TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 478.931 | Formula: C24H23ClN6O3
H donors: 1 H acceptors: 6 LogP: 3.63 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)Cn1nnc2c1nc(nc2O)C1CCN(CC1)C(=O)c1ccccc1Cl
InChi: 1S/C24H23ClN6O3/c1-34-17-6-4-5-15(13-17)14-31-22-20(28-29-31)23(32)27-21(26-22)16-9-11-30(12-10-16)24(33)18-7-2-3-8-19(18)25/h2-8,13,16H,9-12,14H2,1H3,(H,26,27,32)
InChiKey: CHCOUWWMNHNKEC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.005	0.1677	0.4534
Brugia malayi	Niemann-Pick C1 protein precursor	0.0095	0.3697	0.8007
Schistosoma mansoni	hypothetical protein	0.0039	0.1199	0.29
Brugia malayi	Cation transporter family protein	0.0021	0.038	0.07
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Brugia malayi	PHD-finger family protein	0.0035	0.1014	0.2097
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0021	0.038	0.1027
Schistosoma mansoni	tar DNA-binding protein	0.0037	0.1088	0.2592
Loa Loa (eye worm)	animal heme peroxidase	0.0025	0.0574	0.1554
Brugia malayi	Cation transporter family protein	0.0021	0.038	0.07
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0604	0.1633
Trichomonas vaginalis	hypothetical protein	0.0236	1	1
Echinococcus granulosus	glycine receptor subunit beta	0.0021	0.038	0.0687
Loa Loa (eye worm)	transcription factor SMAD2	0.0063	0.2279	0.6164
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0021	0.038	0.0687
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0021	0.038	0.07
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Echinococcus granulosus	peroxidasin	0.0025	0.0574	0.104
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0016	0.0152	0.5
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0021	0.038	0.063
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0016	0.0152	0.0412
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0236	1	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0021	0.038	0.063
Loa Loa (eye worm)	jmjC domain-containing protein	0.0043	0.1346	0.364
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Echinococcus granulosus	lysine specific demethylase 5A	0.0043	0.1346	0.2435
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0604	0.1251
Brugia malayi	Animal haem peroxidase family protein	0.0025	0.0574	0.1129
Brugia malayi	TAR-binding protein	0.0037	0.1088	0.226
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0021	0.038	0.07
Echinococcus multilocularis	lamin	0.0026	0.0604	0.1093
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0021	0.038	0.0687
Echinococcus multilocularis	musashi	0.0026	0.0604	0.1093
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0152	0.0199
Echinococcus granulosus	L aminoadipate semialdehyde	0.008	0.3035	0.5492
Loa Loa (eye worm)	TAR-binding protein	0.0037	0.1088	0.2943
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0023	0.0449	0.0301
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.1014	0.2742
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0604	0.1633
Brugia malayi	Peroxidasin	0.0025	0.0574	0.1129
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0021	0.038	0.0687
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.3763	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Entamoeba histolytica	hypothetical protein	0.0023	0.0449	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0016	0.0152	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1265	0.3422
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.008	0.3035	0.7983
Plasmodium falciparum	phd finger protein, putative	0.0035	0.1014	0.0875
Loa Loa (eye worm)	MH2 domain-containing protein	0.0063	0.2279	0.6164
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0021	0.038	0.0687
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.1014	0.1835
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0021	0.038	0.07
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0449	0.0301
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0021	0.038	0.0687
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0236	1	1
Brugia malayi	Bromodomain containing protein	0.0035	0.1014	0.2097
Brugia malayi	CHE-14 protein	0.0041	0.1265	0.265
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Schistosoma mansoni	tar DNA-binding protein	0.0037	0.1088	0.2592
Loa Loa (eye worm)	ACC-1 protein	0.0021	0.038	0.1027
Schistosoma mansoni	lamin	0.0026	0.0604	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.2693	0.7284
Brugia malayi	jmjC domain containing protein	0.0043	0.1346	0.2828
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0449	0.0301
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0021	0.038	0.0687
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0021	0.038	0.0687
Onchocerca volvulus	Peroxidase homolog	0.0025	0.0574	0.1465
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0021	0.038	0.0687
Schistosoma mansoni	tar DNA-binding protein	0.0037	0.1088	0.2592
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0021	0.038	0.07
Brugia malayi	excitatory GABA receptor EXP-1A	0.0021	0.038	0.07
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0021	0.038	0.0687
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0021	0.038	0.07
Echinococcus granulosus	expressed conserved protein	0.0089	0.3439	0.6224
Onchocerca volvulus		0.0025	0.0574	0.1465
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0582	0.1575
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0023	0.0449	0.0301
Schistosoma mansoni	tar DNA-binding protein	0.0037	0.1088	0.2592
