Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.3543 | 0.3543 |
Onchocerca volvulus | 0.005 | 0.1054 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0221 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0164 | 0.0248 |
Brugia malayi | hypothetical protein | 0.002 | 0.0164 | 0.0248 |
Schistosoma mansoni | loxhd1 | 0.002 | 0.0164 | 0.0164 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0022 | 0.0221 | 0.0221 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0164 | 0.0164 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0164 | 0.0164 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0135 | 0.5 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0164 | 0.0164 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0022 | 0.0221 | 0.0221 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0164 | 0.0164 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0022 | 0.0221 | 0.0221 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.3543 | 0.3543 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0221 | 0.0334 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0132 | 0.3543 | 0.536 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 0.3543 | 0.536 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0022 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | abnormal epIthelia family member | 0.0023 | 0.0254 | 0.0385 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0135 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0132 | 0.3543 | 0.3543 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0023 | 0.0254 | 0.0254 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0135 | 0.0135 |
Brugia malayi | laminin-like protein K08C7.3 precursor | 0.0023 | 0.0254 | 0.0385 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0221 | 0.0221 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0221 | 0.0334 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0221 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0254 | 0.0385 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.002 | 0.0164 | 0.0164 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.002 | 0.0164 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0135 | 0.5 |
Loa Loa (eye worm) | doublecortin family protein | 0.002 | 0.0164 | 0.0248 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0022 | 0.0221 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0221 | 0.0334 |
Leishmania major | squalene monooxygenase-like protein | 0.0164 | 0.4528 | 1 |
Brugia malayi | Thrombospondin N-terminal -like domain containing protein | 0.0023 | 0.0254 | 0.0385 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0221 | 0.0334 |
Echinococcus multilocularis | RUN | 0.002 | 0.0164 | 0.0164 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0022 | 0.0221 | 0.0221 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0221 | 0.0221 |
Echinococcus granulosus | RUN | 0.002 | 0.0164 | 0.0164 |
Schistosoma mansoni | cell polarity protein | 0.0023 | 0.0254 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.3543 | 0.536 |
Schistosoma mansoni | lipoxygenase | 0.002 | 0.0164 | 0.0164 |
Schistosoma mansoni | polycystin 1-related | 0.002 | 0.0164 | 0.0164 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0221 | 0.0334 |
Brugia malayi | hypothetical protein | 0.002 | 0.0164 | 0.0248 |
Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.0221 | 0.0334 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0164 | 0.4528 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.034 | 0.9851 | 0.9851 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0164 | 0.4528 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0135 | 0.0205 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0233 | 0.6609 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0233 | 0.6609 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0254 | 0.0385 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.3543 | 0.3543 |
Schistosoma mansoni | chondroitin sulfate proteoglycan-related | 0.0023 | 0.0254 | 0.0254 |
Brugia malayi | laminin alpha chain | 0.0023 | 0.0254 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0221 | 0.0334 |
Brugia malayi | Doublecortin family protein | 0.002 | 0.0164 | 0.0248 |
Schistosoma mansoni | gliotactin | 0.0022 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | carboxylesterase | 0.0132 | 0.3543 | 0.536 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0221 | 0.0334 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0022 | 0.0221 | 0.0221 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0135 | 0.0205 |
Onchocerca volvulus | 0.0022 | 0.0221 | 0.2095 | |
Onchocerca volvulus | 0.002 | 0.0164 | 0.1555 | |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0057 | 0.1277 | 0.1277 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0.0221 | 1 |
Echinococcus multilocularis | slit 2 protein | 0.0023 | 0.0254 | 0.0254 |
Onchocerca volvulus | 0.0022 | 0.0221 | 0.2095 | |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0221 | 0.0334 |
Schistosoma mansoni | acetylcholinesterase | 0.0022 | 0.0221 | 0.0221 |
Echinococcus granulosus | slit 2 protein | 0.0023 | 0.0254 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.3543 | 0.536 |
Onchocerca volvulus | 0.0022 | 0.0221 | 0.2095 | |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.1054 | 0.1054 |
Schistosoma mansoni | lipoxygenase | 0.0057 | 0.1277 | 0.1277 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0023 | 0.0254 | 0.0254 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0022 | 0.0221 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0135 | 0.0135 |
Onchocerca volvulus | 0.002 | 0.0164 | 0.1555 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0022 | 0.0221 | 0.0221 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 0.3543 | 0.536 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0057 | 0.1277 | 0.1277 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0132 | 0.3543 | 0.3543 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0221 | 0.0221 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0135 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0135 | 0.0135 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.3543 | 0.3543 |
Echinococcus granulosus | carboxylesterase 5A | 0.0132 | 0.3543 | 0.3543 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0022 | 0.0221 | 0.0221 |
Onchocerca volvulus | 0.0022 | 0.0221 | 0.2095 | |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0254 | 0.0385 |
Echinococcus multilocularis | pikachurin | 0.0023 | 0.0254 | 0.0254 |
Onchocerca volvulus | 0.0022 | 0.0221 | 0.2095 | |
Echinococcus granulosus | pikachurin | 0.0023 | 0.0254 | 0.0254 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0.0221 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1054 | 0.1594 |
Echinococcus granulosus | neuroligin | 0.0022 | 0.0221 | 0.0221 |
Plasmodium falciparum | LCCL domain-containing protein | 0.002 | 0.0164 | 1 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0164 | 0.4528 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.002 | 0.0164 | 0.0164 |
Brugia malayi | EGF-like domain containing protein | 0.0023 | 0.0254 | 0.0385 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0221 | 0.0334 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0022 | 0.0221 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.034 | 0.9851 | 0.9851 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0221 | 0.0334 |
Echinococcus multilocularis | neuroligin | 0.0022 | 0.0221 | 0.0221 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0023 | 0.0254 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0164 | 0.0248 |
Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.0221 | 0.0334 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0164 | 0.0164 |
Echinococcus multilocularis | geminin | 0.0345 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0022 | 0.0221 | 1 |
Schistosoma mansoni | slit | 0.0023 | 0.0254 | 0.0254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.