TDR Targets

Basic information

Technical information

TDR Targets ID: 829521
Name: N-tert-butyl-2-[5,7-dimethyl-1-oxo-6-(phenylm ethyl)pyrrolo[3,4-d]pyridazin-2-yl]acetamide
MW: 366.457 | Formula: C21H26N4O2
H donors: 1 H acceptors: 2 LogP: 2.35 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NC(C)(C)C)Cn1ncc2c(c1=O)c(C)n(c2C)Cc1ccccc1
InChi: 1S/C21H26N4O2/c1-14-17-11-22-25(13-18(26)23-21(3,4)5)20(27)19(17)15(2)24(14)12-16-9-7-6-8-10-16/h6-11H,12-13H2,1-5H3,(H,23,26)
InChiKey: STZMONLEFLPTOD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-tert-butyl-2-[5,7-dimethyl-1-oxo-6-(phenylmethyl)-2-pyrrolo[3,4-d]pyridazinyl]acetamide
2-[6-(benzyl)-1-keto-5,7-dimethyl-pyrrolo[3,4-d]pyridazin-2-yl]-N-tert-butyl-acetamide
N-tert-butyl-2-[5,7-dimethyl-1-oxo-6-(phenylmethyl)pyrrolo[3,4-d]pyridazin-2-yl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	abcb9, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.2177	0.2177
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.003	0.0331	0.092
Schistosoma mansoni	smdr2	0.0073	0.2177	0.2177
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0073	0.2177	0.9943
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (large chain)	0.0075	0.2273	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0053	0.1309	0.1309
Schistosoma mansoni	multidrug resistance protein	0.0073	0.2177	0.2177
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0028	0.0224	0.0224
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0053	0.1309	0.1309
Loa Loa (eye worm)	hypothetical protein	0.0073	0.2189	0.5486
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	Arginase, putative	0.0253	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.2177	0.2177
Echinococcus multilocularis	multidrug resistance protein 1	0.0051	0.122	0.122
Trichomonas vaginalis	ABC transporter, putative	0.0073	0.2177	0.2177
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0028	0.0224	0.0562
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0073	0.2189	0.2189
Loa Loa (eye worm)	inositol-1	0.0035	0.055	0.1379
Entamoeba histolytica	P-glycoprotein-2	0.0073	0.2177	0.2177
Plasmodium vivax	arginase, putative	0.0253	1	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0028	0.0224	0.0562
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (small chain)	0.003	0.0331	0.1455
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0053	0.1309	0.4351
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0051	0.122	0.122
Schistosoma mansoni	multidrug resistance protein	0.0073	0.2177	0.2177
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0918	0.0918
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.2177	0.2177
Echinococcus multilocularis	arginase 2, mitochondrial	0.0253	1	1
Trypanosoma cruzi	arginase, putative	0.0092	0.3008	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0073	0.2177	0.2177
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0028	0.0224	0.0224
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0039	0.069	0.2294
Echinococcus multilocularis	multidrug resistance protein 1	0.0073	0.2177	0.2177
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0035	0.055	0.1829
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0073	0.2177	0.5455
Trichomonas vaginalis	conserved hypothetical protein	0.0253	1	1
Mycobacterium ulcerans	carbon monoxyde dehydrogenase medium chain CoxM	0.0054	0.1346	0.3745
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0047	0.1061	0.2952
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Brugia malayi	Inositol-1	0.0035	0.055	0.1379
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0918	0.0918
Echinococcus granulosus	multidrug resistance protein 1	0.0073	0.2177	0.2177
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxL_2	0.0075	0.2273	0.6323
Plasmodium falciparum	multidrug resistance protein 1	0.0073	0.2177	0.2177
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0053	0.1309	0.1309
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0712	0.0712
Trichomonas vaginalis	conserved hypothetical protein	0.0253	1	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Treponema pallidum	hypothetical protein	0.0026	0.0134	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0073	0.2177	0.2177
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0918	0.0918
Echinococcus granulosus	multidrug resistance protein 1	0.0073	0.2177	0.2177
Echinococcus multilocularis	inositol monophosphatase 1	0.0035	0.055	0.055
Trypanosoma cruzi	arginase, putative	0.0092	0.3008	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0073	0.2177	0.2177
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0073	0.2177	0.2177
Entamoeba histolytica	P-glycoprotein-2	0.0073	0.2177	0.2177
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0159	0.5932	0.5932
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0028	0.0224	0.0224
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0918	0.0918
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.2177	0.2177
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	taga, putative	0.0073	0.2177	0.2177
Entamoeba histolytica	P-glycoprotein-1	0.0073	0.2177	0.2177
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0073	0.2177	0.2177
Trichomonas vaginalis	ABC transporter, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0159	0.5932	0.5932
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0035	0.055	0.2513
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0059	0.1592	0.1592
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0918	0.2299
Brugia malayi	ABC transporter family protein	0.0073	0.2177	0.5455
Schistosoma mansoni	arginase	0.0253	1	1
Echinococcus multilocularis		0.0253	1	1
Trichomonas vaginalis	ABC transporter, putative	0.0073	0.2177	0.2177
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0918	0.0918
Echinococcus granulosus	arginase 2 mitochondrial	0.0253	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2142	0.5368
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Loa Loa (eye worm)	hypothetical protein	0.0073	0.2177	0.5455
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.2177	0.2177
Leishmania major	arginase	0.0253	1	1
Schistosoma mansoni	multidrug resistance protein	0.0073	0.2177	0.2177
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0073	0.2177	0.2177
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0073	0.2177	0.2177
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0073	0.2189	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	inositol monophosphatase, putative	0.0035	0.055	0.055
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0039	0.069	0.069
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0053	0.1309	0.1309
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0389	0.171
