TDR Targets

Basic information

Technical information

TDR Targets ID: 828368
Name: 4-(butylaminomethyl)-1-[(2-fluorophenyl)methy l]-2,5-dimethylpyrrole-3-carboxylic acid
MW: 332.412 | Formula: C19H25FN2O2
H donors: 2 H acceptors: 2 LogP: 1.02 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCNCc1c(C)n(c(c1C(=O)O)C)Cc1ccccc1F
InChi: 1S/C19H25FN2O2/c1-4-5-10-21-11-16-13(2)22(14(3)18(16)19(23)24)12-15-8-6-7-9-17(15)20/h6-9,21H,4-5,10-12H2,1-3H3,(H,23,24)
InChiKey: YJEKVEWQALLNTA-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

4-(butylaminomethyl)-1-[(2-fluorophenyl)methyl]-2,5-dimethyl-pyrrole-3-carboxylic acid
4-(butylaminomethyl)-1-[(2-fluorophenyl)methyl]-2,5-dimethyl-3-pyrrolecarboxylic acid
4-(butylaminomethyl)-1-(2-fluorobenzyl)-2,5-dimethyl-pyrrole-3-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0062	0.4093	0.4093
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0076	0.6322	1
Echinococcus granulosus	orexin receptor type 2	0.0062	0.4093	0.6475
Echinococcus multilocularis	orexin receptor type 2	0.0062	0.4093	0.6475
Schistosoma mansoni	hypothetical protein	0.0062	0.4093	0.6475
Echinococcus multilocularis	neuropeptide receptor	0.0062	0.4093	0.6475
Echinococcus multilocularis	g-protein coupled receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Schistosoma mansoni	neuropeptide receptor	0.0062	0.4093	0.6475
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0059	0.3603	0.5699
Loa Loa (eye worm)	G-protein coupled receptor	0.0062	0.4093	0.4093
Schistosoma mansoni	amine GPCR	0.0062	0.4093	0.6475
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0059	0.3603	0.5699
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0062	0.4093	0.6475
Echinococcus granulosus	G protein coupled receptor 139	0.0062	0.4093	0.6475
Schistosoma mansoni	neuropeptide receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	biogenic amine receptor	0.0062	0.4093	0.6475
Echinococcus multilocularis	g protein coupled receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus granulosus	neuropeptide receptor A26	0.0062	0.4093	0.6475
Echinococcus multilocularis	neuropeptide receptor A26	0.0062	0.4093	0.6475
Onchocerca volvulus		0.0062	0.4093	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0062	0.4093	0.4093
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Echinococcus granulosus	dro:myosuppressin receptor	0.0062	0.4093	0.6475
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Brugia malayi	Dopamine receptor protein 1	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus multilocularis	g protein coupled receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.4093	0.6475
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0059	0.3603	0.5699
Echinococcus granulosus	sex peptide receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0076	0.6322	1
Brugia malayi	Proteasome A-type and B-type family protein	0.0076	0.6322	0.6322
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0062	0.4093	0.4093
Brugia malayi	putative neuropeptide receptor NPR1	0.0062	0.4093	0.4093
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0062	0.4093	0.6475
Echinococcus granulosus	g protein coupled receptor	0.0062	0.4093	0.6475
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0062	0.4093	0.6475
Echinococcus granulosus	neuropeptides capa receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	neuropeptide f receptor 76f	0.0062	0.4093	0.6475
Onchocerca volvulus		0.0062	0.4093	0.5
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0076	0.6322	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Brugia malayi	hypothetical protein	0.0062	0.4093	0.4093
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus multilocularis	serotonin receptor	0.0062	0.4093	0.6475
Brugia malayi	GnHR receptor homolog	0.0062	0.4093	0.4093
Brugia malayi	Serotonin receptor	0.0062	0.4093	0.4093
Echinococcus granulosus	g-protein coupled receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0062	0.4093	0.4093
Brugia malayi	hypothetical protein	0.0062	0.4093	0.4093
Schistosoma mansoni	hypothetical protein	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Plasmodium falciparum	proteasome subunit beta type-5	0.0076	0.6322	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0062	0.4093	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	neuropeptide receptor	0.0062	0.4093	0.6475
Onchocerca volvulus		0.0062	0.4093	0.5
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Schistosoma mansoni	hypothetical protein	0.0062	0.4093	0.6475
Echinococcus granulosus	serotonin receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.4093	0.6475
Schistosoma mansoni	opsin-like receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Brugia malayi	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus multilocularis	neuropeptide receptor	0.0062	0.4093	0.6475
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0059	0.3603	0.5699
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0062	0.4093	0.5
Schistosoma mansoni	adenoreceptor	0.0062	0.4093	0.6475
Schistosoma mansoni	neuropeptide receptor	0.0062	0.4093	0.6475
Echinococcus granulosus	tm gpcr rhodopsin	0.0062	0.4093	0.6475
