TDR Targets

Basic information

Technical information

TDR Targets ID: 831048
Name: 6-(3-methoxyphenyl)-2-propan-2-ylimidazo[2,1- b][1,3,4]thiadiazole
MW: 273.353 | Formula: C14H15N3OS
H donors: 0 H acceptors: 2 LogP: 3.64 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)c1cn2c(n1)sc(n2)C(C)C
InChi: 1S/C14H15N3OS/c1-9(2)13-16-17-8-12(15-14(17)19-13)10-5-4-6-11(7-10)18-3/h4-9H,1-3H3
InChiKey: RFPJGUGCMIKXEI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-isopropyl-6-(3-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole
6-(3-methoxyphenyl)-2-propan-2-yl-imidazo[2,1-b][1,3,4]thiadiazole
ZINC07994987

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.002	0.0017
Echinococcus multilocularis	muscleblind protein 1	0.0169	0.0376	0.0344
Plasmodium falciparum	vacuolar protein sorting-associated protein 4	0.0032	0.0033	0.0038
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0075	0.0142	0.0378
Brugia malayi	Muscleblind-like protein	0.0169	0.0376	0.0366
Mycobacterium tuberculosis	Conserved hypothetical protein	0.1175	0.2901	0.2901
Trypanosoma brucei	uridine phosphorylase	0.1175	0.2901	1
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.1175	0.2901	0.2877
Schistosoma mansoni	pyruvate kinase	0.0075	0.0142	0.0109
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0075	0.0142	0.0122
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0075	0.0142	0.0142
Mycobacterium tuberculosis	Putative conserved ATPase	0.0374	0.0891	0.0891
Trypanosoma cruzi	katanin, putative	0.0032	0.0033	0.0000021515
Treponema pallidum	uridine phosphorylase (udp)	0.3199	0.7981	1
Brugia malayi	ATPase, AAA family protein	0.0032	0.0033	0.0024
Giardia lamblia	UPL-1	0.1175	0.2901	0.2877
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0593	0.144	0.1412
Echinococcus multilocularis	purine nucleoside phosphorylase	0.2829	0.7051	0.7041
Loa Loa (eye worm)	fidgetin protein	0.0032	0.0033	0.0043
Echinococcus multilocularis	muscleblind protein	0.0169	0.0376	0.0344
Plasmodium vivax	pyruvate kinase, putative	0.0075	0.0142	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0376	0.0529
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	0.1175	0.2901	1
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0259	0.0601	0.057
Brugia malayi	fidgetin protein	0.0032	0.0033	0.0024
Echinococcus multilocularis	pyruvate kinase	0.0075	0.0142	0.0109
Plasmodium falciparum	pyruvate kinase	0.0075	0.0142	0.0174
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	0.4004	1	1
Echinococcus granulosus	uridine phosphorylase 1	0.1175	0.2901	0.2877
Trichomonas vaginalis	proteasome-activating nucleotidase, putative	0.0148	0.0323	0.0291
Chlamydia trachomatis	pyruvate kinase	0.0075	0.0142	0.0479
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.002	0.001
Echinococcus granulosus	purine nucleoside phosphorylase	0.4004	1	1
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	0.4004	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.002	0.0017
Loa Loa (eye worm)	pyruvate kinase	0.0075	0.0142	0.0197
Brugia malayi	transitional endoplasmic reticulum ATPase TER94, putative	0.0259	0.0601	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0142	0.0197
Plasmodium vivax	pyruvate kinase 2, putative	0.0039	0.005	0.0059
Treponema pallidum	purine nucleoside phosphorylase (deoD)	0.3199	0.7981	1
Trypanosoma cruzi	katanin, putative	0.0032	0.0033	0.0000021515
Entamoeba histolytica	hypothetical protein	0.1175	0.2901	0.362
Entamoeba histolytica	vacuolar sorting protein-associating protein 4A (VPS4), putative	0.0032	0.0033	0.0017
Giardia lamblia	AAA family ATPase	0.0374	0.0891	0.0861
Leishmania major	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	0.0593	0.144	0.4931
