Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cathepsin b | 0.0766 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0766 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0164 | 0 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0164 | 0 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0164 | 0 | 0.5 |
Onchocerca volvulus | 0.0164 | 0 | 0.5 | |
Giardia lamblia | Cathepsin B precursor | 0.0279 | 0.1912 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0164 | 0 | 0.5 |
Onchocerca volvulus | 0.0164 | 0 | 0.5 | |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0279 | 0.1912 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0279 | 0.1912 | 0.1912 |
Onchocerca volvulus | Cathepsin L homolog | 0.0164 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0766 | 1 | 1 |
Toxoplasma gondii | cathepsin B | 0.0279 | 0.1912 | 1 |
Onchocerca volvulus | 0.0164 | 0 | 0.5 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0279 | 0.1912 | 0.1912 |
Plasmodium vivax | vivapain-2 | 0.0164 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0279 | 0.1912 | 1 |
Onchocerca volvulus | 0.0164 | 0 | 0.5 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0164 | 0 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0766 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0766 | 1 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0279 | 0.1912 | 0.1912 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0766 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0279 | 0.1912 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0164 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0766 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0766 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0164 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0766 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0279 | 0.1912 | 0.5 |
Onchocerca volvulus | 0.0164 | 0 | 0.5 | |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0766 | 1 | 1 |
Onchocerca volvulus | 0.0164 | 0 | 0.5 | |
Giardia lamblia | Cathepsin B precursor | 0.0279 | 0.1912 | 0.5 |
Onchocerca volvulus | 0.0164 | 0 | 0.5 | |
Plasmodium vivax | vivapain-2 | 0.0164 | 0 | 0.5 |
Onchocerca volvulus | 0.0164 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.