Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.1062 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.1062 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.3135 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0032 | 0.533 | 0.4775 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.3135 | 0.2319 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.1062 | 0.1062 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.1062 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.3135 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0046 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.3135 | 0.3135 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0032 | 0.533 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0046 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.1062 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.3135 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.1062 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3135 | 0.2319 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.1062 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0046 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.1062 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.3135 | 0.2319 |
Schistosoma mansoni | DNA polymerase eta | 0.0046 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.3135 | 0.2319 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.3135 | 0.2319 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0046 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.1062 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0032 | 0.533 | 0.4775 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.