Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0112 | 0.1388 | 0.2257 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0142 | 0.1892 | 0.1892 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.012 | 0.1528 | 0.3713 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0289 | 0.0695 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0627 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.1875 | 0.3126 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.012 | 0.1528 | 0.3713 |
Schistosoma mansoni | chromobox protein | 0.0083 | 0.0896 | 0.138 |
Toxoplasma gondii | hexokinase | 0.0094 | 0.1094 | 0.6976 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0164 | 0.2257 | 0.548 |
Plasmodium vivax | glutathione reductase, putative | 0.0056 | 0.0452 | 0.0364 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0627 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0371 | 0.5727 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.1388 | 0.3371 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0144 | 0.192 | 0.4058 |
Echinococcus granulosus | hexokinase | 0.0094 | 0.1094 | 0.191 |
Loa Loa (eye worm) | glutaminase 2 | 0.0275 | 0.4116 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0056 | 0.0452 | 0.0789 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0112 | 0.1388 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0081 | 0.0876 | 0.5955 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0081 | 0.0876 | 0.5955 |
Echinococcus granulosus | chromobox protein 1 | 0.0083 | 0.0896 | 0.1564 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0304 | 0.4598 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0304 | 0.4598 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0123 | 0.0214 |
Trichomonas vaginalis | chromobox protein, putative | 0.005 | 0.0347 | 0.0844 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0112 | 0.1388 | 0.2423 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0092 | 0.0199 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.1875 | 0.3126 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0164 | 0.2257 | 0.394 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.1388 | 0.3371 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0111 | 0.1364 | 0.2381 |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.0036 | 0.0109 | 0.0237 |
Trichomonas vaginalis | chromobox protein, putative | 0.0083 | 0.0896 | 0.2177 |
Mycobacterium ulcerans | glutaminase | 0.0275 | 0.4116 | 0.4116 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0164 | 0.2257 | 0.548 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0112 | 0.1388 | 0.3367 |
Onchocerca volvulus | 0.0094 | 0.1094 | 0.768 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0121 | 0.0288 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.012 | 0.1528 | 0.145 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0112 | 0.1388 | 0.3018 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.012 | 0.1528 | 1 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.0092 | 0.0199 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0038 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | hexokinase | 0.0094 | 0.1094 | 0.2652 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0043 | 0.0229 | 0.0498 |
Loa Loa (eye worm) | glutathione reductase | 0.0056 | 0.0452 | 0.1092 |
Mycobacterium tuberculosis | Probable reductase | 0.0128 | 0.1653 | 0.1653 |
Brugia malayi | chromobox protein homolog 3 | 0.0046 | 0.0289 | 0.0695 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0592 | 0.1431 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0111 | 0.1364 | 0.1364 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0304 | 0.4598 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0.0334 | 0.1688 |
Schistosoma mansoni | hypothetical protein | 0.0371 | 0.5727 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0627 | 1 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0627 | 1 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0627 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0063 | 0.0152 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.0092 | 0.0199 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0111 | 0.1364 | 0.2965 |
Plasmodium falciparum | hexokinase | 0.0094 | 0.1094 | 0.1011 |
Onchocerca volvulus | 0.0094 | 0.1094 | 0.768 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0063 | 0.0152 |
Brugia malayi | glutaminase DH11.1 | 0.0275 | 0.4116 | 1 |
Brugia malayi | Hexokinase family protein | 0.0094 | 0.1094 | 0.2652 |
Loa Loa (eye worm) | hexokinase | 0.0059 | 0.0505 | 0.1221 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0081 | 0.0876 | 0.5955 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0123 | 0.0298 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0111 | 0.1364 | 0.2381 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.1388 | 0.3371 |
Plasmodium vivax | hexokinase, putative | 0.0094 | 0.1094 | 0.1011 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0056 | 0.0452 | 0.0789 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.1388 | 0.3371 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0123 | 0.0298 |
Echinococcus granulosus | geminin | 0.0371 | 0.5727 | 1 |
Onchocerca volvulus | 0.0094 | 0.1094 | 0.768 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0123 | 0.0298 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0111 | 0.1364 | 0.2823 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.0289 | 0.0701 |
Brugia malayi | hexokinase type II | 0.003 | 0.0016 | 0.0033 |
Schistosoma mansoni | glutaminase | 0.0275 | 0.4116 | 0.7125 |
Echinococcus granulosus | chromobox protein 1 | 0.0083 | 0.0896 | 0.1564 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0142 | 0.1892 | 0.1892 |
Brugia malayi | Heterochromatin protein 1 | 0.0083 | 0.0896 | 0.2171 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0252 | 0.3733 | 0.8119 |
Echinococcus granulosus | hexokinase type 2 | 0.0094 | 0.1094 | 0.191 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0112 | 0.1388 | 0.2423 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 0.0442 | 0.1073 |
Leishmania major | trypanothione reductase | 0.0056 | 0.0452 | 0.0983 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0111 | 0.1364 | 0.3308 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.0123 | 0.0298 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0052 | 0.0385 | 0.0838 |