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0376	0.0529
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	0.2829	0.7051	0.7041
Schistosoma mansoni	pyruvate kinase	0.0039	0.005	0.0016
Echinococcus multilocularis	pyruvate kinase	0.0059	0.0102	0.0069
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0024
Echinococcus granulosus	pyruvate kinase	0.0039	0.005	0.0016
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	0.0259	0.0601	0.057
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.002	0.0017
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.1175	0.2901	0.2877
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.3199	0.7981	0.7974
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	0.4004	1	1
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.3199	0.7981	1
Echinococcus multilocularis	pyruvate kinase	0.0039	0.005	0.0016
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.3199	0.7981	0.7974
Mycobacterium ulcerans	hypothetical protein	0.0027	0.002	0.0017
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0625	0.1521	0.1493
Brugia malayi	uridine phosphorylase family protein	0.1175	0.2901	0.2894
Echinococcus multilocularis	purine nucleoside phosphorylase	0.4004	1	1
Echinococcus granulosus	pyruvate kinase	0.0075	0.0142	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0024
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.1175	0.2901	0.362
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.002	0.0017
Loa Loa (eye worm)	S-methyl-5'-thioadenosine phosphorylase MTAP	0.1175	0.2901	0.4112
Loa Loa (eye worm)	pyruvate kinase-PB	0.0053	0.0084	0.0116
Echinococcus granulosus	purine nucleoside phosphorylase	0.4004	1	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.002	0.002
Trypanosoma cruzi	vacuolar protein sorting-associated protein 4, putative	0.0032	0.0033	0.0000021515
Trypanosoma cruzi	vesicular transport protein (CDC48 homologue), putative	0.0032	0.0033	0.0000021515
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	0.4004	1	1
Leishmania major	katanin-like protein,serine peptidase, Clan SJ, family S16, putative	0.0032	0.0033	0.0047
Trypanosoma cruzi	metalloprotease, putative	0.0032	0.0033	0.0000021515
Trypanosoma cruzi	katanin, putative	0.0032	0.0033	0.0000021515
Toxoplasma gondii	phosphorylase family protein	0.1175	0.2901	0.3609
Toxoplasma gondii	pyruvate kinase PyKII	0.0039	0.005	0.002
Leishmania major	katanin, putative,serine peptidase, Clan SJ, family S16, putative	0.0032	0.0033	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.1175	0.2901	0.2877
Brugia malayi	SAP1 protein	0.0032	0.0033	0.0024
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.1175	0.2901	0.2877
Loa Loa (eye worm)	pyruvate kinase	0.0075	0.0142	0.0197
Loa Loa (eye worm)	ATPase	0.0032	0.0033	0.0043
Echinococcus multilocularis	purine nucleoside phosphorylase	0.4004	1	1
Loa Loa (eye worm)	hypothetical protein	0.0367	0.0873	0.1234
Trypanosoma cruzi	Valosin-containing protein, putative	0.0593	0.144	0.4907
Mycobacterium ulcerans	5'-methylthioadenosine phosphorylase	0.1175	0.2901	0.2899
Trichomonas vaginalis	conserved hypothetical protein	0.1175	0.2901	0.2877
Echinococcus multilocularis	purine nucleoside phosphorylase	0.4004	1	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.4004	1	1
Schistosoma mansoni	methylthioadenosine phosphorylase	0.1175	0.2901	0.2877
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.002	0.0017
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.1175	0.2901	0.362
Mycobacterium ulcerans	pyruvate kinase	0.0075	0.0142	0.0139
Echinococcus multilocularis	pyruvate kinase	0.0039	0.005	0.0016
Echinococcus granulosus	purine nucleoside phosphorylase	0.4004	1	1
