Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0161 | 0 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0161 | 0 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0161 | 0 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0757 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0161 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0757 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0275 | 0.1924 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0161 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0275 | 0.1924 | 0.1924 |
Onchocerca volvulus | 0.0161 | 0 | 0.5 | |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0275 | 0.1924 | 1 |
Onchocerca volvulus | 0.0161 | 0 | 0.5 | |
Toxoplasma gondii | cathepsin B | 0.0275 | 0.1924 | 1 |
Onchocerca volvulus | 0.0161 | 0 | 0.5 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0161 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0757 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0275 | 0.1924 | 1 |
Onchocerca volvulus | 0.0161 | 0 | 0.5 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0275 | 0.1924 | 0.1924 |
Plasmodium vivax | vivapain-2 | 0.0161 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0757 | 1 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0275 | 0.1924 | 0.1924 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0161 | 0 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0757 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0161 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0757 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0275 | 0.1924 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0161 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0757 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0757 | 1 | 1 |
Onchocerca volvulus | 0.0161 | 0 | 0.5 | |
Onchocerca volvulus | 0.0161 | 0 | 0.5 | |
Plasmodium vivax | vivapain-2 | 0.0161 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0757 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0275 | 0.1924 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0161 | 0 | 0.5 |
Onchocerca volvulus | 0.0161 | 0 | 0.5 | |
Onchocerca volvulus | 0.0161 | 0 | 0.5 | |
Giardia lamblia | Cathepsin B precursor | 0.0275 | 0.1924 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0757 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.