Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0399 | 0.1234 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0399 | 0.1234 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.115 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0399 | 0.1234 | 0.5 |
Leishmania major | trypanothione reductase | 0.115 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0399 | 0.1234 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0399 | 0.1234 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.115 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0399 | 0.1234 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0399 | 0.1234 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.115 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.115 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.115 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.115 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.115 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.115 | 1 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0399 | 0.1234 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.115 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0399 | 0.1234 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0399 | 0.1234 | 0.1234 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.115 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0399 | 0.1234 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.115 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.115 | 1 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.115 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0399 | 0.1234 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.