TDR Targets

Basic information

Technical information

TDR Targets ID: 829428
Name: N-butyl-2-[6-[(4-fluorophenyl)methyl]-5,7-dim ethyl-1-oxopyrrolo[3,4-d]pyridazin-2-yl]-N-me thylacetamide
MW: 398.474 | Formula: C22H27FN4O2
H donors: 0 H acceptors: 2 LogP: 2.9 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN(C(=O)Cn1ncc2c(c1=O)c(C)n(c2C)Cc1ccc(cc1)F)C
InChi: 1S/C22H27FN4O2/c1-5-6-11-25(4)20(28)14-27-22(29)21-16(3)26(15(2)19(21)12-24-27)13-17-7-9-18(23)10-8-17/h7-10,12H,5-6,11,13-14H2,1-4H3
InChiKey: QGUZZNYONPIOLX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-butyl-2-[6-[(4-fluorophenyl)methyl]-5,7-dimethyl-1-oxo-pyrrolo[3,4-d]pyridazin-2-yl]-N-methyl-acetamide
N-butyl-2-[6-[(4-fluorophenyl)methyl]-5,7-dimethyl-1-oxo-2-pyrrolo[3,4-d]pyridazinyl]-N-methylacetamide
N-butyl-2-[6-(4-fluorobenzyl)-1-keto-5,7-dimethyl-pyrrolo[3,4-d]pyridazin-2-yl]-N-methyl-acetamide
N-butyl-2-[6-[(4-fluorophenyl)methyl]-5,7-dimethyl-1-oxo-pyrrolo[3,4-d]pyridazin-2-yl]-N-methyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	steroid hormone receptor ad4bp	0.015	0.168	0.168
Echinococcus multilocularis	protein patched	0.0329	0.3978	0.3978
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0776	0.0776
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.015	0.168	0.168
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0071	0.0668	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0539	0.0539
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0715	0.8919	0.8919
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0073	0.0696	0.0696
Schistosoma mansoni	coup transcription factor	0.015	0.168	0.168
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0337	0.0337
Loa Loa (eye worm)	fli-1 protein	0.0215	0.2515	0.2515
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.015	0.168	0.168
Schistosoma mansoni	thyroid hormone receptor	0.015	0.168	0.168
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.08	1	1
Brugia malayi	nuclear receptor NHR-88	0.0071	0.0668	0.0668
Brugia malayi	Ets-domain containing protein	0.0071	0.0671	0.0671
Echinococcus multilocularis	Niemann Pick C1 protein	0.0329	0.3978	0.3978
Echinococcus granulosus	sterol regulatory element binding protein	0.0329	0.3978	0.3978
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0668	0.0668
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.015	0.168	0.168
Schistosoma mansoni	hypothetical protein	0.0035	0.0215	0.0215
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0337	0.0337
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0337	0.0337
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.015	0.168	0.168
Echinococcus multilocularis	microsomal glutathione S transferase 3	0.0109	0.1165	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0668	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0388	0.0388
Onchocerca volvulus		0.0071	0.0668	0.2286
Loa Loa (eye worm)	hypothetical protein	0.015	0.168	0.168
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0071	0.0668	0.0668
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.015	0.168	0.168
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0668	0.0668
Brugia malayi	ecdysone receptor	0.0071	0.0668	0.0668
Schistosoma mansoni	membrane associated proteins in eicosanoid and glutathione metabolism family member	0.0477	0.5874	0.5874
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.015	0.168	0.168
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0375	0.4566	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0337	0.0337
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0071	0.0668	0.0668
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.015	0.168	0.168
Brugia malayi	Nuclear hormone receptor-like 1	0.015	0.168	0.168
Loa Loa (eye worm)	hypothetical protein	0.015	0.168	0.168
Trichomonas vaginalis	conserved hypothetical protein	0.0329	0.3978	0.8712
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.08	1	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0368	0.0368
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.08	1	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0215	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.015	0.168	0.168
Schistosoma mansoni	zinc finger protein	0.0071	0.0668	0.0668
Schistosoma mansoni	hypothetical protein	0.0047	0.0368	0.0368
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.015	0.168	0.168
Schistosoma mansoni	retinoic acid receptor RXR	0.015	0.168	0.168
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0668	0.0668
Schistosoma mansoni	thyroid hormone receptor	0.015	0.168	0.168
Echinococcus multilocularis	nuclear receptor nhr 48	0.0071	0.0668	0.0668
Schistosoma mansoni	ets-related	0.0215	0.2515	0.2515
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0079	0.0776	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2723	0.2723
Entamoeba histolytica	hypothetical protein	0.0035	0.0215	1
Brugia malayi	ecdysteroid receptor	0.015	0.168	0.168
Brugia malayi	photoreceptor-specific nuclear receptor	0.015	0.168	0.168
Echinococcus multilocularis	FTZ F1 alpha	0.015	0.168	0.168
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0668	0.0668
Loa Loa (eye worm)	hypothetical protein	0.015	0.168	0.168
Brugia malayi	hypothetical protein	0.0071	0.0668	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0668	0.0668
