Detailed information for compound 827010

Basic information

Technical information
  • TDR Targets ID: 827010
  • Name: methyl 6-hydroxy-4-(3-methoxyphenyl)-6-methyl -3-oxo-2,4,5,7-tetrahydro-1H-indazole-5-carbo xylate
  • MW: 332.351 | Formula: C17H20N2O5
  • H donors: 3 H acceptors: 4 LogP: 1.23 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1C(c2cccc(c2)OC)c2c(O)[nH]nc2CC1(C)O
  • InChi: 1S/C17H20N2O5/c1-17(22)8-11-13(15(20)19-18-11)12(14(17)16(21)24-3)9-5-4-6-10(7-9)23-2/h4-7,12,14,22H,8H2,1-3H3,(H2,18,19,20)
  • InChiKey: NPXLGNAPIFIVDK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-hydroxy-4-(3-methoxyphenyl)-6-methyl-3-oxo-2,4,5,7-tetrahydro-1H-indazole-5-carboxylic acid methyl ester
  • 6-hydroxy-3-keto-4-(3-methoxyphenyl)-6-methyl-2,4,5,7-tetrahydro-1H-indazole-5-carboxylic acid methyl ester
  • BAS 11409595
  • A3908/0166181

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0157 0.8748 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0577 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0577 0.0577
Loa Loa (eye worm) tubulin gamma chain 0.0014 0.0206 0.0206
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.091 0.2532
Schistosoma mansoni tubulin subunit beta 0.0014 0.0206 0.022
Echinococcus granulosus tubulin alpha chain 0.0014 0.0206 0.022
Leishmania major alpha tubulin 0.0014 0.0206 0.0345
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.2886 0.3087
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0577 0.0617
Giardia lamblia Gamma tubulin 0.0014 0.0206 0.0674
Trypanosoma brucei alpha tubulin 0.0014 0.0206 0.0345
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.3155 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1741 0.5115
Echinococcus granulosus tubulin alpha 3 chain 0.0014 0.0206 0.022
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0063 0.3155 0.9509
Toxoplasma gondii hypothetical protein 0.002 0.0565 0.0543
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.6297 0.6297
Echinococcus granulosus alpha tubulin 0.0014 0.0206 0.022
Loa Loa (eye worm) hypothetical protein 0.002 0.0577 0.0577
Schistosoma mansoni alpha tubulin 0.0014 0.0206 0.022
Toxoplasma gondii hypothetical protein 0.0056 0.2688 0.2997
Plasmodium vivax tubulin alpha chain, putative 0.0014 0.0206 0.0128
Plasmodium falciparum tubulin beta chain 0.0014 0.0206 0.0128
Toxoplasma gondii alpha-tubulin I, putative 0.0014 0.0206 0.0128
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0577 0.0617
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0577 0.0577
Leishmania major DNA polymerase eta, putative 0.0039 0.1667 0.4885
Loa Loa (eye worm) hypothetical protein 0.002 0.0565 0.0565
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0157 0.8748 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0043 0.1945 0.5747
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0577 0.0617
Brugia malayi Tubulin beta-1 chain 0.0014 0.0206 0.0206
Brugia malayi tubulin alpha chain - mouse 0.0014 0.0206 0.0206
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0028 0.1033 0.1105
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.091 0.0942
Echinococcus multilocularis tubulin alpha chain 0.0014 0.0206 0.022
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Trypanosoma brucei unspecified product 0.0027 0.1 0.2813
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0577 0.0577
Echinococcus granulosus Tubulin alpha 1 chain 0.0014 0.0206 0.022
Loa Loa (eye worm) alpha-tubulin 0.0014 0.0206 0.0206
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0157 0.8748 0.5
Brugia malayi Probable ClpP-like protease 0.0157 0.8748 0.8748
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0063 0.3155 1
Leishmania major alpha tubulin 0.0014 0.0206 0.0345
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0577 0.0577
Leishmania major alpha tubulin 0.0014 0.0206 0.0345
Echinococcus granulosus peroxisome assembly protein 26 0.0014 0.0206 0.022
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.1741 0.5205
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.2886 0.3225
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.1 0.2813
Leishmania major DNA polymerase eta, putative 0.0066 0.3313 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0577 0.0577
Schistosoma mansoni hypothetical protein 0.0012 0.0052 0.0056
Trypanosoma brucei epsilon tubulin 0.0014 0.0206 0.0345
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.2591 0.2884
Trypanosoma cruzi epsilon tubulin, putative 0.0014 0.0206 0.0345
Leishmania major alpha tubulin 0.0014 0.0206 0.0345
Echinococcus granulosus dna polymerase eta 0.0066 0.3313 0.3545
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0028 0.1033 0.2802
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0577 0.0617
Echinococcus multilocularis tubulin alpha chain 0.0014 0.0206 0.022
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0063 0.3155 0.3376
Leishmania major alpha tubulin 0.0014 0.0206 0.0345
Loa Loa (eye worm) tubulin alpha-2 chain 0.0014 0.0206 0.0206
