Detailed information for compound 829699

Basic information

Technical information
  • TDR Targets ID: 829699
  • Name: 3-[3-(4-bromophenyl)-5-methyl-7-oxopyrano[5,6 -f][1]benzoxol-6-yl]propanoic acid
  • MW: 427.245 | Formula: C21H15BrO5
  • H donors: 1 H acceptors: 3 LogP: 4.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCc1c(=O)oc2c(c1C)cc1c(c2)occ1c1ccc(cc1)Br
  • InChi: 1S/C21H15BrO5/c1-11-14(6-7-20(23)24)21(25)27-19-9-18-16(8-15(11)19)17(10-26-18)12-2-4-13(22)5-3-12/h2-5,8-10H,6-7H2,1H3,(H,23,24)
  • InChiKey: QCLNXCSEPQKIPZ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-[3-(4-bromophenyl)-5-methyl-7-oxo-pyrano[5,6-f]benzofuran-6-yl]propanoic acid
  • 3-[3-(4-bromophenyl)-5-methyl-7-oxo-6-pyrano[5,6-f]benzofuranyl]propanoic acid
  • 3-[3-(4-bromophenyl)-7-keto-5-methyl-pyrano[5,6-f]benzofuran-6-yl]propionic acid
  • 3-[3-(4-bromophenyl)-5-methyl-7-oxo-pyrano[5,6-f][1]benzoxol-6-yl]propanoic acid
  • STOCK1N-32669

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0112 0.1236 0.1756
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0263 0.3131 0.4464
Toxoplasma gondii proteasome subunit 0.0112 0.1236 0.1756
Schistosoma mansoni thyroid hormone receptor 0.0263 0.3131 0.4464
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0411 0.0587
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0571 0.7004 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0112 0.1236 0.1429
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0112 0.1236 0.123
Brugia malayi nuclear receptor NHR-88 0.0124 0.1385 0.1378
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0571 0.7004 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0185 0.0185
Echinococcus granulosus Proteasome subunit alpha type 7 0.0112 0.1236 0.1765
Loa Loa (eye worm) hypothetical protein 0.0176 0.2039 0.2039
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0263 0.3131 0.3125
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0112 0.1236 0.1756
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0229 0.0222
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0139 0.1572 0.1572
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0112 0.1236 0.123
Schistosoma mansoni nuclear receptor 0.0124 0.1385 0.1969
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0124 0.1385 0.1977
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0263 0.3131 0.3131
Brugia malayi nuclear receptor NHR-67 0.0124 0.1385 0.1378
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0112 0.1236 0.123
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0018 0.0058 0.0072
Giardia lamblia Proteasome subunit beta type 1 0.0444 0.5402 0.7711
Echinococcus granulosus thyroid hormone receptor alpha 0.0124 0.1385 0.1977
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.008 0.0086
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0139 0.1572 0.2236
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0112 0.1236 0.1756
Onchocerca volvulus Huntingtin homolog 0.0121 0.1346 0.3942
Brugia malayi Proteasome subunit alpha type 7-1 0.0112 0.1236 0.123
Schistosoma mansoni hypothetical protein 0.0494 0.6031 0.861
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0229 0.0222
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0112 0.1236 0.123
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0185 0.0254
Schistosoma mansoni hypothetical protein 0.0205 0.2397 0.3415
Toxoplasma gondii proteasome subunit beta type, putative 0.0571 0.7004 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0112 0.1236 0.1429
Loa Loa (eye worm) hypothetical protein 0.0124 0.1385 0.1385
Brugia malayi ABC transporter family protein 0.0016 0.0022 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0274 0.0267
Onchocerca volvulus 0.0093 0.0995 0.275
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0112 0.1236 0.1756
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0112 0.1236 0.123
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0112 0.1236 0.1756
Trypanosoma cruzi sterol C-24 reductase, putative 0.0018 0.0053 0.0046
Leishmania major proteasome beta 7 subunit, putative 0.0112 0.1236 0.123
Loa Loa (eye worm) PAS-3 protein 0.0112 0.1236 0.1236
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0263 0.3131 0.447
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0112 0.1236 0.1756
Plasmodium vivax proteasome subunit beta type-6, putative 0.0112 0.1236 0.1756
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0263 0.3131 1
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0112 0.1236 0.1765
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0139 0.1572 0.2236
Trypanosoma brucei ATP-binding cassette protein, putative 0.0018 0.0058 0.005
Echinococcus granulosus Nuclear hormone receptor HR96 0.0124 0.1385 0.1977
Plasmodium vivax proteasome subunit beta type-3, putative 0.0112 0.1236 0.1756
Echinococcus granulosus ATP binding cassette sub family G 0.0018 0.0058 0.0082
Loa Loa (eye worm) hypothetical protein 0.0263 0.3131 0.3131
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Loa Loa (eye worm) hypothetical protein 0.0263 0.3131 0.3131
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0674 0.0674
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0263 0.3131 0.3131
Mycobacterium ulcerans hypothetical protein 0.0154 0.1756 0.25