Echinococcus multilocularis	glycine receptor subunit beta	0.0021	0.038	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Schistosoma mansoni	hypothetical protein	0.0039	0.1199	0.29
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0021	0.038	0.063
Brugia malayi	Animal haem peroxidase family protein	0.0025	0.0574	0.1129
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0236	1	1
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0016	0.0152	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Schistosoma mansoni	nAChR subunit	0.0021	0.038	0.063
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.354	0.9383
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Echinococcus multilocularis	glycine receptor subunit beta	0.0021	0.038	0.0687
Schistosoma mansoni	nAChR subunit	0.0021	0.038	0.063
Mycobacterium leprae	conserved hypothetical protein	0.0023	0.0449	0.0301
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0021	0.038	0.063
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0021	0.038	0.1027
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0021	0.038	0.07
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0021	0.038	0.07
Echinococcus granulosus	lamin dm0	0.0026	0.0604	0.1093
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.1346	0.2435
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0021	0.038	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Loa Loa (eye worm)	blistered cuticle protein 3	0.0025	0.0574	0.1554
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.4602	0.8328
Schistosoma mansoni	hypothetical protein	0.0039	0.1199	0.29
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0016	0.0152	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0021	0.038	0.1027
Schistosoma mansoni	nAChR subunit	0.0021	0.038	0.063
Onchocerca volvulus		0.0021	0.038	0.0789
Schistosoma mansoni	peroxidasin	0.0025	0.0574	0.1169
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0021	0.038	0.07
Giardia lamblia	PHD finger protein 15	0.0035	0.1014	0.5
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.1632	0.2953
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0037	0.1088	0.2943
Onchocerca volvulus	Alhambra homolog	0.0035	0.1014	0.2989
Echinococcus granulosus	peregrin	0.0035	0.1014	0.1835
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0021	0.038	0.0687
Brugia malayi	Animal haem peroxidase family protein	0.0025	0.0574	0.1129
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.1014	0.0875
Onchocerca volvulus		0.0021	0.038	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0095	0.3697	1
Schistosoma mansoni	nAChR subunit	0.0021	0.038	0.063
Echinococcus multilocularis	tar DNA binding protein	0.0037	0.1088	0.1969
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.1265	0.229
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0604	0.1194
Echinococcus multilocularis	peregrin	0.0035	0.1014	0.1835
Loa Loa (eye worm)	hypothetical protein	0.006	0.2141	0.5789
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0021	0.038	0.07
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0023	0.0449	0.0301
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0016	0.0152	0.0412
Loa Loa (eye worm)	animal heme peroxidase	0.0025	0.0574	0.1554
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0021	0.038	0.07
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.1014	0.0875
Brugia malayi	hypothetical protein	0.0025	0.0574	0.1129
Echinococcus multilocularis	peroxidasin	0.0025	0.0574	0.104
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0095	0.3697	1
Loa Loa (eye worm)	oxidoreductase	0.0016	0.0152	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0152	0.0412
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.008	0.3035	0.6548
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.1265	0.3422
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.1346	0.3305
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0021	0.038	0.07
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.1014	0.1835
Onchocerca volvulus		0.008	0.3035	1
Echinococcus granulosus	lamin	0.0026	0.0604	0.1093
Echinococcus granulosus	nAChR subunit	0.0021	0.038	0.0687
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0021	0.038	0.0687
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0021	0.038	0.0687
Echinococcus granulosus	glycine receptor subunit beta	0.0021	0.038	0.0687
Onchocerca volvulus		0.0026	0.0604	0.1567
Loa Loa (eye worm)	ACC-1 protein	0.0021	0.038	0.1027
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Schistosoma mansoni	patched 1	0.0041	0.1265	0.3082
Onchocerca volvulus		0.0021	0.038	0.0789
Onchocerca volvulus	Peroxidasin homolog	0.0025	0.0574	0.1465
Schistosoma mansoni	peroxidasin	0.0025	0.0574	0.1169
Onchocerca volvulus	Peroxidase homolog	0.0025	0.0574	0.1465
Schistosoma mansoni	hypothetical protein	0.0039	0.1199	0.29
Echinococcus multilocularis	L aminoadipate semialdehyde	0.008	0.3035	0.5492
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Onchocerca volvulus	Dual oxidase homolog	0.0025	0.0574	0.1465
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.1014	0.2386
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.1346	0.3305
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.1265	0.229
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0016	0.0152	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Brugia malayi	Blistered cuticle protein 3	0.0025	0.0574	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Echinococcus multilocularis	protein dispatched 1	0.0047	0.1524	0.2757
