.0158	0.0617
Plasmodium vivax	vivapain-2	0.0331	0.1137	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0052	0.0158	0.0617
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0006	0.0006
Onchocerca volvulus		0.0239	0.0815	0.717
Giardia lamblia	Cysteine protease	0.0078	0.025	0.2577
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Trypanosoma cruzi	cysteine peptidase, putative	0.0181	0.0609	0.2379
Loa Loa (eye worm)	hypothetical protein	0.0235	0.0801	0.3129
Onchocerca volvulus		0.0052	0.0158	0.1391
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0158	0.0617
Echinococcus multilocularis	MAM	0.0018	0.0039	0.0039
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0052	0.0158	0.0158
Giardia lamblia	Cathepsin B precursor	0.0282	0.0964	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0052	0.0158	0.0158
Brugia malayi	Papain family cysteine protease containing protein	0.0078	0.025	0.0975
Schistosoma mansoni	calcium binding atopy-related autoantigen	0.0007	0.0002	0.0006
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0052	0.0158	0.1391
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0022	0.0055	0.0213
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0331	0.1137	1
Loa Loa (eye worm)	ctsf protein	0.0331	0.1137	0.4439
Entamoeba histolytica	cysteine protease, putative	0.0078	0.025	0.2197
Echinococcus granulosus	Smad4	0.0008	0.0006	0.0006
Plasmodium vivax	unspecified product	0.0078	0.025	0.2197

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 826144