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.015	0.168	0.168
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0337	0.0337
Brugia malayi	nuclear hormone receptor	0.015	0.168	0.168
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0776	0.0776
Brugia malayi	Ets-domain containing protein	0.0071	0.0671	0.0671
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.015	0.168	0.168
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.015	0.168	0.168
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0215	0.0215
Onchocerca volvulus		0.0071	0.0668	0.2286
Loa Loa (eye worm)	DR-78	0.0071	0.0668	0.0668
Schistosoma mansoni	nuclear receptor	0.0071	0.0668	0.0668
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.015	0.168	0.168
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.015	0.168	0.168
Schistosoma mansoni	nuclear hormone receptor	0.0071	0.0668	0.0668
Echinococcus granulosus	ecdysone induced protein 78C	0.015	0.168	0.168
Brugia malayi	hypothetical protein	0.0079	0.0776	0.0776
Loa Loa (eye worm)	nuclear hormone receptor	0.0071	0.0668	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0668	0.0668
Echinococcus multilocularis	protein dispatched 1	0.0329	0.3978	0.3978
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.015	0.168	0.168
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.08	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.015	0.168	0.168
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0388	0.0388
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0071	0.0671	0.0671
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0071	0.0668	0.0668
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0071	0.0668	0.0668
Entamoeba histolytica	hypothetical protein	0.0035	0.0215	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.015	0.168	0.168
Schistosoma mansoni	hypothetical protein	0.0166	0.1885	0.1885
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.015	0.168	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.015	0.168	0.168
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.015	0.168	0.168
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0	0.5
Echinococcus granulosus	geminin	0.0166	0.1885	0.1885
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.015	0.168	0.168
Onchocerca volvulus	Protein ultraspiracle homolog	0.015	0.168	1
Brugia malayi	steroid hormone receptor	0.015	0.168	0.168
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0337	0.0337
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0715	0.8919	0.8919
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.08	1	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.015	0.168	0.168
Echinococcus multilocularis	geminin	0.0166	0.1885	0.1885
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0071	0.0668	0.0668
Schistosoma mansoni	memapsin-2 (A01 family)	0.0428	0.5237	0.5237
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0071	0.0668	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0668	0.0668
Schistosoma mansoni	nuclear hormone receptor	0.0071	0.0668	0.0668
Brugia malayi	nuclear receptor NHR-67	0.0071	0.0668	0.0668
Brugia malayi	nuclear receptor NHR-88	0.015	0.168	0.168
Onchocerca volvulus	Bile acid receptor homolog	0.015	0.168	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.015	0.168	0.168
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.015	0.168	0.168
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0776	0.0776
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.08	1	1
Schistosoma mansoni	nuclear receptor	0.0071	0.0668	0.0668
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.015	0.168	0.168
Echinococcus multilocularis	GA binding protein alpha chain	0.0071	0.0671	0.0671
Schistosoma mansoni	gabp alpha	0.0071	0.0671	0.0671
Brugia malayi	orphan nuclear receptor NR2E1	0.0071	0.0668	0.0668
Entamoeba histolytica	hypothetical protein	0.0035	0.0215	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.015	0.168	0.168
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0368	0.0368
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.2723	0.2723
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0375	0.4566	1
Loa Loa (eye worm)	hypothetical protein	0.08	1	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0776	0.0776
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0715	0.8919	0.8919
Brugia malayi	CHE-14 protein	0.0329	0.3978	0.3978
Schistosoma mansoni	hypothetical protein	0.0166	0.1885	0.1885
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0071	0.0668	0.0668
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0071	0.0668	0.2286
Brugia malayi	hypothetical protein	0.0035	0.0215	0.0215
Brugia malayi	Steroid receptor seven-up type 2	0.015	0.168	0.168
Loa Loa (eye worm)	hypothetical protein	0.015	0.168	0.168
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.015	0.168	0.168
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.015	0.168	0.168
Loa Loa (eye worm)	steroid hormone receptor	0.015	0.168	0.168
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0776	0.0776
Brugia malayi	nuclear receptor RXR	0.0079	0.0776	0.0776
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0079	0.0776	0.0776
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0079	0.0776	0.0776
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0071	0.0668	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0329	0.3978	0.3978
