Detailed information for compound 827770

Basic information

Technical information
  • TDR Targets ID: 827770
  • Name: N-(4-ethoxyphenyl)-2-[(2-oxo-3,4-dihydro-1H-q uinolin-6-yl)sulfonylamino]-2-phenylacetamide
  • MW: 479.548 | Formula: C25H25N3O5S
  • H donors: 3 H acceptors: 4 LogP: 2.97 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)NC(=O)C(c1ccccc1)NS(=O)(=O)c1ccc2c(c1)CCC(=O)N2
  • InChi: 1S/C25H25N3O5S/c1-2-33-20-11-9-19(10-12-20)26-25(30)24(17-6-4-3-5-7-17)28-34(31,32)21-13-14-22-18(16-21)8-15-23(29)27-22/h3-7,9-14,16,24,28H,2,8,15H2,1H3,(H,26,30)(H,27,29)
  • InChiKey: MUKPAVWTFKUHTK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-ethoxyphenyl)-2-[(2-oxo-3,4-dihydro-1H-quinolin-6-yl)sulfonylamino]-2-phenyl-acetamide
  • N-(4-ethoxyphenyl)-2-[(2-keto-3,4-dihydro-1H-quinolin-6-yl)sulfonylamino]-2-phenyl-acetamide
  • N-(4-ethoxyphenyl)-2-[(2-oxo-3,4-dihydro-1H-quinolin-6-yl)sulfonylamino]-2-phenyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0079 0.034 1
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.0079 0.034 0.1514
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.0079 0.034 0.5
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.0079 0.034 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0381 0.2244 1
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.0079 0.034 0.0053
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0079 0.034 1
Loa Loa (eye worm) hypothetical protein 0.0321 0.1861 0.8292
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0381 0.2244 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0 0.5
Echinococcus granulosus single minded 2 0.0071 0.0289 0.1287
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.0079 0.034 0.1514
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.0079 0.034 0.0261
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0381 0.2244 1
Schistosoma mansoni single-minded 0.0096 0.0445 0.0553
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.1614 1 1
Brugia malayi hypoxia-induced factor 1 0.0296 0.1705 0.7241
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0079 0.034 1
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.0079 0.034 0.1514
Brugia malayi hypothetical protein 0.0321 0.1861 0.804
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0381 0.2244 1
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0079 0.034 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0096 0.0445 0.0553
Onchocerca volvulus 0.0071 0.0289 1
Echinococcus multilocularis transfer RNA-Lys 0.0071 0.0289 0.1287
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0079 0.034 1
Mycobacterium ulcerans proteasome PrcA 0.1614 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0381 0.2244 1
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0042 0.011 0.3796
Loa Loa (eye worm) hypoxia-induced factor 1 0.0296 0.1705 0.7596
Brugia malayi PAS domain containing protein 0.0096 0.0445 0.0799
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.0079 0.034 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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