Detailed information for compound 828137

Basic information

Technical information
  • TDR Targets ID: 828137
  • Name: 1-morpholin-4-yl-2,3-di(phenyl)hexan-3-ol
  • MW: 339.471 | Formula: C22H29NO2
  • H donors: 1 H acceptors: 1 LogP: 3.56 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(C(c1ccccc1)CN1CCOCC1)(c1ccccc1)O
  • InChi: 1S/C22H29NO2/c1-2-13-22(24,20-11-7-4-8-12-20)21(19-9-5-3-6-10-19)18-23-14-16-25-17-15-23/h3-12,21,24H,2,13-18H2,1H3
  • InChiKey: HRDCJVIMZVXUNA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-morpholino-2,3-di(phenyl)hexan-3-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0013 0.0031
Onchocerca volvulus 0.0163 0.0653 0.0628
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.005 0.0178 0.1926
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0222 0.0901 1
Brugia malayi diacylglycerol kinase 0.0156 0.0621 0.3631
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0222 0.0901 0.0895
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0068 0.0253 0.6386
Echinococcus granulosus Diacylglycerol kinase theta 0.0156 0.0621 0.2377
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0222 0.5598
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0011 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0901 0.3454
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0115 0.0434
Brugia malayi Variant SH3 domain containing protein 0.0156 0.0621 0.3631
Loa Loa (eye worm) hypothetical protein 0.0156 0.0621 0.0615
Brugia malayi RhoGAP domain containing protein 0.0156 0.0621 0.3631
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0178 0.1981
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0222 0.0901 0.0895
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0163 0.0653 0.2501
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0178 0.4464
Echinococcus granulosus unc 13 munc13 0.0163 0.0653 0.2501
Brugia malayi wnt family protein 0.0085 0.0325 0.1881
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0155 0.0587
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0392 0.4353
Brugia malayi wnt family protein 0.0085 0.0325 0.1881
Loa Loa (eye worm) hypothetical protein 0.0085 0.0325 0.0319
Echinococcus granulosus Protein Wnt-5 0.0085 0.0325 0.1239
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0222 0.0901 0.2593
Schistosoma mansoni hypothetical protein 0.001 0.0007 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0392 0.4353
Entamoeba histolytica protein kinase, putative 0.0015 0.0028 0.0188
Brugia malayi jmjC domain containing protein 0.0096 0.0368 0.2141
Loa Loa (eye worm) hypothetical protein 0.0156 0.0621 0.0615
Loa Loa (eye worm) hypothetical protein 0.2164 0.9066 0.9065
Schistosoma mansoni diacylglycerol kinase theta 0.0156 0.0621 0.2377
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0392 0.4353
Echinococcus granulosus Protein Wnt-04 0.0085 0.0325 0.1239
Loa Loa (eye worm) hypothetical protein 0.0163 0.0653 0.0647
Loa Loa (eye worm) AGC/AKT protein kinase 0.0222 0.0901 0.0895
Echinococcus granulosus protein kinase C gamma type 0.0472 0.1949 0.7486
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0392 1
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0256 0.1044 0.1039
Giardia lamblia Kinase, CMGC CLK 0.0068 0.0253 0.6443
Echinococcus multilocularis death associated protein kinase 1 0.0833 0.3467 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0215 0.0872 0.9676
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0068 0.0253 0.6386
Brugia malayi wnt family protein 0.0085 0.0325 0.1881
Brugia malayi RhoGAP domain containing protein 0.0156 0.0621 0.3631
Trichomonas vaginalis AGC family protein kinase 0.0222 0.0901 1
Loa Loa (eye worm) Wnt2 protein 0.0085 0.0325 0.0319
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0089 0.0929
Loa Loa (eye worm) hypothetical protein 0.0397 0.1637 0.1631
Schistosoma mansoni wnt related 0.0085 0.0325 0.1239
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0089 0.0929
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0155 0.0587
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.0621 0.2377
Schistosoma mansoni vav2 0.0156 0.0621 0.2377
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.065 0.2489
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.007 0.2605
