Detailed information for compound 830369

Basic information

Technical information
  • TDR Targets ID: 830369
  • Name: N-[3-(butyl-ethylamino)propyl]-2-[5-[(4-fluor ophenyl)methyl]-4-oxopyridazino[5,4-b]indol-3 -yl]acetamide
  • MW: 491.6 | Formula: C28H34FN5O2
  • H donors: 1 H acceptors: 2 LogP: 4.35 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(CCCNC(=O)Cn1ncc2c(c1=O)n(Cc1ccc(cc1)F)c1c2cccc1)CC
  • InChi: 1S/C28H34FN5O2/c1-3-5-16-32(4-2)17-8-15-30-26(35)20-34-28(36)27-24(18-31-34)23-9-6-7-10-25(23)33(27)19-21-11-13-22(29)14-12-21/h6-7,9-14,18H,3-5,8,15-17,19-20H2,1-2H3,(H,30,35)
  • InChiKey: CWIDANQBVKCYPI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(butyl-ethyl-amino)propyl]-2-[5-[(4-fluorophenyl)methyl]-4-oxo-pyridazino[5,4-b]indol-3-yl]acetamide
  • N-[3-(butyl-ethylamino)propyl]-2-[5-[(4-fluorophenyl)methyl]-4-oxo-3-pyridazino[5,4-b]indolyl]acetamide
  • N-[3-(butyl-ethyl-amino)propyl]-2-[5-(4-fluorobenzyl)-4-keto-pyridazino[5,4-b]indol-3-yl]acetamide
  • N-[3-(butyl-ethyl-amino)propyl]-2-[5-[(4-fluorophenyl)methyl]-4-oxo-pyridazino[5,4-b]indol-3-yl]ethanamide
  • C880-2333
  • NCGC00114032-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0062 0.0014 0.0014
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0062 0.0014 0.0021
Trichomonas vaginalis AGC family protein kinase 0.2133 1 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0711 0.3139 0.4723
Echinococcus multilocularis serine:threonine protein kinase 38 0.0711 0.3139 0.4723
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0062 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0711 0.3139 0.3139
Loa Loa (eye worm) hypothetical protein 0.0137 0.0373 0.0373
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0711 0.3139 0.4723
Leishmania major regulatory subunit of protein kinase a-like protein 0.0062 0.0014 0.1564
Leishmania major cyclic nucleotide-binding protein-like protein 0.0062 0.0014 0.1564
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0062 0.0014 0.0014
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0075 0.0074 0.0074
Echinococcus granulosus cGMP dependent protein kinase 0.0078 0.0088 0.0132
Trypanosoma cruzi cAMP binding protein, putative 0.0062 0.0014 0.0021
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0075 0.0074 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0088 0.0132
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0078 0.0088 0.009
Loa Loa (eye worm) hypothetical protein 0.0411 0.1692 0.1692
Entamoeba histolytica protein kinase, putative 0.2133 1 1
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0075 0.0074 0.0111
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0062 0.0014 0.0021
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0094 0.0164 0.0164
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0473 0.1994 0.2999
Trypanosoma cruzi protein kinase A regulatory subunit 0.0062 0.0014 0.0021
Trypanosoma brucei protein kinase, putative 0.0075 0.0074 0.0074
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0094 0.0164 0.0246
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0094 0.0164 0.0246
Leishmania major protein kinase A regulatory subunit, putative 0.0062 0.0014 0.1564
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0137 0.0373 0.0562
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0114 1
Schistosoma mansoni serine/threonine protein kinase 0.0711 0.3139 0.4723
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Schistosoma mansoni atypical protein kinase C 0.0711 0.3139 0.4723
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0711 0.3139 0.3139
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0062 0.0014 0.0014
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0114 1
Schistosoma mansoni serine/threonine protein kinase 0.0711 0.3139 0.4723
Onchocerca volvulus 0.0062 0.0014 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.2133 1 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0075 0.0074 0.0111
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0473 0.1994 0.1994
Trypanosoma cruzi Protein kinase B 0.1438 0.6647 1
Mycobacterium tuberculosis Conserved protein 0.0062 0.0014 0.5
Loa Loa (eye worm) AGC/NDR protein kinase 0.0711 0.3139 0.3139
Trypanosoma cruzi NIMA-related kinase, putative 0.0075 0.0074 0.0111
Schistosoma mansoni 60S ribosomal protein L21 0.0075 0.0072 0.0108
Echinococcus granulosus cGMP dependent protein kinase 1 0.0078 0.0088 0.0132
Brugia malayi Hr1 repeat family protein 0.0711 0.3139 0.3139
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0711 0.3139 0.4723
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0088 0.0132
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0062 0.0014 0.0021
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0062 0.0014 0.0014
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0062 0.0014 0.0021
Entamoeba histolytica protein kinase, putative 0.0075 0.0074 0.0074
Trypanosoma cruzi rac serine-threonine kinase, putative 0.1378 0.6359 0.9567
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0062 0.0014 0.0021
Echinococcus multilocularis serine:threonine protein kinase N2 0.0711 0.3139 0.4723