Echinococcus multilocularis Tubulin beta 2C chain 0.0014 0.0206 0.022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0577 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.3155 1
Loa Loa (eye worm) tubulin alpha chain 0.0014 0.0206 0.0206
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0028 0.1033 0.2802
Loa Loa (eye worm) hypothetical protein 0.002 0.0577 0.0577
Loa Loa (eye worm) tubulin beta-1 chain 0.0014 0.0206 0.0206
Echinococcus multilocularis tubulin alpha chain 0.0014 0.0206 0.022
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0014 0.0206 0.022
Schistosoma mansoni tubulin subunit alpha 0.0014 0.0206 0.022
Toxoplasma gondii beta-1 tubulin, putative 0.0014 0.0206 0.0128
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.1741 0.2377
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0103 0.5512 1
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Echinococcus granulosus Tubulin alpha 1 chain 0.0014 0.0206 0.022
Toxoplasma gondii hypothetical protein 0.002 0.0565 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.2688 0.8416
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Brugia malayi Tubulin alpha-2 chain 0.0014 0.0206 0.0206
Toxoplasma gondii GAF domain-containing protein 0.002 0.0565 0.0543
Schistosoma mansoni hypothetical protein 0.0167 0.9347 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0052 0.0056
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.3155 1
Brugia malayi beta-tubulin, identical 0.0014 0.0206 0.0206
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0063 0.3155 0.3376
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0054 0.2591 0.2475
Leishmania major alpha tubulin 0.0014 0.0206 0.0345
Loa Loa (eye worm) hypothetical protein 0.0014 0.0206 0.0206
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.2886 0.3225
Echinococcus granulosus Tubulin beta 2C chain 0.0014 0.0206 0.022
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.1741 0.5115
Echinococcus multilocularis geminin 0.0167 0.9347 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0577 0.0577
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0577 0.0577
Schistosoma mansoni tubulin subunit alpha 0.0014 0.0206 0.022
Loa Loa (eye worm) hypothetical protein 0.002 0.0577 0.0577
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.2591 0.2884
Schistosoma mansoni tubulin subunit beta 0.0014 0.0206 0.022
Trypanosoma cruzi epsilon tubulin, putative 0.0014 0.0206 0.0345
Loa Loa (eye worm) hypothetical protein 0.002 0.0577 0.0577
Echinococcus granulosus FTZ F1 alpha 0.002 0.0577 0.0617
Trypanosoma brucei beta tubulin 0.0014 0.0206 0.0345
Mycobacterium ulcerans putative regulatory protein 0.002 0.0565 0.0543
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0577 0.0617
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1741 0.5115
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1741 0.5115
Giardia lamblia Beta tubulin 0.0014 0.0206 0.0674
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Echinococcus multilocularis peptidase Clp (S14 family) 0.0103 0.5512 0.5897
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.2886 0.4691
Leishmania major alpha tubulin 0.0014 0.0206 0.0345
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.2886 0.3225
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.1741 0.5115
Trypanosoma brucei beta tubulin 0.0014 0.0206 0.0345
Echinococcus multilocularis tubulin alpha 1C chain 0.0014 0.0206 0.022
Giardia lamblia Beta tubulin 0.0014 0.0206 0.0674
Echinococcus granulosus Tubulin beta 2C chain 0.0014 0.0206 0.022
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.2886 0.3087
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0577 0.0617
Echinococcus multilocularis dna polymerase kappa 0.004 0.1741 0.1863
Loa Loa (eye worm) hypothetical protein 0.0012 0.0095 0.0095
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0577 0.0617
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.3313 0.3313
Echinococcus granulosus peptidase Clp S14 family 0.0103 0.5512 0.5897
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.1741 0.5115
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.1 0.2813
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.091 0.0942
Leishmania major epsilon tubulin, putative 0.0014 0.0206 0.0345
Echinococcus multilocularis Tubulin alpha 1 chain 0.0014 0.0206 0.022
Echinococcus multilocularis tubulin alpha 3 chain 0.0014 0.0206 0.022
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0043 0.1945 0.5894
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.2688 0.8416
Leishmania major DNA polymerase kappa, putative 0.004 0.1741 0.5115
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0577 0.0577
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0577 0.0617
Schistosoma mansoni hypothetical protein 0.0167 0.9347 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.1033 0.1033
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0565 0.1218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0577 0.0577
Echinococcus multilocularis Tubulin beta 2C chain 0.0014 0.0206 0.022
Schistosoma mansoni alpha tubulin 0.0014 0.0206 0.022
Leishmania major alpha tubulin 0.0014 0.0206 0.0345