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0112 0.1236 0.1756
Schistosoma mansoni coup transcription factor 0.0263 0.3131 0.4464
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0094 0.0124
Brugia malayi nuclear hormone receptor 0.0124 0.1385 0.1378
Brugia malayi tailless protein 0.0124 0.1385 0.1378
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0112 0.1236 0.1697
Loa Loa (eye worm) hypothetical protein 0.0124 0.1385 0.1385
Leishmania major proteasome alpha 2 subunit, putative 0.0112 0.1236 0.123
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0112 0.1236 0.1765
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0411 0.0577
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0112 0.1236 0.1756
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0274 0.0312
Brugia malayi proteasome subunit alpha type 3 0.0112 0.1236 0.123
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0112 0.1236 0.1697
Loa Loa (eye worm) hypothetical protein 0.0077 0.0791 0.0791
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0112 0.1236 0.1236
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0112 0.1236 0.1756
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0185 0.0237
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0124 0.1385 0.1385
Schistosoma mansoni cpg binding protein 0.0035 0.0261 0.0363
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0112 0.1236 0.123
Brugia malayi nuclear hormone receptor family member odr-7 0.0124 0.1385 0.1378
Echinococcus multilocularis proteasome subunit alpha type 2 0.0112 0.1236 0.1765
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Loa Loa (eye worm) hypothetical protein 0.0121 0.1346 0.1346
Loa Loa (eye worm) hypothetical protein 0.0263 0.3131 0.3131
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0444 0.5402 0.7695
Toxoplasma gondii proteasome subunit alpha1, putative 0.0112 0.1236 0.1756
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0275 0.3281 0.4679
Schistosoma mansoni DNA polymerase eta 0.0077 0.0798 0.113
Loa Loa (eye worm) hypothetical protein 0.0139 0.1572 0.1572
Echinococcus multilocularis FTZ F1 alpha 0.0263 0.3131 0.447
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0263 0.3131 0.3125
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0094 0.0124
Brugia malayi steroid hormone receptor 0.0263 0.3131 0.3125
Trypanosoma cruzi C-8 sterol isomerase, putative 0.081 1 1
Toxoplasma gondii heat shock protein hslv, putative 0.0112 0.1236 0.1756
Trypanosoma brucei Emopamil binding protein, putative 0.0151 0.1726 0.172
Schistosoma mansoni nuclear hormone receptor 0.0263 0.3131 0.4464
Giardia lamblia 20S proteasome alpha subunit 7 0.0112 0.1236 0.1756
Trypanosoma brucei proteasome alpha 7 subunit 0.0112 0.1236 0.123
Echinococcus multilocularis proteasome subunit beta type 6 0.0112 0.1236 0.1765
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0185 0.0184
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0112 0.1236 0.123
Echinococcus granulosus ecdysone induced protein 78C 0.0263 0.3131 0.447
Schistosoma mansoni retinoic acid receptor RXR 0.0263 0.3131 0.4464
Echinococcus granulosus lamin dm0 0.0029 0.0187 0.0267
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0112 0.1236 0.1756
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0263 0.3131 0.3131
Giardia lamblia Proteasome subunit beta type 2 0.0275 0.3281 0.4679
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0112 0.1236 0.123
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0275 0.3281 0.4468
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0263 0.3131 0.3125
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0112 0.1236 0.123
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0275 0.3281 0.4679
Echinococcus granulosus geminin 0.0205 0.2397 0.3422
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0411 0.0404
Onchocerca volvulus Huntingtin homolog 0.0121 0.1346 0.3942
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0411 0.0404
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0112 0.1236 0.1429
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0274 0.0392
Loa Loa (eye worm) hypothetical protein 0.0124 0.1385 0.1385
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0263 0.3131 0.447
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.052 0.0742
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0112 0.1236 0.1756
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0444 0.5402 0.762
Echinococcus granulosus dna polymerase eta 0.0077 0.0798 0.1139
Echinococcus multilocularis proteasome subunit beta type 7 0.0112 0.1236 0.1765
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0112 0.1236 0.1756
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0112 0.1236 0.5
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0112 0.1236 0.1756
Schistosoma mansoni lamin 0.0029 0.0187 0.0257
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0341 0.0334
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0185 0.0178
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0274 0.0382
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0263 0.3131 0.3125
Giardia lamblia 20S proteasome alpha subunit 2 0.0112 0.1236 0.1756
Schistosoma mansoni zinc finger protein 0.0124 0.1385 0.1969
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0124 0.1385 0.4072
