Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0174 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0174 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0092 | 0.1466 | 0.1466 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0082 | 0.0443 | 0.0443 |
Brugia malayi | nuclear receptor NHR-67 | 0.0082 | 0.0443 | 0.0443 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0174 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0078 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0174 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0092 | 0.1466 | 0.1071 |
Brugia malayi | nuclear hormone receptor | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0092 | 0.1466 | 0.1466 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0078 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0174 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0174 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0078 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Brugia malayi | nuclear hormone receptor | 0.0082 | 0.0443 | 0.0443 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0174 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0082 | 0.0443 | 0.0443 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1466 | 0.1466 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0174 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0174 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0174 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0174 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0082 | 0.0443 | 0.0443 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0082 | 0.0443 | 0.0443 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0174 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0174 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0174 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0174 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0174 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0174 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0174 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0092 | 0.1466 | 0.1466 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1466 | 0.1466 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1466 | 0.1466 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0092 | 0.1466 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0092 | 0.1466 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0174 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0092 | 0.1466 | 0.1466 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1466 | 0.1466 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0082 | 0.0443 | 0.0443 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0174 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0174 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Brugia malayi | hypothetical protein | 0.0092 | 0.1466 | 0.1466 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0092 | 0.1466 | 0.1466 |
Trypanosoma brucei | cytochrome P450, putative | 0.0078 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0082 | 0.0443 | 0.0443 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0082 | 0.0443 | 0.0443 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0174 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0082 | 0.0443 | 0.0443 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0174 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0082 | 0.0443 | 0.0443 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0174 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0092 | 0.1466 | 0.1071 |
Onchocerca volvulus | 0.0174 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1466 | 0.1466 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0174 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0082 | 0.0443 | 0.0443 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0174 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0082 | 0.0443 | 0.0443 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0174 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0174 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.009 | 0.1331 | 0.1331 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0174 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0174 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0082 | 0.0443 | 0.0443 |
Brugia malayi | tailless protein | 0.0082 | 0.0443 | 0.0443 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0174 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0078 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0174 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0174 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0174 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0082 | 0.0443 | 0.0443 |
Schistosoma mansoni | thyroid hormone receptor | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0443 | 0.0443 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0174 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0082 | 0.0443 | 0.0443 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.009 | 0.1331 | 0.1331 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0174 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.