Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0013 | 0.0013 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0061 | 0.0029 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0013 | 0.0011 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2017 | 0.3886 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0013 | 0.0011 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.5166 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0013 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0013 | 0.1865 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0033 | 0.5092 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.5166 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0013 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0061 | 0.9877 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2017 | 0.3886 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0326 | 0.0602 | 0.0878 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.5166 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.2017 | 0.3886 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.5166 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.5166 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2017 | 0.3886 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.5166 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0062 | 0.0049 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.5166 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2017 | 0.3886 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2017 | 0.3886 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0013 | 0.0011 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.5166 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2017 | 0.3886 | 0.5 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0002 | 0.0002 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0013 | 0.0011 |
Onchocerca volvulus | 0.0048 | 0.0061 | 1 | |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.2017 | 0.3886 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.2017 | 0.3886 | 0.3878 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0013 | 0.0013 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2017 | 0.3886 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0062 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.5166 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0013 | 0.1865 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2017 | 0.3886 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.5166 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0033 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0286 | 0.0255 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2017 | 0.3886 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.5166 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.5166 | 1 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0002 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0062 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0062 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0013 | 0.1865 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0013 | 0.0011 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.5166 | 1 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0326 | 0.0602 | 0.0878 |
Leishmania major | dihydroorotate dehydrogenase | 0.5166 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0286 | 0.0255 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0013 | 0.0011 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.