TDR Targets

Basic information

Technical information

TDR Targets ID: 829584
Name: 2-[5,7-dimethyl-6-[(4-methylphenyl)methyl]-1- oxopyrrolo[3,4-d]pyridazin-2-yl]-N-[(4-methox yphenyl)methyl]acetamide
MW: 444.526 | Formula: C26H28N4O3
H donors: 1 H acceptors: 2 LogP: 3.2 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)CNC(=O)Cn1ncc2c(c1=O)c(C)n(c2C)Cc1ccc(cc1)C
InChi: 1S/C26H28N4O3/c1-17-5-7-21(8-6-17)15-29-18(2)23-14-28-30(26(32)25(23)19(29)3)16-24(31)27-13-20-9-11-22(33-4)12-10-20/h5-12,14H,13,15-16H2,1-4H3,(H,27,31)
InChiKey: MCUWSNZALNNZFW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[5,7-dimethyl-6-[(4-methylphenyl)methyl]-1-oxo-pyrrolo[3,4-d]pyridazin-2-yl]-N-[(4-methoxyphenyl)methyl]acetamide
2-[5,7-dimethyl-6-[(4-methylphenyl)methyl]-1-oxo-2-pyrrolo[3,4-d]pyridazinyl]-N-[(4-methoxyphenyl)methyl]acetamide
2-[1-keto-5,7-dimethyl-6-(4-methylbenzyl)pyrrolo[3,4-d]pyridazin-2-yl]-N-(4-methoxybenzyl)acetamide
2-[5,7-dimethyl-6-[(4-methylphenyl)methyl]-1-oxo-pyrrolo[3,4-d]pyridazin-2-yl]-N-[(4-methoxyphenyl)methyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	allatostatin A receptor	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.8837	0.8837
Schistosoma mansoni	hypothetical protein	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0022	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.0021	0.8837	0.8294
Schistosoma mansoni	neuropeptide receptor	0.0021	0.8837	0.8837
Onchocerca volvulus	Cathepsin L homolog	0.0022	1	1
Brugia malayi	Cathepsin L-like precursor	0.0015	0.3182	0.3182
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0021	0.8837	0.8837
Echinococcus granulosus	neuropeptide receptor	0.0021	0.8837	0.8837
Brugia malayi	putative neuropeptide receptor NPR1	0.0021	0.8837	0.8837
Brugia malayi	hypothetical protein	0.0021	0.8837	0.8837
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0021	0.8837	0.8837
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.8837	0.8837
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0022	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0022	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	1	1
Echinococcus multilocularis	g-protein coupled receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	neuropeptide receptor A26	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.8837	0.8837
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.8837	0.8837
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0022	1	1
Onchocerca volvulus		0.0021	0.8837	0.8294
Echinococcus granulosus	g protein coupled receptor	0.0021	0.8837	0.8837
Echinococcus multilocularis	serotonin receptor	0.0021	0.8837	0.8837
Brugia malayi	neuropeptide F receptor	0.0021	0.8837	0.8837
Brugia malayi	hypothetical protein	0.0021	0.8837	0.8837
Schistosoma mansoni	myosin xvIII	0.0021	0.8837	0.8837
Brugia malayi	follicle stimulating hormone receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.8837	0.8837
Brugia malayi	sulfakinin receptor protein	0.0021	0.8837	0.8837
Onchocerca volvulus		0.0021	0.8837	0.8294
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.8837	0.8837
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Brugia malayi	ORL1-like opioid receptor	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.8837	0.8837
Brugia malayi	Melatonin receptor type 1A	0.0021	0.8837	0.8837
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Schistosoma mansoni	growth hormone secretagogue receptor	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Brugia malayi	G-protein coupled receptor	0.0021	0.8837	0.8837
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	1	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Brugia malayi	neuropeptide F receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0021	0.8837	0.8837
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus multilocularis	neuropeptide receptor A26	0.0021	0.8837	0.8837
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.8837	0.8837
Onchocerca volvulus		0.0022	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	1	1
Brugia malayi	hypothetical protein	0.0021	0.8837	0.8837
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0022	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0022	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.8837	0.8837
Trypanosoma cruzi	cruzipain precursor, putative	0.0022	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0015	0.3182	0.3182
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.8837	0.8837
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.8837	0.8837
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0022	1	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	1	1
Echinococcus multilocularis	sex peptide receptor	0.0021	0.8837	0.8837
Leishmania major	cathepsin L-like protease	0.0022	1	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0021	0.8837	0.8837
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Leishmania major	cathepsin L-like protease	0.0022	1	0.5
Brugia malayi	hypothetical protein	0.0021	0.8837	0.8837
Plasmodium vivax	vivapain-2	0.0022	1	1
Schistosoma mansoni	amine GPCR	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.8837	0.8294
Onchocerca volvulus		0.0021	0.8837	0.8294
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0021	0.8837	0.8837
Brugia malayi	Serotonin receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.8837	0.8837
