Detailed information for compound 828362

Basic information

Technical information
  • TDR Targets ID: 828362
  • Name: 2-[3-(4-methoxyphenyl)-4,9-dimethyl-7-oxopyra no[6,5-g][1]benzoxol-8-yl]acetic acid
  • MW: 378.375 | Formula: C22H18O6
  • H donors: 1 H acceptors: 3 LogP: 3.66 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1coc2c1c(C)cc1c2c(C)c(c(=O)o1)CC(=O)O
  • InChi: 1S/C22H18O6/c1-11-8-17-20(12(2)15(9-18(23)24)22(25)28-17)21-19(11)16(10-27-21)13-4-6-14(26-3)7-5-13/h4-8,10H,9H2,1-3H3,(H,23,24)
  • InChiKey: ZWLIRLYLDAQMSI-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[3-(4-methoxyphenyl)-4,9-dimethyl-7-oxo-pyrano[6,5-g]benzofuran-8-yl]acetic acid
  • 2-[3-(4-methoxyphenyl)-4,9-dimethyl-7-oxo-8-pyrano[6,5-g]benzofuranyl]acetic acid
  • 2-[7-keto-3-(4-methoxyphenyl)-4,9-dimethyl-pyrano[6,5-g]benzofuran-8-yl]acetic acid
  • 2-[3-(4-methoxyphenyl)-4,9-dimethyl-7-oxo-pyrano[6,5-g][1]benzoxol-8-yl]ethanoic acid
  • D129-0130
  • NCGC00116345-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0242 0.2646 0.3546
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.0246 0.0092
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0099 0.087 0.087
Loa Loa (eye worm) PDE1B protein 0.0176 0.1822 0.1822
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0242 0.2646 0.4501
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0099 0.087 0.148
Brugia malayi G-protein coupled receptor 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0107 0.0971 0.0971
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0246 0.0092
Schistosoma mansoni myosin xvIII 0.0048 0.0246 0.0092
Echinococcus granulosus proteasome subunit beta type 7 0.0099 0.087 0.0641
Loa Loa (eye worm) nuclear hormone receptor 0.0095 0.0829 0.0829
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0099 0.087 0.0501
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0099 0.087 0.0501
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0099 0.087 0.0501
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0099 0.087 0.0728
Brugia malayi AKH receptor 0.0048 0.0246 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0202 0.2155 0.2155
Toxoplasma gondii proteasome subunit 0.0099 0.087 0.0878
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0202 0.2155 0.1962
Loa Loa (eye worm) hypothetical protein 0.0095 0.0829 0.0829
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.9979 1
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0099 0.087 0.0728
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.0246 0.0246
Schistosoma mansoni neuropeptide receptor 0.0048 0.0246 0.0092
Onchocerca volvulus 0.0048 0.0246 0.1141
Brugia malayi nuclear hormone receptor 0.0095 0.0829 0.0829
Schistosoma mansoni opsin-like receptor 0.0048 0.0246 0.0092
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0099 0.087 0.087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0202 0.2155 0.2155
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0503 0.588 0.5713
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0202 0.2155 0.2155
Brugia malayi Proteasome A-type and B-type family protein 0.0503 0.588 0.588
Brugia malayi hypothetical protein 0.0048 0.0246 0.0246
Toxoplasma gondii proteasome beta subunit 0.0099 0.087 0.0878
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0095 0.0829 0.3847
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0099 0.087 0.0728
Echinococcus granulosus ecdysone induced protein 78C 0.0202 0.2155 0.1962
Brugia malayi Steroid receptor seven-up type 2 0.0202 0.2155 0.2155
Leishmania major proteasome beta 2 subunit, putative 0.0242 0.2646 0.2646
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0202 0.2155 0.2155
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0099 0.087 0.0728
Loa Loa (eye worm) hypothetical protein 0.0202 0.2155 0.2155
Onchocerca volvulus 0.0048 0.0246 0.1141
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0099 0.087 0.0501
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0242 0.2646 0.2349
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0202 0.2155 0.1962
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Brugia malayi ecdysone receptor 0.0095 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Brugia malayi Proteasome A-type and B-type family protein 0.0099 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.0095 0.0829 0.0829
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.0246 0.0092
Brugia malayi neuropeptide F receptor 0.0048 0.0246 0.0246
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.0246 0.0092
Plasmodium vivax proteasome subunit beta type-1, putative 0.0391 0.4489 0.7467
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0099 0.087 0.148
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0099 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Schistosoma mansoni nuclear hormone receptor 0.0202 0.2155 0.2036
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0099 0.087 0.0501