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0035	0.055	0.153
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0059	0.1592	0.399
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0073	0.2177	0.2177
Toxoplasma gondii	hypothetical protein	0.0039	0.0712	0.3252
Echinococcus multilocularis	ATP binding cassette sub family B	0.0072	0.2142	0.2142
Plasmodium vivax	multidrug resistance protein 1, putative	0.0073	0.2177	0.2177
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0134	0.0373
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0712	0.0712
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0028	0.0224	0.0224
Brugia malayi	MH2 domain containing protein	0.0115	0.3991	1
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0073	0.2177	0.9577
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0053	0.1309	0.1309
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0073	0.2177	0.9943
Trypanosoma brucei	agmatinase, putative	0.0092	0.3008	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.2177	0.2177
Entamoeba histolytica	P-glycoprotein 5, putative	0.0073	0.2177	0.2177
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0073	0.2189	0.2189
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0053	0.1309	0.4351
Trypanosoma cruzi	agmatinase, putative	0.0092	0.3008	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Echinococcus multilocularis	multidrug resistance protein 1	0.0073	0.2177	0.2177
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0073	0.2189	0.2189
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.2177	0.2177
Loa Loa (eye worm)	MH2 domain-containing protein	0.0115	0.3991	1
Loa Loa (eye worm)	multidrug resistance protein 3	0.0073	0.2177	0.5455
Leishmania major	p-glycoprotein	0.0073	0.2177	0.2177
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0053	0.1309	0.1309
Schistosoma mansoni	inositol monophosphatase	0.0035	0.055	0.055
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0028	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0073	0.2177	0.5455
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0053	0.1309	0.1309
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0059	0.1592	0.399
Trichomonas vaginalis	ABC transporter, putative	0.0073	0.2177	0.2177
Echinococcus granulosus	multidrug resistance protein 1	0.0051	0.122	0.122
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0073	0.2189	0.2189
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0035	0.055	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0073	0.2177	0.2177
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0073	0.2189	0.2189
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0224	0.0562
Trichomonas vaginalis	aldehyde oxidase, putative	0.0159	0.5932	0.5932
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (medium chain)	0.0054	0.1346	0.5923
Entamoeba histolytica	P-glycoprotein-2, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0035	0.055	0.055
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0053	0.1309	0.4351
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0039	0.069	0.069
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0053	0.1309	0.1309
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0053	0.1309	0.1309
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0059	0.1592	0.1592
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0072	0.2142	0.2142
Entamoeba histolytica	P-glycoprotein-5	0.0073	0.2177	0.2177
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.1309	0.1309
Entamoeba histolytica	Arginase, putative	0.0253	1	1
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0053	0.1309	0.1309
Onchocerca volvulus		0.0073	0.2177	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0115	0.3991	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Plasmodium falciparum	arginase	0.0253	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0053	0.1309	0.1309
Brugia malayi	multidrug resistance protein 3	0.0073	0.2177	0.5455
Echinococcus granulosus	inositol monophosphatase 1	0.0035	0.055	0.055
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.2177	0.2177
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0073	0.2189	1
Schistosoma mansoni	inositol monophosphatase	0.0035	0.055	0.055
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.2177	0.2177
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0035	0.055	0.1829
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0035	0.055	0.055
Leishmania major	agmatinase-like protein	0.0092	0.3008	0.3008
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	abcb9, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	abcb9, putative	0.0073	0.2177	0.2177
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0053	0.1309	0.1309
Echinococcus granulosus	multidrug resistance protein 1	0.0051	0.122	0.122
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0035	0.055	0.055
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0918	0.2299
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.2177	0.2177
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0053	0.1309	0.4351
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0712	0.0712
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0053	0.1309	0.4351
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0028	0.0224	0.0224
Echinococcus granulosus	multidrug resistance protein 1	0.0073	0.2177	0.2177
Trypanosoma cruzi	agmatinase, putative	0.0092	0.3008	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0073	0.2177	0.2177
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0035	0.055	0.055
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0073	0.2177	0.2177
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxM_2	0.0054	0.1346	0.3745
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0053	0.1309	0.1309
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0073	0.2177	0.2177
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0918	0.0918
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0075	0.2273	0.6323
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0918	0.0918
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0073	0.2177	0.2177
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0389	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0035	0.055	0.1829
Entamoeba histolytica	P-glyco protein 6, putative	0.0073	0.2177	0.2177
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.003	0.0331	0.092
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0073	0.2177	0.5
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0053	0.1309	0.1309
Mycobacterium ulcerans	carbon monoxide dehydrogenase	0.0105	0.3595	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0053	0.1309	0.1309

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 829521