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0157 0.8748 0.5
Brugia malayi MH2 domain containing protein 0.0116 0.6297 0.6297
Loa Loa (eye worm) hypothetical protein 0.0157 0.8748 0.8748
Loa Loa (eye worm) hypothetical protein 0.0026 0.091 0.091
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0063 0.3155 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0565 0.0543
Schistosoma mansoni tubulin subunit beta 0.0014 0.0206 0.022
Brugia malayi hypothetical protein 0.0149 0.8265 0.8265
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0577 0.0577
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.091 0.2532
Echinococcus multilocularis peroxisome assembly protein 26 0.0014 0.0206 0.022
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Schistosoma mansoni peptidase Clp (S14 family) 0.0157 0.8748 0.936
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0014 0.0206 0.0128
Trypanosoma brucei beta tubulin 0.0014 0.0206 0.0345
Schistosoma mansoni tubulin subunit beta 0.0014 0.0206 0.022
Brugia malayi hypothetical protein 0.0017 0.0359 0.0359
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.1741 0.1741
Loa Loa (eye worm) hypothetical protein 0.0178 1 1
Leishmania major alpha tubulin 0.0014 0.0206 0.0345
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0577 0.0617
Trypanosoma brucei epsilon tubulin 0.0014 0.0206 0.0345
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0028 0.1033 0.1105
Plasmodium falciparum tubulin epsilon chain, putative 0.0014 0.0206 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1741 0.5115
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1741 0.5115
Leishmania major gamma-tubulin 0.0014 0.0206 0.0345
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0577 0.0617
Trypanosoma brucei tubulin gamma chain 0.0014 0.0206 0.0345
Echinococcus granulosus beta tubulin 0.0014 0.0206 0.022
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0577 0.0617
Brugia malayi nuclear receptor NHR-88 0.002 0.0577 0.0577
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0157 0.8748 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0577 0.0577
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0052 0.0056
Plasmodium vivax tubulin epsilon chain, putative 0.0014 0.0206 0.0128
Echinococcus multilocularis tubulin beta 1 chain 0.0014 0.0206 0.022
Echinococcus granulosus dna polymerase kappa 0.004 0.1741 0.1863
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0103 0.5512 0.6045
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.1741 0.5115
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1741 0.5115
Brugia malayi Tubulin gamma chain 0.0014 0.0206 0.0206
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0063 0.3155 0.9509
Trypanosoma brucei alpha tubulin 0.0014 0.0206 0.0345
Echinococcus granulosus tubulin beta 4A class IVa 0.0014 0.0206 0.022
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Trypanosoma brucei unspecified product 0.004 0.1741 0.5115
Mycobacterium ulcerans putative regulatory protein 0.002 0.0565 0.0543
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.1741 0.5205
Loa Loa (eye worm) hypothetical protein 0.0066 0.3313 0.3313
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0577 0.0617
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.1741 0.1863
Loa Loa (eye worm) BEN-1 protein 0.0014 0.0206 0.0206
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.6297 0.6297
Trypanosoma cruzi alpha tubulin, putative 0.0014 0.0206 0.0345
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0577 0.0617
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0577 0.0617
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0577 0.0617
Loa Loa (eye worm) BEN-1 protein 0.0014 0.0206 0.0206
Echinococcus multilocularis tubulin epsilon chain 0.0014 0.0206 0.022
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Brugia malayi polk-prov protein 0.0012 0.0095 0.0095
Echinococcus multilocularis tubulin alpha 0.0014 0.0206 0.022
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0014 0.0206 0.022
Echinococcus multilocularis dna polymerase eta 0.0066 0.3313 0.3545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0577 0.0577
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0157 0.8748 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.1741 0.2377
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.1741 0.1863
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0157 0.8748 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.1741 1
Trypanosoma brucei alpha tubulin 0.0014 0.0206 0.0345
Echinococcus multilocularis tubulin alpha 1C chain 0.0014 0.0206 0.022
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0577 0.0617
Plasmodium vivax tubulin alpha chain, putative 0.0014 0.0206 0.0128
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.091 0.0942
Loa Loa (eye worm) tubulin beta chain 0.0014 0.0206 0.0206
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Toxoplasma gondii alpha tubulin TUBA1 0.0014 0.0206 0.0128
Brugia malayi nuclear hormone receptor 0.002 0.0577 0.0577
Echinococcus granulosus tubulin alpha chain 0.0014 0.0206 0.022