Echinococcus granulosus nervana 2 0.1363 0.6286 0.9456
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0094 0.0164 0.0164
Entamoeba histolytica PH domain containing protein kinase, putative 0.1438 0.6647 0.6647
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0062 0.0014 0.0014
Schistosoma mansoni voltage-gated potassium channel 0.0094 0.0164 0.0246
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.2074 0.9712 0.9712
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0075 0.0074 0.0111
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0114 0.0179
Echinococcus granulosus NDR protein kinase 0.0711 0.3139 0.4723
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0473 0.1994 0.2999
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0014 0.0014
Schistosoma mansoni voltage-gated potassium channel 0.0137 0.0373 0.0562
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0062 0.0014 0.0021
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.0114 0.0171
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0062 0.0014 0.0021
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0114 1
Brugia malayi Protein kinase domain containing protein 0.0711 0.3139 0.3139
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0075 0.0074 0.0111
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0062 0.0014 0.0022
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0094 0.0164 0.0164
Echinococcus multilocularis expressed conserved protein 0.0078 0.0088 0.0132
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0075 0.0074 0.0111
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0062 0.0014 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Echinococcus multilocularis Glutaredoxin protein 5 0.1363 0.6286 0.9456
Entamoeba histolytica protein kinase, putative 0.0075 0.0074 0.0074
Leishmania major hypothetical protein, unknown function 0.0062 0.0014 0.1564
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0094 0.0164 0.0246
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.1363 0.6286 0.9456
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0062 0.0014 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0094 0.0164 0.0164
Brugia malayi Protein kinase domain containing protein 0.0711 0.3139 0.3139
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0062 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0094 0.0164 0.0164
Loa Loa (eye worm) AGC/PKG protein kinase 0.0078 0.0088 0.0088
Entamoeba histolytica p21-activated kinase 0.0075 0.0074 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.0711 0.3139 0.4723
Schistosoma mansoni voltage-gated potassium channel 0.0516 0.2203 0.3315
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0062 0.0014 0.5
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0075 0.0074 0.8436
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.1378 0.6359 0.9567
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0062 0.0014 0.0014
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0094 0.0164 0.0246
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0072 0.0108
Leishmania major protein kinase, putative 0.0075 0.0074 0.8436
Echinococcus granulosus Glutaredoxin protein 5 0.1363 0.6286 0.9456
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0062 0.0014 0.0021
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0062 0.0014 0.0021
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0062 0.0014 0.0014
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Echinococcus granulosus patatin phospholipase domain containing protein 0.0062 0.0014 0.0021
Brugia malayi protein kinase C II. 0.0711 0.3139 0.3139
Leishmania major protein kinase, putative 0.0078 0.0088 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0114 0.0114
Plasmodium falciparum calcium-dependent protein kinase 7 0.0075 0.0074 0.0116
Trypanosoma cruzi rac serine-threonine kinase, putative 0.1438 0.6647 1
Trichomonas vaginalis AGC family protein kinase 0.2133 1 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0711 0.3139 0.4723
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0075 0.0074 0.0111
Entamoeba histolytica protein kinase, putative 0.2074 0.9712 0.9712
Entamoeba histolytica protein kinase, putative 0.0075 0.0074 0.0074
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0094 0.0164 0.0246
Echinococcus multilocularis protein kinase c iota type 0.0711 0.3139 0.4723
Echinococcus granulosus protein kinase c iota type 0.0711 0.3139 0.4723
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Leishmania major hypothetical protein, conserved 0.0062 0.0014 0.1564
Trichomonas vaginalis AGC family protein kinase 0.0711 0.3139 0.3139
Echinococcus granulosus serine/threonine protein kinase 0.1438 0.6647 1
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0062 0.0014 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0014 0.0021
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0062 0.0014 0.0014
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0473 0.1994 0.1994
Entamoeba histolytica hypothetical protein 0.0075 0.0074 0.0074
Entamoeba histolytica protein kinase, putative 0.2133 1 1
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0062 0.0014 0.0022