Brugia malayi	larval opioid receptor	0.0062	0.4093	0.4093
Trypanosoma brucei	proteasome beta 6 subunit	0.0059	0.3603	0.5699
Echinococcus multilocularis	somatostatin receptor	0.0062	0.4093	0.6475
Onchocerca volvulus		0.0062	0.4093	0.5
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	neuropeptide F receptor	0.0062	0.4093	0.4093
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0059	0.3603	0.5699
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0062	0.4093	0.4093
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0076	0.6322	1
Echinococcus granulosus	neuropeptide receptor	0.0062	0.4093	0.6475
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0062	0.4093	0.4093
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0076	0.6322	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Onchocerca volvulus		0.0062	0.4093	0.5
Brugia malayi	Melatonin receptor type 1A	0.0062	0.4093	0.4093
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0059	0.3603	0.5699
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0062	0.4093	0.6475
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0059	0.3603	0.3603
Echinococcus granulosus	biogenic amine 5HT receptor	0.0062	0.4093	0.6475
Toxoplasma gondii	proteasome subunit beta type, putative	0.0076	0.6322	1
Brugia malayi	RE15519p	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus granulosus	tm gpcr rhodopsin	0.0062	0.4093	0.6475
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0076	0.6322	1
Brugia malayi	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus multilocularis	neuropeptide s receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0062	0.4093	0.4093
Brugia malayi	G protein-coupled receptor F59B2.13	0.0062	0.4093	0.4093
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.4979	0.4979
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	growth hormone secretagogue receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	opsin-like receptor	0.0062	0.4093	0.6475
Brugia malayi	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0076	0.6322	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.4093	0.6475
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0062	0.4093	0.6475
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0062	0.4093	0.6475
Onchocerca volvulus		0.0062	0.4093	0.5
Onchocerca volvulus		0.0062	0.4093	0.5
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0059	0.3603	0.5699
Schistosoma mansoni	hypothetical protein	0.0062	0.4093	0.6475
Echinococcus multilocularis	allatostatin A receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0062	0.4093	0.6475
Echinococcus granulosus	neuropeptide Y receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus multilocularis	serotonin receptor	0.0062	0.4093	0.6475
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0062	0.4093	0.6475
Onchocerca volvulus		0.0062	0.4093	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus granulosus	g protein coupled receptor	0.0062	0.4093	0.6475
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Schistosoma mansoni	neuropeptide F-like receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Schistosoma mansoni	amine GPCR	0.0062	0.4093	0.6475
Echinococcus multilocularis	fmrfamide receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0099	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0062	0.4093	0.6475
Brugia malayi	hypothetical protein	0.0062	0.4093	0.4093
Schistosoma mansoni	biogenic amine receptor	0.0062	0.4093	0.6475
Brugia malayi	Serotonin receptor	0.0062	0.4093	0.4093
Giardia lamblia	Proteasome subunit beta type 1	0.0059	0.3603	0.5699
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	opsin-like receptor	0.0062	0.4093	0.6475
Echinococcus granulosus	neuropeptides capa receptor	0.0062	0.4093	0.6475
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0076	0.6322	0.5
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus multilocularis	neuropeptides capa receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0062	0.4093	0.6475
Echinococcus granulosus	allatostatin A receptor	0.0062	0.4093	0.6475
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0059	0.3603	0.5699
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0059	0.3603	0.5699
Brugia malayi	putative neuropeptide receptor	0.0062	0.4093	0.4093
Echinococcus multilocularis	sex peptide receptor	0.0062	0.4093	0.6475
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0076	0.6322	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.4093	0.6475
Schistosoma mansoni	biogenic amine receptor	0.0062	0.4093	0.6475
Brugia malayi	sulfakinin receptor protein	0.0062	0.4093	0.4093
Onchocerca volvulus		0.0062	0.4093	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	amine GPCR	0.0062	0.4093	0.6475
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0062	0.4093	0.6475
Brugia malayi	neuropeptide F receptor	0.0062	0.4093	0.4093
Onchocerca volvulus		0.0062	0.4093	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0062	0.4093	0.6475
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0062	0.4093	0.6475
Onchocerca volvulus		0.0062	0.4093	0.5
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0062	0.4093	0.6475