Loa Loa (eye worm)	hypothetical protein	0.2829	0.7051	1
Plasmodium vivax	cell division cycle ATPase, putative	0.0226	0.0521	0.0649
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0003	0.0003
Plasmodium falciparum	purine nucleoside phosphorylase	0.3199	0.7981	1
Echinococcus multilocularis	pyruvate kinase	0.0075	0.0142	0.0109
Leishmania major	pyruvate kinase	0.0075	0.0142	0.0423
Trichomonas vaginalis	pyruvate kinase, putative	0.0075	0.0142	0.0109
Onchocerca volvulus	Pyruvate kinase homolog	0.0075	0.0142	0.0122
Leishmania major	pyruvate kinase	0.0075	0.0142	0.0423
Leishmania major	nucleoside phosphorylase-like protein	0.1175	0.2901	1
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.1175	0.2901	1
Mycobacterium tuberculosis	Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase	0.1175	0.2901	0.2901
Trichomonas vaginalis	spermatogenesis associated factor, putative	0.0625	0.1521	0.1493
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0024
Mycobacterium leprae	probable uridine phosphorylase	0.1175	0.2901	0.2887
Entamoeba histolytica	cdc48-like protein, putative	0.0593	0.144	0.1785
Schistosoma mansoni	purine nucleoside phosphorylase	0.4004	1	1
Echinococcus granulosus	pyruvate kinase	0.0039	0.005	0.0016
Trypanosoma brucei	pyruvate kinase 1, putative	0.0075	0.0142	0.0378
Entamoeba histolytica	pyruvate kinase, putative	0.0053	0.0084	0.0081
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.3199	0.7981	1
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0075	0.0142	0.0378
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.002	0.001
Trypanosoma cruzi	katanin-like protein, putative	0.0032	0.0033	0.0000021515
Toxoplasma gondii	cell division protein CDC48AP	0.0374	0.0891	0.108
Entamoeba histolytica	MTA/SAH nucleosidase, putative	0.1175	0.2901	0.362
Mycobacterium tuberculosis	Hypothetical protein	0.1175	0.2901	0.2901
Mycobacterium ulcerans	ATPase	0.0374	0.0891	0.0889
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.1175	0.2901	0.2877
Echinococcus granulosus	transitional endoplasmic reticulum atpase	0.0625	0.1521	0.1493
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.1175	0.2901	1
Toxoplasma gondii	phosphorylase family protein	0.1175	0.2901	0.3609
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	0.4004	1	1
Schistosoma mansoni	purine nucleoside phosphorylase	0.4004	1	1
Schistosoma mansoni	uridine phosphorylase	0.1175	0.2901	0.2877
Trypanosoma brucei	Valosin-containing protein	0.0593	0.144	0.4907
Plasmodium vivax	cell division cycle protein 48 homologue, putative	0.0593	0.144	0.1802
Echinococcus multilocularis	purine nucleoside phosphorylase	0.2829	0.7051	0.7041
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.1175	0.2901	0.362
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0075	0.0142	0.0132
Loa Loa (eye worm)	pyruvate kinase	0.0075	0.0142	0.0197
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.1175	0.2901	0.2877
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.002	0.0017
Chlamydia trachomatis	AMP nucleosidase	0.1175	0.2901	1
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.1175	0.2901	1
Trypanosoma cruzi	vacuolar transport protein 4A, putative	0.0032	0.0033	0.0000021515
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0084	0.0116
Toxoplasma gondii	cell division protein CDC48CY	0.0625	0.1521	0.1872
Loa Loa (eye worm)	vesicle-fusing ATPase	0.0367	0.0873	0.1234
Trypanosoma brucei	pyruvate kinase 1	0.0075	0.0142	0.0378
Echinococcus granulosus	pyruvate kinase	0.0075	0.0142	0.0109
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.1175	0.2901	1
Brugia malayi	valosin containing protein	0.0367	0.0873	0.0864
