TDR Targets

Basic information

Technical information

TDR Targets ID: 827384
Name: 3-[[2-(2-fluorophenoxy)acetyl]amino]-N-(2-met hoxyphenyl)-1-benzofuran-2-carboxamide
MW: 434.416 | Formula: C24H19FN2O5
H donors: 2 H acceptors: 2 LogP: 4.99 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1NC(=O)c1oc2c(c1NC(=O)COc1ccccc1F)cccc2
InChi: 1S/C24H19FN2O5/c1-30-20-13-7-4-10-17(20)26-24(29)23-22(15-8-2-5-11-18(15)32-23)27-21(28)14-31-19-12-6-3-9-16(19)25/h2-13H,14H2,1H3,(H,26,29)(H,27,28)
InChiKey: MIYHKRHSQYIDME-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[[2-(2-fluorophenoxy)acetyl]amino]-N-(2-methoxyphenyl)benzofuran-2-carboxamide
3-[[2-(2-fluorophenoxy)-1-oxoethyl]amino]-N-(2-methoxyphenyl)-2-benzofurancarboxamide
3-[2-(2-fluorophenoxy)ethanoylamino]-N-(2-methoxyphenyl)-1-benzofuran-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0216	0.0209
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Plasmodium vivax	bromodomain protein, putative	0.0309	0.0587	0.7704
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0141	0.0216	0.0233
Plasmodium vivax	hypothetical protein, conserved	0.0309	0.0587	0.7704
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Loa Loa (eye worm)	hypothetical protein	0.4553	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0141	0.0216	0.0206
Giardia lamblia	Histone acetyltransferase GCN5	0.0077	0.0074	0.0029
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0049	0.001	0.0011
Echinococcus granulosus	transcription initiation factor TFIID subunit 1	0.0309	0.0587	0.0634
Toxoplasma gondii	histone deacetylase HDAC1	0.0162	0.0262	0.0615
Plasmodium falciparum	bromodomain protein 1	0.0309	0.0587	1
Brugia malayi	Nuclear hormone receptor E75	0.0067	0.005	0.004
Loa Loa (eye worm)	steroid hormone receptor	0.0141	0.0216	0.0209
Trichomonas vaginalis	hypothetical protein	0.0309	0.0587	0.0519
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Echinococcus granulosus	Bromodomain containing protein	0.0309	0.0587	0.0634
Schistosoma mansoni	zinc finger protein	0.0067	0.005	0.0054
Echinococcus multilocularis	histone deacetylase 6	0.0162	0.0262	0.0283
Leishmania major	histone deacetylase, putative	0.0162	0.0262	0.3165
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0141	0.0216	0.0206
Trypanosoma brucei	bromodomain factor 2 protein, putative	0.0309	0.0587	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0309	0.0587	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0067	0.005	0.0054
Brugia malayi	histone deacetylase 3 (HD3)	0.0095	0.0112	0.0102
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0075	0.0068	0.0073
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0067	0.005	0.0043
Plasmodium vivax	histone deacetylase 2, putative	0.0162	0.0262	0.3368
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Toxoplasma gondii	SWI2/SNF2 Brahma-like putative	0.0309	0.0587	0.1407
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Schistosoma mansoni	histone deacetylase hda2	0.0049	0.001	0.0011
Entamoeba histolytica	bromodomain-containing protein	0.0309	0.0587	0.1272
Echinococcus granulosus	ATPase family AAA domain containing protein 2B	0.0309	0.0587	0.0634
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0067	0.005	0.0043
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0067	0.005	0.0054
Loa Loa (eye worm)	histone deacetylase	0.0162	0.0262	0.0256
Schistosoma mansoni	bromodomain containing	0.0464	0.0931	0.1006
Brugia malayi	Nuclear hormone receptor-like 1	0.0141	0.0216	0.0206
Plasmodium falciparum	histone deacetylase 1	0.0095	0.0112	0.0951
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0386	0.0758	0.1826
Trichomonas vaginalis	bromodomain containing protein, putative	0.0309	0.0587	0.0519
Echinococcus granulosus	thyroid hormone receptor alpha	0.0067	0.005	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0067	0.005	0.0043
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Echinococcus granulosus	histone deacetylase 6	0.0162	0.0262	0.0283
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0067	0.005	0.0054
Loa Loa (eye worm)	DR-78	0.0067	0.005	0.0043
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0067	0.005	0.0097
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0309	0.0587	0.7704
Echinococcus multilocularis	nuclear receptor nhr 48	0.0067	0.005	0.0054
Brugia malayi	nuclear hormone receptor	0.0067	0.005	0.004
