Detailed information for compound 828051

Basic information

Technical information
  • TDR Targets ID: 828051
  • Name: 3-methyl-1-[5-(phenylmethylamino)-3-pyridin-3 -yl-1,2,4-triazol-1-yl]butan-1-one
  • MW: 335.403 | Formula: C19H21N5O
  • H donors: 1 H acceptors: 4 LogP: 4.1 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CC(=O)n1nc(nc1NCc1ccccc1)c1cccnc1)C
  • InChi: 1S/C19H21N5O/c1-14(2)11-17(25)24-19(21-12-15-7-4-3-5-8-15)22-18(23-24)16-9-6-10-20-13-16/h3-10,13-14H,11-12H2,1-2H3,(H,21,22,23)
  • InChiKey: PDLVRSUWHORMQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-methyl-1-[5-(phenylmethylamino)-3-(3-pyridyl)-1,2,4-triazol-1-yl]butan-1-one
  • 1-[5-(benzylamino)-3-(3-pyridyl)-1,2,4-triazol-1-yl]-3-methyl-butan-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0316 0.0997
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0029 0.0032
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0338 0.3629 0.6713
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.037 0.0404
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0338 0.3629 0.3965
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0327 0.0606
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0044 0.0359 0.0665
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0064 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3094 1
Toxoplasma gondii endonuclease IV APN 0.0086 0.0824 0.2835
Onchocerca volvulus 0.0032 0.0225 0.0401
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0064 0.0191
Schistosoma mansoni zinc finger protein 0.0159 0.1641 0.1793
Onchocerca volvulus Bile acid receptor homolog 0.0338 0.3629 0.6713
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0129 0.1305 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0338 0.3629 0.6719
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0059 0.0519 0.0961
Trichomonas vaginalis DNA topoisomerase II, putative 0.0059 0.0519 0.1654
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0271 0.2885 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0338 0.3629 0.3965
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0316 0.0895
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0338 0.3629 0.3965
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0023 0.0118 0.0203
Brugia malayi CXXC zinc finger family protein 0.0032 0.0225 0.0417
Chlamydia trachomatis endonuclease IV 0.0086 0.0824 0.2382
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.029 0.3094 0.5728
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0043 0.0343 0.0343
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0625 0.2112
Mycobacterium ulcerans beta-lactamase 0.004 0.0316 0.1034
Mycobacterium tuberculosis Conserved protein 0.004 0.0316 0.0895
Loa Loa (eye worm) hypothetical protein 0.0178 0.1854 0.3433
Brugia malayi intermediate filament protein 0.0033 0.0229 0.0425
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0043 0.0343 0.0635
Schistosoma mansoni hypothetical protein 0.0018 0.0064 0.0069
Loa Loa (eye worm) helicase 0.0013 0.0009 0.0017
Brugia malayi Probable DNA topoisomerase II 0.0059 0.0519 0.0961
Leishmania major DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0586
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0338 0.3629 0.6719
Mycobacterium ulcerans endonuclease IV 0.0086 0.0824 0.2807
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0009 0.0009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0338 0.3629 0.3965
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0059 0.0519 0.0961
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0108 0.0118
Leishmania major mitochondrial DNA topoisomerase II 0.0103 0.1019 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0338 0.3629 0.3629
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0316 0.1034
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0159 0.1641 0.1793
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0009 0.001
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0292 0.0541
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0101 0.099 0.1081
Brugia malayi hypothetical protein 0.0159 0.1641 0.3039
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0029 0.0032
Echinococcus multilocularis thyroid hormone receptor alpha 0.0338 0.3629 0.3629
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0053 0.0141
Loa Loa (eye worm) hypothetical protein 0.0055 0.0485 0.0897
Echinococcus granulosus neuropeptide s receptor 0.0519 0.5645 0.6167
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0103 0.1019 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0159 0.1641 0.1641
Schistosoma mansoni thyroid hormone receptor 0.0338 0.3629 0.3965
Echinococcus multilocularis RUN 0.0044 0.0359 0.0359
Brugia malayi nuclear hormone receptor 0.0159 0.1641 0.3039
Onchocerca volvulus 0.0021 0.0104 0.0175
Mycobacterium leprae Probable lipase LipE 0.004 0.0316 0.1668
Schistosoma mansoni retinoic acid receptor RXR 0.0448 0.4861 0.531
Chlamydia trachomatis DNA gyrase subunit A 0.0271 0.2885 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0108 0.032
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0178 0.1854 0.3433
