Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0143 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0143 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0143 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0067 | 0.3911 | 0.3911 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0143 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.1644 | 0.1644 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0143 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0075 | 0.4563 | 0.4563 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0143 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0067 | 0.3911 | 0.3911 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0143 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0143 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0066 | 0.378 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0143 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0067 | 0.3911 | 0.3911 |
Brugia malayi | nuclear receptor NHR-67 | 0.0067 | 0.3911 | 0.3911 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.1186 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0143 | 1 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0143 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0143 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0075 | 0.4563 | 0.4563 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0143 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0067 | 0.3911 | 0.3911 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0075 | 0.4563 | 0.4563 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0143 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0075 | 0.4563 | 0.4563 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0067 | 0.3911 | 0.3911 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.4563 | 0.4563 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0067 | 0.3911 | 0.3911 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2253 | 0.2253 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0994 | 0.0994 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0143 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0143 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0143 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0143 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0067 | 0.3911 | 0.3911 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.4563 | 0.4563 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0067 | 0.3911 | 0.3911 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0143 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0067 | 0.3911 | 0.3911 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0067 | 0.3911 | 0.3911 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0067 | 0.3911 | 0.3911 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Brugia malayi | nuclear receptor RXR | 0.0075 | 0.4563 | 0.4563 |
Brugia malayi | hypothetical protein | 0.0075 | 0.4563 | 0.4563 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0143 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.1644 | 0.1644 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0143 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0067 | 0.3911 | 0.3911 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.4563 | 0.4563 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0143 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0067 | 0.3911 | 0.3911 |
Brugia malayi | conserved hypotetical protein | 0.0067 | 0.3911 | 0.3911 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0143 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.1377 | 0.1377 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0066 | 0.378 | 0.378 |
Brugia malayi | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0143 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0075 | 0.4563 | 0.4563 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.1377 | 0.1377 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0143 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0067 | 0.3911 | 0.3911 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0019 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0067 | 0.3911 | 0.3911 |
Schistosoma mansoni | nuclear receptor | 0.0067 | 0.3911 | 0.3911 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0143 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0075 | 0.4563 | 0.4563 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0143 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.4563 | 0.4563 |
Brugia malayi | hypothetical protein | 0.0075 | 0.4563 | 0.4563 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0067 | 0.3911 | 0.3911 |
Schistosoma mansoni | nuclear hormone receptor | 0.0143 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0067 | 0.3911 | 0.3911 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0067 | 0.3911 | 0.3911 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.1186 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0067 | 0.3911 | 0.3911 |
Brugia malayi | nuclear hormone receptor | 0.0067 | 0.3911 | 0.3911 |
Schistosoma mansoni | nuclear hormone receptor | 0.0067 | 0.3911 | 0.3911 |
Brugia malayi | nuclear hormone receptor | 0.0143 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0143 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0067 | 0.3911 | 0.3911 |
Brugia malayi | nuclear receptor RXR | 0.0067 | 0.3911 | 0.3911 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0143 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0067 | 0.3911 | 0.3911 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0066 | 0.378 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0143 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0143 | 1 | 1 | |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0143 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0066 | 0.378 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0066 | 0.378 | 0.378 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0143 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0067 | 0.3911 | 0.3911 |
Schistosoma mansoni | coup transcription factor | 0.0143 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0067 | 0.3911 | 0.3911 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0019 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0143 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0143 | 1 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.1377 | 0.1377 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0067 | 0.3911 | 0.3911 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0143 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0066 | 0.378 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0143 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Brugia malayi | Cytochrome P450 family protein | 0.0066 | 0.378 | 0.378 |
Brugia malayi | tailless protein | 0.0067 | 0.3911 | 0.3911 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0066 | 0.378 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0067 | 0.3911 | 0.3911 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0143 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0067 | 0.3911 | 0.3911 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0075 | 0.4563 | 0.4563 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.4563 | 0.4563 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0143 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0143 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0067 | 0.3911 | 0.3911 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0066 | 0.378 | 0.378 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0143 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0143 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0143 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0019 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0143 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0143 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0067 | 0.3911 | 0.3911 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Brugia malayi | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0067 | 0.3911 | 0.3911 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Schistosoma mansoni | nuclear hormone receptor | 0.0067 | 0.3911 | 0.3911 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Brugia malayi | Cytochrome P450 family protein | 0.0066 | 0.378 | 0.378 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.1377 | 0.1377 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3911 | 0.3911 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.