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Schistosoma mansoni	hypothetical protein	0.0309	0.0587	0.0634
Trichomonas vaginalis	bromodomain and PHD finger-containing protein, putative	0.0309	0.0587	0.0519
Echinococcus granulosus	histone deacetylase 1	0.0095	0.0112	0.0121
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0141	0.0216	0.0209
Brugia malayi	Bromodomain containing protein	0.0309	0.0587	0.0577
Trypanosoma brucei	Bromodomain, putative	0.0309	0.0587	1
Echinococcus granulosus	CREB binding protein	0.0407	0.0805	0.087
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0067	0.005	0.004
Echinococcus multilocularis	histone deacetylase 8	0.0049	0.001	0.0011
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0141	0.0216	0.0206
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0049	0.001	0.0011
Onchocerca volvulus		0.0141	0.0216	0.0502
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Echinococcus multilocularis	bromodomain containing 2	0.4216	0.9253	1
Giardia lamblia	Transcription regulatory protein SNF2	0.0309	0.0587	0.1296
Brugia malayi	nuclear receptor NHR-88	0.0067	0.005	0.004
Echinococcus multilocularis	histone deacetylase 1	0.0095	0.0112	0.0121
Schistosoma mansoni	nuclear receptor	0.0067	0.005	0.0054
Brugia malayi	Bromodomain containing protein	0.0314	0.0598	0.0588
Plasmodium falciparum	histone deacetylase, putative	0.0162	0.0262	0.3814
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Giardia lamblia	Hypothetical protein	0.0309	0.0587	0.1296
Trypanosoma cruzi	histone deacetylase 1, putative	0.0095	0.0112	0.1765
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Schistosoma mansoni	thyroid hormone receptor	0.0141	0.0216	0.0233
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Trypanosoma brucei	histone deacetylase, putative	0.0162	0.0262	0.4371
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Schistosoma mansoni	histone deacetylase hda2	0.0169	0.0276	0.0298
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0691	0.0685
Brugia malayi	Bromodomain containing protein	0.051	0.1034	0.1025
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0265	0.049	0.0529
Echinococcus multilocularis	polybromo 1	0.0356	0.0692	0.0748
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0141	0.0216	0.0209
Echinococcus granulosus	polybromo 1	0.0356	0.0692	0.0748
Echinococcus multilocularis	histone deacetylase 6	0.0169	0.0276	0.0298
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0141	0.0216	0.0233
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Trichomonas vaginalis	lymphoid specific helicase, putative	0.0309	0.0587	0.0519
Entamoeba histolytica	ankyrin repeat protein, putative	0.0309	0.0587	0.1272
Echinococcus multilocularis	Bromodomain containing protein	0.0309	0.0587	0.0634
Brugia malayi	Nuclear hormone receptor-like 1	0.0075	0.0068	0.0058
Trypanosoma brucei	Bromodomain factor 1	0.0309	0.0587	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Onchocerca volvulus		0.0067	0.005	0.0097
Loa Loa (eye worm)	bromodomain containing protein	0.0309	0.0587	0.058
Brugia malayi	ecdysone receptor	0.0067	0.005	0.004
Brugia malayi	nuclear hormone receptor family member odr-7	0.0067	0.005	0.004
Loa Loa (eye worm)	hypothetical protein	0.0067	0.005	0.0043
Trypanosoma brucei	histone deacetylase 3	0.0162	0.0262	0.4371
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.031	0.0589	0.0521
Echinococcus multilocularis	zinc finger protein	0.0314	0.0598	0.0646
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0141	0.0216	0.0233
Brugia malayi	BRM protein	0.0309	0.0587	0.0577
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0386	0.0758	1
Echinococcus granulosus	bromodomain containing 2	0.4216	0.9253	1
Trypanosoma cruzi	Bromodomain factor 1	0.0309	0.0587	1
Trichomonas vaginalis	hypothetical protein	0.0309	0.0587	0.0519
Brugia malayi	Bromodomain containing protein	0.0657	0.136	0.1351
Toxoplasma gondii	histone acetyltransferase TAF1/250	0.0309	0.0587	0.1407
Brugia malayi	hypothetical protein	0.1924	0.4168	0.4163
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0216	0.0209
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Echinococcus multilocularis	histone deacetylase 3	0.0095	0.0112	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0216	0.0209
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Toxoplasma gondii	bromodomain-containing protein	0.0309	0.0587	0.1407