Brugia malayi Protein kinase domain containing protein 0.014 0.0554 0.3237
Trypanosoma brucei polo-like protein kinase 0.0101 0.0392 0.4313
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0178 0.0508
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0137 0.0519
Echinococcus granulosus protein Wnt 2 0.0085 0.0325 0.1239
Echinococcus multilocularis protein kinase c iota type 0.0378 0.1555 0.4481
Toxoplasma gondii diacylglycerol kinase, putative 0.0156 0.0621 0.6868
Loa Loa (eye worm) hypothetical protein 0.0156 0.0621 0.0615
Loa Loa (eye worm) AGC/NDR protein kinase 0.0222 0.0901 0.0895
Loa Loa (eye worm) RasGEF domain-containing protein 0.0156 0.0621 0.0615
Giardia lamblia Kinase, CMGC CDK 0.005 0.0178 0.4552
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0011 0.0011 0.0026
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0222 1
Loa Loa (eye worm) tnks protein 0.0068 0.0253 0.0247
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0156 0.0621 0.1785
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0143
Schistosoma mansoni kinase 0.0055 0.0197 0.0747
Echinococcus granulosus protein kinase c eta type 0.0156 0.0621 0.2377
Plasmodium falciparum phd finger protein, putative 0.0029 0.0089 0.3373
Schistosoma mansoni wnt-5 0.0085 0.0325 0.1239
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0155 0.0441
Loa Loa (eye worm) hypothetical protein 0.0156 0.0621 0.0615
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0385 0.1587 0.1582
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.022 0.0214
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0222 1
Brugia malayi hypothetical protein 0.0016 0.0034 0.0162
Loa Loa (eye worm) hypothetical protein 0.232 0.972 0.972
Echinococcus multilocularis WNT 0.0085 0.0325 0.093
Entamoeba histolytica hypothetical protein 0.0156 0.0621 0.685
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.005 0.0178 0.0172
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0009 0.0006 0.0015
Echinococcus granulosus protein Wnt 1 0.0085 0.0325 0.1239
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0178 0.0677
Schistosoma mansoni wnt related 0.0085 0.0325 0.1239
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0242 0.0983 0.283
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0002 0.5
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0089 0.0335
Leishmania major protein kinase, putative 0.0068 0.0253 0.6386
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0178 0.4464
Echinococcus granulosus NDR protein kinase 0.0222 0.0901 0.3454
Loa Loa (eye worm) hypothetical protein 0.0085 0.0325 0.0319
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0156 0.0621 0.2377
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0368 0.1408
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0089 0.0251
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0156 0.0621 0.2377
Loa Loa (eye worm) hypothetical protein 0.005 0.0177 0.0171
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0137 0.039
Echinococcus multilocularis serine:threonine protein kinase 38 0.0222 0.0901 0.2593
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0007 0.0017
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.0002 0.5
Trypanosoma brucei rac serine-threonine kinase, putative 0.0222 0.0901 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.0621 0.0615
Echinococcus granulosus cyclin dependent kinase 1 0.005 0.0178 0.0677
Echinococcus granulosus RNA directed DNA polymerase 0.0242 0.0983 0.377
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0011 0.0011 0.0035
Trypanosoma brucei poly(adp-ribose) polymerase 0.0011 0.0011 0.0058
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.0392 0.0386
Trypanosoma brucei cdc2-related kinase 3 0.005 0.0178 0.1926
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0127
Entamoeba histolytica protein kinase, putative 0.0222 0.0901 1
Echinococcus multilocularis Diacylglycerol kinase theta 0.0156 0.0621 0.1785
Schistosoma mansoni tankyrase 0.0075 0.0281 0.107
Entamoeba histolytica protein kinase, putative 0.0222 0.0901 1
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0068 0.0253 0.2755
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0011 0.0011 0.0134
Giardia lamblia Kinase, PLK 0.0101 0.0392 1
