Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4565 | 0.4565 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4565 | 0.4565 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4565 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4565 | 0.405 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0866 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0866 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4565 | 0.405 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4565 | 0.405 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4565 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4565 | 0.4565 |
Brugia malayi | hypothetical protein | 0.003 | 0.0866 | 0.0866 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3162 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.