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0695 0.3065 0.3065
Schistosoma mansoni serine/threonine protein kinase 0.0711 0.3139 0.4723
Echinococcus multilocularis serine:threonine protein kinase N2 0.0711 0.3139 0.4723
Echinococcus multilocularis voltage gated potassium channel 0.0137 0.0373 0.0562
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0062 0.0014 0.0021
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0062 0.0014 0.0022
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0094 0.0164 0.0246
Echinococcus granulosus serine threonine protein kinase nrc 0.1378 0.6359 0.9567
Schistosoma mansoni serine/threonine protein kinase 0.0711 0.3139 0.4723
Brugia malayi N-terminal motif family protein 0.0062 0.0014 0.0014
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0062 0.0014 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Trypanosoma cruzi Flagellar Member 6 0.0062 0.0014 0.0021
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0075 0.0074 0.0074
Echinococcus multilocularis protein kinase c epsilon type 0.0711 0.3139 0.4723
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0711 0.3139 0.3139
Leishmania major protein kinase, putative 0.0078 0.0088 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0094 0.0164 0.0164
Schistosoma mansoni voltage-gated potassium channel 0.0516 0.2203 0.3315
Brugia malayi Egg laying defective protein 4 0.0078 0.0088 0.0088
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0075 0.0074 0.8436
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0062 0.0014 0.0021
Trichomonas vaginalis AGC family protein kinase 0.077 0.3427 0.3427
Trypanosoma brucei Flagellar Member 6 0.0062 0.0014 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0088 0.0132
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.1363 0.6286 0.9456
Onchocerca volvulus 0.0062 0.0014 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0137 0.0373 0.0562
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.0074 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0062 0.0014 0.0014
Trichomonas vaginalis AGC family protein kinase 0.0711 0.3139 0.3139
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0078 0.0088 0.0132
Echinococcus granulosus serine:threonine protein kinase N2 0.0711 0.3139 0.4723
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0062 0.0014 0.0021
Entamoeba histolytica PH domain containing protein kinase, putative 0.1438 0.6647 0.6647
Trichomonas vaginalis AGC family protein kinase 0.2133 1 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.0074 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0442 0.1844 0.1844
Trypanosoma cruzi cAMP response protein 1 0.0062 0.0014 0.0021
Trypanosoma brucei cAMP binding protein, putative 0.0062 0.0014 0.0014
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0078 0.0088 0.0132
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.0114 0.0171
Trypanosoma cruzi NIMA-related kinase, putative 0.0075 0.0074 0.0111
Brugia malayi p70 ribosomal S6 kinase beta 0.2074 0.9712 0.9712
Schistosoma mansoni voltage-gated potassium channel 0.0137 0.0373 0.0562
Schistosoma mansoni serine/threonine protein kinase 0.0711 0.3139 0.4723
Trypanosoma brucei protein kinase A regulatory subunit 0.0062 0.0014 0.0014
Entamoeba histolytica protein kinase, putative 0.0075 0.0074 0.0074
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0062 0.0014 0.0021
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0094 0.0164 0.0246
Trichomonas vaginalis AGC family protein kinase 0.0711 0.3139 0.3139
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.0074 0.0074
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0062 0.0014 0.0014
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.1378 0.6359 1
Entamoeba histolytica protein kinase, putative 0.0075 0.0074 0.0074
Entamoeba histolytica protein kinase, putative 0.0711 0.3139 0.3139
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0711 0.3139 0.4723
Trichomonas vaginalis AGC family protein kinase 0.2133 1 1
Toxoplasma gondii protein kinase domain-containing protein 0.0075 0.0074 0.0076
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.0014 0.5
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0711 0.3139 0.4723
Echinococcus granulosus cGMP dependent protein kinase 1 0.0078 0.0088 0.0132
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0094 0.0164 0.0246
Echinococcus multilocularis nervana 2 0.1363 0.6286 0.9456
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0062 0.0014 0.0021
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0062 0.0014 0.0014
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0075 0.0074 0.0074
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.1378 0.6359 0.9567
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0062 0.0014 0.0021
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.0074 0.0074
Brugia malayi Probable ClpP-like protease 0.0083 0.0114 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.0711 0.3139 0.4723
Loa Loa (eye worm) hypothetical protein 0.0062 0.0014 0.0014
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0711 0.3139 0.3139
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0062 0.0014 0.0021