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0099 0.087 0.148
Brugia malayi nuclear receptor NHR-88 0.0095 0.0829 0.0829
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0246 0.0092
Brugia malayi Melatonin receptor type 1A 0.0048 0.0246 0.0246
Brugia malayi Serotonin receptor 0.0048 0.0246 0.0246
Plasmodium vivax proteasome subunit beta type-6, putative 0.0099 0.087 0.0878
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0202 0.2155 0.2036
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0391 0.4489 0.4359
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0099 0.087 0.0501
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0099 0.087 0.0501
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.0246 0.0092
Leishmania major C-8 sterol isomerase-like protein 0.0835 1 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0099 0.087 0.5
Onchocerca volvulus 0.0048 0.0246 0.1141
Brugia malayi G protein-coupled receptor 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0099 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.006 0.0392 0.0392
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.0246 0.0246
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0246 0.0092
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.0829 0.0599
Brugia malayi proteasome subunit beta type 1 0.0391 0.4489 0.4489
Loa Loa (eye worm) hypothetical protein 0.0095 0.0829 0.0829
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0099 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.0107 0.0971 0.0971
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0099 0.087 0.148
Brugia malayi proteasome subunit alpha type 2 0.0099 0.087 0.087
Mycobacterium ulcerans proteasome PrcA 0.0099 0.087 0.148
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0079 0.0628 0.0628
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.0246 0.0092
Schistosoma mansoni neuropeptide receptor 0.0048 0.0246 0.0092
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0246 0.0092
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0242 0.2646 0.3546
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0099 0.087 0.0501
Brugia malayi hypothetical protein 0.0048 0.0246 0.0246
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0099 0.087 0.0641
Schistosoma mansoni thyroid hormone receptor 0.0202 0.2155 0.2036
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0246 0.0092
Schistosoma mansoni neuropeptide receptor 0.0048 0.0246 0.0092
Onchocerca volvulus 0.0048 0.0246 0.1141
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0099 0.087 0.0728
Loa Loa (eye worm) hypothetical protein 0.0095 0.0829 0.0829
Plasmodium falciparum proteasome subunit beta type-5 0.0503 0.588 1
Brugia malayi Nuclear hormone receptor E75 0.0095 0.0829 0.0829
Schistosoma mansoni nuclear hormone receptor 0.0095 0.0829 0.0686
Trypanosoma brucei proteasome beta 6 subunit 0.0391 0.4489 0.4266
Brugia malayi RE15519p 0.0048 0.0246 0.0246
Onchocerca volvulus 0.0048 0.0246 0.1141
Schistosoma mansoni zinc finger protein 0.0095 0.0829 0.0686
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0099 0.087 0.0878
Loa Loa (eye worm) hypothetical protein 0.0202 0.2155 0.2155
Schistosoma mansoni hypothetical protein 0.0048 0.0246 0.0092
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0099 0.087 0.0501
Onchocerca volvulus 0.0048 0.0246 0.1141
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0099 0.087 0.0878
Loa Loa (eye worm) proteasome subunit beta type 3 0.0099 0.087 0.087
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0202 0.2155 0.2036
Onchocerca volvulus 0.0048 0.0246 0.1141
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0099 0.087 0.0501
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0202 0.2155 0.2036
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.0246 0.0246
Echinococcus multilocularis nuclear receptor nhr 48 0.0095 0.0829 0.0599
Schistosoma mansoni histamine h1 receptor 0.0048 0.0246 0.0092
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Leishmania major hypothetical protein, conserved 0.0156 0.1579 0.1579
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0095 0.0829 0.0599
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.0246 0.0092
Schistosoma mansoni biogenic amine receptor 0.0048 0.0246 0.0092
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0099 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.0246 0.0246
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0246 0.0092
Onchocerca volvulus 0.0095 0.0829 0.3847
Brugia malayi photoreceptor-specific nuclear receptor 0.0202 0.2155 0.2155
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0099 0.087 0.0878
Echinococcus granulosus Proteasome subunit alpha type 7 0.0099 0.087 0.0641
Loa Loa (eye worm) proteasome subunit beta type 2 0.0242 0.2646 0.2646
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.0246 0.0246
Brugia malayi follicle stimulating hormone receptor 0.0048 0.0246 0.0246