Brugia malayi protein kinase C3,putative 0.0162 0.065 0.3803
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0191 0.2124
Brugia malayi Wnt-4 protein precursor 0.0085 0.0325 0.1881
Echinococcus multilocularis unc 13 (munc13) 0.0163 0.0653 0.1878
Echinococcus granulosus Protein kinase C brain isozyme 0.0627 0.2603 1
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0002 0.5
Brugia malayi Protein kinase domain containing protein 0.0222 0.0901 0.5286
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0068 0.0253 0.0247
Echinococcus granulosus protein kinase c iota type 0.0378 0.1555 0.5968
Schistosoma mansoni serine/threonine protein kinase 0.0627 0.2603 1
Giardia lamblia Kinase, NEK 0.0008 0 0.0011
Plasmodium falciparum protein kinase 5 0.005 0.0178 0.6991
Trichomonas vaginalis AGC family protein kinase 0.0222 0.0901 1
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0901 0.3454
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0554 0.2121
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.0392 0.228
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0155 0.0149
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0011 0.0011 0.0035
Echinococcus multilocularis tankyrase 0.0075 0.028 0.0802
Echinococcus multilocularis protein kinase c epsilon type 0.0385 0.1587 0.4574
Schistosoma mansoni rac gtpase activating protein 0.0156 0.0621 0.2377
Loa Loa (eye worm) hypothetical protein 0.0085 0.0325 0.0319
Loa Loa (eye worm) hypothetical protein 0.0156 0.0621 0.0615
Echinococcus granulosus lysine specific demethylase 6a 0.0009 0.0006 0.0015
Echinococcus granulosus cyclin dependent kinase 19 0.014 0.0554 0.2121
Echinococcus granulosus phd:f box containing protein 0.0009 0.0006 0.0015
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0222 0.2414
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0162 0.065 0.2489
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.005 0.0178 0.0677
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0392 0.4353
Leishmania major protein kinase, putative 0.0068 0.0253 0.6386
Loa Loa (eye worm) raf kinase 0.0156 0.0621 0.0615
Schistosoma mansoni protein phosphatase 2C 0.0009 0.0006 0.0015
Schistosoma mansoni unc-13 (munc13) 0.0163 0.0653 0.2501
Echinococcus granulosus Protein Wnt-11b 0.0085 0.0325 0.1239
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.007 0.1663
Brugia malayi Hr1 repeat family protein 0.0222 0.0901 0.5286
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0368 0.1057
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0392 0.4353
Echinococcus multilocularis lysine specific demethylase 6a 0.0009 0.0006 0.0011
Giardia lamblia Kinase, CMGC CDK 0.005 0.0178 0.4552
Brugia malayi Protein kinase domain containing protein 0.005 0.0178 0.1018
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0156 0.0621 0.2377
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0115 0.0109
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0222 0.0901 0.3454
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0068 0.0253 0.2755
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0191 0.2124
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0222 0.0901 0.3454
Echinococcus multilocularis myotubularin protein 13 0.0156 0.0621 0.1785
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0009 0.0006 0.0011
Echinococcus multilocularis protein Wnt 1 0.0085 0.0325 0.093
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0178 0.0677
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.0392 0.1125
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0014 0.0023 0.0193
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0162 0.065 0.1869
Echinococcus granulosus raf serine:threonine protein kinase 0.0156 0.0621 0.2377
Entamoeba histolytica diacylglycerol kinase, putative 0.0156 0.0621 0.685
Echinococcus granulosus cyclin dependent kinase 5 0.005 0.0178 0.0677
Echinococcus granulosus jumonji domain containing 1A 0.0009 0.0006 0.0015
Entamoeba histolytica protein kinase, putative 0.0222 0.0901 1
Brugia malayi Protein kinase domain containing protein 0.0222 0.0901 0.5286
Echinococcus multilocularis cyclin dependent kinase 0.005 0.0178 0.0508
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0162 0.065 0.3803
Echinococcus multilocularis dual specificity protein kinase clk2 0.0068 0.0253 0.0723