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0023	0.0449	0.0301
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0021	0.038	0.07
Schistosoma mansoni	nAChR subunit	0.0021	0.038	0.063
Onchocerca volvulus		0.0021	0.038	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1014	0.2742
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0021	0.038	0.07
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0236	1	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0021	0.038	0.07
Brugia malayi	RNA binding protein	0.0037	0.1088	0.226
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Echinococcus multilocularis	protein patched	0.0041	0.1265	0.229
Echinococcus granulosus	tar DNA binding protein	0.0037	0.1088	0.1969
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0023	0.0449	0.0301
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.1632	0.2953
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0021	0.038	0.07
Brugia malayi	jmjC domain containing protein	0.0115	0.4602	1
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0449	1
Brugia malayi	Animal haem peroxidase family protein	0.0025	0.0574	0.1129
Loa Loa (eye worm)	hypothetical protein	0.008	0.3035	0.8208
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.4602	0.8328
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0021	0.038	0.0687
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0021	0.038	0.0687
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0021	0.038	0.063
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0.0449	0.5
Echinococcus multilocularis	lamin dm0	0.0026	0.0604	0.1093
Brugia malayi	Animal haem peroxidase family protein	0.0025	0.0574	0.1129
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0021	0.038	0.1027
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0449	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0021	0.038	0.1027
Echinococcus multilocularis	expressed conserved protein	0.0089	0.3439	0.6224
Onchocerca volvulus	Putative nachr subunit	0.0021	0.038	0.0789
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0236	1	1
Brugia malayi	intermediate filament protein	0.0026	0.0604	0.1194
Onchocerca volvulus	Peroxidasin homolog	0.0025	0.0574	0.1465
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0236	1	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Schistosoma mansoni	lamin	0.0026	0.0604	0.1251
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0021	0.038	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Onchocerca volvulus		0.0021	0.038	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0604	0.1633
Onchocerca volvulus		0.0025	0.0574	0.1465
Loa Loa (eye worm)	RNA binding protein	0.0037	0.1088	0.2943
Loa Loa (eye worm)	animal heme peroxidase	0.0025	0.0574	0.1554
Brugia malayi	RNA recognition motif domain containing protein	0.0037	0.1088	0.226
Echinococcus granulosus	intermediate filament protein	0.0026	0.0604	0.1093
Echinococcus multilocularis	Niemann Pick C1 protein	0.0136	0.5526	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0095	0.3697	0.6691
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0062	0.0168
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.1265	0.229
Schistosoma mansoni	hypothetical protein	0.0035	0.1014	0.2386
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0021	0.038	0.063
Schistosoma mansoni	nAChR subunit	0.0021	0.038	0.063
Loa Loa (eye worm)	animal heme peroxidase	0.0025	0.0574	0.1554
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0021	0.038	0.0687
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0236	1	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0021	0.038	0.07
Schistosoma mansoni	nAChR subunit	0.0021	0.038	0.063
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Brugia malayi	MH2 domain containing protein	0.0063	0.2279	0.4883
Brugia malayi	Cation transporter family protein	0.0021	0.038	0.07
Onchocerca volvulus		0.0026	0.0604	0.1567
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Onchocerca volvulus		0.0021	0.038	0.0789
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0449	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Onchocerca volvulus		0.0025	0.0574	0.1465
Loa Loa (eye worm)	hypothetical protein	0.0021	0.038	0.1027
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0449	0.0301
Schistosoma mansoni	tar DNA-binding protein	0.0037	0.1088	0.2592
Echinococcus multilocularis	nAChR subunit	0.0021	0.038	0.0687
Echinococcus multilocularis	Niemann Pick C1 protein	0.0095	0.3697	0.6691
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0021	0.038	0.0687
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.1014	0.0875
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0021	0.038	0.1027
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0021	0.038	0.0687
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0152	0.0199
Loa Loa (eye worm)	LGC-31 protein	0.0021	0.038	0.1027
Echinococcus granulosus	Niemann Pick C1 protein	0.0136	0.5526	1
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0021	0.038	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0574	0.1554
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0021	0.038	0.0687
Onchocerca volvulus	Chorion peroxidase homolog	0.0025	0.0574	0.1465

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	14.1254 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1715253
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 828259