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0444 0.5402 0.5399
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0674 0.0674
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0112 0.1236 0.1429
Brugia malayi hypothetical protein 0.0121 0.1346 0.134
Brugia malayi GYF domain containing protein 0.0077 0.0791 0.0784
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0124 0.1385 0.1977
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.075 0.1061
Echinococcus multilocularis proteasome subunit alpha type 6 0.0112 0.1236 0.1765
Loa Loa (eye worm) hypothetical protein 0.0414 0.5026 0.5026
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0112 0.1236 0.1697
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0411 0.0561
Brugia malayi CXXC zinc finger family protein 0.0035 0.0261 0.0254
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0151 0.1726 0.172
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0263 0.3131 0.447
Loa Loa (eye worm) ABC transporter 0.0016 0.0022 0.0022
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0112 0.1236 0.1756
Giardia lamblia Proteasome subunit beta type 3 0.0112 0.1236 0.1756
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0263 0.3131 0.4464
Loa Loa (eye worm) RNA binding protein 0.0068 0.0674 0.0674
Brugia malayi nuclear receptor RXR 0.0124 0.1385 0.1378
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0275 0.3281 0.4685
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0112 0.1236 0.1756
Leishmania major DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Plasmodium falciparum proteasome subunit beta type-5 0.0571 0.7004 1
Loa Loa (eye worm) hypothetical protein 0.0263 0.3131 0.3131
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0112 0.1236 0.1756
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0124 0.1385 0.1977
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0263 0.3131 0.447
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0185 0.0178
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0112 0.1236 0.1697
Plasmodium falciparum proteasome subunit beta type-4 0.0112 0.1236 0.1756
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.3491 0.3487
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0341 0.0334
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0274 0.0392
Echinococcus granulosus lamin 0.0029 0.0187 0.0267
Loa Loa (eye worm) hypothetical protein 0.0029 0.0187 0.0187
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0341 0.0334
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0112 0.1236 0.1756
Trypanosoma brucei proteasome beta 7 subunit 0.0112 0.1236 0.123
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0112 0.1236 0.123
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Toxoplasma gondii hypothetical protein 0.0047 0.0417 0.0585
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0112 0.1236 0.1756
Echinococcus granulosus proteasome subunit alpha type 6 0.0112 0.1236 0.1765
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0112 0.1236 0.1756
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0274 0.0312
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0124 0.1385 0.1977
Echinococcus multilocularis nuclear receptor nhr 48 0.0124 0.1385 0.1977
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.156 0.1554
Onchocerca volvulus Protein ultraspiracle homolog 0.0263 0.3131 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0185 0.0237
Brugia malayi nuclear receptor NHR-88 0.0263 0.3131 0.3125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0263 0.3131 0.3131
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0112 0.1236 0.1756
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0263 0.3131 0.3125
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0263 0.3131 0.3125
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0798 0.0791
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1756 0.2487
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.052 0.0742
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0112 0.1236 0.1756
Echinococcus multilocularis geminin 0.0205 0.2397 0.3422
Brugia malayi Steroid receptor seven-up type 2 0.0263 0.3131 0.3125
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0112 0.1236 0.1765
Echinococcus granulosus proteasome subunit beta type 6 0.0112 0.1236 0.1765
Echinococcus granulosus proteasome subunit alpha type 2 0.0112 0.1236 0.1765
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0018 0.0058 0.0072
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0112 0.1236 0.1697
Giardia lamblia 20S proteasome alpha subunit 6 0.0112 0.1236 0.1756
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0341 0.0334
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0112 0.1236 0.1756
Loa Loa (eye worm) hypothetical protein 0.0263 0.3131 0.3131
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.1848 0.2639
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0112 0.1236 0.1236
Giardia lamblia ABC transporter 0.0018 0.0055 0.0068
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0112 0.1236 0.1756
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0185 0.0178
Loa Loa (eye worm) hypothetical protein 0.0077 0.0798 0.0798
Schistosoma mansoni alpha-glucosidase 0.0139 0.1566 0.2228
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0411 0.0577
