Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0048 | 0.2138 |
Onchocerca volvulus | 0.0025 | 0.0048 | 0.5 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0048 | 0.0041 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0007 | 0.0007 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0615 | 0.3835 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1574 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0048 | 0.0041 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1574 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0048 | 0.0041 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0198 | 0.0151 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1574 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0615 | 0.3835 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0615 | 0.3835 | 0.3806 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.1044 | 0.0863 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1574 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0615 | 0.3835 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1574 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1574 | 1 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1574 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0615 | 0.3835 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0048 | 0.0041 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1574 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0615 | 0.3835 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0048 | 0.0041 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0007 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0615 | 0.3835 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0048 | 0.0048 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0615 | 0.3835 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0615 | 0.3835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0048 | 0.2138 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0615 | 0.3835 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0198 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1574 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1574 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0615 | 0.3835 | 1 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.1044 | 0.0863 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0048 | 0.0041 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0615 | 0.3835 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1574 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1574 | 1 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0048 | 0.0048 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0048 | 0.0041 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1574 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.018 | 0.1044 | 0.2325 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0048 | 0.0041 |
Echinococcus granulosus | geminin | 0.018 | 0.1044 | 0.2325 |
Leishmania major | dihydroorotate dehydrogenase | 0.1574 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0048 | 0.2138 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.