Schistosoma mansoni tubulin subunit epsilon 0.0014 0.0206 0.022
Onchocerca volvulus 0.0149 0.8265 0.8159
Echinococcus granulosus Tubulin beta 2C chain 0.0014 0.0206 0.022
Schistosoma mansoni coup transcription factor 0.002 0.0577 0.0617
Schistosoma mansoni tubulin subunit beta 0.0014 0.0206 0.022
Brugia malayi tubulin alpha-2 chain 0.0014 0.0206 0.0206
Echinococcus granulosus Tubulin alpha 1 chain 0.0014 0.0206 0.022
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.2886 0.3087
Echinococcus multilocularis tubulin subunit TubB 0.0014 0.0206 0.022
Echinococcus granulosus tubulin alpha 1C chain 0.0014 0.0206 0.022
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0157 0.8748 0.936
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0577 0.0577
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0577 0.0617
Brugia malayi steroid hormone receptor 0.002 0.0577 0.0577
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0028 0.1033 0.2802
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0063 0.3155 1
Toxoplasma gondii beta-tubulin, putative 0.0014 0.0206 0.0128
Brugia malayi alpha-tubulin 0.0014 0.0206 0.0206
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0577 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.2688 0.8416
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0577 0.0617
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0063 0.3155 0.9509
Schistosoma mansoni tubulin subunit alpha 0.0014 0.0206 0.022
Echinococcus granulosus tubulin alpha 3 chain 0.0014 0.0206 0.022
Echinococcus granulosus Tubulin beta 2C chain 0.0014 0.0206 0.022
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0577 0.0617
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0063 0.3155 0.9509
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.3155 1
Trypanosoma brucei beta tubulin 0.0014 0.0206 0.0345
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.1741 0.1741
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.2886 0.3087
Echinococcus granulosus Tubulin beta 2C chain 0.0014 0.0206 0.022
Echinococcus multilocularis Tubulin alpha 1 chain 0.0014 0.0206 0.022
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.1741 0.5115
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1741 0.5115
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0577 0.0617
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.1667 0.1817
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0577 0.0577
Brugia malayi Tubulin alpha chain 0.0014 0.0206 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1741 0.5115
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.1741 0.1863
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0028 0.1033 0.1105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0577 0.0577
Echinococcus multilocularis Tubulin beta 2C chain 0.0014 0.0206 0.022
Plasmodium falciparum alpha tubulin 1 0.0014 0.0206 0.0128
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0577 0.0617
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Leishmania major alpha tubulin 0.0014 0.0206 0.0345
Plasmodium vivax hypothetical protein, conserved 0.002 0.0565 0.0543
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.1 0.2813
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.091 0.2532
Echinococcus granulosus tubulin gamma 1 chain 0.0014 0.0206 0.022
Toxoplasma gondii hypothetical protein 0.0054 0.2591 0.2884
Giardia lamblia Beta tubulin 0.0014 0.0206 0.0674
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0157 0.8748 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0157 0.8748 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0063 0.3155 1
Loa Loa (eye worm) tubulin alpha chain 0.0014 0.0206 0.0206
Plasmodium vivax tubulin gamma chain, putative 0.0014 0.0206 0.0128
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Schistosoma mansoni thyroid hormone receptor 0.002 0.0577 0.0617
Trypanosoma cruzi beta tubulin, putative 0.0014 0.0206 0.0345
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0063 0.3155 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.3155 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0577 0.0577
Echinococcus granulosus beta tubulin 0.0014 0.0206 0.022
Echinococcus granulosus tubulin beta 1 chain 0.0014 0.0206 0.022
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0043 0.1945 0.5894
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Brugia malayi hypothetical protein 0.0026 0.091 0.091
Leishmania major alpha tubulin 0.0014 0.0206 0.0345
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0014 0.0206 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1741 0.5115
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0063 0.3155 0.9509
Schistosoma mansoni alpha tubulin 0.0014 0.0206 0.022
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0157 0.8748 0.936
Echinococcus multilocularis tubulin alpha chain 0.0014 0.0206 0.022
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0577 0.0617
Trypanosoma brucei beta tubulin 0.0014 0.0206 0.0345
Schistosoma mansoni DNA polymerase eta 0.0066 0.3313 0.3545
Plasmodium vivax tubulin beta chain, putative 0.0014 0.0206 0.0128
