Detailed information for compound 828350

Basic information

Technical information
  • TDR Targets ID: 828350
  • Name: 4-(1-butylbenzimidazol-2-yl)-1-(4-ethoxypheny l)pyrrolidin-2-one
  • MW: 377.479 | Formula: C23H27N3O2
  • H donors: 0 H acceptors: 2 LogP: 3.81 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCn1c(nc2c1cccc2)C1CC(=O)N(C1)c1ccc(cc1)OCC
  • InChi: 1S/C23H27N3O2/c1-3-5-14-25-21-9-7-6-8-20(21)24-23(25)17-15-22(27)26(16-17)18-10-12-19(13-11-18)28-4-2/h6-13,17H,3-5,14-16H2,1-2H3
  • InChiKey: YIDLUPQYEQHHSI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(1-butyl-2-benzimidazolyl)-1-(4-ethoxyphenyl)-2-pyrrolidinone
  • 4-(1-butylbenzimidazol-2-yl)-1-(4-ethoxyphenyl)-2-pyrrolidone
  • D125-2178
  • NCGC00116183-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.1509 0.3661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.022 0.4121 0.4121
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0087 0.1357 0.1357
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.1509 1
Schistosoma mansoni survival motor neuron protein 0.0103 0.1688 0.2539
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.022 0.4121 0.4121
Brugia malayi Nuclear hormone receptor family member nhr-1 0.022 0.4121 0.4121
Loa Loa (eye worm) hypothetical protein 0.0104 0.171 0.171
Brugia malayi hypothetical protein 0.0026 0.009 0.009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0116 0.1968 0.1968
Trichomonas vaginalis CAMK family protein kinase 0.013 0.2243 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.171 0.171
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1509 0.572
Echinococcus multilocularis ecdysone induced protein 78C 0.022 0.4121 0.4121
Brugia malayi nuclear receptor RXR 0.0104 0.171 0.171
Loa Loa (eye worm) hypothetical protein 0.0104 0.171 0.171
Brugia malayi nuclear hormone receptor 0.0104 0.171 0.171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0472 0.0711
Schistosoma mansoni kinase 0.0048 0.0552 0.0831
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.022 0.4121 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0601 0.0601
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0472 0.0711
Brugia malayi Nuclear hormone receptor family member nhr-41 0.022 0.4121 0.4121
Brugia malayi Nuclear hormone receptor-like 1 0.0116 0.1968 0.1968
Loa Loa (eye worm) hypothetical protein 0.022 0.4121 0.4121
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.022 0.4121 0.4121
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0087 0.1357 0.1357
Loa Loa (eye worm) hypothetical protein 0.0104 0.171 0.171
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.092 0.092
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.2106 0.2106
Schistosoma mansoni Tr4/Tr2 (homologue) 0.022 0.4121 0.62
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0472 0.0711
Brugia malayi hypothetical protein 0.0104 0.171 0.171
Onchocerca volvulus 0.0103 0.1688 0.4095
Brugia malayi nuclear hormone receptor family member odr-7 0.0104 0.171 0.171
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0472 0.0472
Echinococcus granulosus Nuclear hormone receptor HR96 0.0104 0.171 0.171
Brugia malayi Kinase associated domain 1 family protein 0.0043 0.0444 0.0444
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.022 0.4121 0.4121
Echinococcus granulosus geminin 0.0342 0.6646 0.6646
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.022 0.4121 0.4121
Schistosoma mansoni hypothetical protein 0.0043 0.0444 0.0668
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.1509 0.1509
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.022 0.4121 0.4121
Loa Loa (eye worm) hypothetical protein 0.022 0.4121 0.4121
Schistosoma mansoni hypothetical protein 0.0342 0.6646 1
Echinococcus granulosus ecdysone induced protein 78C 0.022 0.4121 0.4121
Loa Loa (eye worm) hypothetical protein 0.022 0.4121 0.4121
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.022 0.4121 0.4121
Brugia malayi nuclear receptor RXR 0.0116 0.1968 0.1968
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1509 0.572
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.1509 0.1509
Brugia malayi Nuclear hormone receptor family member nhr-49 0.022 0.4121 0.4121
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0104 0.171 0.171
Schistosoma mansoni coup transcription factor 0.022 0.4121 0.62
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0104 0.171 0.2573
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1509 0.572
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1509 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.022 0.4121 0.4121
Brugia malayi Protein kinase domain containing protein 0.013 0.2243 0.2243
Schistosoma mansoni hypothetical protein 0.0342 0.6646 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.022 0.4121 0.4121
Brugia malayi Nuclear hormone receptor-like 1 0.0116 0.1968 0.1968
Loa Loa (eye worm) hypothetical protein 0.0104 0.171 0.171
Schistosoma mansoni lipoxygenase 0.0089 0.1408 0.2118
Brugia malayi hypothetical protein 0.0104 0.171 0.171
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0457 0.0688
Loa Loa (eye worm) hypothetical protein 0.0504 1 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.1509 0.1509
Schistosoma mansoni retinoid-x-receptor (RXR) 0.022 0.4121 0.62
Schistosoma mansoni nuclear receptor 0.0104 0.171 0.2573
Schistosoma mansoni zinc finger protein 0.0104 0.171 0.2573