Loa Loa (eye worm) hypothetical protein 0.2164 0.9066 0.9065
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0222 0.0845
Schistosoma mansoni protein kinase C mu 0.0162 0.065 0.2489
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0089 0.0083
Echinococcus granulosus JmjC domain containing protein 4 0.0009 0.0006 0.0015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0155 0.0441
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.007 0.0717
Trichomonas vaginalis AGC family protein kinase 0.0222 0.0901 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.007 0.0717
Brugia malayi PHD-finger family protein 0.001 0.0007 0.0003
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0156 0.0621 0.0615
Giardia lamblia Kinase, NEK 0.0008 0 0.0011
Trichomonas vaginalis AGC family protein kinase 0.0222 0.0901 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0178 0.0172
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0089 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0127
Trichomonas vaginalis ferritin, putative 0.0008 0.0002 0.0025
Plasmodium vivax serine/threonine kinase-1, putative 0.0068 0.0253 1
Schistosoma mansoni serine/threonine protein kinase 0.0385 0.1587 0.6093
Loa Loa (eye worm) hypothetical protein 0.2164 0.9066 0.9065
Brugia malayi Protein kinase domain containing protein 0.0222 0.0901 0.5286
Echinococcus multilocularis protein Wnt 2 0.0085 0.0325 0.093
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.0392 0.428
Echinococcus multilocularis serine threonine protein kinase 0.0472 0.1949 0.562
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0286 0.109
Echinococcus multilocularis cyclin dependent kinase 19 0.014 0.0554 0.1592
Echinococcus multilocularis protein kinase c eta type 0.0156 0.0621 0.1785
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.005 0.0178 0.4464
Trichomonas vaginalis AGC family protein kinase 0.0222 0.0901 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0178 0.1981
Echinococcus granulosus protein kinase c epsilon type 0.0385 0.1587 0.6093
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.0392 1
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0178 0.1879
Loa Loa (eye worm) AGC/PKN protein kinase 0.0222 0.0901 0.0895
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.0392 0.1499
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0115 0.0434
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0222 0.0635
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0222 0.0901 0.2593
Echinococcus granulosus Rac GTPase activating protein 1 0.0156 0.0621 0.2377
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0007 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0901 0.3454
Echinococcus multilocularis N chimaerin 0.0156 0.0621 0.1785
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0222 0.0845
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.007 0.1663
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0127
Echinococcus multilocularis wingless type MMTV integration site family 0.0085 0.0325 0.093
Loa Loa (eye worm) hypothetical protein 0.0242 0.0983 0.0977
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0013 0.0042
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0162 0.065 0.0644
Brugia malayi cell division control protein 2 homolog 0.005 0.0178 0.1018
Plasmodium falciparum protein serine/threonine kinase-1 0.0068 0.0253 1
Schistosoma mansoni serine/threonine kinase 0.0222 0.0901 0.3454
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0127
Loa Loa (eye worm) gastrulation defective protein 1 0.0133 0.0525 0.0519
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0392 0.4353
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0178 0.4464
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.005 0.0178 0.4464
Trypanosoma brucei cdc2-related kinase 1 0.005 0.0178 0.1926
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0011 0.0011 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0901 0.3454
Loa Loa (eye worm) wnt-4 protein 0.0085 0.0325 0.0319
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0011 0.0011 0.0026
Loa Loa (eye worm) hypothetical protein 0.0085 0.0325 0.0319
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0253 0.0962
