TDR Targets

Basic information

Technical information

TDR Targets ID: 829306
Name: N-(4-acetamidophenyl)-1-(4-methylphenyl)sulfo nyl-2,3-dihydroindole-5-carboxamide
MW: 449.522 | Formula: C24H23N3O4S
H donors: 2 H acceptors: 4 LogP: 3.04 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)Nc1ccc(cc1)NC(=O)c1ccc2c(c1)CCN2S(=O)(=O)c1ccc(cc1)C
InChi: 1S/C24H23N3O4S/c1-16-3-10-22(11-4-16)32(30,31)27-14-13-18-15-19(5-12-23(18)27)24(29)26-21-8-6-20(7-9-21)25-17(2)28/h3-12,15H,13-14H2,1-2H3,(H,25,28)(H,26,29)
InChiKey: FUEFWRFPHNCFOI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-acetamidophenyl)-1-(4-methylphenyl)sulfonyl-indoline-5-carboxamide
N-(4-acetamidophenyl)-1-(4-methylphenyl)sulfonyl-5-indolinecarboxamide
D256-0384
NCGC00117649-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	polymerase (DNA directed), beta	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania infantum	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Trypanosoma brucei gambiense	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania major	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania mexicana	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania donovani	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Mycobacterium tuberculosis	Conserved hypothetical protein	Get druggable targets OG5_130965	All targets in OG5_130965
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	Get druggable targets OG5_130965	All targets in OG5_130965
Trypanosoma brucei	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_130965	All targets in OG5_130965
Leishmania braziliensis	mitochondrial DNA polymerase beta	Get druggable targets OG5_130965	All targets in OG5_130965

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	polymerase (DNA directed), beta	335 aa	303 aa	32.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0493	0.1195	0.1177
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.0031	0.0046
Onchocerca volvulus	Protein melted homolog	0.0096	0.002	0.5
Onchocerca volvulus		0.0096	0.002	0.5
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0112	0.0068	0.0071
Schistosoma mansoni	atypical protein kinase C	0.1154	0.3155	0.4741
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Echinococcus granulosus	Glutaredoxin protein 5	0.2214	0.6295	0.9458
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0121	0.0094	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0165	0.0222	0.0202
Trypanosoma cruzi	NIMA-related kinase, putative	0.0121	0.0094	0.0111
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0531	0.1307	0.1289
Echinococcus granulosus	Protein kinase C brain isozyme	0.1154	0.3155	0.4725
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Entamoeba histolytica	hypothetical protein	0.0121	0.0094	0.0074
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0568	0.1417	0.14
Leishmania major	folate/biopterin transporter, putative	0.0121	0.0094	0.0928
Onchocerca volvulus		0.0096	0.002	0.5
Schistosoma mansoni	hypothetical protein	0.0096	0.002	0.003
Onchocerca volvulus		0.0096	0.002	0.5
Trichomonas vaginalis	AGC family protein kinase	0.3464	1	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.0222	0.0202
Brugia malayi	Hr1 repeat family protein	0.1154	0.3155	0.3141
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.2239	0.6368	0.957
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Loa Loa (eye worm)	AGC/AKT protein kinase	0.3464	1	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0568	0.1417	0.2106
Trichomonas vaginalis	AGC family protein kinase	0.1251	0.344	0.3427
Schistosoma mansoni	serine/threonine protein kinase	0.1154	0.3155	0.4741
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0096	0.002	0.003
Entamoeba histolytica	protein kinase 2, putative	0.2239	0.6368	0.6361
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.2239	0.6368	1
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.1154	0.3155	0.4725
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0096	0.002	0.5
Leishmania major	protein kinase, putative	0.0121	0.0094	0.0928
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Entamoeba histolytica	protein kinase, putative	0.0121	0.0094	0.0074
Schistosoma mansoni	serine/threonine-protein kinase	0.2335	0.6654	1
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0121	0.0094	0.0111
Echinococcus multilocularis	nervana 2	0.2214	0.6295	0.9458
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0121	0.0094	0.0074