Trypanosoma brucei DNA topoisomerase ii 0.0103 0.1019 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0108 0.0155
Trypanosoma cruzi DNA topoisomerase II, putative 0.0049 0.0415 0.3957
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0229 0.0425
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3094 1
Schistosoma mansoni lipoxygenase 0.0194 0.203 0.2218
Onchocerca volvulus Glucosylceramidase homolog 0.019 0.1984 0.3662
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Brugia malayi Kringle domain containing protein 0.0021 0.0104 0.0192
Brugia malayi nuclear hormone receptor 0.0338 0.3629 0.6719
Echinococcus granulosus Polycystic kidney disease protein 0.0044 0.0359 0.0392
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0583 0.108
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0586
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0159 0.1641 0.1641
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0043 0.0343 0.0635
Echinococcus multilocularis Polycystic kidney disease protein 0.0044 0.0359 0.0359
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0159 0.1641 0.1793
Echinococcus multilocularis Protein lozenge 0.0062 0.0561 0.0561
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0359 0.1218
Onchocerca volvulus 0.0114 0.1132 0.2083
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.9154 1
Echinococcus granulosus geminin 0.019 0.1984 0.2167
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0586
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0583 0.1841
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.002 0.0037
Onchocerca volvulus 0.0033 0.0229 0.0409
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0009 0.001
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0043 0.0343 0.6551
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0583 0.0637
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0489 0.0906
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0086 0.0824 0.1526
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0159 0.1641 0.3039
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0059 0.0519 0.0946
Schistosoma mansoni hypothetical protein 0.0038 0.0292 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0338 0.3629 0.6719
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0104 0.0835
Schistosoma mansoni hypothetical protein 0.0021 0.0104 0.0113
Schistosoma mansoni hypothetical protein 0.019 0.1984 0.2167
Trypanosoma brucei unspecified product 0.0015 0.0033 0.0126
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Brugia malayi nuclear receptor NHR-88 0.0338 0.3629 0.6719
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0194 0.203 0.203
Echinococcus granulosus chromobox protein 2 0.0013 0.0009 0.001
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0108 0.0305
Loa Loa (eye worm) hypothetical protein 0.0178 0.1854 0.3433
Plasmodium vivax hypothetical protein, conserved 0.004 0.0316 0.1069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0338 0.3629 0.3629
Loa Loa (eye worm) hypothetical protein 0.0036 0.0267 0.0493
Brugia malayi Cytochrome P450 family protein 0.0014 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0032 0.0223 0.0412
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0086 0.0824 0.2835
Brugia malayi Nuclear hormone receptor-like 1 0.0178 0.1854 0.3433
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0338 0.3629 0.3629
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Onchocerca volvulus 0.0055 0.0485 0.0882
Brugia malayi Steroid receptor seven-up type 2 0.0338 0.3629 0.6719
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0053 0.0141
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0359 0.0359
Schistosoma mansoni lamin 0.0033 0.0229 0.0251
Schistosoma mansoni intermediate filament proteins 0.0033 0.0229 0.0251
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3094 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.009 0.0264
Brugia malayi ecdysone receptor 0.0159 0.1641 0.3039
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0189
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Echinococcus granulosus microtubule associated protein 2 0.0833 0.9154 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0586
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.009 0.0264
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0159 0.1641 0.3039
Brugia malayi steroid hormone receptor 0.0338 0.3629 0.6719
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0064 0.0191
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0104 0.0329
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0338 0.3629 0.3629
Brugia malayi nuclear receptor RXR 0.0159 0.1641 0.3039
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Loa Loa (eye worm) hypothetical protein 0.0497 0.5402 1
Echinococcus multilocularis dnaJ subfamily B 0.0459 0.4978 0.4978
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Onchocerca volvulus Protein ultraspiracle homolog 0.0338 0.3629 0.6713
Echinococcus multilocularis neuropeptide receptor A26 0.0519 0.5645 0.5645