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.007 0.2605
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0392 0.1499
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0222 0.0901 0.0895
Brugia malayi wnt family protein 0.0085 0.0325 0.1881
Echinococcus multilocularis cyclin dependent kinase 5 0.005 0.0178 0.0508
Brugia malayi Bromodomain containing protein 0.0029 0.0089 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0127
Schistosoma mansoni jumonji domain containing protein 0.0009 0.0006 0.0015
Echinococcus multilocularis Rac GTPase activating protein 1 0.0156 0.0621 0.1785
Trichomonas vaginalis AGC family protein kinase 0.0222 0.0901 1
Onchocerca volvulus Tankyrase homolog 0.0067 0.0248 0.0177
Loa Loa (eye worm) hypothetical protein 0.0156 0.0621 0.0615
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0222 0.0845
Echinococcus granulosus poly ADP ribose polymerase 1 0.0011 0.0011 0.0035
Brugia malayi AF-10 protein 0.001 0.0007 0.0003
Echinococcus granulosus serine:threonine protein kinase N2 0.0222 0.0901 0.3454
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0156 0.0621 0.0615
Brugia malayi PHD-finger family protein 0.0029 0.0089 0.0491
Schistosoma mansoni diacylglycerol kinase theta 0.0156 0.0621 0.2377
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0222 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0155 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0127
Echinococcus multilocularis serine:threonine protein kinase N2 0.0222 0.0901 0.2593
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0089 0.3373
Brugia malayi C1-like domain containing protein 0.0162 0.065 0.3803
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0115 0.0326
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0042
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0011 0.0011 0.0005
Echinococcus multilocularis WNT 0.0085 0.0325 0.093
Entamoeba histolytica diacylglycerol kinase, putative 0.0156 0.0621 0.685
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.014 0.0554 0.0548
Leishmania major hypothetical protein, conserved 0.0025 0.007 0.1663
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0011 0.0011 0.0134
Loa Loa (eye worm) hypothetical protein 0.0061 0.0223 0.0217
Echinococcus multilocularis phd:f box containing protein 0.0009 0.0006 0.0011
Brugia malayi Tnks protein 0.0074 0.0276 0.1597
Brugia malayi p70 ribosomal S6 kinase beta 0.0222 0.0901 0.5286
Loa Loa (eye worm) hypothetical protein 0.0156 0.0621 0.0615
Brugia malayi diacylglycerol kinase 0.0156 0.0621 0.3631
Schistosoma mansoni phd/f-box containing protein 0.0009 0.0006 0.0015
Echinococcus granulosus hypothetical protein 0.0061 0.0223 0.085
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0127
Echinococcus multilocularis 0.0061 0.0223 0.0638
Echinococcus multilocularis RNA directed DNA polymerase 0.0242 0.0983 0.283
Echinococcus granulosus poly adp ribose polymerase 2 0.0011 0.0011 0.0035
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0009 0.0006 0.0015
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0068 0.0253 0.2755
Giardia lamblia PHD finger protein 15 0.0029 0.0089 0.2278
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.0392 0.0337
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0178 0.1879
Echinococcus granulosus cyclin dependent kinase 0.005 0.0178 0.0677
Brugia malayi WGR domain containing protein 0.0011 0.0011 0.0031
Echinococcus granulosus dual specificity protein kinase clk2 0.0068 0.0253 0.0962
Echinococcus granulosus Protein Wnt-111 0.0085 0.0325 0.1239
Brugia malayi Protein kinase c protein 2 0.0412 0.1698 1
Brugia malayi Pleckstrin Homology Domain 0.0156 0.0621 0.3631
Schistosoma mansoni atypical protein kinase C 0.0378 0.1555 0.5968
Brugia malayi Ras association domain family 1 isoform A 0.0156 0.0621 0.3631
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0155 0.0587
Onchocerca volvulus 0.0156 0.0621 0.0592
Brugia malayi jmjC domain containing protein 0.0035 0.0115 0.0644
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0115 0.0434
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0222 0.0901 0.3454
Echinococcus multilocularis serine:threonine protein kinase N2 0.0222 0.0901 0.2593
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.007 0.2605