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0112 0.1236 0.1765
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0454 0.0447
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0112 0.1236 0.1742
Brugia malayi nuclear hormone receptor 0.0263 0.3131 0.3125
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.3491 0.3487
Echinococcus granulosus proteasome subunit beta t family 0.0112 0.1236 0.1765
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0139 0.1572 0.2244
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1848 0.2639
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0112 0.1236 0.1697
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0185 0.0254
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0124 0.1385 0.1977
Schistosoma mansoni hypothetical protein 0.0015 0.002 0.0017
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.3491 0.3487
Schistosoma mansoni lamin 0.0029 0.0187 0.0257
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Schistosoma mansoni hypothetical protein 0.0205 0.2397 0.3415
Trypanosoma brucei C-14 sterol reductase, putative 0.0018 0.0053 0.0046
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0018 0.0058 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0263 0.3131 0.3131
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0112 0.1236 0.123
Brugia malayi intermediate filament protein 0.0029 0.0187 0.018
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0112 0.1236 0.123
Loa Loa (eye worm) hypothetical protein 0.0029 0.0185 0.0185
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0112 0.1236 0.123
Plasmodium vivax proteasome subunit beta type-4, putative 0.0112 0.1236 0.1756
Leishmania major hypothetical protein, conserved 0.0151 0.1726 0.172
Brugia malayi RNA binding protein 0.0068 0.0674 0.0667
Brugia malayi ecdysone receptor 0.0124 0.1385 0.1378
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0151 0.1726 0.172
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0263 0.3131 0.447
Brugia malayi conserved hypotetical protein 0.0124 0.1385 0.1378
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0275 0.3281 0.4679
Loa Loa (eye worm) hypothetical protein 0.0139 0.1572 0.1572
Loa Loa (eye worm) hypothetical protein 0.081 1 1
Leishmania major C-8 sterol isomerase-like protein 0.081 1 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0112 0.1236 0.123
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0674 0.0963
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0112 0.1236 0.1236
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0444 0.5402 0.7714
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0112 0.1236 0.1765
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0263 0.3131 0.3131
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0112 0.1236 0.1429
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0263 0.3131 0.3125
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0263 0.3131 0.3125
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0112 0.1236 0.1756
Onchocerca volvulus 0.0263 0.3131 1
Echinococcus multilocularis dna polymerase eta 0.0077 0.0798 0.1139
Onchocerca volvulus 0.0035 0.0261 0.0258
Leishmania major proteasome alpha 1 subunit, putative 0.0112 0.1236 0.123
Trypanosoma brucei unspecified product 0.0032 0.0229 0.0222
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0112 0.1236 0.1697
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0674 0.0953
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0112 0.1236 0.1697
Leishmania major proteasome beta 5 subunit, putative 0.0571 0.7004 0.7001
Schistosoma mansoni nuclear hormone receptor 0.0124 0.1385 0.1969
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0274 0.0267
Onchocerca volvulus 0.0151 0.1726 0.5231
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0263 0.3131 0.4464
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0263 0.3131 0.4464
Brugia malayi Nuclear hormone receptor-like 1 0.0139 0.1572 0.1565
Brugia malayi hypothetical protein 0.0139 0.1572 0.1565
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0112 0.1236 0.1756
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0112 0.1236 0.1756
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0112 0.1236 0.1236
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0112 0.1236 0.1697
Trypanosoma brucei ABC transporter, putative 0.0018 0.0058 0.005
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0112 0.1236 0.123
Loa Loa (eye worm) hypothetical protein 0.0263 0.3131 0.3131
Plasmodium vivax proteasome subunit beta type-1, putative 0.0444 0.5402 0.7711
Plasmodium falciparum ABC transporter G family member 2 0.0018 0.0058 0.0072
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0112 0.1236 0.1429
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0571 0.7004 0.7001
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0018 0.0058 0.005
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0124 0.1385 0.1378
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0185 0.0184
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0018 0.0058 0.0072
Echinococcus granulosus FTZ F1 alpha 0.0263 0.3131 0.447
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0185 0.0254
Schistosoma mansoni intermediate filament proteins 0.0029 0.0187 0.0257