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.022 0.4121 0.4121
Echinococcus multilocularis thyroid hormone receptor alpha 0.022 0.4121 0.4121
Schistosoma mansoni hypothetical protein 0.0034 0.0271 0.0407
Echinococcus multilocularis calcium activated potassium channel 0.0043 0.0457 0.0457
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0104 0.171 0.415
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.009 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0116 0.1968 0.2961
Loa Loa (eye worm) hypothetical protein 0.022 0.4121 0.4121
Echinococcus granulosus FTZ F1 alpha 0.022 0.4121 0.4121
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0457 0.0688
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1509 0.572
Echinococcus multilocularis nuclear receptor nhr 48 0.0104 0.171 0.171
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.092 0.5
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.1509 1
Schistosoma mansoni thyroid hormone receptor 0.022 0.4121 0.62
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.092 0.1384
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.022 0.4121 0.62
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.2106 0.2106
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.022 0.4121 0.4121
Schistosoma mansoni retinoic acid receptor RXR 0.022 0.4121 0.62
Brugia malayi Steroid receptor seven-up type 2 0.022 0.4121 0.4121
Loa Loa (eye worm) hypothetical protein 0.0104 0.171 0.171
Loa Loa (eye worm) hypothetical protein 0.0104 0.171 0.171
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1509 0.572
Loa Loa (eye worm) hypothetical protein 0.0116 0.1968 0.1968
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.022 0.4121 0.4121
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.022 0.4121 0.62
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0104 0.171 0.171
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.092 0.1384
Echinococcus multilocularis survival motor neuron protein 1 0.0504 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.022 0.4121 0.62
Schistosoma mansoni hypothetical protein 0.0103 0.1688 0.2539
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.022 0.4121 0.4121
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0365 0.0549
Loa Loa (eye worm) hypothetical protein 0.0104 0.171 0.171
Schistosoma mansoni thyroid hormone receptor 0.022 0.4121 0.62
Brugia malayi photoreceptor-specific nuclear receptor 0.022 0.4121 0.4121
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0104 0.171 0.171
Loa Loa (eye worm) hypothetical protein 0.022 0.4121 0.4121
Brugia malayi follicle stimulating hormone receptor 0.0236 0.4446 0.4446
Brugia malayi ecdysone receptor 0.0104 0.171 0.171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.022 0.4121 0.4121
Brugia malayi Nuclear hormone receptor E75 0.0104 0.171 0.171
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0043 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0271 0.0271
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.022 0.4121 0.4121
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0104 0.171 0.171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0472 0.0472
Schistosoma mansoni nuclear receptor nhr-48 0.0104 0.171 0.2573
Schistosoma mansoni RAR-like nuclear receptor 0.022 0.4121 0.62
Schistosoma mansoni lipoxygenase 0.0128 0.2204 0.3316
Schistosoma mansoni steroid hormone receptor ad4bp 0.022 0.4121 0.62
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0116 0.1968 0.2961
Brugia malayi orphan nuclear receptor NR2E1 0.0104 0.171 0.171
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.013 0.2243 0.2243
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.092 0.5
Loa Loa (eye worm) hypothetical protein 0.0104 0.171 0.171
Brugia malayi Nuclear hormone receptor family member nhr-19 0.022 0.4121 0.4121
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0104 0.171 0.2573
Brugia malayi nuclear hormone receptor 0.022 0.4121 0.4121
Brugia malayi tailless protein 0.0104 0.171 0.171
Loa Loa (eye worm) hypothetical protein 0.0104 0.171 0.171
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0128 0.2204 0.2204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.022 0.4121 0.4121
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1509 0.227
Loa Loa (eye worm) hypothetical protein 0.0043 0.0444 0.0444
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.092 0.5
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0043 0.0457 0.0457
Brugia malayi nuclear receptor NHR-88 0.0104 0.171 0.171
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1509 0.572
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0365 0.0365
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.1509 0.1509
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0472 0.0472
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.009 1
Trypanosoma brucei polo-like protein kinase 0.0094 0.1509 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.092 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.022 0.4121 0.4121
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.022 0.4121 0.4121
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0116 0.1968 0.1968
Echinococcus multilocularis geminin 0.0342 0.6646 0.6646
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0043 0.0457 0.0457
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0128 0.2204 0.2204
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0104 0.171 0.171
