Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0191 | 0.2492 | 0.3123 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0433 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0191 | 0.2492 | 0.3123 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0208 | 0.3013 | 0.1782 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0191 | 0.2492 | 0.3123 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0173 | 0.1936 | 0.1589 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0368 | 0.7978 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0191 | 0.2492 | 0.3123 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0259 | 0.46 | 0.5766 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0191 | 0.2492 | 0.3123 |
Echinococcus multilocularis | thymidylate synthase | 0.0208 | 0.3013 | 0.3777 |
Onchocerca volvulus | 0.0208 | 0.3013 | 0.5 | |
Echinococcus granulosus | nmda type glutamate receptor | 0.0157 | 0.1431 | 0.1794 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0368 | 0.7978 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0191 | 0.2492 | 0.3123 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.46 | 0.4368 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0157 | 0.1431 | 0.1794 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0259 | 0.46 | 0.441 |
Brugia malayi | thymidylate synthase | 0.0208 | 0.3013 | 0.2712 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.3433 | 0.315 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0191 | 0.2492 | 0.3123 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0191 | 0.2492 | 0.3123 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0208 | 0.3013 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 5 activator 1 | 0.0259 | 0.46 | 0.5766 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0292 | 0.5642 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0191 | 0.2492 | 0.3123 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0173 | 0.1936 | 0.2427 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0173 | 0.1936 | 0.1589 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0127 | 0.0505 | 0.0633 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0283 | 0.5369 | 0.5681 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0292 | 0.5642 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0173 | 0.1936 | 0.1589 |
Echinococcus granulosus | glutamate receptor 2 | 0.0127 | 0.0505 | 0.0633 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0208 | 0.3013 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0208 | 0.3013 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0208 | 0.3013 | 0.2712 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0368 | 0.7978 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0292 | 0.5642 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0433 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0173 | 0.1936 | 0.1589 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0191 | 0.2492 | 0.3123 |
Echinococcus granulosus | thymidylate synthase | 0.0208 | 0.3013 | 0.3777 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0433 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.