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.015	0.168	0.168
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.015	0.168	0.168
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.015	0.168	0.168
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0071	0.0668	0.0668
Brugia malayi	conserved hypotetical protein	0.0071	0.0668	0.0668
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0071	0.0668	0.0668
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0071	0.0668	0.0668
Brugia malayi	nuclear receptor RXR	0.0071	0.0668	0.0668
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0329	0.3978	0.3978
Echinococcus granulosus	Protein patched homolog 1	0.0329	0.3978	0.3978
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0071	0.0668	0.0668
Echinococcus granulosus	Niemann Pick C1 protein	0.0329	0.3978	0.3978
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0668	0.0668
Echinococcus multilocularis	sterol regulatory element binding protein	0.0329	0.3978	0.3978
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0715	0.8919	0.8919
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.015	0.168	0.168
Schistosoma mansoni	nuclear receptor nhr-48	0.0071	0.0668	0.0668
Loa Loa (eye worm)	hypothetical protein	0.015	0.168	0.168
Echinococcus granulosus	GA binding protein alpha chain	0.0071	0.0671	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0668	0.0668
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0715	0.8919	0.8919
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0668	0.0668
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0337	0.0337
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.015	0.168	0.168
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0388	0.0388
Loa Loa (eye worm)	hypothetical protein	0.015	0.168	0.168
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.015	0.168	0.168
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0215	0.0215
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.015	0.168	0.168
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.08	1	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0668	0.0668
Brugia malayi	Nuclear hormone receptor E75	0.0071	0.0668	0.0668
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0079	0.0776	0.0776
Toxoplasma gondii	MAPEG family protein	0.0109	0.1165	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.015	0.168	0.168
Schistosoma mansoni	nuclear hormone receptor	0.015	0.168	0.168
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0071	0.0668	0.0668
Schistosoma mansoni	RAR-like nuclear receptor	0.015	0.168	0.168
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0071	0.0668	0.0668
Echinococcus granulosus	microsomal glutathione S transferase 3	0.0109	0.1165	0.1165
Brugia malayi	Nuclear hormone receptor-like 1	0.0079	0.0776	0.0776
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0388	0.0388
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.08	1	1
Brugia malayi	hypothetical protein	0.0231	0.2723	0.2723
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0	0.5
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0375	0.4566	1
Schistosoma mansoni	patched 1	0.0329	0.3978	0.3978
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0071	0.0668	0.2286
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0079	0.0776	0.0776
Brugia malayi	Fli-1 protein	0.0215	0.2515	0.2515
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0071	0.0668	0.0668
Schistosoma mansoni	microsomal glutathione s-transferase	0.0109	0.1165	0.1165
Schistosoma mansoni	hypothetical protein	0.0033	0.0191	0.0191
Echinococcus multilocularis	ecdysone induced protein 78C	0.015	0.168	0.168
Brugia malayi	nuclear hormone receptor	0.0071	0.0668	0.0668
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0375	0.4566	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0337	0.0337
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.015	0.168	0.168
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.015	0.168	0.168
Brugia malayi	hypothetical protein	0.0071	0.0668	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0668	0.0668
Echinococcus granulosus	thyroid hormone receptor alpha	0.0071	0.0668	0.0668
Brugia malayi	hypothetical protein	0.0079	0.0776	0.0776
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0073	0.0696	0.0696
Brugia malayi	Nuclear hormone receptor-like 1	0.0079	0.0776	0.0776
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.015	0.168	0.168
Loa Loa (eye worm)	hypothetical protein	0.015	0.168	0.168
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0337	0.0337
Echinococcus granulosus	FTZ F1 alpha	0.015	0.168	0.168
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0215	0.0215
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.015	0.168	0.168
Echinococcus multilocularis	thyroid hormone receptor alpha	0.015	0.168	0.168
Brugia malayi	nuclear hormone receptor family member odr-7	0.0071	0.0668	0.0668
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0329	0.3978	0.3978
Onchocerca volvulus		0.015	0.168	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0071	0.0668	0.0668
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.015	0.168	0.168
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.2723	0.2723
Brugia malayi	tailless protein	0.0071	0.0668	0.0668

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 829428