Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.013 | 0.0525 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0086 | 0.0082 | 0.009 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Echinococcus multilocularis | peroxidasin | 0.0522 | 0.4494 | 0.4494 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.0276 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0086 | 0.0082 | 0.0082 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0086 | 0.0082 | 0.009 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0003 | 0.0003 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0099 | 0.0215 | 0.0215 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0099 | 0.0215 | 0.0215 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0099 | 0.0215 | 0.0234 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0078 | 0.0003 | 0.0003 |
Echinococcus granulosus | GPCR family 2 | 0.0078 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0522 | 0.4494 | 0.491 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.013 | 0.0525 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.017 | 0.0925 | 0.1011 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.013 | 0.0525 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1066 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0105 | 0.0276 | 0.0276 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.0276 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0522 | 0.4494 | 0.491 |
Brugia malayi | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Onchocerca volvulus | Peroxidasin homolog | 0.0522 | 0.4494 | 0.491 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0522 | 0.4494 | 0.491 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0003 | 0.0003 |
Brugia malayi | Isocitrate dehydrogenase | 0.0099 | 0.0215 | 0.0234 |
Brugia malayi | Peroxidasin | 0.0522 | 0.4494 | 0.491 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0099 | 0.0215 | 0.4082 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0078 | 0.0003 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.0276 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.013 | 0.0525 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0105 | 0.0276 | 0.0276 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0099 | 0.0215 | 0.4082 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0086 | 0.0082 | 0.0082 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0086 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.0925 | 0.1011 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0248 | 0.172 | 0.1879 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0522 | 0.4494 | 0.491 |
Brugia malayi | MH2 domain containing protein | 0.035 | 0.2751 | 0.3005 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.013 | 0.0525 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0078 | 0.0003 | 0.0003 |
Brugia malayi | isocitrate dehydrogenase | 0.0099 | 0.0215 | 0.0234 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0078 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Brugia malayi | Blistered cuticle protein 3 | 0.0522 | 0.4494 | 0.491 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Echinococcus multilocularis | GPCR, family 2 | 0.0078 | 0.0003 | 0.0003 |
Brugia malayi | hypothetical protein | 0.0982 | 0.9154 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Loa Loa (eye worm) | hypothetical protein | 0.0982 | 0.9154 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0248 | 0.172 | 0.1879 |
Echinococcus granulosus | snurportin 1 | 0.0348 | 0.2728 | 0.2728 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0099 | 0.0215 | 0.0215 |
Onchocerca volvulus | Peroxidase homolog | 0.0522 | 0.4494 | 0.491 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.0276 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Brugia malayi | Animal haem peroxidase family protein | 0.0522 | 0.4494 | 0.491 |
Onchocerca volvulus | Dual oxidase homolog | 0.0522 | 0.4494 | 0.491 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.035 | 0.2751 | 0.3005 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0078 | 0.0003 | 0.0003 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0248 | 0.172 | 0.1879 |
Brugia malayi | Animal haem peroxidase family protein | 0.0522 | 0.4494 | 0.491 |
Echinococcus multilocularis | snurportin 1 | 0.0348 | 0.2728 | 0.2728 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Echinococcus granulosus | peroxidasin | 0.0522 | 0.4494 | 0.4494 |
Brugia malayi | Pax transcription factor protein 2 | 0.0219 | 0.1429 | 0.1561 |
Brugia malayi | RNA, U transporter 1 | 0.0093 | 0.0146 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0078 | 0.0003 | 0.0003 |
Brugia malayi | hypothetical protein | 0.013 | 0.0525 | 0.0574 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0099 | 0.0215 | 0.0215 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.035 | 0.2751 | 0.3005 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0525 | 0.0574 |
Onchocerca volvulus | 0.0522 | 0.4494 | 0.491 | |
Trypanosoma brucei | PAB1-binding protein , putative | 0.013 | 0.0525 | 1 |
Onchocerca volvulus | 0.0219 | 0.1429 | 0.1561 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0522 | 0.4494 | 0.491 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0522 | 0.4494 | 0.491 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0099 | 0.0215 | 0.0215 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0078 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.013 | 0.0525 | 1 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0276 | 0.0301 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0003 | 0.0003 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0105 | 0.0276 | 0.0276 |
Schistosoma mansoni | peroxidasin | 0.0522 | 0.4494 | 0.4494 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.4494 | 0.491 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0522 | 0.4494 | 0.491 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0099 | 0.0215 | 0.0215 |
Schistosoma mansoni | hypothetical protein | 0.1066 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0086 | 0.0082 | 0.0082 |
Schistosoma mansoni | peroxidasin | 0.0522 | 0.4494 | 0.4494 |
Onchocerca volvulus | 0.0522 | 0.4494 | 0.491 | |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0219 | 0.1429 | 0.1561 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0086 | 0.0082 | 0.0082 |
Onchocerca volvulus | Peroxidase homolog | 0.0522 | 0.4494 | 0.491 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0099 | 0.0215 | 0.0215 |
Onchocerca volvulus | Peroxidasin homolog | 0.0522 | 0.4494 | 0.491 |
Onchocerca volvulus | 0.0982 | 0.9154 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.013 | 0.0525 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0099 | 0.0215 | 0.5 |
Brugia malayi | hypothetical protein | 0.0084 | 0.0059 | 0.0064 |
Onchocerca volvulus | 0.0522 | 0.4494 | 0.491 | |
Schistosoma mansoni | hypothetical protein | 0.0348 | 0.2728 | 0.2728 |
Giardia lamblia | High cysteine protein | 0.0078 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.172 | 0.1879 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0522 | 0.4494 | 0.491 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0348 | 0.2728 | 0.298 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0086 | 0.0082 | 0.0082 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.0925 | 0.0925 |
Brugia malayi | Animal haem peroxidase family protein | 0.0522 | 0.4494 | 0.491 |
Echinococcus multilocularis | geminin | 0.1066 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0086 | 0.0082 | 0.0082 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.