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0275 0.3281 0.3276
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.008 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0263 0.3131 0.3125
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0571 0.7004 1
Echinococcus granulosus ATP binding cassette sub family G 0.0018 0.0058 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0112 0.1236 0.1756
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.052 0.0732
Brugia malayi nuclear hormone receptor family member nhr-6 0.0124 0.1385 0.1378
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0112 0.1236 0.123
Loa Loa (eye worm) proteasome subunit beta type 2 0.0275 0.3281 0.3281
Brugia malayi Nuclear hormone receptor E75 0.0124 0.1385 0.1378
Leishmania major proteasome alpha 7 subunit, putative 0.0112 0.1236 0.123
Onchocerca volvulus Notchless protein homolog 0.0112 0.1236 0.3568
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0112 0.1236 0.123
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0411 0.0509
Onchocerca volvulus 0.0124 0.1385 0.4072
Giardia lamblia 20S proteasome alpha subunit 5 0.0112 0.1236 0.1756
Brugia malayi Nuclear hormone receptor-like 1 0.0263 0.3131 0.3125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0124 0.1385 0.1977
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Echinococcus granulosus proteasome subunit beta type 7 0.0112 0.1236 0.1765
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0112 0.1236 0.123
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0112 0.1236 0.1765
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.1848 0.1848
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0263 0.3131 0.447
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0411 0.0587
Loa Loa (eye worm) nuclear hormone receptor 0.0124 0.1385 0.1385
Brugia malayi Proteasome A-type and B-type family protein 0.0571 0.7004 0.7001
Loa Loa (eye worm) hypothetical protein 0.0124 0.1385 0.1385
Loa Loa (eye worm) hypothetical protein 0.0124 0.1385 0.1385
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0112 0.1236 0.1756
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0651 0.092
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0411 0.0561
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0263 0.3131 0.447
Echinococcus granulosus dnaJ subfamily B 0.0494 0.6031 0.8612
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0112 0.1236 0.1429
Trypanosoma brucei proteasome beta 6 subunit 0.0444 0.5402 0.5399
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0112 0.1236 0.123
Leishmania major sterol C-24 reductase, putative 0.0018 0.0053 0.0046
Loa Loa (eye worm) hypothetical protein 0.0124 0.1385 0.1385
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0112 0.1236 0.123
Leishmania major proteasome alpha 7 subunit, putative 0.0112 0.1236 0.123
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0571 0.7004 0.7004
Brugia malayi Nuclear hormone receptor E75 0.0124 0.1385 0.1378
Trypanosoma brucei unspecified product 0.0032 0.0229 0.0222
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.008 0.0086
Brugia malayi ecdysteroid receptor 0.0263 0.3131 0.3125
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0112 0.1236 0.1429
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0674 0.0953
Schistosoma mansoni RAR-like nuclear receptor 0.0263 0.3131 0.4464
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0261 0.0261
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.052 0.0513
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0112 0.1236 0.1697
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0263 0.3131 0.3125
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0185 0.0254
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0018 0.0058 0.0072
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0112 0.1236 0.1697
Leishmania major proteasome beta-1 subunit, putative 0.0112 0.1236 0.123
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0112 0.1236 0.123
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0112 0.1236 0.123
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Brugia malayi Proteasome A-type and B-type family protein 0.0112 0.1236 0.123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.052 0.0742
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.052 0.0742
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0674 0.0953
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0444 0.5402 0.7711
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0112 0.1236 0.123
Leishmania major DNA polymerase eta, putative 0.0045 0.0394 0.0387
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0274 0.0267
Trypanosoma cruzi Emopamil binding protein, putative 0.0151 0.1726 0.172
Brugia malayi 20S proteasome alpha5 subunit 0.0112 0.1236 0.123
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0444 0.5402 0.7711
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.052 0.0732
Mycobacterium ulcerans proteasome PrcB 0.0571 0.7004 1
Giardia lamblia 20S proteasome alpha subunit 4 0.0112 0.1236 0.1756
Echinococcus multilocularis ATP binding cassette sub family G 0.0018 0.0058 0.0082
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0185 0.0184
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0571 0.7004 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0185 0.0178