Toxoplasma gondii proteasome subunit alpha type, putative 0.0099 0.087 0.0878
Loa Loa (eye worm) hypothetical protein 0.0095 0.0829 0.0829
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0246 0.0092
Onchocerca volvulus 0.0048 0.0246 0.1141
Brugia malayi Dopamine receptor 0.0048 0.0246 0.0246
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0099 0.087 0.148
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0095 0.0829 0.0599
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0155 0.0155
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0202 0.2155 0.1962
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0099 0.087 0.0641
Leishmania major proteasome alpha 2 subunit, putative 0.0099 0.087 0.087
Leishmania major proteasome alpha 7 subunit, putative 0.0099 0.087 0.087
Plasmodium vivax proteasome subunit beta type-7, putative 0.0099 0.087 0.0878
Echinococcus granulosus subfamily T1A non peptidase ue 0.0099 0.087 0.0641
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0202 0.2155 0.1962
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0099 0.087 0.0501
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0156 0.1579 0.1239
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0095 0.0829 0.0829
Brugia malayi proteasome subunit alpha type 3 0.0099 0.087 0.087
Onchocerca volvulus Protein ultraspiracle homolog 0.0202 0.2155 1
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0099 0.087 0.148
Brugia malayi nuclear hormone receptor family member odr-7 0.0095 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0835 1 1
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0099 0.087 0.148
Loa Loa (eye worm) hypothetical protein 0.0202 0.2155 0.2155
Brugia malayi nuclear receptor NHR-67 0.0095 0.0829 0.0829
Onchocerca volvulus 0.0048 0.0246 0.1141
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0099 0.087 0.0728
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Brugia malayi hypothetical protein 0.0048 0.0246 0.0246
Echinococcus granulosus thyroid hormone receptor alpha 0.0095 0.0829 0.0599
Loa Loa (eye worm) hypothetical protein 0.0107 0.0971 0.0971
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Giardia lamblia Proteasome subunit beta type 1 0.0391 0.4489 0.7224
Schistosoma mansoni opsin-like receptor 0.0048 0.0246 0.0092
Brugia malayi nuclear hormone receptor 0.0202 0.2155 0.2155
Echinococcus granulosus proteasome subunit beta t family 0.0099 0.087 0.0641
Brugia malayi Dopamine receptor protein 1 0.0048 0.0246 0.0246
Onchocerca volvulus 0.0048 0.0246 0.1141
Brugia malayi orphan nuclear receptor NR2E1 0.0095 0.0829 0.0829
Schistosoma mansoni nuclear receptor nhr-48 0.0095 0.0829 0.0686
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0107 0.0971 0.083
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0242 0.2646 0.3546
Schistosoma mansoni thyroid hormone receptor 0.0202 0.2155 0.2036
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0503 0.588 0.5713
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0246 0.0092
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0099 0.087 0.0728
Loa Loa (eye worm) hypothetical protein 0.0095 0.0829 0.0829
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0099 0.087 0.0501
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Schistosoma mansoni nuclear receptor 0.0095 0.0829 0.0686
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0099 0.087 0.0878
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0202 0.2155 0.2155
Brugia malayi nuclear hormone receptor family member nhr-6 0.0095 0.0829 0.0829
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0202 0.2155 0.2155
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0095 0.0829 0.3847
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0176 0.1822 0.162
Brugia malayi hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0202 0.2155 0.2155
Onchocerca volvulus 0.0048 0.0246 0.1141
Brugia malayi Serotonin receptor 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0095 0.0829 0.0829
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0099 0.087 0.0641
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0075 0.0576 0.0576
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0099 0.087 0.0641
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0176 0.1822 0.1697
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0099 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.0202 0.2155 0.2155
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0099 0.087 0.0501
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0202 0.2155 0.1962
Plasmodium vivax proteasome subunit beta type-3, putative 0.0099 0.087 0.0878
Brugia malayi nuclear receptor RXR 0.0107 0.0971 0.0971
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0246 0.0246
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0107 0.0971 0.0745
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0099 0.087 0.0641
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0099 0.087 0.0878