Loa Loa (eye worm)	CBP-B	0.0377	0.0737	0.0731
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Trichomonas vaginalis	bromodomain containing protein, putative	0.2629	0.5734	0.615
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0067	0.005	0.0054
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0309	0.0587	0.1407
Loa Loa (eye worm)	histone deacetylase 11	0.0049	0.001	0.0004
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0062	0.0056
Brugia malayi	nuclear receptor RXR	0.0067	0.005	0.004
Schistosoma mansoni	histone deacetylase	0.0095	0.0112	0.0121
Echinococcus granulosus	PHD finger protein rhinoceros	0.0072	0.0062	0.0067
Toxoplasma gondii	bromodomain-containing protein	0.0309	0.0587	0.1407
Plasmodium falciparum	bromodomain protein 2, putative	0.0309	0.0587	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0067	0.005	0.004
Brugia malayi	hypothetical protein	0.0075	0.0068	0.0058
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Onchocerca volvulus	Protein ultraspiracle homolog	0.0141	0.0216	0.0502
Schistosoma mansoni	bromodomain containing protein	0.0314	0.0598	0.0646
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Brugia malayi	PHD-finger family protein	0.0314	0.0598	0.0588
Plasmodium vivax	histone deacetylase, putative	0.0162	0.0262	0.3368
Echinococcus granulosus	histone deacetylase 8	0.0049	0.001	0.0011
Onchocerca volvulus		0.1895	0.4106	1
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0075	0.0068	0.0073
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.1895	0.4106	0.4369
Echinococcus granulosus	global transcription activator snf2l2	0.0309	0.0587	0.0634
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0141	0.0216	0.0233
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0141	0.0216	0.0233
Onchocerca volvulus		0.051	0.1034	0.2499
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0067	0.005	0.0054
Brugia malayi	tailless protein	0.0067	0.005	0.004
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Toxoplasma gondii	histone deacetylase HDAC3	0.0095	0.0112	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0067	0.005	0.0043
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Trypanosoma brucei	histone deacetylase 4	0.0162	0.0262	0.4371
Leishmania major	hypothetical protein, conserved,predicted bromodomain protein	0.0309	0.0587	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0112	0.0105
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Echinococcus granulosus	CREB binding protein	0.0369	0.072	0.0778
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0067	0.005	0.0054
Leishmania major	hypothetical protein, conserved	0.0309	0.0587	1
Leishmania major	histone deacetylase, putative	0.0162	0.0262	0.3165
Brugia malayi	Nuclear hormone receptor-like 1	0.0075	0.0068	0.0058
Schistosoma mansoni	nuclear receptor nhr-48	0.0067	0.005	0.0054
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0141	0.0216	0.0233
Schistosoma mansoni	retinoic acid receptor RXR	0.0668	0.1384	0.1496
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0141	0.0216	0.0233
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0141	0.0216	0.0233
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Trypanosoma cruzi	histone deacetylase 1, putative	0.0095	0.0112	0.1765
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Echinococcus multilocularis	protein kinase C binding protein 1	0.0309	0.0587	0.0634
Schistosoma mansoni	bromodomain-containing protein 3 brd3	0.4216	0.9253	1
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0141	0.0216	0.0233
Trichomonas vaginalis	conserved hypothetical protein	0.0149	0.0232	0.0131
Echinococcus granulosus	zinc finger protein	0.0314	0.0598	0.0646
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0072	0.0062	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0068	0.0061
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.031	0.0589	0.0521
Leishmania major	hypothetical protein, conserved	0.0309	0.0587	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0141	0.0216	0.0233
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Schistosoma mansoni	CREB-binding protein 1 (SmCBP1)	0.0407	0.0805	0.087
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0587	0.058
Schistosoma mansoni	phd finger protein	0.0327	0.0628	0.0679
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0386	0.0758	0.1826
Trichomonas vaginalis	conserved hypothetical protein	0.2629	0.5734	0.615