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0028 0.1033 0.1033
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.1741 0.5115
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Trypanosoma cruzi tubulin gamma chain 0.0014 0.0206 0.0345
Schistosoma mansoni nuclear hormone receptor 0.002 0.0577 0.0617
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Giardia lamblia Alpha-tubulin 0.0014 0.0206 0.0674
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0577 0.0617
Echinococcus granulosus geminin 0.0167 0.9347 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0157 0.8748 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0577 0.0577
Leishmania major hypothetical protein, conserved 0.0026 0.091 0.2532
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0157 0.8748 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0063 0.3155 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0103 0.5512 1
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0577 0.0617
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0577 0.0617
Echinococcus granulosus tubulin subunit TubB 0.0014 0.0206 0.022
Loa Loa (eye worm) alpha-tubulin 0.0014 0.0206 0.0206
Loa Loa (eye worm) tubulin beta-4 chain 0.0014 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.002 0.0577 0.0577
Giardia lamblia Alpha-tubulin 0.0014 0.0206 0.0674
Echinococcus multilocularis hypothetical protein 0.0014 0.0206 0.022
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0577 0.0577
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0063 0.3155 1
Echinococcus granulosus tubulin subunit beta 0.0014 0.0206 0.022
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.2886 0.8671
Toxoplasma gondii beta tubulin 0.0014 0.0206 0.0128
Leishmania major alpha tubulin 0.0014 0.0206 0.0345
Echinococcus multilocularis Tubulin alpha 1 chain 0.0014 0.0206 0.022
Trypanosoma brucei unspecified product 0.0027 0.1 0.2813
Echinococcus granulosus tubulin alpha 0.0014 0.0206 0.022
Trypanosoma brucei epsilon tubulin 0.0014 0.0206 0.0345
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.1741 0.5115
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0577 0.0577
Echinococcus multilocularis Tubulin beta 2C chain 0.0014 0.0206 0.022
Loa Loa (eye worm) hypothetical protein 0.0149 0.8265 0.8265
Loa Loa (eye worm) hypothetical protein 0.002 0.0577 0.0577
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.3313 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0577 0.0577
Echinococcus granulosus tubulin epsilon chain 0.0014 0.0206 0.022
Echinococcus granulosus tubulin alpha 1C chain 0.0014 0.0206 0.022
Echinococcus multilocularis beta tubulin 0.0014 0.0206 0.022
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.1741 0.1863
Loa Loa (eye worm) tubulin beta-2A chain 0.0014 0.0206 0.0206
Mycobacterium ulcerans DNA polymerase IV 0.004 0.1741 0.1902
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0095 0.0102
Schistosoma mansoni tubulin subunit beta 0.0014 0.0206 0.022
Giardia lamblia DINP protein human, muc B family 0.004 0.1741 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0577 0.0577
Loa Loa (eye worm) beta-tubulin 0.0014 0.0206 0.0206
Echinococcus multilocularis tubulin alpha chain 0.0014 0.0206 0.022
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.091 0.0942
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0577 0.0617
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.3313 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0577 0.0577
Echinococcus multilocularis Tubulin beta 2C chain 0.0014 0.0206 0.022
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0063 0.3155 0.3376
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0577 0.0577
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.1667 0.4885
Leishmania major beta tubulin 0.0014 0.0206 0.0345
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.1741 0.5115
Brugia malayi Tubulin alpha-2 chain 0.0014 0.0206 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1741 0.5115
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0028 0.1033 0.1033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0577 0.0577
Echinococcus granulosus tubulin alpha chain 0.0014 0.0206 0.022
Plasmodium falciparum tubulin gamma chain 0.0014 0.0206 0.0128
Plasmodium falciparum GAF domain-related protein, putative 0.002 0.0565 0.0543
Echinococcus multilocularis beta tubulin 0.0014 0.0206 0.022
Echinococcus granulosus tubulin alpha chain 0.0014 0.0206 0.022
Echinococcus granulosus tubulin alpha chain 0.0014 0.0206 0.022
Trypanosoma brucei alpha tubulin 0.0014 0.0206 0.0345
Plasmodium falciparum alpha tubulin 2 0.0014 0.0206 0.0128
Mycobacterium ulcerans DNA polymerase IV 0.004 0.1741 0.1902
Brugia malayi ecdysteroid receptor 0.002 0.0577 0.0577
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0063 0.3155 1
Echinococcus multilocularis tubulin subunit beta 0.0014 0.0206 0.022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.2886 0.3225
Schistosoma mansoni tubulin subunit gamma 0.0014 0.0206 0.022

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.