TDR Targets

Basic information

Technical information

TDR Targets ID: 828834
Name: N-(1,1-dioxo-2,3-dihydrothiophen-3-yl)-N-phen yl-3-(trifluoromethyl)benzamide
MW: 381.369 | Formula: C18H14F3NO3S
H donors: 0 H acceptors: 3 LogP: 3.24 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N(C1C=CS(=O)(=O)C1)c1ccccc1)c1cccc(c1)C(F)(F)F
InChi: 1S/C18H14F3NO3S/c19-18(20,21)14-6-4-5-13(11-14)17(23)22(15-7-2-1-3-8-15)16-9-10-26(24,25)12-16/h1-11,16H,12H2
InChiKey: LEHSFRHCVOKDPJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(1,1-diketo-2,3-dihydrothiophen-3-yl)-N-phenyl-3-(trifluoromethyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	CYP4Cod1	0.0011	0.0125	0.0034
Schistosoma mansoni	cytochrome P450	0.0011	0.0125	0.0125
Loa Loa (eye worm)	RNA binding protein	0.0064	0.1143	0.1061
Onchocerca volvulus		0.0064	0.1143	0.0701
Schistosoma mansoni	laminin gamma-3 chain	0.0064	0.1143	0.1143
Onchocerca volvulus		0.0064	0.1143	0.0701
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0011	0.0125	0.5
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0011	0.0125	0.5
Echinococcus multilocularis	neural cadherin	0.0064	0.1143	0.1091
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0046	0.5
Echinococcus multilocularis	cpg binding protein	0.003	0.0506	0.0451
Schistosoma mansoni	hypothetical protein	0.0103	0.1909	0.1909
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0011	0.0125	0.5
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Echinococcus multilocularis	slit 2 protein	0.0064	0.1143	0.1091
Brugia malayi	EGF-like domain containing protein	0.0064	0.1143	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Brugia malayi	hypothetical protein	0.0036	0.0615	0.053
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0046	0.5
Echinococcus multilocularis	neurogenic locus protein delta	0.0064	0.1143	0.1091
Echinococcus multilocularis	neurogenic locus protein delta	0.0064	0.1143	0.1091
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0011	0.0125	0.5
Echinococcus granulosus	delta-like protein 1	0.0064	0.1143	0.1091
Brugia malayi	hypothetical protein	0.0149	0.2791	0.2726
Schistosoma mansoni	cell polarity protein	0.0064	0.1143	0.1143
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Schistosoma mansoni	cpg binding protein	0.003	0.0506	0.0506
Brugia malayi	EGF-like domain containing protein	0.0064	0.1143	0.1063
Onchocerca volvulus	Chorion peroxidase homolog	0.0524	1	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0046	0.5
Onchocerca volvulus	Peroxidase homolog	0.0524	1	1
Trichomonas vaginalis	helicase, putative	0.0007	0.0046	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0011	0.0125	0.5
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0971	0.8306
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0011	0.0125	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.0011	0.0125	0.5
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Schistosoma mansoni	hypothetical protein	0.0036	0.0615	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1143	0.1143
Echinococcus multilocularis	peroxidasin	0.0524	1	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Schistosoma mansoni	hypothetical protein	0.0064	0.1143	0.1143
Brugia malayi	Animal haem peroxidase family protein	0.0524	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.0524	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0011	0.0125	0.5
Echinococcus multilocularis	protein jagged 1	0.0064	0.1143	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0011	0.0125	0.5
Entamoeba histolytica	hypothetical protein	0.0036	0.0615	0.5
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Echinococcus granulosus	neurogenic locus notch protein 4	0.0064	0.1143	0.1091
Brugia malayi	Cadherin domain containing protein	0.0064	0.1143	0.1063
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1143	0.1143
Brugia malayi	EGF-like domain containing protein	0.0064	0.1143	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Schistosoma mansoni	hypothetical protein	0.0064	0.1143	0.1143
Onchocerca volvulus		0.0149	0.2791	0.2432
Schistosoma mansoni	hypothetical protein	0.0064	0.1143	0.1143
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0011	0.0125	0.5
Schistosoma mansoni	septate junction protein	0.0064	0.1143	0.1143
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0046	0.5
Echinococcus multilocularis		0.0011	0.0125	0.0068
Echinococcus multilocularis	protein jagged 1	0.0064	0.1143	0.1091
Brugia malayi	Animal haem peroxidase family protein	0.0524	1	1
Brugia malayi	Muscle positioning protein 4	0.0064	0.1143	0.1063
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0011	0.0125	0.5
Brugia malayi	Delta serrate ligand family protein	0.0064	0.1143	0.1063
Schistosoma mansoni	notch	0.0064	0.1143	0.1143
Schistosoma mansoni	hypothetical protein	0.0064	0.1143	0.1143
Echinococcus granulosus	neurogenic locus notch protein	0.0064	0.1143	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.0524	1	1
Onchocerca volvulus		0.0064	0.1143	0.0701
Echinococcus granulosus	slit 2 protein	0.0064	0.1143	0.1091