Leishmania major	cathepsin L-like protease	0.0022	1	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0021	0.8837	0.8837
Echinococcus multilocularis	orexin receptor type 2	0.0021	0.8837	0.8837
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.8837	0.8837
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0021	0.8837	0.8837
Entamoeba histolytica	cysteine proteinase, putative	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0021	0.8837	0.8837
Onchocerca volvulus		0.0021	0.8837	0.8294
Schistosoma mansoni	amine GPCR	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0021	0.8837	0.8837
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Onchocerca volvulus		0.0021	0.8837	0.8294
Leishmania major	cathepsin L-like protease	0.0022	1	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0021	0.8837	0.8837
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.8837	0.8837
Schistosoma mansoni	biogenic amine receptor	0.0021	0.8837	0.8837
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0021	0.8837	0.8837
Plasmodium vivax	vivapain-2	0.0022	1	1
Schistosoma mansoni	neuropeptide receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	sex peptide receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	G protein coupled receptor 139	0.0021	0.8837	0.8837
Brugia malayi	hypothetical protein	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Schistosoma mansoni	neuropeptide receptor	0.0021	0.8837	0.8837
Brugia malayi	Dopamine receptor protein 1	0.0021	0.8837	0.8837
Onchocerca volvulus		0.0022	1	1
Schistosoma mansoni	amine GPCR	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.8837	0.8837
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.8837	0.8837
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.8837	0.8837
Onchocerca volvulus		0.0022	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0022	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0021	0.8837	0.8837
Leishmania major	cathepsin L-like protease	0.0022	1	0.5
Onchocerca volvulus		0.0021	0.8837	0.8294
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.8837	0.8837
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	fmrfamide receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	somatostatin receptor	0.0021	0.8837	0.8837
Schistosoma mansoni	biogenic amine receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	neuropeptide receptor	0.0021	0.8837	0.8837
Brugia malayi	hypothetical protein	0.0021	0.8837	0.8837
Schistosoma mansoni	biogenic amine receptor	0.0021	0.8837	0.8837
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0021	0.8837	0.8837
Brugia malayi	cathepsin L-like precursor	0.0015	0.3182	0.3182
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0021	0.8837	0.8294
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0021	0.8837	0.8294
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.8837	0.8294
Brugia malayi	Cathepsin L-like precursor	0.0015	0.3182	0.3182
Brugia malayi	Cathepsin L-like precursor	0.0022	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	1	1
Onchocerca volvulus		0.0022	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0021	0.8837	0.8837
Brugia malayi	hypothetical protein	0.0021	0.8837	0.8837
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.8837	0.8837
Echinococcus granulosus	serotonin receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	1	1
Onchocerca volvulus		0.0021	0.8837	0.8294
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.8837	0.8837
Echinococcus granulosus	dro:myosuppressin receptor	0.0021	0.8837	0.8837
Schistosoma mansoni	cathepsin F (C01 family)	0.0015	0.3182	0.3182
Brugia malayi	AKH receptor	0.0021	0.8837	0.8837
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	1	1
Onchocerca volvulus		0.0022	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0022	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0021	0.8837	0.8294
Entamoeba histolytica	cysteine proteinase, putative	0.0022	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Brugia malayi	hypothetical protein	0.0021	0.8837	0.8837
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0022	1	1
Brugia malayi	RE15519p	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Toxoplasma gondii	cathepsin CPL	0.0022	1	0.5
Leishmania major	cathepsin L-like protease	0.0022	1	0.5
Onchocerca volvulus		0.0021	0.8837	0.8294
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.8837	0.8837
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0021	0.8837	0.8837
Echinococcus multilocularis	serotonin receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.8837	0.8294
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0021	0.8837	0.8837
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0021	0.8837	0.8294
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0021	0.8837	0.8837
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Schistosoma mansoni	neuropeptide receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	7tm_1 domain containing protein	0.0021	0.8837	0.8837
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.8837	0.8837
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	1	1
Echinococcus granulosus	orexin receptor type 2	0.0021	0.8837	0.8837
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0015	0.3182	0.3182
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0021	0.8837	0.8837
Onchocerca volvulus		0.0021	0.8837	0.8294
Brugia malayi	larval opioid receptor	0.0021	0.8837	0.8837