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0571 0.7004 0.7001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0263 0.3131 0.3125
Schistosoma mansoni cpg binding protein 0.0037 0.0286 0.0399
Loa Loa (eye worm) hypothetical protein 0.0029 0.0185 0.0185
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0263 0.3131 0.447
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0094
Brugia malayi Proteasome A-type and B-type family protein 0.0112 0.1236 0.123
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0112 0.1236 0.1756
Brugia malayi Proteasome A-type and B-type family protein 0.0112 0.1236 0.123
Loa Loa (eye worm) hypothetical protein 0.0139 0.1572 0.1572
Plasmodium vivax ABC transporter G family member 2, putative 0.0018 0.0058 0.0072
Echinococcus multilocularis musashi 0.0029 0.0187 0.0267
Giardia lamblia 20S proteasome alpha subunit 3 0.0112 0.1236 0.1756
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0187 0.0187
Giardia lamblia DINP protein human, muc B family 0.0047 0.0411 0.0577
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0112 0.1236 0.1697
Loa Loa (eye worm) hypothetical protein 0.0139 0.1572 0.1572
Loa Loa (eye worm) hypothetical protein 0.0263 0.3131 0.3131
Plasmodium vivax proteasome subunit beta type-7, putative 0.0112 0.1236 0.1756
Echinococcus granulosus Nuclear hormone receptor HR96 0.0124 0.1385 0.1977
Echinococcus multilocularis ecdysone induced protein 78C 0.0263 0.3131 0.447
Plasmodium vivax proteasome subunit beta type-5, putative 0.0571 0.7004 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0112 0.1236 0.123
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1848 0.2639
Toxoplasma gondii proteasome subunit alpha type, putative 0.0112 0.1236 0.1756
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0112 0.1236 0.123
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0229 0.0222
Trypanosoma brucei glucosidase, putative 0.0036 0.0274 0.0267
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0571 0.7004 0.7001
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0112 0.1236 0.1765
Onchocerca volvulus 0.0077 0.0791 0.2057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.052 0.052
Schistosoma mansoni ABC transporter 0.0016 0.0022 0.0021
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0124 0.1385 0.1385
Brugia malayi Nuclear hormone receptor-like 1 0.0139 0.1572 0.1565
Loa Loa (eye worm) hypothetical protein 0.0124 0.1385 0.1385
Echinococcus multilocularis lamin 0.0029 0.0187 0.0267
Loa Loa (eye worm) steroid hormone receptor 0.0263 0.3131 0.3131
Loa Loa (eye worm) hypothetical protein 0.0124 0.1385 0.1385
Loa Loa (eye worm) hypothetical protein 0.0124 0.1385 0.1385
Mycobacterium ulcerans proteasome PrcA 0.0112 0.1236 0.1756
Leishmania major DNA polymerase eta, putative 0.0077 0.0798 0.0791
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0094
Echinococcus multilocularis proteasome (prosome, macropain) 0.0571 0.7004 1
Trypanosoma cruzi C-14 sterol reductase, putative 0.0018 0.0053 0.0046
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0112 0.1236 0.1765
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0411 0.0411
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0112 0.1236 0.123
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0263 0.3131 0.3125
Leishmania major proteasome alpha 3 subunit, putative 0.0112 0.1236 0.123
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0444 0.5402 0.5399
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0275 0.3281 0.3276
Trypanosoma cruzi ABC transporter, putative 0.0018 0.0058 0.005
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0112 0.1236 0.1541
Echinococcus granulosus dna polymerase kappa 0.0047 0.0411 0.0587
Schistosoma mansoni cpg binding protein 0.0037 0.0286 0.0399
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0112 0.1236 0.123
Brugia malayi proteasome subunit alpha type 6 0.0112 0.1236 0.123
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0275 0.3281 0.4679
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0411 0.0587
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0275 0.3281 0.4641
Toxoplasma gondii proteasome beta subunit 0.0112 0.1236 0.1756
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0411 0.0404
Giardia lamblia 20S proteasome alpha subunit 1 0.0112 0.1236 0.1756
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.6031 0.8612
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0263 0.3131 0.3131
Brugia malayi nuclear receptor RXR 0.0139 0.1572 0.1565
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0274 0.0267
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0185 0.0254
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0411 0.0404
Echinococcus granulosus proteasome prosome macropain 0.0571 0.7004 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0019 0.0019
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.156 0.1554
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0263 0.3131 0.447
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.008 0.0086
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0112 0.1236 0.123
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0571 0.7004 1
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0094 0.0124
Loa Loa (eye worm) hypothetical protein 0.0263 0.3131 0.3131