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0338 0.3629 0.3965
Plasmodium falciparum DNA gyrase subunit A 0.0271 0.2885 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Brugia malayi nuclear hormone receptor family member nhr-6 0.0159 0.1641 0.3039
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0271 0.2885 1
Brugia malayi SET domain containing protein 0.0013 0.0017 0.0031
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0101 0.099 0.1081
Echinococcus granulosus chromobox protein 1 0.0013 0.0009 0.001
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0086 0.0824 0.2695
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0045 0.0366 0.2089
Brugia malayi ecdysteroid receptor 0.0338 0.3629 0.6719
Brugia malayi hypothetical protein 0.0178 0.1854 0.3433
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0064 0.0191
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0108 0.0155
Echinococcus multilocularis FTZ F1 alpha 0.0338 0.3629 0.3629
Schistosoma mansoni hypothetical protein 0.0018 0.0064 0.0069
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0359 0.0359
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0338 0.3629 0.3965
Loa Loa (eye worm) nuclear hormone receptor 0.0159 0.1641 0.3039
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0316 0.0346
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0338 0.3629 0.3965
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0316 0.0346
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0229 0.0425
Loa Loa (eye worm) hypothetical protein 0.0497 0.5402 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.0126
Brugia malayi hypothetical protein 0.0114 0.1132 0.2096
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0108 0.0108
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0108 0.0305
Schistosoma mansoni rab6-interacting 0.0044 0.0359 0.0392
Brugia malayi hypothetical protein 0.0044 0.0359 0.0665
Loa Loa (eye worm) nuclear receptor NHR-67 0.0159 0.1641 0.3039
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.002 0.0037
Toxoplasma gondii ABC1 family protein 0.004 0.0316 0.1069
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0064 0.0438
Schistosoma mansoni chromobox protein 0.0013 0.0009 0.001
Echinococcus granulosus lamin dm0 0.0033 0.0229 0.0251
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0625 0.0683
Loa Loa (eye worm) hypothetical protein 0.0033 0.0229 0.0425
Echinococcus multilocularis lamin 0.0033 0.0229 0.0229
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0061 0.0113
Brugia malayi Heterochromatin protein 1 0.0013 0.0009 0.0017
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0043 0.0343 0.3234
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0064 0.0438
Schistosoma mansoni lipoxygenase 0.0115 0.1143 0.1249
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Schistosoma mansoni cpg binding protein 0.0032 0.0225 0.0246
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0359 0.0392
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0064 0.0118
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0108 0.0118
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0316 0.0895
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0229 0.0425
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0042 0.0045
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0108 0.0876
Mycobacterium ulcerans hypothetical protein 0.0023 0.0118 0.0343
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.9154 0.9154
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0104 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3094 1
Brugia malayi M-phase phosphoprotein, mpp8 0.0114 0.1132 0.2096
Mycobacterium leprae conserved hypothetical protein 0.004 0.0316 0.1668
Echinococcus granulosus ecdysone induced protein 78C 0.0338 0.3629 0.3965
Schistosoma mansoni coup transcription factor 0.0338 0.3629 0.3965
Echinococcus multilocularis chromobox protein 1 0.0013 0.0009 0.0009
Echinococcus granulosus tumor protein p63 0.0379 0.4089 0.4467
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0316 0.0346
Onchocerca volvulus 0.0338 0.3629 0.6713
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0316 0.2966
Onchocerca volvulus 0.0013 0.0017 0.0015
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0625 0.0625
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0338 0.3629 0.6719
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0043 0.0343 0.3234
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0192
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0064 0.0438
Schistosoma mansoni chromobox protein 0.0013 0.0009 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0316 0.0586
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0297 0.0934
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0043 0.0343 0.1162
Entamoeba histolytica hypothetical protein 0.004 0.0316 0.6019
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0316 0.0895
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0338 0.3629 0.6719
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0316 0.1034
