Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glutathione reductase, putative | 0.0399 | 0.1234 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.115 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.115 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.115 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.115 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0399 | 0.1234 | 0.1234 |
Toxoplasma gondii | thioredoxin reductase | 0.115 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.115 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.115 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0399 | 0.1234 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0399 | 0.1234 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0399 | 0.1234 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0399 | 0.1234 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0399 | 0.1234 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0399 | 0.1234 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.115 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0399 | 0.1234 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.115 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.115 | 1 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.115 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.115 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0399 | 0.1234 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0399 | 0.1234 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.115 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.115 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0399 | 0.1234 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.