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.022 0.4121 0.4121
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0457 0.0688
Loa Loa (eye worm) DR-78 0.0104 0.171 0.171
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0116 0.1968 0.1968
Onchocerca volvulus 0.0104 0.171 0.415
Brugia malayi MH2 domain containing protein 0.0123 0.2106 0.2106
Loa Loa (eye worm) nuclear receptor NHR-67 0.0104 0.171 0.171
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0104 0.171 0.171
Echinococcus granulosus survival motor neuron protein 1 0.0504 1 1
Schistosoma mansoni nuclear hormone receptor 0.022 0.4121 0.62
Loa Loa (eye worm) hypothetical protein 0.022 0.4121 0.4121
Onchocerca volvulus 0.022 0.4121 1
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0457 0.0688
Echinococcus granulosus retinoic acid receptor rxr beta a 0.022 0.4121 0.4121
Brugia malayi nuclear hormone receptor family member nhr-6 0.0104 0.171 0.171
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1509 1
Echinococcus multilocularis hypothetical protein 0.0043 0.0444 0.0444
Echinococcus granulosus thyroid hormone receptor alpha 0.0104 0.171 0.171
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.009 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.171 0.171
Echinococcus granulosus Nuclear hormone receptor HR96 0.0104 0.171 0.171
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.1357 0.4836
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0043 0.0457 0.0457
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.022 0.4121 0.62
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.022 0.4121 0.4121
Echinococcus multilocularis FTZ F1 alpha 0.022 0.4121 0.4121
Brugia malayi Nuclear hormone receptor-like 1 0.022 0.4121 0.4121
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.092 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0601 0.0601
Loa Loa (eye worm) nuclear hormone receptor 0.0104 0.171 0.171
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0116 0.1968 0.1968
Onchocerca volvulus Protein ultraspiracle homolog 0.022 0.4121 1
Onchocerca volvulus Bile acid receptor homolog 0.022 0.4121 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0271 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-3 0.022 0.4121 0.4121
Loa Loa (eye worm) hypothetical protein 0.0104 0.171 0.171
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0104 0.171 0.415
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0457 0.0688
Brugia malayi steroid hormone receptor 0.022 0.4121 0.4121
Schistosoma mansoni serine/threonine kinase 0.013 0.2243 0.3376
Brugia malayi ecdysteroid receptor 0.022 0.4121 0.4121
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0116 0.1968 0.1968
Brugia malayi nuclear receptor NHR-67 0.0104 0.171 0.171
Onchocerca volvulus 0.0104 0.171 0.415
Brugia malayi hypothetical protein 0.0039 0.0365 0.0365
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.022 0.4121 0.4121
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0104 0.171 0.171
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.092 0.092
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.022 0.4121 0.4121
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1509 0.572
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.1688 0.1688
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0472 0.0472
Echinococcus granulosus nuclear receptor 2DBD gamma 0.022 0.4121 0.4121
Schistosoma mansoni nuclear hormone receptor 0.0104 0.171 0.2573
Loa Loa (eye worm) hypothetical protein 0.022 0.4121 0.4121
Echinococcus granulosus calcium activated potassium channel 0.0043 0.0457 0.0457
Brugia malayi conserved hypotetical protein 0.0104 0.171 0.171
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.4446 0.4446
Schistosoma mansoni hypothetical protein 0.0039 0.0365 0.0549
Brugia malayi Nuclear hormone receptor E75 0.0104 0.171 0.171
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0104 0.171 0.171
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.092 0.5852
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.022 0.4121 0.4121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.022 0.4121 0.4121
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0104 0.171 0.171
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.1357 0.4836
Brugia malayi hypothetical protein 0.0116 0.1968 0.1968
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0472 0.0472
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.022 0.4121 0.4121
Loa Loa (eye worm) hypothetical protein 0.0104 0.171 0.171
Schistosoma mansoni hypothetical protein 0.0043 0.0444 0.0668
Brugia malayi Nuclear hormone receptor family member nhr-31 0.022 0.4121 0.4121
Loa Loa (eye worm) hypothetical protein 0.0116 0.1968 0.1968
Giardia lamblia Kinase, PLK 0.0094 0.1509 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0601 0.0601
Schistosoma mansoni nuclear receptor 0.0104 0.171 0.2573
Brugia malayi nuclear receptor NHR-88 0.022 0.4121 0.4121
Loa Loa (eye worm) hypothetical protein 0.0116 0.1968 0.1968
Echinococcus granulosus nuclear receptor 2DBD gamma 0.022 0.4121 0.4121
Echinococcus granulosus nuclear receptor nhr 48 0.0104 0.171 0.171
Brugia malayi hypothetical protein 0.0116 0.1968 0.1968
Schistosoma mansoni nuclear hormone receptor 0.0104 0.171 0.2573
Loa Loa (eye worm) steroid hormone receptor 0.022 0.4121 0.4121

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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