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0202 0.2155 0.2036
Brugia malayi putative neuropeptide receptor 0.0048 0.0246 0.0246
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0099 0.087 0.087
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0391 0.4489 0.4266
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0099 0.087 0.0641
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0099 0.087 0.148
Brugia malayi Nuclear hormone receptor-like 1 0.0107 0.0971 0.0971
Echinococcus granulosus Nuclear hormone receptor HR96 0.0095 0.0829 0.0599
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0099 0.087 0.087
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0095 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0107 0.0971 0.0971
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0099 0.087 0.0641
Brugia malayi hypothetical protein 0.0048 0.0246 0.0246
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0202 0.2155 0.1962
Echinococcus multilocularis proteasome (prosome, macropain) 0.0503 0.588 0.5788
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.0246 0.0092
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0099 0.087 0.0728
Echinococcus granulosus proteasome prosome macropain 0.0503 0.588 0.5788
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0246 0.0092
Brugia malayi proteasome subunit beta type 3 0.0099 0.087 0.087
Brugia malayi larval opioid receptor 0.0048 0.0246 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0202 0.2155 0.2155
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0099 0.087 0.087
Brugia malayi hypothetical protein 0.0107 0.0971 0.0971
Leishmania major proteasome alpha 7 subunit, putative 0.0099 0.087 0.087
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0246 0.0246
Brugia malayi ORL1-like opioid receptor 0.0048 0.0246 0.0246
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.0246 0.0246
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0099 0.087 0.0728
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0099 0.087 0.0878
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0202 0.2155 0.2036
Loa Loa (eye worm) hypothetical protein 0.0202 0.2155 0.2155
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0503 0.588 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0099 0.087 0.087
Leishmania major proteasome beta 7 subunit, putative 0.0099 0.087 0.087
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0099 0.087 0.0501
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.0246 0.0092
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0099 0.087 0.0728
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0503 0.588 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0503 0.588 0.588
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0202 0.2155 0.1962
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0202 0.2155 0.2155
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0391 0.4489 0.7224
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0246 0.0092
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0246 0.0092
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.0246 0.0246
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.006 0.0388 0.0146
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0099 0.087 0.0501
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0099 0.087 0.087
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0099 0.087 0.0501
Brugia malayi proteasome subunit beta type 2 0.0242 0.2646 0.2646
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0391 0.4489 0.7635
Loa Loa (eye worm) hypothetical protein 0.0202 0.2155 0.2155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0202 0.2155 0.2155
Echinococcus multilocularis proteasome subunit beta type 7 0.0099 0.087 0.0641
Onchocerca volvulus 0.0095 0.0829 0.3847
Brugia malayi G-protein coupled receptor 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0202 0.2155 0.2155
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0099 0.087 0.148
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0202 0.2155 0.2155
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0099 0.087 0.0878
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0503 0.588 0.5827
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0242 0.2646 0.2349
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0095 0.0829 0.0829
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0095 0.0829 0.0599
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0503 0.588 1
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0099 0.087 0.148
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0099 0.087 0.0728
Onchocerca volvulus 0.0202 0.2155 1
Brugia malayi Proteasome A-type and B-type family protein 0.0099 0.087 0.087
Schistosoma mansoni amine GPCR 0.0048 0.0246 0.0092
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0202 0.2155 0.2155
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0099 0.087 0.148
