Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.0022 | 0.0248 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3939 | 0.3881 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0022 | 0.0248 | 0.0243 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0022 | 0.0248 | 0.0385 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0696 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2588 | 0.2533 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0022 | 0.0248 | 0.0243 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0082 | 0.3939 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0124 | 0.6437 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.3355 | 0.3306 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0124 | 0.6437 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3355 | 0.5212 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0093 | 0.002 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0696 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.3355 | 0.3292 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3355 | 0.5212 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0696 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0696 | 0.1081 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0696 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0022 | 0.0248 | 0.0243 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0124 | 0.6437 | 1 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0022 | 0.0248 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0248 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0082 | 0.3939 | 0.6119 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0082 | 0.3939 | 0.6119 |
Toxoplasma gondii | melibiase subfamily protein | 0.0124 | 0.6437 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0093 | 0.002 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0039 | 0.1301 | 0.1237 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0022 | 0.0248 | 0.0176 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3355 | 0.5212 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.7678 | 0.7661 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0124 | 0.6437 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0248 | 0.0156 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0022 | 0.0248 | 0.0243 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0022 | 0.0248 | 0.0243 |
Echinococcus multilocularis | Mastin | 0.0022 | 0.0248 | 0.0243 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0248 | 0.0385 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0248 | 0.0156 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1433 | 0.137 |
Brugia malayi | RNA binding protein | 0.0073 | 0.3355 | 0.3306 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0248 | 0.0385 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.3355 | 0.5142 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0093 | 0.0145 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2588 | 0.2533 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0039 | 0.1301 | 0.1219 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0124 | 0.6437 | 1 |
Brugia malayi | Melibiase family protein | 0.0082 | 0.3939 | 0.3894 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.1518 | 0.2359 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.7678 | 0.7656 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.3355 | 0.3306 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0696 | 0.5 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0248 | 0.0176 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 0.0248 | 0.0243 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0696 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0022 | 0.0248 | 0.0243 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0696 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3355 | 0.5212 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0093 | 0.0145 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0124 | 0.6437 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0022 | 0.0248 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0248 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0248 | 0.0156 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.3355 | 0.3292 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 0.0248 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0039 | 0.1301 | 0.1904 |
Echinococcus granulosus | Mastin | 0.0022 | 0.0248 | 0.0243 |
Loa Loa (eye worm) | trypsin family protein | 0.0022 | 0.0248 | 0.0156 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0039 | 0.1301 | 0.1904 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0022 | 0.0248 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0248 | 0.0156 |
Brugia malayi | Trypsin family protein | 0.0022 | 0.0248 | 0.0176 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2588 | 0.2518 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0989 | 0.0904 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.7678 | 0.7656 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0124 | 0.6437 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2588 | 0.2518 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0093 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1433 | 0.1353 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0696 | 0.0627 |
Echinococcus granulosus | enteropeptidase | 0.0022 | 0.0248 | 0.0243 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.1518 | 0.2359 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3355 | 0.5212 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0696 | 0.0608 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Brugia malayi | Trypsin family protein | 0.0022 | 0.0248 | 0.0176 |
Onchocerca volvulus | 0.0182 | 1 | 1 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.3355 | 0.3292 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1433 | 0.2227 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0022 | 0.0248 | 0.0385 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.3355 | 0.5142 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0093 | 0.0145 |
Brugia malayi | Trypsin family protein | 0.0022 | 0.0248 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0248 | 0.0156 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.