Brugia malayi	G-protein coupled receptor	0.0021	0.8837	0.8837
Schistosoma mansoni	neuropeptide f receptor 76f	0.0021	0.8837	0.8837
Brugia malayi	Dopamine receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	1	1
Entamoeba histolytica	cysteine protease, putative	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus multilocularis	cysteine protease	0.0022	1	1
Schistosoma mansoni	opsin-like receptor	0.0021	0.8837	0.8837
Brugia malayi	Cathepsin L-like precursor	0.0022	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus granulosus	g protein coupled receptor	0.0021	0.8837	0.8837
Onchocerca volvulus		0.0022	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.3182	0.3182
Schistosoma mansoni	hypothetical protein	0.0021	0.8837	0.8837
Onchocerca volvulus		0.0021	0.8837	0.8294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.8837	0.8837
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	1	1
Brugia malayi	Dopamine receptor protein 2	0.0021	0.8837	0.8837
Onchocerca volvulus		0.0021	0.8837	0.8294
Onchocerca volvulus		0.0022	1	1
Onchocerca volvulus		0.0021	0.8837	0.8294
Loa Loa (eye worm)	fibroinase	0.0022	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Brugia malayi	Serotonin receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Loa Loa (eye worm)	melatonin receptor type 1A	0.0021	0.8837	0.8294
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.3182	0.3182
Brugia malayi	G protein-coupled receptor	0.0021	0.8837	0.8837
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Schistosoma mansoni	opsin-like receptor	0.0021	0.8837	0.8837
Onchocerca volvulus		0.0021	0.8837	0.8294
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus multilocularis	somatostatin receptor	0.0021	0.8837	0.8837
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.8837	0.8837
Echinococcus multilocularis	dro:myosuppressin receptor	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Echinococcus multilocularis	cysteine protease	0.0022	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	1	1
Echinococcus granulosus	cathepsin l1	0.0022	1	1
Brugia malayi	Cathepsin L-like precursor	0.0022	1	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0021	0.8837	0.8837
Schistosoma mansoni	histamine h1 receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Onchocerca volvulus	Cathepsin F homolog	0.0022	1	1
Echinococcus granulosus	g protein coupled receptor	0.0021	0.8837	0.8837
Leishmania major	cathepsin L-like protease	0.0022	1	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Schistosoma mansoni	hypothetical protein	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Loa Loa (eye worm)	ctsf protein	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.8837	0.8837
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0021	0.8837	0.8837
Onchocerca volvulus		0.0021	0.8837	0.8294
Echinococcus multilocularis	G protein coupled receptor 139	0.0021	0.8837	0.8837
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.8837	0.8837
Echinococcus granulosus	cathepsin l1	0.0015	0.3182	0.3182
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	1	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0021	0.8837	0.8294
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0021	0.8837	0.8294
Brugia malayi	hypothetical protein	0.0021	0.8837	0.8837
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	allatostatin A receptor	0.0021	0.8837	0.8837
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.8837	0.8837
Onchocerca volvulus		0.0021	0.8837	0.8294
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.8837	0.8837
Schistosoma mansoni	hypothetical protein	0.0021	0.8837	0.8837
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	1	1
Echinococcus granulosus	g-protein coupled receptor	0.0021	0.8837	0.8837
Schistosoma mansoni	adenoreceptor	0.0021	0.8837	0.8837
Schistosoma mansoni	amine GPCR	0.0021	0.8837	0.8837
Schistosoma mansoni	amine GPCR	0.0021	0.8837	0.8837
Brugia malayi	GnHR receptor homolog	0.0021	0.8837	0.8837
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.8837	0.8294
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Onchocerca volvulus		0.0021	0.8837	0.8294
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.8837	0.8837
Brugia malayi	putative neuropeptide receptor	0.0021	0.8837	0.8837
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.8837	0.8837
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.8837	0.8837
Loa Loa (eye worm)	cysteine protease	0.0022	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0021	0.8837	0.8837
Brugia malayi	Cathepsin L-like precursor	0.0022	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.8837	0.8837
Brugia malayi	Cathepsin L-like precursor	0.0022	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0021	0.8837	0.8294
Echinococcus granulosus	hypothetical protein	0.0021	0.8837	0.8837
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0021	0.8837	0.8837
Brugia malayi	hypothetical protein	0.0021	0.8837	0.8837
Leishmania major	cathepsin L-like protease	0.0022	1	0.5
Onchocerca volvulus		0.0021	0.8837	0.8294
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0021	0.8837	0.8837
Schistosoma mansoni	opsin-like receptor	0.0021	0.8837	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Loa Loa (eye worm)	hypothetical protein	0.0021	0.8837	0.8294
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0015	0.3182	0.3182

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 829584