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0099 0.087 0.0878
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0095 0.0829 0.0599
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0099 0.087 0.0501
Loa Loa (eye worm) hypothetical protein 0.0095 0.0829 0.0829
Schistosoma mansoni coup transcription factor 0.0202 0.2155 0.2036
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0099 0.087 0.0641
Leishmania major proteasome beta-1 subunit, putative 0.0099 0.087 0.087
Echinococcus multilocularis proteasome subunit beta type 6 0.0099 0.087 0.0641
Loa Loa (eye worm) hypothetical protein 0.0427 0.4938 0.4938
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0202 0.2155 0.1962
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0099 0.087 0.0878
Onchocerca volvulus Bile acid receptor homolog 0.0202 0.2155 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Brugia malayi neuropeptide F receptor 0.0048 0.0246 0.0246
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0099 0.087 0.0501
Brugia malayi proteasome subunit alpha type 1 0.0099 0.087 0.087
Onchocerca volvulus 0.0079 0.0628 0.2913
Echinococcus granulosus microtubule associated protein 2 0.0833 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.0246 0.0246
Schistosoma mansoni steroid hormone receptor ad4bp 0.0202 0.2155 0.2036
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0202 0.2155 0.2155
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.0829 0.0599
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0048 0.0246 0.1141
Loa Loa (eye worm) hypothetical protein 0.0095 0.0829 0.0829
Echinococcus multilocularis proteasome subunit alpha type 6 0.0099 0.087 0.0641
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0242 0.2646 0.2536
Brugia malayi hypothetical protein 0.0048 0.0246 0.0246
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0391 0.4489 0.4359
Schistosoma mansoni amine GPCR 0.0048 0.0246 0.0092
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0176 0.1822 0.162
Echinococcus multilocularis ecdysone induced protein 78C 0.0202 0.2155 0.1962
Brugia malayi nuclear receptor NHR-88 0.0202 0.2155 0.2155
Brugia malayi hypothetical protein 0.0107 0.0971 0.0971
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0099 0.087 0.0501
Onchocerca volvulus 0.0048 0.0246 0.1141
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0835 1 1
Schistosoma mansoni amine GPCR 0.0048 0.0246 0.0092
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0202 0.2155 0.1962
Echinococcus granulosus Nuclear hormone receptor HR96 0.0095 0.0829 0.0599
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0246 0.0092
Schistosoma mansoni amine GPCR 0.0048 0.0246 0.0092
Toxoplasma gondii peptidase, T1 family protein 0.0099 0.087 0.0878
Mycobacterium ulcerans proteasome PrcB 0.0503 0.588 1
Onchocerca volvulus 0.0048 0.0246 0.1141
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0246 0.0092
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0246 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0246 0.0092
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0242 0.2646 0.2536
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0099 0.087 0.0501
Brugia malayi Nuclear hormone receptor-like 1 0.0202 0.2155 0.2155
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0099 0.087 0.087
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0099 0.087 0.0501
Echinococcus granulosus FTZ F1 alpha 0.0202 0.2155 0.1962
Toxoplasma gondii proteasome subunit beta type, putative 0.0503 0.588 1
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0099 0.087 0.0501
Brugia malayi Proteasome subunit alpha type 7-1 0.0099 0.087 0.087
Brugia malayi tailless protein 0.0095 0.0829 0.0829
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0202 0.2155 0.2155
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.0246 0.0246
Schistosoma mansoni amine GPCR 0.0048 0.0246 0.0092
Brugia malayi hypothetical protein 0.0048 0.0246 0.0246
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0156 0.1579 0.1239
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0099 0.087 0.0501
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0246 0.0246
Brugia malayi GYF domain containing protein 0.0079 0.0628 0.0628
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0099 0.087 0.148
Brugia malayi proteasome subunit alpha type 4 0.0099 0.087 0.087
Brugia malayi Nuclear hormone receptor-like 1 0.0107 0.0971 0.0971
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0099 0.087 0.0501
Echinococcus granulosus proteasome subunit alpha type 6 0.0099 0.087 0.0641
Loa Loa (eye worm) nuclear receptor NHR-67 0.0095 0.0829 0.0829
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0099 0.087 0.0728
Loa Loa (eye worm) hypothetical protein 0.0107 0.0971 0.0971
Brugia malayi hypothetical protein 0.0095 0.0829 0.0829
Brugia malayi hypothetical protein 0.0048 0.0246 0.0246
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0099 0.087 0.148