Brugia malayi	Bromodomain containing protein	0.0573	0.1174	0.1165
Echinococcus granulosus	histone deacetylase 3	0.0095	0.0112	0.0121
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0075	0.0068	0.0073
Plasmodium vivax	SET domain containing protein	0.0309	0.0587	0.7704
Loa Loa (eye worm)	histone deacetylase 1	0.0095	0.0112	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0049	0.001	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Brugia malayi	polybromodomain protein	0.0349	0.0677	0.0667
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0141	0.0216	0.0233
Plasmodium falciparum	bromodomain protein, putative	0.0309	0.0587	1
Schistosoma mansoni	transcription initiation factor tfiid	0.0309	0.0587	0.0634
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0141	0.0216	0.0233
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Loa Loa (eye worm)	hypothetical protein	0.1672	0.3611	0.3607
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0587	0.058
Loa Loa (eye worm)	nuclear hormone receptor	0.0067	0.005	0.0043
Echinococcus multilocularis	PH interacting protein	0.0309	0.0587	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0657	0.136	0.1354
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0141	0.0216	0.0233
Echinococcus granulosus	E3 ubiquitin protein ligase TRIM33	0.0202	0.035	0.0378
Entamoeba histolytica	bromodomain-containing protein	0.1895	0.4106	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0141	0.0216	0.0233
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0141	0.0216	0.0233
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Brugia malayi	hypothetical protein	0.0075	0.0068	0.0058
Schistosoma mansoni	bromodomain containing protein	0.0314	0.0598	0.0646
Echinococcus granulosus	histone deacetylase 6	0.0169	0.0276	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0067	0.005	0.0043
Entamoeba histolytica	histone deacetylase, putative	0.0095	0.0112	0.0095
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0587	0.058
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Echinococcus multilocularis	Bromodomain containing protein	0.1895	0.4106	0.4437
Schistosoma mansoni	nuclear receptor	0.0067	0.005	0.0054
Trichomonas vaginalis	bromodomain containing protein, putative	0.0309	0.0587	0.0519
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Brugia malayi	steroid hormone receptor	0.0141	0.0216	0.0206
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Brugia malayi	Nuclear hormone receptor E75	0.0067	0.005	0.004
Schistosoma mansoni	nuclear hormone receptor	0.0141	0.0216	0.0233
Trypanosoma brucei	AAA ATPase, putative	0.0309	0.0587	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0668	0.1384	0.1496
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Echinococcus multilocularis	histone deacetylase	0.0162	0.0262	0.0283
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0141	0.0216	0.0209
Trypanosoma cruzi	Bromodomain, putative	0.0309	0.0587	1
Toxoplasma gondii	bromodomain-containing protein	0.1895	0.4106	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.4216	0.9253	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0067	0.005	0.004
Schistosoma mansoni	nuclear hormone receptor	0.0067	0.005	0.0054
Trypanosoma brucei	histone deacetylase 1	0.0095	0.0112	0.1765
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0279	0.0521	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0067	0.005	0.0043
Echinococcus multilocularis	peregrin	0.0592	0.1216	0.1314
Brugia malayi	hypothetical protein	0.0067	0.005	0.004
Brugia malayi	ATPase, AAA family protein	0.0309	0.0587	0.0577
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0141	0.0216	0.0209
Brugia malayi	nuclear hormone receptor	0.0141	0.0216	0.0206
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Trichomonas vaginalis	bromodomain-containing protein 3, brd3, putative	0.0309	0.0587	0.0519
Echinococcus granulosus	bromodomain containing protein 7	0.0155	0.0246	0.0266
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0075	0.0068	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0216	0.0209
Brugia malayi	Histone deacetylase 1	0.0095	0.0112	0.0102
Entamoeba histolytica	bromodomain-containing protein	0.0309	0.0587	0.1272
Onchocerca volvulus	Bile acid receptor homolog	0.1672	0.3611	0.8793
Leishmania major	DNA-binding protein, putative,predicted bromodomain protein	0.0309	0.0587	1