Echinococcus granulosus hyperpolarization activated cyclic 0.0094 0.0164 0.0246
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0062 0.0014 0.0021
Entamoeba histolytica hypothetical protein 0.0075 0.0074 0.0074
Trypanosoma cruzi cAMP response protein 1, putative 0.0062 0.0014 0.0021
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.1378 0.6359 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0114 0.0117
Echinococcus multilocularis hyperpolarization activated cyclic 0.0094 0.0164 0.0246
Echinococcus granulosus hyperpolarization activated cyclic 0.0094 0.0164 0.0246
Leishmania major serine/threonine-protein kinase a, putative 0.0075 0.0074 0.8436
Schistosoma mansoni serine/threonine-protein kinase 0.1438 0.6647 1
Leishmania major hypothetical protein, conserved 0.0062 0.0014 0.1564
Echinococcus multilocularis hyperpolarization activated cyclic 0.0094 0.0164 0.0246
Schistosoma mansoni hypothetical protein 0.0062 0.0014 0.0021
Leishmania major folate/biopterin transporter, putative 0.0075 0.0074 0.8436
Trichomonas vaginalis AGC family protein kinase 0.2133 1 1
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0062 0.0014 0.5
Schistosoma mansoni serine/threonine-protein kinase 0.1438 0.6647 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.0114 0.5
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0062 0.0014 0.0014
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0094 0.0164 0.0246
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0075 0.0074 0.0116
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0062 0.0014 0.0014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.0014 0.5
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0114 1
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0075 0.0074 0.0074
Toxoplasma gondii AGC kinase 0.2074 0.9712 1
Schistosoma mansoni serine/threonine kinase 0.0711 0.3139 0.4723
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0075 0.0074 0.0111
Leishmania major hypothetical protein, conserved 0.0062 0.0014 0.1564
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0711 0.3139 0.4723
Trichomonas vaginalis AGC family protein kinase 0.2133 1 1
Leishmania major protein kinase, putative 0.0075 0.0074 0.8436
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0114 1
Echinococcus multilocularis rac serine:threonine kinase 0.1438 0.6647 1
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Trypanosoma brucei cAMP response protein 1, putative 0.0062 0.0014 0.0014
Entamoeba histolytica protein kinase 2, putative 0.1378 0.6359 0.6359
Trichomonas vaginalis AGC family protein kinase 0.2133 1 1
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Echinococcus granulosus protein kinase c epsilon type 0.0711 0.3139 0.4723
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0075 0.0074 0.0111
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Plasmodium falciparum cGMP-dependent protein kinase 0.0078 0.0088 0.0138
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0062 0.0014 0.0021
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0137 0.0373 0.0373
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0094 0.0164 0.0246
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0442 0.1844 0.1844
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0062 0.0014 0.0014
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0062 0.0014 0.0021
Echinococcus granulosus protein kinase C gamma type 0.0711 0.3139 0.4723
Loa Loa (eye worm) AGC/PKN protein kinase 0.0711 0.3139 0.3139
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0711 0.3139 0.3139
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0062 0.0014 0.0021
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.0114 0.0171
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.0114 0.0179
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0094 0.0164 0.0246
Giardia lamblia Kinase, AGC PKA 0.1378 0.6359 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0094 0.0164 0.0246
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0062 0.0014 1
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0062 0.0014 0.5
Echinococcus granulosus nervana 2 0.1363 0.6286 0.9456
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.0114 1
Echinococcus multilocularis nervana 2 0.1363 0.6286 0.9456
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0062 0.0014 0.0021
Echinococcus multilocularis serine threonine protein kinase 0.0711 0.3139 0.4723
Echinococcus granulosus voltage gated potassium channel 0.0137 0.0373 0.0562
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Loa Loa (eye worm) AGC/AKT protein kinase 0.2133 1 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0114 0.0117
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0711 0.3139 0.4723
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0075 0.0074 0.0074
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0075 0.0074 0.0074
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0062 0.0014 0.0014
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0074 0.0074

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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