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0202 0.2155 0.1962
Plasmodium vivax proteasome subunit beta type-4, putative 0.0099 0.087 0.0878
Loa Loa (eye worm) proteasome subunit beta type 1 0.0391 0.4489 0.4489
Schistosoma mansoni hypothetical protein 0.0048 0.0246 0.0092
Schistosoma mansoni hypothetical protein 0.0048 0.0246 0.0092
Loa Loa (eye worm) DR-78 0.0095 0.0829 0.0829
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0099 0.087 0.087
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0099 0.087 0.087
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0099 0.087 0.0878
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0503 0.588 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0503 0.588 0.5713
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0202 0.2155 0.1962
Brugia malayi conserved hypotetical protein 0.0095 0.0829 0.0829
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0202 0.2155 0.1962
Brugia malayi nuclear receptor RXR 0.0095 0.0829 0.0829
Onchocerca volvulus Notchless protein homolog 0.0099 0.087 0.4037
Toxoplasma gondii heat shock protein hslv, putative 0.0099 0.087 0.0878
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0099 0.087 0.0501
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0246 0.0246
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0391 0.4489 0.4489
Echinococcus granulosus nuclear receptor nhr 48 0.0095 0.0829 0.0599
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0099 0.087 0.0501
Trypanosoma brucei proteasome beta 7 subunit 0.0099 0.087 0.0501
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Trypanosoma cruzi Emopamil binding protein, putative 0.0156 0.1579 0.1239
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0095 0.0829 0.0599
Loa Loa (eye worm) steroid hormone receptor 0.0202 0.2155 0.2155
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0202 0.2155 0.2036
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0202 0.2155 0.2155
Leishmania major proteasome alpha 3 subunit, putative 0.0099 0.087 0.087
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0242 0.2646 0.4112
Leishmania major proteasome alpha 1 subunit, putative 0.0099 0.087 0.087
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0392 0.0392
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.0246 0.0092
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0391 0.4489 0.7224
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0391 0.4489 0.7467
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.006 0.0388 0.0146
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0107 0.0971 0.083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0095 0.0829 0.0829
Giardia lamblia Proteasome subunit beta type 2 0.0242 0.2646 0.3546
Onchocerca volvulus 0.0048 0.0246 0.1141
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0099 0.087 0.0641
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0503 0.588 1
Brugia malayi hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0202 0.2155 0.2155
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0099 0.087 0.0501
Schistosoma mansoni biogenic amine receptor 0.0048 0.0246 0.0092
Brugia malayi proteasome subunit alpha type 6 0.0099 0.087 0.087
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0099 0.087 0.0501
Leishmania major proteasome beta 3 subunit, putative 0.0099 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Trypanosoma brucei proteasome alpha 7 subunit 0.0099 0.087 0.0501
Echinococcus granulosus proteasome subunit alpha type 2 0.0099 0.087 0.0641
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0099 0.087 0.0878
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Schistosoma mansoni biogenic amine receptor 0.0048 0.0246 0.0092
Brugia malayi steroid hormone receptor 0.0202 0.2155 0.2155
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.0246 0.0246
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0391 0.4489 0.4266
Onchocerca volvulus 0.0156 0.1579 0.7326
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0156 0.1579 0.1579
Brugia malayi Proteasome A-type and B-type family protein 0.0099 0.087 0.087
Echinococcus multilocularis proteasome subunit alpha type 2 0.0099 0.087 0.0641
Brugia malayi sulfakinin receptor protein 0.0048 0.0246 0.0246
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0095 0.0829 0.0686
Trypanosoma cruzi Emopamil binding protein, putative 0.0156 0.1579 0.1239
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.0246 0.0092
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.0246 0.0246
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0099 0.087 0.0501
Echinococcus multilocularis FTZ F1 alpha 0.0202 0.2155 0.1962
Schistosoma mansoni adenoreceptor 0.0048 0.0246 0.0092
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.0246 0.0246
Trypanosoma cruzi 20S proteasome subunit 0.0242 0.2646 0.2349
Brugia malayi GnHR receptor homolog 0.0048 0.0246 0.0246
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0099 0.087 0.148
