Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0448 | 0.7352 | 0.7224 |
Loa Loa (eye worm) | proteasome subunit alpha type 1 | 0.0113 | 0.0461 | 0.0461 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0577 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0448 | 0.7352 | 0.7224 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0278 | 0.3843 | 0.3843 |
Loa Loa (eye worm) | proteasome subunit alpha type 2 | 0.0113 | 0.0461 | 0.0461 |
Mycobacterium ulcerans | proteasome PrcB | 0.0577 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0278 | 0.3843 | 0.3546 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0113 | 0.0461 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0278 | 0.3843 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0278 | 0.3843 | 0.3546 |
Brugia malayi | proteasome subunit beta type 3 | 0.0113 | 0.0461 | 0.0461 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0278 | 0.3843 | 0.3546 |
Loa Loa (eye worm) | 20S proteasome alpha5 subunit | 0.0113 | 0.0461 | 0.0461 |
Brugia malayi | Proteasome subunit alpha type 7-1 | 0.0113 | 0.0461 | 0.0461 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0278 | 0.3843 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0577 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0577 | 1 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0113 | 0.0461 | 0.0461 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0278 | 0.3843 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0577 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0448 | 0.7352 | 0.7224 |
Brugia malayi | proteasome subunit beta type 2 | 0.0278 | 0.3843 | 0.3843 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0278 | 0.3843 | 0.3546 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0448 | 0.7352 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0577 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0448 | 0.7352 | 0.7224 |
Brugia malayi | Proteasome subunit alpha type 1 | 0.0113 | 0.0461 | 0.0461 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0113 | 0.0461 | 0.0461 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0448 | 0.7352 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0577 | 1 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0113 | 0.0461 | 0.0461 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0577 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0448 | 0.7352 | 0.7352 |
Brugia malayi | proteasome subunit alpha type 2 | 0.0113 | 0.0461 | 0.0461 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0577 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0577 | 1 | 1 |
Onchocerca volvulus | Notchless protein homolog | 0.0113 | 0.0461 | 1 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0448 | 0.7352 | 0.7224 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0448 | 0.7352 | 0.7224 |
Loa Loa (eye worm) | proteasome subunit alpha type 3 | 0.0113 | 0.0461 | 0.0461 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0278 | 0.3843 | 0.3546 |
Brugia malayi | proteasome subunit alpha type 3 | 0.0113 | 0.0461 | 0.0461 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0577 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0577 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit alpha type 7-1 | 0.0113 | 0.0461 | 0.0461 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0448 | 0.7352 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0278 | 0.3843 | 0.3546 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0113 | 0.0461 | 0.0461 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0448 | 0.7352 | 0.7224 |
Brugia malayi | proteasome subunit beta type 1 | 0.0448 | 0.7352 | 0.7352 |
Brugia malayi | proteasome subunit alpha type 6 | 0.0113 | 0.0461 | 0.0461 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0278 | 0.3843 | 0.3546 |
Loa Loa (eye worm) | proteasome subunit beta type 3 | 0.0113 | 0.0461 | 0.0461 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0278 | 0.3843 | 0.3546 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0577 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0577 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0577 | 1 | 1 |
Brugia malayi | 20S proteasome alpha5 subunit | 0.0113 | 0.0461 | 0.0461 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0448 | 0.7352 | 0.7224 |
Brugia malayi | proteasome subunit alpha type 1 | 0.0113 | 0.0461 | 0.0461 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0278 | 0.3843 | 0.3546 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0113 | 0.0461 | 0.0461 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0278 | 0.3843 | 0.3546 |
Brugia malayi | proteasome subunit alpha type 4 | 0.0113 | 0.0461 | 0.0461 |
Loa Loa (eye worm) | proteasome subunit alpha type 6 | 0.0113 | 0.0461 | 0.0461 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0577 | 1 | 1 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0448 | 0.7352 | 0.7224 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0577 | 1 | 1 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0278 | 0.3843 | 0.3546 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0113 | 0.0461 | 0.0461 |
Loa Loa (eye worm) | PAS-3 protein | 0.0113 | 0.0461 | 0.0461 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0278 | 0.3843 | 0.3546 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0448 | 0.7352 | 0.7224 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.