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0112	0.0068	0.0102
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0112	0.0068	0.0102
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.1154	0.3155	0.4725
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Loa Loa (eye worm)	AGC/NDR protein kinase	0.1154	0.3155	0.3141
Echinococcus granulosus	protein kinase c epsilon type	0.1154	0.3155	0.4725
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0112	0.0068	0.0071
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0246	0.0341
Echinococcus granulosus	serine/threonine protein kinase	0.2335	0.6654	1
Schistosoma mansoni	hypothetical protein	0.0096	0.002	0.003
Loa Loa (eye worm)	AGC/PKN protein kinase	0.1154	0.3155	0.3141
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Leishmania major	protein kinase, putative	0.01	0.0031	0.0132
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0096	0.002	0.003
Entamoeba histolytica	protein kinase, putative	0.1154	0.3155	0.3141
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.1154	0.3155	0.4725
Trypanosoma cruzi	NIMA-related kinase, putative	0.0121	0.0094	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.1154	0.3155	0.3141
Schistosoma mansoni	zinc finger protein	0.0096	0.002	0.003
Echinococcus multilocularis	serine:threonine protein kinase N2	0.1154	0.3155	0.4725
Leishmania major	protein kinase, putative	0.0121	0.0094	0.0928
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0246	0.2841
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.01	0.0031	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.3464	1	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0121	0.0094	0.0111
Echinococcus multilocularis	nervana 2	0.2214	0.6295	0.9458
Echinococcus granulosus	nervana 2	0.2214	0.6295	0.9458
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0112	0.0068	0.0071
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.1154	0.3155	0.3141
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0121	0.0094	0.0074
Trypanosoma cruzi	Protein kinase B	0.2335	0.6654	1
Echinococcus multilocularis	Glutaredoxin protein 5	0.2214	0.6295	0.9458
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0112	0.0068	0.0048
Echinococcus multilocularis	serine:threonine protein kinase 38	0.1154	0.3155	0.4725
Trichomonas vaginalis	AGC family protein kinase	0.3464	1	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0112	0.0068	0.0071
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0112	0.0068	0.0071
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0096	0.002	0.003
Echinococcus granulosus	hyperpolarization activated cyclic	0.0112	0.0068	0.0071
Leishmania major	serine/threonine-protein kinase a, putative	0.0121	0.0094	0.0928
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0121	0.0094	0.0111
Entamoeba histolytica	protein kinase, putative	0.3464	1	1
Entamoeba histolytica	protein kinase, putative	0.0121	0.0094	0.0074
Schistosoma mansoni	serine/threonine protein kinase	0.1154	0.3155	0.4741
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.1154	0.3155	0.3141
Entamoeba histolytica	protein kinase, putative	0.3368	0.9714	0.9714
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.0031	0.0046
Onchocerca volvulus	outspread protein homolog	0.0096	0.002	0.5
Trypanosoma brucei	protein kinase, putative	0.0121	0.0094	0.0074
Schistosoma mansoni	serine/threonine protein kinase	0.1154	0.3155	0.4741
Entamoeba histolytica	hypothetical protein	0.0121	0.0094	0.0074
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0121	0.0094	0.0111
Mycobacterium ulcerans	hypothetical protein	0.0192	0.0304	0.5
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0112	0.0068	0.0048
Echinococcus granulosus	serine:threonine protein kinase N2	0.1154	0.3155	0.4725
Echinococcus multilocularis	protein kinase c epsilon type	0.1154	0.3155	0.4725
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0173	0.0246	0.0226
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0112	0.0068	0.0102
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.2239	0.6368	0.957
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0568	0.1417	0.14
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0121	0.0094	0.0076
Echinococcus multilocularis	protein kinase c iota type	0.1154	0.3155	0.4725
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.1154	0.3155	0.4725
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Echinococcus granulosus	voltage gated potassium channel	0.0165	0.0222	0.0305
