Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1165 | 0.1893 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1165 | 0.1893 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0125 | 0.6154 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1165 | 0.1893 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0125 | 0.6154 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1165 | 0.1893 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0119 | 0.5759 | 0.5759 |
Echinococcus multilocularis | geminin | 0.0181 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.