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0185 0.0254
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0124 0.1385 0.1969
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0112 0.1236 0.1236
Brugia malayi orphan nuclear receptor NR2E1 0.0124 0.1385 0.1378
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0112 0.1236 0.1756
Trypanosoma cruzi Emopamil binding protein, putative 0.0151 0.1726 0.172
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0112 0.1236 0.123
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0112 0.1236 0.123
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0124 0.1385 0.1969
Echinococcus multilocularis cpg binding protein 0.0037 0.0286 0.0409
Echinococcus granulosus ATP binding cassette sub family G 0.0018 0.0058 0.0082
Loa Loa (eye worm) nuclear receptor NHR-67 0.0124 0.1385 0.1385
Brugia malayi hypothetical protein 0.0124 0.1385 0.1378
Trypanosoma cruzi C-14 sterol reductase, putative 0.0018 0.0053 0.0046
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0112 0.1236 0.1756
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0112 0.1236 0.1765
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0112 0.1236 0.1756
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0151 0.1726 0.172
Brugia malayi proteasome subunit alpha type 2 0.0112 0.1236 0.123
Leishmania major proteasome beta 2 subunit, putative 0.0275 0.3281 0.3276
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0112 0.1236 0.123
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0263 0.3131 0.447
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0263 0.3131 0.447
Schistosoma mansoni thyroid hormone receptor 0.0263 0.3131 0.4464
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0112 0.1236 0.123
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0112 0.1236 0.123
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0094 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0185 0.0254
Brugia malayi proteasome subunit beta type 1 0.0444 0.5402 0.5399
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0112 0.1236 0.1429
Brugia malayi Proteasome subunit alpha type 1 0.0112 0.1236 0.123
Leishmania major proteasome beta 3 subunit, putative 0.0112 0.1236 0.123
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0411 0.0203
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.156 0.1554
Brugia malayi hypothetical protein 0.0139 0.1572 0.1565
Echinococcus multilocularis ATP binding cassette sub family G 0.0018 0.0058 0.0082
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0112 0.1236 0.1697
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0263 0.3131 0.4464
Echinococcus multilocularis lamin dm0 0.0029 0.0187 0.0267
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0112 0.1236 0.123
Loa Loa (eye worm) hypothetical protein 0.0124 0.1385 0.1385
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0275 0.3281 0.4685
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0112 0.1236 0.1756
Trypanosoma cruzi 20S proteasome subunit 0.0275 0.3281 0.3276
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0112 0.1236 0.1236
Brugia malayi proteasome subunit alpha type 1 0.0112 0.1236 0.123
Echinococcus granulosus cpg binding protein 0.0037 0.0286 0.0409
Loa Loa (eye worm) proteasome subunit beta type 3 0.0112 0.1236 0.1236
Trypanosoma brucei unspecified product 0.0047 0.0411 0.0404
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0263 0.3131 0.447
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0112 0.1236 0.123
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0112 0.1236 0.1756
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0444 0.5402 0.7711
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0112 0.1236 0.1236
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0571 0.7004 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.3491 0.3487
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0263 0.3131 0.447
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0112 0.1236 0.1697
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0019 0.0012
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0112 0.1236 0.1236
Echinococcus multilocularis lamin b receptor 0.0018 0.0053 0.0076
Toxoplasma gondii peptidase, T1 family protein 0.0112 0.1236 0.1756
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0112 0.1236 0.123
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.1848 0.1842
Schistosoma mansoni Lamin B receptor (ERG24) 0.0018 0.0053 0.0065
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0112 0.1236 0.1756
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0112 0.1236 0.1765
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0798 0.0791
Onchocerca volvulus 0.0029 0.0187 0.0006
Plasmodium vivax proteasome subunit beta type-2, putative 0.0275 0.3281 0.4679
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0187 0.0187
Brugia malayi photoreceptor-specific nuclear receptor 0.0263 0.3131 0.3125
Schistosoma mansoni nuclear hormone receptor 0.0124 0.1385 0.1969
Loa Loa (eye worm) DR-78 0.0124 0.1385 0.1385
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0798 0.0791
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0275 0.3281 0.4468
Loa Loa (eye worm) hypothetical protein 0.0121 0.1346 0.1346
Schistosoma mansoni alpha-glucosidase 0.0139 0.1566 0.2228