Giardia lamblia	Kinase, AGC PKA	0.2239	0.6368	0.5
Schistosoma mansoni	oxysterol-binding protein 1	0.0096	0.002	0.003
Schistosoma mansoni	serine/threonine protein kinase	0.1154	0.3155	0.4741
Echinococcus granulosus	NDR protein kinase	0.1154	0.3155	0.4725
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0121	0.0094	0.0074
Brugia malayi	Protein kinase domain containing protein	0.1154	0.3155	0.3141
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.2335	0.6654	1
Schistosoma mansoni	voltage-gated potassium channel	0.0165	0.0222	0.0334
Schistosoma mansoni	dynamin	0.0096	0.002	0.003
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0121	0.0094	0.0928
Trichomonas vaginalis	AGC family protein kinase	0.1154	0.3155	0.3141
Plasmodium falciparum	cGMP-dependent protein kinase	0.01	0.0031	0.0016
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.01	0.0031	0.0016
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Schistosoma mansoni	voltage-gated potassium channel	0.062	0.1572	0.2363
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.1154	0.3155	0.3141
Entamoeba histolytica	protein kinase, putative	0.0121	0.0094	0.0074
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0112	0.0068	0.0102
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Schistosoma mansoni	myotubularin-related protein	0.0096	0.002	0.003
Trichomonas vaginalis	AGC family protein kinase	0.3464	1	1
Brugia malayi	p70 ribosomal S6 kinase beta	0.3368	0.9714	0.9714
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.2214	0.6295	0.9458
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0568	0.1417	0.2106
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.0815	0.1199
Echinococcus multilocularis	expressed conserved protein	0.01	0.0031	0.0016
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.1154	0.3155	0.4725
Entamoeba histolytica	protein kinase, putative	0.0121	0.0094	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.3464	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Schistosoma mansoni	oxysterol-binding protein 1	0.0096	0.002	0.003
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0112	0.0068	0.0102
Trypanosoma brucei	rac serine-threonine kinase, putative	0.3464	1	1
Schistosoma mansoni	centaurin alpha	0.0096	0.002	0.003
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Leishmania major	mitochondrial DNA polymerase beta	0.0365	0.0815	1
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0096	0.002	0.003
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0121	0.0094	0.0074
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0112	0.0068	0.0071
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0192	0.0304	0.5
Schistosoma mansoni	rho gtpase activating protein	0.0096	0.002	0.003
Echinococcus multilocularis	voltage gated potassium channel	0.0165	0.0222	0.0305
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0121	0.0094	0.0928
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0096	0.002	0.5
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0121	0.0094	0.0111
Entamoeba histolytica	PH domain containing protein kinase, putative	0.2335	0.6654	0.6647
Onchocerca volvulus		0.0096	0.002	0.5
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0112	0.0068	0.0048
Echinococcus multilocularis	rac serine:threonine kinase	0.2335	0.6654	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0121	0.0094	0.0111
Schistosoma mansoni	voltage-gated potassium channel	0.062	0.1572	0.2363
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.01	0.0031	0.0016
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0531	0.1307	0.1289
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0165	0.0222	0.0305
Echinococcus granulosus	protein kinase c iota type	0.1154	0.3155	0.4725
Trichomonas vaginalis	AGC family protein kinase	0.3464	1	1
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.2239	0.6368	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.2239	0.6368	0.957
Toxoplasma gondii	AGC kinase	0.3368	0.9714	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0165	0.0222	0.0305
Leishmania major	protein kinase, putative	0.01	0.0031	0.0132
Echinococcus granulosus	cGMP dependent protein kinase 1	0.01	0.0031	0.0016
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0112	0.0068	0.0071
Trichomonas vaginalis	AGC family protein kinase	0.1154	0.3155	0.3141
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0121	0.0094	0.0111