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0007 0.0006
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0007 0.0006
Echinococcus granulosus tankyrase 0.0075 0.028 0.1069
Brugia malayi Protein kinase domain containing protein 0.0162 0.065 0.3803
Trichomonas vaginalis AGC family protein kinase 0.0222 0.0901 1
Onchocerca volvulus 0.2164 0.9066 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0068 0.0253 0.6386
Trichomonas vaginalis AGC family protein kinase 0.0222 0.0901 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0222 0.0901 0.0895
Echinococcus multilocularis JmjC domain containing protein 4 0.0009 0.0006 0.0011
Schistosoma mansoni wnt related 0.0085 0.0325 0.1239
Schistosoma mansoni hypothetical protein 0.0156 0.0621 0.2377
Echinococcus multilocularis wnt family member wnt11 2 0.0085 0.0325 0.093
Echinococcus multilocularis peregrin 0.0029 0.0089 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0011 0.0127
Schistosoma mansoni unc-13 (munc13) 0.0163 0.0653 0.2501
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0222 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.001 0.0007 0.002
Brugia malayi protein kinase C II. 0.0385 0.1587 0.9342
Brugia malayi RhoGEF domain containing protein 0.0156 0.0621 0.3631
Brugia malayi hypothetical protein 0.0025 0.007 0.0379
Onchocerca volvulus 0.0156 0.0621 0.0592
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0068 0.0253 0.6386
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0156 0.0621 0.0615
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0253 0.2805
Schistosoma mansoni phosphatidylserine receptor 0.0009 0.0006 0.0015
Echinococcus granulosus myotubularin protein 13 0.0156 0.0621 0.2377
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0178 0.1981
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.065 0.2489
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0007 0.0003
Echinococcus multilocularis raf serine:threonine protein kinase 0.0156 0.0621 0.1785
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0178 0.0172
Loa Loa (eye worm) hypothetical protein 0.0156 0.0621 0.0615
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0155 0.0879
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0163 0.0653 0.1878
Trichomonas vaginalis AGC family protein kinase 0.0222 0.0901 1
Trichomonas vaginalis AGC family protein kinase 0.0222 0.0901 1
Schistosoma mansoni wnt related 0.0085 0.0325 0.1239
Loa Loa (eye worm) hypothetical protein 0.0056 0.0204 0.0198
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0253 0.0962
Echinococcus multilocularis jumonji domain containing 1A 0.0009 0.0006 0.0011
Echinococcus granulosus N chimaerin 0.0156 0.0621 0.2377
Schistosoma mansoni protein kinase C 0.0163 0.0653 0.2501
Brugia malayi Protein kinase domain containing protein 0.0068 0.0253 0.1456
Entamoeba histolytica protein kinase, putative 0.0222 0.0901 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0222 0.0901 0.2593
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0007 0.0006
Plasmodium vivax hypothetical protein, conserved 0.001 0.0007 0.002
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0627 0.2603 0.7507
Toxoplasma gondii AGC kinase 0.0222 0.0901 1
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0178 0.0508
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0178 0.4464
Brugia malayi Wnt-2 protein precursor 0.0085 0.0325 0.1881
Echinococcus granulosus peregrin 0.0029 0.0089 0.0335
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0162 0.065 0.0644
Brugia malayi WGR domain containing protein 0.0011 0.0011 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0627 0.2603 1
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0392 0.4353
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0392 1
Entamoeba histolytica protein kinase, putative 0.0015 0.0028 0.0188
Schistosoma mansoni protein kinase C mu 0.0156 0.0621 0.2377
Plasmodium vivax protein kinase Crk2 0.005 0.0178 0.6991
Loa Loa (eye worm) hypothetical protein 0.0085 0.0325 0.0319
Schistosoma mansoni hypothetical protein 0.0029 0.0089 0.0335
Loa Loa (eye worm) CWN-2 protein 0.0085 0.0325 0.0319
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0155 0.0587

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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