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3094 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0338 0.3629 0.3629
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0064 0.0118
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0064 0.0069
Loa Loa (eye worm) hypothetical protein 0.0044 0.0359 0.0665
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0108 0.0118
Entamoeba histolytica hypothetical protein 0.004 0.0316 0.6019
Schistosoma mansoni hypothetical protein 0.0018 0.0064 0.0069
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.013 0.1318 0.4446
Schistosoma mansoni nuclear hormone receptor 0.0159 0.1641 0.1793
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0583 0.5638
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0316 0.0997
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0103 0.1019 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0338 0.3629 0.6719
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.0126
Echinococcus granulosus dnaJ subfamily B 0.0459 0.4978 0.5438
Echinococcus multilocularis tumor protein p63 0.0379 0.4089 0.4089
Trypanosoma brucei unspecified product 0.0015 0.0033 0.0126
Loa Loa (eye worm) hypothetical protein 0.0114 0.1132 0.2096
Brugia malayi hypothetical protein 0.004 0.0316 0.0585
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0199
Leishmania major DNA polymerase eta, putative 0.0022 0.0108 0.0876
Onchocerca volvulus 0.0159 0.1641 0.3027
Echinococcus granulosus Chromobox protein 3 0.0013 0.0009 0.001
Echinococcus multilocularis musashi 0.0033 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0448 0.4861 0.531
Echinococcus multilocularis GPCR, family 2 0.0018 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0219
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.027 0.2873 0.2873
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0583 0.0583
Echinococcus multilocularis nuclear receptor nhr 48 0.0159 0.1641 0.1641
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0338 0.3629 0.6719
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0327 0.0606
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0625 0.2112
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0316 0.0895
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0043 0.0343 0.1162
Echinococcus multilocularis lamin dm0 0.0033 0.0229 0.0229
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0338 0.3629 0.3629
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0535 0.0991
Entamoeba histolytica DNA topoisomerase II, putative 0.0059 0.0519 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Plasmodium falciparum DNA topoisomerase 2 0.0059 0.0519 0.1774
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0316 0.0316
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0009 0.001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Schistosoma mansoni nuclear hormone receptor 0.0159 0.1641 0.1793
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0064 0.0191
Schistosoma mansoni hypothetical protein 0.004 0.0316 0.0345
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0104 0.0113
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0059 0.0519 0.0519
Brugia malayi nuclear hormone receptor family member odr-7 0.0159 0.1641 0.3039
Echinococcus granulosus dna polymerase kappa 0.0022 0.0108 0.0118
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0104 0.0104
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0546 0.1869
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0338 0.3629 0.6719
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0159 0.1641 0.1793
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0316 0.0895
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0338 0.3629 0.6719
Loa Loa (eye worm) hypothetical protein 0.0028 0.018 0.0333
Echinococcus granulosus GPCR family 2 0.0018 0.0064 0.0069
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0271 0.2885 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0316 0.0586
Schistosoma mansoni DNA topoisomerase II 0.0059 0.0519 0.0567
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.009 0.0264
Brugia malayi isocitrate dehydrogenase 0.0018 0.0064 0.0118
Echinococcus granulosus neuropeptide receptor A26 0.0519 0.5645 0.6167
Onchocerca volvulus 0.004 0.0316 0.057
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0061 0.0113
Brugia malayi photoreceptor-specific nuclear receptor 0.0338 0.3629 0.6719
Schistosoma mansoni cpg binding protein 0.0034 0.0246 0.0269
Plasmodium vivax multidomain scavenger receptor, putative 0.0044 0.0359 0.1218
Schistosoma mansoni RAR-like nuclear receptor 0.0338 0.3629 0.3965
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0108 0.0199
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0064 0.0069
Brugia malayi Nuclear hormone receptor E75 0.0159 0.1641 0.3039
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0064 0.0064
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0064 0.0064
Entamoeba histolytica hypothetical protein 0.004 0.0316 0.6019
Giardia lamblia DNA topoisomerase II 0.0054 0.0474 1
Schistosoma mansoni thyroid hormone receptor 0.0338 0.3629 0.3965