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0067	0.005	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0216	0.0209
Schistosoma mansoni	hypothetical protein	0.0309	0.0587	0.0634
Trypanosoma cruzi	Bromodomain, putative	0.0309	0.0587	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0141	0.0216	0.0209
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0309	0.0587	0.0519
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0309	0.0587	0.0519
Trichomonas vaginalis	bromodomain-containing protein 4, brd4, putative	0.1895	0.4106	0.4369
Trypanosoma cruzi	Bromodomain, putative	0.0309	0.0587	1
Loa Loa (eye worm)	hypothetical protein	0.051	0.1034	0.1028
Echinococcus granulosus	bromodomain containing protein 8	0.0309	0.0587	0.0634
Entamoeba histolytica	hypothetical protein	0.0309	0.0587	0.1272
Trypanosoma brucei	Bromodomain, putative	0.0309	0.0587	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.0168	0.0161
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0067	0.005	0.0043
Brugia malayi	conserved hypotetical protein	0.0067	0.005	0.004
Toxoplasma gondii	bromodomain-containing protein	0.0309	0.0587	0.1407
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Trichomonas vaginalis	bromodomain containing protein, putative	0.0309	0.0587	0.0519
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0141	0.0216	0.0209
Brugia malayi	nuclear receptor NHR-88	0.0141	0.0216	0.0206
Plasmodium vivax	histone deacetylase 1, putative	0.0095	0.0112	0.136
Onchocerca volvulus	Brd8 homolog	0.0309	0.0587	0.1407
Echinococcus multilocularis	histone deacetylase 7	0.0162	0.0262	0.0283
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0141	0.0216	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0067	0.005	0.0043
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0141	0.0216	0.0206
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0309	0.0587	0.0519
Echinococcus multilocularis	global transcription activator snf2l2	0.0309	0.0587	0.0634
Plasmodium falciparum	histone deacetylase 2	0.0162	0.0262	0.3814
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0141	0.0216	0.0233
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0141	0.0216	0.0209
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0386	0.0758	0.0819
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0314	0.0598	0.0646
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Schistosoma mansoni	helicase	0.0309	0.0587	0.0634
Echinococcus multilocularis	histone deacetylase 6	0.0162	0.0262	0.0283
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0386	0.0758	0.0707
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Brugia malayi	acetyltransferase, GNAT family protein	0.0589	0.1208	0.1199
Onchocerca volvulus	Alhambra homolog	0.0072	0.0062	0.0127
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0141	0.0216	0.0233
Brugia malayi	Histone deacetylase family protein	0.0162	0.0262	0.0253
Trichomonas vaginalis	bromodomain containing protein, putative	0.1895	0.4106	0.4369
Trypanosoma cruzi	histone deacetylase, putative	0.0162	0.0262	0.4371
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Loa Loa (eye worm)	cytochrome P450 family protein	0.008	0.0079	0.0072
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Schistosoma mansoni	histone deacetylase 1 2 3	0.0049	0.001	0.0011
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0067	0.005	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Schistosoma mansoni	hypothetical protein	0.0309	0.0587	0.0634
Loa Loa (eye worm)	acetyltransferase	0.0589	0.1208	0.1202
Echinococcus granulosus	histone deacetylase	0.0162	0.0262	0.0283
Brugia malayi	photoreceptor-specific nuclear receptor	0.0141	0.0216	0.0206
Loa Loa (eye worm)	histone deacetylase 3	0.0095	0.0112	0.0105
Brugia malayi	Bromodomain containing protein	0.0309	0.0587	0.0577
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0067	0.005	0.0054
Trichomonas vaginalis	bromodomain-containing protein, putative	0.4216	0.9253	1
Giardia lamblia	Kinase, putative	0.1895	0.4106	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.2629	0.5734	0.615
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Trypanosoma cruzi	Bromodomain, putative	0.0309	0.0587	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Trypanosoma cruzi	Bromodomain, putative	0.0309	0.0587	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0141	0.0216	0.0206