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0263 0.3131 0.3125
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0394 0.0387
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0444 0.5402 0.7714
Brugia malayi proteasome subunit alpha type 4 0.0112 0.1236 0.123
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0444 0.5402 0.5399
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0411 0.0203
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0411 0.0577
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0185 0.0178
Brugia malayi TAR-binding protein 0.0068 0.0674 0.0667
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0112 0.1236 0.1756
Leishmania major proteasome beta 2 subunit, putative 0.0112 0.1236 0.123
Schistosoma mansoni nuclear receptor nhr-48 0.0124 0.1385 0.1969
Loa Loa (eye worm) hypothetical protein 0.0124 0.1385 0.1385
Loa Loa (eye worm) hypothetical protein 0.0073 0.0741 0.0741
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Loa Loa (eye worm) proteasome subunit beta type 1 0.0444 0.5402 0.5402
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0112 0.1236 0.1756
Brugia malayi hypothetical protein 0.0124 0.1385 0.1378
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0124 0.1385 0.4072
Onchocerca volvulus Bile acid receptor homolog 0.0263 0.3131 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0124 0.1385 0.1977
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0411 0.0404
Echinococcus granulosus nuclear receptor nhr 48 0.0124 0.1385 0.1977
Loa Loa (eye worm) hypothetical protein 0.0139 0.1572 0.1572
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0112 0.1236 0.1429
Mycobacterium ulcerans hypothetical protein 0.0029 0.0185 0.0254
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0018 0.0058 0.005
Echinococcus granulosus intermediate filament protein 0.0029 0.0187 0.0267
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0674 0.0953
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0112 0.1236 0.1756
Echinococcus multilocularis thyroid hormone receptor alpha 0.0263 0.3131 0.447
Schistosoma mansoni alpha glucosidase 0.0036 0.0274 0.0382
Echinococcus multilocularis ATP binding cassette sub family G 0.0018 0.0058 0.0082
Leishmania major proteasome alpha 1 subunit, putative 0.0112 0.1236 0.123
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0112 0.1236 0.123
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0112 0.1236 0.1236
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0674 0.0667
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0112 0.1236 0.123
Echinococcus granulosus tar DNA binding protein 0.0068 0.0674 0.0963
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0112 0.1236 0.1756
Schistosoma mansoni nuclear receptor 0.0124 0.1385 0.1969
Trypanosoma brucei C-8 sterol isomerase, putative 0.081 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.018 0.018
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0112 0.1236 0.1429
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.052 0.0732
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0112 0.1236 0.1756
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0112 0.1236 0.123
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0139 0.1572 0.2244
Trypanosoma cruzi sterol C-24 reductase, putative 0.0018 0.0053 0.0046
Echinococcus granulosus subfamily T1A non peptidase ue 0.0112 0.1236 0.1765
Onchocerca volvulus 0.0029 0.0187 0.0006
Loa Loa (eye worm) hypothetical protein 0.0124 0.1385 0.1385
Brugia malayi proteasome subunit beta type 2 0.0275 0.3281 0.3276
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0112 0.1236 0.1429
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0112 0.1236 0.1756
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0674 0.0953
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0112 0.1236 0.1756
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0274 0.0274
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0187 0.018
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0112 0.1236 0.1765
Schistosoma mansoni steroid hormone receptor ad4bp 0.0263 0.3131 0.4464
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0094
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0112 0.1236 0.1697
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0185 0.0178
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0263 0.3131 0.4464
Leishmania major C-14 sterol reductase, putative 0.0018 0.0053 0.0046
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0394 0.0552
Brugia malayi proteasome subunit beta type 3 0.0112 0.1236 0.123
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0112 0.1236 0.1697
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0411 0.0577
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0411 0.0404
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0112 0.1236 0.1765
Echinococcus granulosus Proteasome subunit alpha beta 0.0112 0.1236 0.1765
Onchocerca volvulus 0.0124 0.1385 0.4072
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0018 0.0058 0.0072
Echinococcus granulosus lamin b receptor 0.0018 0.0053 0.0076
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0094 0.0107

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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