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0316 0.0997
Mycobacterium ulcerans lipase LipD 0.004 0.0316 0.1034
Echinococcus multilocularis chromobox protein 2 0.0013 0.0009 0.0009
Schistosoma mansoni lozenge 0.0062 0.0561 0.0613
Onchocerca volvulus 0.0033 0.0229 0.0409
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.009 0.0264
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0338 0.3629 0.6719
Loa Loa (eye worm) hypothetical protein 0.0028 0.018 0.0333
Brugia malayi hypothetical protein 0.0497 0.5402 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0064 0.0438
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0104 0.0329
Echinococcus granulosus FTZ F1 alpha 0.0338 0.3629 0.3965
Echinococcus granulosus Chromo domain 0.0013 0.0009 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.009 0.0264
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0189
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0047 0.0122
Loa Loa (eye worm) hypothetical protein 0.0038 0.0292 0.0541
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0586
Echinococcus granulosus thyroid hormone receptor alpha 0.0159 0.1641 0.1793
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0583 0.1966
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0316 0.0345
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0159 0.1641 0.1641
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Echinococcus granulosus cpg binding protein 0.0034 0.0246 0.0269
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0065
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0065
Loa Loa (eye worm) heterochromatin protein 1 0.0013 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0178 0.1854 0.3433
Leishmania major hypothetical protein, conserved 0.0021 0.0104 0.0835
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0108 0.0876
Schistosoma mansoni lamin 0.0033 0.0229 0.0251
Echinococcus multilocularis cpg binding protein 0.0034 0.0246 0.0246
Mycobacterium ulcerans DNA gyrase subunit B 0.013 0.1318 0.4531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0338 0.3629 0.6719
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0101 0.099 0.099
Loa Loa (eye worm) doublecortin family protein 0.0044 0.0359 0.0665
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2098 0.6772
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0108 0.0199
Brugia malayi nuclear receptor RXR 0.0178 0.1854 0.3433
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.009 0.0264
Schistosoma mansoni DNA polymerase eta 0.0022 0.0108 0.0118
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0009 0.0017
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0059 0.0519 0.0946
Onchocerca volvulus 0.004 0.0316 0.057
Loa Loa (eye worm) steroid hormone receptor 0.0338 0.3629 0.6719
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0064 0.0438
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0043 0.0343 0.1083
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0108 0.0876
Brugia malayi orphan nuclear receptor NR2E1 0.0159 0.1641 0.3039
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0108 0.0108
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0059 0.0519 0.0567
Echinococcus multilocularis dna polymerase eta 0.0022 0.0108 0.0108
Schistosoma mansoni polycystin 1-related 0.0044 0.0359 0.0392
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0118
Onchocerca volvulus 0.0159 0.1641 0.3027
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0077
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0064 0.007
Schistosoma mansoni nuclear hormone receptor 0.0338 0.3629 0.3965
Schistosoma mansoni hypothetical protein 0.0044 0.0359 0.0392
Loa Loa (eye worm) hypothetical protein 0.0178 0.1854 0.3433
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0338 0.3629 0.6719
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0338 0.3629 0.6719
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0583 0.0637
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0194 0.203 0.2218
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0316 0.2966
Loa Loa (eye worm) hypothetical protein 0.004 0.0316 0.0586
Trypanosoma cruzi DNA topoisomerase II, putative 0.0049 0.0415 0.3957
Leishmania major DNA topoisomerase ii 0.0049 0.0415 0.3957
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0338 0.3629 0.6719
Schistosoma mansoni rab6-interacting 0.0044 0.0359 0.0392
Brugia malayi beta-lactamase family protein 0.004 0.0316 0.0586
Schistosoma mansoni hypothetical protein 0.019 0.1984 0.2167
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0009 0.0009
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0178 0.1854 0.1854
Brugia malayi tailless protein 0.0159 0.1641 0.3039
Loa Loa (eye worm) DR-78 0.0159 0.1641 0.3039
Brugia malayi nuclear receptor NHR-67 0.0159 0.1641 0.3039
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0108 0.1934
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0316 0.0895
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0338 0.3629 0.3965
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0178 0.1854 0.2026