Loa Loa (eye worm)	cytochrome P450 family protein	0.0011	0.0125	0.0034
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0011	0.0125	0.5
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0011	0.0125	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1143	0.1143
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0011	0.0125	0.5
Brugia malayi	Peroxidasin	0.0524	1	1
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0011	0.0125	0.5
Brugia malayi	Animal haem peroxidase family protein	0.0524	1	1
Brugia malayi	GCC2 and GCC3 family protein	0.0064	0.1143	0.1063
Brugia malayi	EGF-like domain containing protein	0.0064	0.1143	0.1063
Brugia malayi	notch-like transmembrane receptor	0.0064	0.1143	0.1063
Leishmania major	cytochrome p450-like protein	0.0011	0.0125	0.5
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0011	0.0125	0.5
Brugia malayi	Calcium binding EGF domain containing protein	0.0064	0.1143	0.1063
Loa Loa (eye worm)	cytochrome P450 family protein	0.0011	0.0125	0.0034
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0011	0.0125	0.5
Schistosoma mansoni	notch	0.0064	0.1143	0.1143
Echinococcus granulosus	protein jagged 1	0.0064	0.1143	0.1091
Entamoeba histolytica	hypothetical protein	0.0036	0.0615	0.5
Echinococcus multilocularis	neurogenic locus notch protein	0.0064	0.1143	0.1091
Onchocerca volvulus	Slit protein homolog	0.0064	0.1143	0.0701
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0011	0.0125	0.5
Schistosoma mansoni	notch	0.0064	0.1143	0.1143
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0615	0.056
Onchocerca volvulus		0.0064	0.1143	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.1143	0.1061
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0125	0.0036
Leishmania major	cytochrome p450-like protein	0.0011	0.0125	0.5
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0011	0.0125	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0046	0.5
Echinococcus granulosus	cytochrome P450 2K1	0.0011	0.0125	0.0068
Loa Loa (eye worm)	animal heme peroxidase	0.0524	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0011	0.0125	0.5
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0064	0.1143	0.0701
Schistosoma mansoni	cpg binding protein	0.0029	0.0475	0.0475
Schistosoma mansoni	peroxidasin	0.0524	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0011	0.0125	0.5
Echinococcus granulosus	protein jagged 1	0.0064	0.1143	0.1091
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0011	0.0125	0.5
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0011	0.0125	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0046	0.5
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0011	0.0125	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1096	0.1096
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0046	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0011	0.0125	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0615	0.056
Brugia malayi	EGF-like domain containing protein	0.0064	0.1143	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Brugia malayi	TAR-binding protein	0.0064	0.1143	0.1063
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0011	0.0125	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0046	0.5
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0046	0.5
Brugia malayi	Blistered cuticle protein 3	0.0524	1	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0615	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0046	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0058	0.0058
Trypanosoma brucei	RNA helicase, putative	0.0103	0.1909	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0064	0.1143	0.1063
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0064	0.1143	0.1143
Leishmania major	cytochrome p450-like protein	0.0011	0.0125	0.5
Onchocerca volvulus	Peroxidasin homolog	0.0524	1	1
Echinococcus multilocularis	fibropellin Ia	0.0064	0.1143	0.1091
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0011	0.0125	0.5
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0046	0.5
Giardia lamblia	High cysteine protein	0.0064	0.1143	0.5
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0475	0.0388
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0011	0.0125	0.5
Onchocerca volvulus		0.0524	1	1
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0092	0.0034
Brugia malayi	Animal haem peroxidase family protein	0.0524	1	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0011	0.0125	0.5
Onchocerca volvulus		0.0524	1	1
Echinococcus granulosus	protein jagged 2	0.0064	0.1143	0.1091
Echinococcus multilocularis	neurogenic locus notch protein	0.0064	0.1143	0.1091
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1143	0.1143
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0011	0.0125	0.5
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Onchocerca volvulus	Dual oxidase homolog	0.0524	1	1
Brugia malayi	cytochrome P450	0.0011	0.0125	0.0036
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.1143	0.1061
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0011	0.0125	0.5
Echinococcus granulosus	protein jagged 2	0.0064	0.1143	0.1091