Echinococcus granulosus	cGMP dependent protein kinase	0.01	0.0031	0.0016
Loa Loa (eye worm)	AGC/PKG protein kinase	0.01	0.0031	0.001
Onchocerca volvulus		0.0096	0.002	0.5
Onchocerca volvulus		0.0096	0.002	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.1154	0.3155	0.4741
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0121	0.0094	0.0116
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0121	0.0094	0.0111
Schistosoma mansoni	growth factor receptor-bound protein	0.0096	0.002	0.003
Onchocerca volvulus		0.0096	0.002	0.5
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0112	0.0068	0.0071
Brugia malayi	Protein kinase domain containing protein	0.1154	0.3155	0.3141
Schistosoma mansoni	serine/threonine-protein kinase	0.2335	0.6654	1
Trichomonas vaginalis	AGC family protein kinase	0.3464	1	1
Schistosoma mansoni	syntrophin	0.0096	0.002	0.003
Onchocerca volvulus	Putative zinc finger protein	0.0096	0.002	0.5
Echinococcus granulosus	protein kinase C gamma type	0.1154	0.3155	0.4725
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.1154	0.3155	0.4725
Entamoeba histolytica	protein kinase, putative	0.0121	0.0094	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0112	0.0068	0.0048
Echinococcus granulosus	nervana 2	0.2214	0.6295	0.9458
Loa Loa (eye worm)	hypothetical protein	0.1154	0.3155	0.3141
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0121	0.0094	0.0074
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0365	0.0815	0.0797
Echinococcus multilocularis	serine:threonine protein kinase N2	0.1154	0.3155	0.4725
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.1154	0.3155	0.3141
Schistosoma mansoni	voltage-gated potassium channel	0.0165	0.0222	0.0334
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.0031	0.0046
Schistosoma mansoni	hypothetical protein	0.0096	0.002	0.003
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0112	0.0068	0.0048
Entamoeba histolytica	PH domain containing protein kinase, putative	0.2335	0.6654	0.6647
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0121	0.0094	0.0074
Brugia malayi	protein kinase C II.	0.1154	0.3155	0.3141
Schistosoma mansoni	serine/threonine kinase	0.1154	0.3155	0.4741
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0121	0.0094	0.0116
Echinococcus granulosus	cGMP dependent protein kinase 1	0.01	0.0031	0.0016
Schistosoma mansoni	hypothetical protein	0.0096	0.002	0.003
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.0815	0.1199
Echinococcus granulosus	serine threonine protein kinase nrc	0.2239	0.6368	0.957
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0121	0.0094	0.0074
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0112	0.0068	0.0071
Echinococcus multilocularis	serine threonine protein kinase	0.1154	0.3155	0.4725
Schistosoma mansoni	vav2	0.0096	0.002	0.003
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.2214	0.6295	0.9458
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0121	0.0094	0.0074
Schistosoma mansoni	serine/threonine protein kinase	0.1154	0.3155	0.4741
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Toxoplasma gondii	protein kinase domain-containing protein	0.0121	0.0094	0.0076
Schistosoma mansoni	voltage-gated potassium channel	0.0112	0.0068	0.0102
Entamoeba histolytica	p21-activated kinase	0.0121	0.0094	0.0074
Schistosoma mansoni	goodpasture antigen-binding protein	0.0096	0.002	0.003
Schistosoma mansoni	serine/threonine protein kinase	0.1154	0.3155	0.4741
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0121	0.0094	0.0074
Schistosoma mansoni	hypothetical protein	0.0096	0.002	0.003
Schistosoma mansoni	dynamin	0.0096	0.002	0.003
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.1129	0.3081	0.3067
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.1154	0.3155	0.4725
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.3368	0.9714	0.9714
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0112	0.0068	0.0071
Schistosoma mansoni	zinc finger protein	0.0096	0.002	0.003
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.0094	0.0074
Brugia malayi	Egg laying defective protein 4	0.01	0.0031	0.001
Schistosoma mansoni	goodpasture antigen-binding protein	0.0096	0.002	0.003
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0068	0.0048
Entamoeba histolytica	protein kinase, putative	0.3464	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1475933
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 829306