Mycobacterium ulcerans epimerase 0.0023 0.0118 0.0343
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0625 0.0683
Echinococcus granulosus lamin 0.0033 0.0229 0.0251
Chlamydia trachomatis DNA gyrase subunit B 0.013 0.1318 0.4208
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0338 0.3629 0.6719
Echinococcus granulosus chromobox protein 1 0.0013 0.0009 0.001
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0043 0.0343 0.0375
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0043 0.0343 0.3234
Schistosoma mansoni cpg binding protein 0.0034 0.0246 0.0269
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0159 0.1641 0.3027
Chlamydia trachomatis DNA gyrase subunit B 0.0085 0.0818 0.236
Onchocerca volvulus 0.0114 0.1132 0.2083
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3094 1
Echinococcus multilocularis geminin 0.019 0.1984 0.1984
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0043 0.0343 0.0375
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0108 0.032
Brugia malayi hypothetical protein 0.0044 0.0359 0.0665
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Loa Loa (eye worm) TOPoisomerase family member 0.0059 0.0519 0.0961
Echinococcus granulosus Nuclear hormone receptor HR96 0.0159 0.1641 0.1793
Brugia malayi beta-lactamase family protein 0.004 0.0316 0.0586
Schistosoma mansoni chromobox protein 0.0013 0.0009 0.001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0159 0.1641 0.1793
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0271 0.2885 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0327 0.0327
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Plasmodium vivax DNA topoisomerase II, putative 0.0059 0.0519 0.1774
Mycobacterium tuberculosis Conserved protein 0.004 0.0316 0.0895
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0118 0.0193
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0042 0.0042
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0104 0.0329
Schistosoma mansoni hypothetical protein 0.0018 0.0064 0.0069
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0108 0.0876
Brugia malayi Nuclear hormone receptor-like 1 0.0338 0.3629 0.6719
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0338 0.3629 0.3629
Mycobacterium ulcerans DNA gyrase subunit A 0.0271 0.2885 1
Onchocerca volvulus 0.004 0.0316 0.057
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0075 0.0706 0.2422
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0338 0.3629 0.3965
Loa Loa (eye worm) runx1 0.0062 0.0561 0.1038
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0625 0.2143
Loa Loa (eye worm) hypothetical protein 0.0056 0.0489 0.0906
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0049 0.0415 0.3957
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0338 0.3629 0.3965
Onchocerca volvulus 0.0497 0.5402 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0316 0.2966
Brugia malayi CHD4 protein 0.0015 0.0029 0.0054
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.029 0.3094 0.5728
Trichomonas vaginalis esterase, putative 0.004 0.0316 0.0997
Echinococcus granulosus nuclear receptor nhr 48 0.0159 0.1641 0.1793
Schistosoma mansoni nuclear receptor 0.0159 0.1641 0.1793
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0064 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0043 0.0343 0.0635
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0023 0.0118 0.0343
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0043 0.0343 0.3234
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0159 0.1641 0.1641
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0159 0.1641 0.3027
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0316 0.0997
Loa Loa (eye worm) beta-lactamase 0.004 0.0316 0.0586
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0625 0.2112
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0064 0.0118
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Mycobacterium ulcerans hypothetical protein 0.004 0.0316 0.1034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0159 0.1641 0.1793
Toxoplasma gondii DNA topoisomerase 2, putative 0.0059 0.0519 0.1774
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0485 0.0529
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0101 0.099 0.1081
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Brugia malayi Doublecortin family protein 0.0044 0.0359 0.0665
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0108 0.0876
Brugia malayi Protein kinase domain containing protein 0.0021 0.0104 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.2098 0.6772
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0023 0.0118 0.0219
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0178 0.1854 0.2026
Schistosoma mansoni hypothetical protein 0.0459 0.4978 0.5438
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0338 0.3629 0.6719
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0108 0.0199
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0327 0.0358
Onchocerca volvulus 0.0044 0.0359 0.065
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0017 0.0018