Onchocerca volvulus	Bromodomain adjacent to zinc finger domain protein 1A homolog	0.0309	0.0587	0.1407
Trichomonas vaginalis	bromodomain containing protein, putative	0.0309	0.0587	0.0519
Brugia malayi	hypothetical protein	0.0067	0.005	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Trypanosoma cruzi	bromodomain factor 2 protein	0.0309	0.0587	1
Schistosoma mansoni	hypothetical protein	0.0309	0.0587	0.0634
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0141	0.0216	0.0206
Trypanosoma brucei	Bromodomain, putative	0.0309	0.0587	1
Loa Loa (eye worm)	hypothetical protein	0.0314	0.0598	0.0592
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0141	0.0216	0.0206
Plasmodium falciparum	histone acetyltransferase GCN5	0.0077	0.0074	0.022
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Brugia malayi	Bromodomain containing protein	0.0309	0.0587	0.0577
Echinococcus granulosus	peregrin	0.0592	0.1216	0.1314
Schistosoma mansoni	thyroid hormone receptor	0.0141	0.0216	0.0233
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Schistosoma mansoni	hypothetical protein	0.0155	0.0246	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Echinococcus multilocularis	FTZ F1 alpha	0.0141	0.0216	0.0233
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0141	0.0216	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0587	0.058
Entamoeba histolytica	bromodomain-containing protein	0.1895	0.4106	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.005	0.0043
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0594	0.1219	0.1317
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0589	0.1208	0.1305
Loa Loa (eye worm)	PHD-finger family protein	0.0072	0.0062	0.0056
Giardia lamblia	Hypothetical protein	0.0309	0.0587	0.1296
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0067	0.005	0.0054
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.0062	0.0694
Loa Loa (eye worm)	histone deacetylase 7A	0.0162	0.0262	0.0256
Schistosoma mansoni	polybromo-1	0.0356	0.0692	0.0748
Brugia malayi	nuclear receptor NHR-67	0.0067	0.005	0.004
Brugia malayi	PHD-finger family protein	0.0072	0.0062	0.0052
Trypanosoma cruzi	histone deacetylase, putative	0.0162	0.0262	0.4371
Schistosoma mansoni	zinc finger protein	0.0314	0.0598	0.0646
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0141	0.0216	0.0233
Entamoeba histolytica	bromodomain-containing protein	0.0309	0.0587	0.1272
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Toxoplasma gondii	PHD-finger domain-containing protein	0.0072	0.0062	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0141	0.0216	0.0233
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Echinococcus multilocularis		0.0309	0.0587	0.0634
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Toxoplasma gondii	hypothetical protein	0.0309	0.0587	0.1407
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0154	0.0147
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Echinococcus granulosus	Bromodomain containing protein	0.0309	0.0587	0.0634
Trypanosoma cruzi	histone deacetylase, putative	0.0162	0.0262	0.4371
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0232	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0067	0.005	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0068	0.0061
Schistosoma mansoni	histone deacetylase 4 5	0.0162	0.0262	0.0283
Trypanosoma cruzi	bromodomain-containing protein 3	0.0309	0.0587	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0141	0.0216	0.0502
Loa Loa (eye worm)	hypothetical protein	0.0067	0.005	0.0043
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0067	0.005	0.0097
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0314	0.0598	0.0646
Trichomonas vaginalis	bromodomain-containing protein, putative	0.2629	0.5734	0.615
Schistosoma mansoni	coup transcription factor	0.0141	0.0216	0.0233
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0216	0.0209
Trichomonas vaginalis	bromodomain-containing protein, putative	0.2629	0.5734	0.615
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0068	0.0061
Schistosoma mansoni	bromodomain containing protein	0.0309	0.0587	0.0634
Schistosoma mansoni	transcription intermediary factor 1-related	0.0202	0.035	0.0378
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0587	0.058
Brugia malayi	histone deacetylase 1 (HD1)	0.0095	0.0112	0.0102
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Echinococcus multilocularis	CREB binding protein	0.0376	0.0735	0.0795