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0062	0.4093	0.6475
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0059	0.3603	0.5699
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0062	0.4093	0.6475
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	1	1
Brugia malayi	G protein-coupled receptor	0.0062	0.4093	0.4093
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0062	0.4093	0.6475
Echinococcus granulosus	g protein coupled receptor	0.0062	0.4093	0.6475
Mycobacterium ulcerans	proteasome PrcB	0.0076	0.6322	0.5
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	TYRA-2 protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	melatonin receptor type 1A	0.0062	0.4093	0.4093
Brugia malayi	follicle stimulating hormone receptor	0.0062	0.4093	0.4093
Brugia malayi	AKH receptor	0.0062	0.4093	0.4093
Echinococcus multilocularis	G protein coupled receptor 139	0.0062	0.4093	0.6475
Echinococcus granulosus	7tm_1 domain containing protein	0.0062	0.4093	0.6475
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0062	0.4093	0.6475
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0062	0.4093	0.6475
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0062	0.4093	0.6475
Brugia malayi	Dopamine receptor protein 2	0.0062	0.4093	0.4093
Echinococcus granulosus	neuropeptide receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0067	0.4979	0.4979
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Schistosoma mansoni	hypothetical protein	0.0067	0.4979	0.7875
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0062	0.4093	0.6475
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0059	0.3603	0.5699
Onchocerca volvulus		0.0062	0.4093	0.5
Echinococcus granulosus	proteasome prosome macropain	0.0076	0.6322	1
Brugia malayi	G-protein coupled receptor	0.0062	0.4093	0.4093
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus multilocularis	neuropeptide Y receptor	0.0062	0.4093	0.6475
Onchocerca volvulus		0.0062	0.4093	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0062	0.4093	0.6475
Brugia malayi	proteasome subunit beta type 1	0.0059	0.3603	0.3603
Echinococcus multilocularis	g protein coupled receptor	0.0062	0.4093	0.6475
Echinococcus multilocularis	dro:myosuppressin receptor	0.0062	0.4093	0.6475
Echinococcus granulosus	neuropeptide FF receptor 2	0.0062	0.4093	0.6475
Brugia malayi	Dopamine receptor	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus granulosus	7TM GPCR rhodopsin	0.0062	0.4093	0.6475
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0062	0.4093	0.4093
Onchocerca volvulus		0.0062	0.4093	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.4093	0.6475
Echinococcus granulosus	fmrfamide receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.4093	0.6475
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0062	0.4093	0.4093
Schistosoma mansoni	myosin xvIII	0.0062	0.4093	0.6475
Echinococcus multilocularis	fmrfamide receptor	0.0062	0.4093	0.6475
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0062	0.4093	0.6475
Echinococcus multilocularis	neuropeptide Y receptor	0.0062	0.4093	0.6475
Onchocerca volvulus		0.0062	0.4093	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0062	0.4093	0.4093
Echinococcus granulosus	biogenic amine 5HT receptor	0.0062	0.4093	0.6475
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0062	0.4093	0.6475
Brugia malayi	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Brugia malayi	G-protein coupled receptor	0.0062	0.4093	0.4093
Loa Loa (eye worm)	neuropeptide F receptor	0.0062	0.4093	0.4093
Onchocerca volvulus		0.0062	0.4093	0.5
Echinococcus granulosus	hypothetical protein	0.0062	0.4093	0.6475
Brugia malayi	hypothetical protein	0.0062	0.4093	0.4093
Brugia malayi	neuropeptide F receptor	0.0062	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.4093	0.6475
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.4093	0.6475
Schistosoma mansoni	amine GPCR	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.4093	0.6475
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0062	0.4093	0.6475
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0076	0.6322	0.6322
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0076	0.6322	1
Brugia malayi	ORL1-like opioid receptor	0.0062	0.4093	0.4093
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0076	0.6322	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Brugia malayi	hypothetical protein	0.0062	0.4093	0.4093
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0062	0.4093	0.4093
Onchocerca volvulus		0.0062	0.4093	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0062	0.4093	0.4093
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0062	0.4093	0.6475
Echinococcus granulosus	somatostatin receptor	0.0062	0.4093	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0062	0.4093	0.4093
Loa Loa (eye worm)	G-protein coupled receptor	0.0062	0.4093	0.4093
Schistosoma mansoni	amine GPCR	0.0062	0.4093	0.6475
Leishmania major	proteasome beta 5 subunit, putative	0.0076	0.6322	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0062	0.4093	0.6475
Schistosoma mansoni	histamine h1 receptor	0.0062	0.4093	0.6475

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 828368