Trypanosoma brucei unspecified product 0.0022 0.0108 0.0876
Mycobacterium tuberculosis Conserved protein 0.004 0.0316 0.0895
Loa Loa (eye worm) hypothetical protein 0.0086 0.0824 0.1526
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0338 0.3629 0.6719
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0009 0.0017
Echinococcus granulosus intermediate filament protein 0.0033 0.0229 0.0251
Loa Loa (eye worm) hypothetical protein 0.0114 0.1132 0.2096
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.009 0.0264
Schistosoma mansoni nuclear receptor nhr-48 0.0159 0.1641 0.1793
Brugia malayi nuclear receptor NHR-88 0.0159 0.1641 0.3039
Echinococcus multilocularis chromobox protein 1 0.0013 0.0009 0.0009
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0583 0.1966
Onchocerca volvulus 0.0044 0.0359 0.065
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0043 0.0343 0.1162
Brugia malayi Nuclear hormone receptor E75 0.0159 0.1641 0.3039
Brugia malayi chromobox protein homolog 3 0.0013 0.0009 0.0017
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0009 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0033 0.0126
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0489 0.0906
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0625 0.0683
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0338 0.3629 0.3965
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0225 0.0417
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.1984 0.6402
Brugia malayi Nuclear hormone receptor-like 1 0.0178 0.1854 0.3433
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0625 0.6058
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0043 0.0343 0.1083
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0628 0.0686
Plasmodium vivax DNA gyrase subunit A, putative 0.0271 0.2885 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0359 0.0392
Leishmania major hypothetical protein, conserved 0.004 0.0316 0.2966
Brugia malayi Protein cec-1. 0.0013 0.0009 0.0017
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0043 0.0343 0.0635
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0625 0.199
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0316 0.0345
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0316 0.0997
Brugia malayi hypothetical protein 0.0178 0.1854 0.3433
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0108 0.0876
Loa Loa (eye worm) hypothetical protein 0.0178 0.1854 0.3433
Loa Loa (eye worm) hypothetical protein 0.0338 0.3629 0.6719
Brugia malayi conserved hypotetical protein 0.0159 0.1641 0.3039
Plasmodium vivax DNA gyrase subunit B, putative 0.013 0.1318 0.4552
Echinococcus multilocularis neuropeptide s receptor 0.0519 0.5645 0.5645
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0064 0.0064
Schistosoma mansoni chromobox protein 0.0013 0.0009 0.001
Schistosoma mansoni loxhd1 0.0044 0.0359 0.0392
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0086 0.0824 0.5947
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0297 0.0934
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0059 0.0519 0.0946
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0338 0.3629 0.6719
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.009 0.0264
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0178 0.1854 0.2026
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0009 0.0017
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0029 0.0029
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.037 0.0404
Echinococcus multilocularis Chromo domain 0.0013 0.0009 0.0009
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0049 0.0415 0.3957
Loa Loa (eye worm) CYP4Cod1 0.0014 0.002 0.0037
Schistosoma mansoni steroid hormone receptor ad4bp 0.0338 0.3629 0.3965
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0316 0.0895
Echinococcus granulosus RUN 0.0044 0.0359 0.0392
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0108 0.0876
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0338 0.3629 0.6719
Plasmodium falciparum DNA gyrase subunit B 0.013 0.1318 0.4552
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.2741 0.9489
Brugia malayi Cytochrome P450 family protein 0.0014 0.002 0.0037
Entamoeba histolytica hypothetical protein 0.004 0.0316 0.6019
Schistosoma mansoni nuclear receptor 0.0159 0.1641 0.1793
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0316 0.0316
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0338 0.3629 0.3965
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0086 0.0824 0.2835
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0029 0.0054
Schistosoma mansoni hypothetical protein 0.0013 0.0009 0.001
Brugia malayi beta-lactamase 0.004 0.0316 0.0586
Echinococcus granulosus dna polymerase eta 0.0022 0.0108 0.0118
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0489 0.0906
Loa Loa (eye worm) hypothetical protein 0.0159 0.1641 0.3039
Brugia malayi hypothetical protein 0.0159 0.1641 0.3039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0338 0.3629 0.6719

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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