Onchocerca volvulus	Pyruvate kinase homolog	0.0075	0.0142	0.0122
Leishmania major	katanin-like protein,serine peptidase, Clan SJ, family S16, putative	0.0032	0.0033	0.0047
Brugia malayi	vesicle-fusing ATPase	0.0367	0.0873	0.0864
Echinococcus multilocularis	uridine phosphorylase 1	0.1175	0.2901	0.2877
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	0.0625	0.1521	0.1493
Leishmania major	vacuolar protein sorting-associated protein 4	0.0032	0.0033	0.0047
Echinococcus granulosus	muscleblind protein	0.0169	0.0376	0.0344
Giardia lamblia	Pyruvate kinase	0.0039	0.005	0.0016
Echinococcus granulosus	purine nucleoside phosphorylase	0.4004	1	1
Trypanosoma cruzi	katanin, putative	0.0032	0.0033	0.0000021515
Toxoplasma gondii	transitional endoplasmic reticulum ATPase, putative	0.0374	0.0891	0.108
Schistosoma mansoni	pyruvate kinase	0.0075	0.0142	0.0109
Echinococcus granulosus	methylthioadenosine phosphorylase	0.1175	0.2901	0.2877
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0075	0.0142	0.0132
Mycobacterium ulcerans	bifunctional Mta/Sah nucleosidase Mtn	0.1175	0.2901	0.2899
Trypanosoma cruzi	katanin, putative	0.0032	0.0033	0.0000021515
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.002	0.0017
Toxoplasma gondii	pyruvate kinase PyK1	0.0075	0.0142	0.0136
Entamoeba histolytica	transitional endoplasmic reticulum ATPase, putative	0.0593	0.144	0.1785
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.1175	0.2901	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.4004	1	1
Brugia malayi	vps4b-prov protein	0.0032	0.0033	0.0024
Echinococcus multilocularis	purine nucleoside phosphorylase	0.4004	1	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.4004	1	1
Loa Loa (eye worm)	uridine phosphorylase	0.1175	0.2901	0.4112
Plasmodium falciparum	cell division cycle protein 48 homologue, putative	0.0593	0.144	0.1802
Schistosoma mansoni	methylthioadenosine phosphorylase	0.1175	0.2901	0.2877
Giardia lamblia	Pyruvate kinase	0.0075	0.0142	0.0109
Echinococcus multilocularis	pyruvate kinase	0.0039	0.005	0.0016
Echinococcus granulosus	purine nucleoside phosphorylase	0.4004	1	1
Echinococcus multilocularis	methylthioadenosine phosphorylase	0.1175	0.2901	0.2877
Echinococcus multilocularis	purine nucleoside phosphorylase	0.4004	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.002	0.001
Trichomonas vaginalis	pyruvate kinase, putative	0.0075	0.0142	0.0109
Echinococcus granulosus	pyruvate kinase	0.0039	0.005	0.0016
Echinococcus granulosus	purine nucleoside phosphorylase	0.4004	1	1
Onchocerca volvulus	Transitional endoplasmic reticulum ATPase homolog	0.0625	0.1521	0.1504
Onchocerca volvulus	Pyruvate kinase homolog	0.0075	0.0142	0.0122
Loa Loa (eye worm)	VCP protein	0.0259	0.0601	0.0849
Entamoeba histolytica	ATPase, Vps4 oligomerisation domain containing protein	0.0032	0.0033	0.0017
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.1175	0.2901	0.2877
Mycobacterium ulcerans	purine nucleoside phosphorylase	0.4004	1	1
Schistosoma mansoni	uridine phosphorylase	0.1175	0.2901	0.2877
Leishmania major	methylthioadenosine phosphorylase, putative	0.1175	0.2901	1
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.1175	0.2901	0.2877
Toxoplasma gondii	Purine nucleoside phosphorylase	0.3199	0.7981	1
Plasmodium vivax	purine nucleoside phosphorylase, putative	0.3199	0.7981	1
Loa Loa (eye worm)	vps4b-prov protein	0.0032	0.0033	0.0043
Schistosoma mansoni	methylthioadenosine phosphorylase	0.1175	0.2901	0.2877
Trichomonas vaginalis	26S protease regulatory subunit S10b, putative	0.0148	0.0323	0.0291
Plasmodium falciparum	pyruvate kinase 2	0.0039	0.005	0.0059
Brugia malayi	MTAP	0.1175	0.2901	0.2894

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 831048