Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.1062 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0049 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.1062 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.1062 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.3135 | 0.2319 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.3135 | 0.2319 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.1062 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0049 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.3135 | 0.2319 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3135 | 0.2319 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.1062 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.1062 | 0.1062 |
Echinococcus granulosus | dna polymerase eta | 0.0049 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0035 | 0.533 | 0.4775 |
Echinococcus multilocularis | dna polymerase eta | 0.0049 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.1062 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.1062 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.1062 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0.3135 | 0.3135 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.3135 | 0.2319 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.3135 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0035 | 0.533 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0035 | 0.533 | 0.4775 |
Schistosoma mansoni | DNA polymerase eta | 0.0049 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.3135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0049 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.3135 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.