Schistosoma mansoni	CREB-binding protein 2	0.0407	0.0805	0.087
Echinococcus multilocularis	ATPase family AAA domain containing protein 2B	0.0309	0.0587	0.0634
Trichomonas vaginalis	conserved hypothetical protein	0.1895	0.4106	0.4369
Brugia malayi	Steroid receptor seven-up type 2	0.0141	0.0216	0.0206
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0141	0.0216	0.0206
Echinococcus granulosus	histone deacetylase 7	0.0162	0.0262	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0068	0.0061
Brugia malayi	Histone deacetylase family protein	0.0162	0.0262	0.0253
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Schistosoma mansoni	nuclear hormone receptor	0.0067	0.005	0.0054
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0386	0.0758	0.0707
Echinococcus multilocularis	ecdysone induced protein 78C	0.0141	0.0216	0.0233
Trichomonas vaginalis	conserved hypothetical protein	0.2321	0.505	0.5401
Toxoplasma gondii	bromodomain-containing protein	0.0309	0.0587	0.1407
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Brugia malayi	nuclear receptor RXR	0.0075	0.0068	0.0058
Echinococcus granulosus	nuclear receptor nhr 48	0.0067	0.005	0.0054
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0067	0.005	0.0054
Loa Loa (eye worm)	bromodomain containing protein	0.1895	0.4106	0.4102
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Schistosoma mansoni	histone deacetylase 4 5	0.0162	0.0262	0.0283
Echinococcus granulosus	protein kinase C binding protein 1	0.0309	0.0587	0.0634
Plasmodium vivax	bromodomain protein, putative	0.0309	0.0587	0.7704
Echinococcus multilocularis	bromodomain containing protein 7	0.0155	0.0246	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0309	0.0587	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0068	0.0061
Loa Loa (eye worm)	BRM protein	0.0309	0.0587	0.058
Echinococcus multilocularis	E3 ubiquitin protein ligase TRIM33	0.0202	0.035	0.0378
Echinococcus multilocularis	bromodomain containing protein 8	0.0309	0.0587	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0216	0.0209
Brugia malayi	Cytochrome P450 family protein	0.008	0.0079	0.0069
Schistosoma mansoni	RAR-like nuclear receptor	0.0141	0.0216	0.0233
Brugia malayi	Bromodomain containing protein	0.0309	0.0587	0.0577
Schistosoma mansoni	histone deacetylase	0.0095	0.0112	0.0121
Entamoeba histolytica	bromodomain-containing protein	0.1895	0.4106	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0141	0.0216	0.0233
Toxoplasma gondii	histone deacetylase HDAC2	0.0095	0.0112	0.0248
Echinococcus granulosus	histone deacetylase 6	0.0162	0.0262	0.0283
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0141	0.0216	0.0206
Brugia malayi	polybromodomain protein	0.0356	0.0691	0.0682
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Trichomonas vaginalis	bromodomain-containing protein, putative	0.1895	0.4106	0.4369
Echinococcus granulosus	FTZ F1 alpha	0.0141	0.0216	0.0233
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0075	0.0068	0.0073
Brugia malayi	ecdysteroid receptor	0.1672	0.3611	0.3605
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0141	0.0216	0.0206
Brugia malayi	TAZ zinc finger family protein	0.0407	0.0805	0.0796
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0309	0.0587	0.0519
Echinococcus granulosus	PH interacting protein	0.0309	0.0587	0.0634
Loa Loa (eye worm)	jmjC domain-containing protein	0.0049	0.001	0.0003
Plasmodium vivax	bromodomain protein, putative	0.0309	0.0587	0.7704
Onchocerca volvulus		0.0309	0.0587	0.1407
Loa Loa (eye worm)	hypothetical protein	0.0314	0.0598	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0067	0.005	0.0043
Brugia malayi	Bromodomain containing protein	0.4216	0.9253	0.9252
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0589	0.1208	0.1305
Brugia malayi	bromodomain containing protein	0.0309	0.0587	0.0577
Toxoplasma gondii	PHD-finger domain-containing protein	0.0072	0.0062	0.0127
Schistosoma mansoni	hypothetical protein	0.0072	0.0062	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0141	0.0216	0.0206
Onchocerca volvulus		0.0067	0.005	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0067	0.005	0.0043
Giardia lamblia	Histone deacetylase	0.0095	0.0112	0.0123
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0141	0.0216	0.0206

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 827384