Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0091 | 0.2377 | 0.2377 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0174 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0174 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0082 | 0.1545 | 0.1545 |
Schistosoma mansoni | thyroid hormone receptor | 0.0174 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0174 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0174 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0082 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0174 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0092 | 0.2451 | 0.2451 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0174 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0174 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0174 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0065 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2451 | 0.2451 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0065 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0092 | 0.2451 | 0.2451 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0082 | 0.1545 | 0.1545 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0174 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0174 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0174 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0082 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0174 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0174 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0082 | 0.1545 | 0.1545 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0174 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0092 | 0.2451 | 0.2451 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0174 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0082 | 0.1545 | 0.1545 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0082 | 0.1545 | 0.1545 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0174 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2451 | 0.2451 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0174 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0174 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Brugia malayi | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0174 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Brugia malayi | nuclear receptor RXR | 0.0092 | 0.2451 | 0.2451 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0174 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0065 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0174 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2451 | 0.2451 |
Brugia malayi | nuclear hormone receptor | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0092 | 0.2451 | 0.2451 |
Brugia malayi | hypothetical protein | 0.0092 | 0.2451 | 0.2451 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2451 | 0.2451 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0091 | 0.2377 | 0.2377 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0082 | 0.1545 | 0.1545 |
Brugia malayi | nuclear receptor RXR | 0.0082 | 0.1545 | 0.1545 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0174 | 1 | 1 |
Onchocerca volvulus | 0.0174 | 1 | 1 | |
Echinococcus granulosus | FTZ F1 alpha | 0.0174 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Brugia malayi | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0092 | 0.2451 | 0.1071 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0174 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0174 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Schistosoma mansoni | thyroid hormone receptor | 0.0174 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0174 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0174 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0092 | 0.2451 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0082 | 0.1545 | 0.1545 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0174 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0092 | 0.2451 | 0.1071 |
Brugia malayi | ecdysone receptor | 0.0082 | 0.1545 | 0.1545 |
Brugia malayi | nuclear hormone receptor | 0.0082 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | DR-78 | 0.0082 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0082 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0082 | 0.1545 | 0.1545 |
Brugia malayi | tailless protein | 0.0082 | 0.1545 | 0.1545 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0174 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0082 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0174 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.2451 | 0.2451 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0092 | 0.2451 | 0.1071 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0174 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0065 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0174 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0174 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0065 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0174 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1545 | 0.1545 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0174 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.