Schistosoma mansoni RAR-like nuclear receptor 0.0202 0.2155 0.2036
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0099 0.087 0.0728
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0246 0.0092
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0392 0.0392
Schistosoma mansoni hypothetical protein 0.0048 0.0246 0.0092
Echinococcus granulosus Proteasome subunit alpha beta 0.0099 0.087 0.0641
Schistosoma mansoni nuclear receptor 0.0095 0.0829 0.0686
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0391 0.4489 0.4411
Plasmodium vivax proteasome subunit beta type-5, putative 0.0503 0.588 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.9979 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0048 0.0246 0.1141
Echinococcus multilocularis thyroid hormone receptor alpha 0.0202 0.2155 0.1962
Brugia malayi 20S proteasome alpha5 subunit 0.0099 0.087 0.087
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.0246 0.0246
Schistosoma mansoni opsin-like receptor 0.0048 0.0246 0.0092
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0095 0.0829 0.0829
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0099 0.087 0.148
Loa Loa (eye worm) PAS-3 protein 0.0099 0.087 0.087
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.0246 0.0092
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0099 0.087 0.0728
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0202 0.2155 1
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0099 0.087 0.0501
Schistosoma mansoni neuropeptide receptor 0.0048 0.0246 0.0092
Brugia malayi Dopamine receptor protein 2 0.0048 0.0246 0.0246
Trypanosoma brucei Emopamil binding protein, putative 0.0156 0.1579 0.1239
Onchocerca volvulus 0.0048 0.0246 0.1141
Leishmania major proteasome beta 2 subunit, putative 0.0099 0.087 0.087
Brugia malayi hypothetical protein 0.0095 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0202 0.2155 0.2155
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0202 0.2155 0.2155
Loa Loa (eye worm) hypothetical protein 0.0095 0.0829 0.0829
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0202 0.2155 0.1962
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0099 0.087 0.0878
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0099 0.087 0.0501
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0176 0.1822 0.1822
Onchocerca volvulus 0.0048 0.0246 0.1141
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0099 0.087 0.148
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0099 0.087 0.148
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0242 0.2646 0.2466
Brugia malayi hypothetical protein 0.0048 0.0246 0.0246
Toxoplasma gondii proteasome subunit alpha1, putative 0.0099 0.087 0.0878
Brugia malayi Nuclear hormone receptor E75 0.0095 0.0829 0.0829
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0202 0.2155 0.2155
Onchocerca volvulus 0.0048 0.0246 0.1141
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0099 0.087 0.0641
Leishmania major proteasome beta 5 subunit, putative 0.0503 0.588 0.588
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0107 0.0971 0.0745
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0246 0.0092
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0099 0.087 0.0728
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0099 0.087 0.0641
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0099 0.087 0.0878
Plasmodium vivax proteasome subunit beta type-2, putative 0.0242 0.2646 0.4112
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0099 0.087 0.148
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0202 0.2155 0.2155
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0095 0.0829 0.0686
Echinococcus granulosus proteasome subunit beta type 6 0.0099 0.087 0.0641
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0202 0.2155 0.2155
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0099 0.087 0.087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0246 0.0092
Schistosoma mansoni retinoic acid receptor RXR 0.0202 0.2155 0.2036
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0242 0.2646 0.2466
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0099 0.087 0.0641
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0107 0.0971 0.0971
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.006 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.0246
Schistosoma mansoni nuclear hormone receptor 0.0095 0.0829 0.0686
Brugia malayi Proteasome subunit alpha type 1 0.0099 0.087 0.087
Trypanosoma brucei C-8 sterol isomerase, putative 0.0835 1 1
Leishmania major proteasome alpha 1 subunit, putative 0.0099 0.087 0.087
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0099 0.087 0.087
Brugia malayi ecdysteroid receptor 0.0202 0.2155 0.2155

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.5686 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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