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0011	0.0125	0.5
Brugia malayi	EGF-like domain containing protein	0.0064	0.1143	0.1063
Schistosoma mansoni	cpg binding protein	0.003	0.0506	0.0506
Echinococcus granulosus	notch	0.0064	0.1143	0.1091
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0046	0.5
Onchocerca volvulus	Peroxidase homolog	0.0524	1	1
Schistosoma mansoni	hypothetical protein	0.0064	0.1143	0.1143
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Onchocerca volvulus		0.0064	0.1143	0.0701
Schistosoma mansoni	notch	0.0064	0.1143	0.1143
Loa Loa (eye worm)	cytochrome P450	0.0011	0.0125	0.0034
Schistosoma mansoni	hypothetical protein	0.0064	0.1143	0.1143
Trypanosoma cruzi	cytochrome P450, putative	0.0011	0.0125	0.5
Brugia malayi	Cadherin domain containing protein	0.0064	0.1143	0.1063
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0125	0.0036
Brugia malayi	Calcium binding EGF domain containing protein	0.0064	0.1143	0.1063
Schistosoma mansoni	hypothetical protein	0.0011	0.0125	0.0125
Toxoplasma gondii	EGF family domain-containing protein	0.0064	0.1143	1
Onchocerca volvulus	Neurogenic locus notch homolog	0.0064	0.1143	0.0701
Echinococcus granulosus	fibropellin Ia	0.0064	0.1143	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0046	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.1143	0.1091
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0011	0.0125	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1143	0.1143
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0011	0.0125	0.5
Schistosoma mansoni	notch	0.0064	0.1143	0.1143
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0011	0.0125	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0011	0.0125	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0615	0.0615
Loa Loa (eye worm)	notch protein	0.0064	0.1143	0.1061
Loa Loa (eye worm)	blistered cuticle protein 3	0.0524	1	1
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0011	0.0125	0.5
Onchocerca volvulus	Putative cubilin	0.0064	0.1143	0.0701
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0011	0.0125	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0046	0.5
Echinococcus multilocularis	notch	0.0064	0.1143	0.1091
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0011	0.0125	0.5
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0475	0.0386
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0011	0.0125	0.5
Onchocerca volvulus	Peroxidasin homolog	0.0524	1	1
Schistosoma mansoni	notch	0.0064	0.1143	0.1143
Loa Loa (eye worm)	hypothetical protein	0.0149	0.2791	0.2724
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0125	0.0036
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0011	0.0125	0.5
Brugia malayi	RNA binding protein	0.0064	0.1143	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0064	0.1143	0.1063
Echinococcus multilocularis	protein jagged 2	0.0064	0.1143	0.1091
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0011	0.0125	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0046	0.5
Mycobacterium leprae	Conserved hypothetical protein	0.0011	0.0125	0.5
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0011	0.0125	0.5
Entamoeba histolytica	hypothetical protein	0.0036	0.0615	0.5
Loa Loa (eye worm)	animal heme peroxidase	0.0524	1	1
Brugia malayi	EGF-like domain containing protein	0.0064	0.1143	0.1063
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0011	0.0125	0.5
Schistosoma mansoni	slit	0.0064	0.1143	0.1143
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0125	0.0036
Schistosoma mansoni	peroxidasin	0.0524	1	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Loa Loa (eye worm)	Notch2	0.0064	0.1143	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Echinococcus granulosus	neurogenic locus protein delta	0.0064	0.1143	0.1091
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.1143	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1143	0.1061
Onchocerca volvulus		0.0524	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0046	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0046	0.5
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0011	0.0125	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0092	0.0034
Loa Loa (eye worm)	cytochrome P450 family protein	0.0011	0.0125	0.0034
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0064	0.1143	0.1091
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0064	0.1143	0.1091
Echinococcus granulosus	peroxidasin	0.0524	1	1
Echinococcus granulosus	tar DNA binding protein	0.0064	0.1143	0.1091
Schistosoma mansoni	hypothetical protein	0.0064	0.1143	0.1143
Echinococcus granulosus	neural cadherin	0.0064	0.1143	0.1091
Echinococcus granulosus	cpg binding protein	0.003	0.0506	0.0451
Brugia malayi	Animal haem peroxidase family protein	0.0524	1	1
Echinococcus granulosus	neurogenic locus notch protein	0.0064	0.1143	0.1091
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0011	0.0125	0.5
Mycobacterium leprae	putative cytochrome p450	0.0011	0.0125	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 828834