Trypanosoma cruzi | hexokinase, putative | 0.0094 | 0.1094 | 0.2379 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0112 | 0.1388 | 0.3018 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0043 | 0.0229 | 0.0498 |
Brugia malayi | Thioredoxin reductase | 0.0056 | 0.0452 | 0.1092 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.0289 | 0.0701 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0252 | 0.3733 | 0.8081 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.2257 | 0.394 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0123 | 0.0291 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0123 | 0.0298 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0123 | 0.0298 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0081 | 0.0876 | 0.5955 |
Schistosoma mansoni | hexokinase | 0.0094 | 0.1094 | 0.1733 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0128 | 0.1653 | 0.1653 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.1388 | 0.3371 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0627 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0123 | 0.0267 |
Trypanosoma brucei | hexokinase, putative | 0.0094 | 0.1094 | 0.2224 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0123 | 0.0298 |
Onchocerca volvulus | 0.0095 | 0.11 | 0.7732 | |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0112 | 0.1388 | 0.3018 |
Trypanosoma cruzi | hexokinase, putative | 0.0094 | 0.1094 | 0.2379 |
Trypanosoma brucei | hexokinase | 0.0094 | 0.1094 | 0.2224 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0128 | 0.1653 | 0.1653 |
Leishmania major | hexokinase, putative | 0.0094 | 0.1094 | 0.2379 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0128 | 0.1653 | 0.1653 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0123 | 0.0069 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0111 | 0.1364 | 1 |
Onchocerca volvulus | 0.0059 | 0.0505 | 0.3031 | |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0111 | 0.1364 | 0.2965 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.2257 | 0.394 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0304 | 0.4598 | 1 |
Brugia malayi | Augmenter of liver regeneration | 0.0035 | 0.0092 | 0.0216 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0056 | 0.0452 | 0.1092 |
Trypanosoma brucei | polo-like protein kinase | 0.0112 | 0.1388 | 0.2876 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0035 | 0.0092 | 0.0216 |
Brugia malayi | Hexokinase family protein | 0.0059 | 0.0505 | 0.1221 |
Echinococcus granulosus | hexokinase | 0.0094 | 0.1094 | 0.191 |
Trichomonas vaginalis | chromobox protein, putative | 0.005 | 0.0347 | 0.0844 |
Trichomonas vaginalis | chromobox protein, putative | 0.0083 | 0.0896 | 0.2177 |
Schistosoma mansoni | kinase | 0.0057 | 0.0466 | 0.0613 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.192 | 0.4176 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.012 | 0.1528 | 0.3713 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.1388 | 0.3371 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0016 | 0.0033 |
Loa Loa (eye worm) | hexokinase | 0.0094 | 0.1094 | 0.2652 |
Leishmania major | hypothetical protein, conserved | 0.0252 | 0.3733 | 0.8119 |
Schistosoma mansoni | chromobox protein | 0.0083 | 0.0896 | 0.138 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0081 | 0.0876 | 0.5955 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.0289 | 0.1322 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0252 | 0.3733 | 0.8119 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0056 | 0.0452 | 0.0452 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.012 | 0.1528 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0037 | 0.0127 | 0.0276 |
Brugia malayi | glutathione reductase | 0.0056 | 0.0452 | 0.1092 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.0092 | 0.0199 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.192 | 0.4176 |
Trypanosoma brucei | trypanothione reductase | 0.0056 | 0.0452 | 0.08 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.016 | 0.2192 | 0.2192 |
Schistosoma mansoni | hypothetical protein | 0.0371 | 0.5727 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0043 | 0.0229 | 0.0305 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0083 | 0.0896 | 0.2171 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0072 | 0.0722 | 0.0722 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0112 | 0.1388 | 0.3371 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0123 | 0.0298 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0123 | 0.0217 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0123 | 0.0267 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.0123 | 0.0298 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.0092 | 0.016 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0055 | 0.0442 | 0.1073 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0142 | 0.1892 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0094 | 0.1094 | 0.7678 |
Echinococcus multilocularis | hexokinase type 2 | 0.0094 | 0.1094 | 0.191 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0016 | 0.0033 |
Toxoplasma gondii | thioredoxin reductase | 0.0056 | 0.0452 | 0.2508 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.012 | 0.1528 | 0.145 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0128 | 0.1653 | 0.1653 |
Plasmodium falciparum | glutathione reductase | 0.0056 | 0.0452 | 0.0364 |
Echinococcus multilocularis | hexokinase | 0.0094 | 0.1094 | 0.191 |
Echinococcus multilocularis | chromobox protein 1 | 0.0083 | 0.0896 | 0.1564 |
Mycobacterium ulcerans | hypothetical protein | 0.016 | 0.2192 | 0.2192 |
Brugia malayi | hexokinase | 0.0094 | 0.1094 | 0.2652 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0123 | 0.0214 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0056 | 0.0452 | 0.0364 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0627 | 1 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0072 | 0.0722 | 0.4388 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.0092 | 0.016 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0111 | 0.1364 | 0.2214 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0111 | 0.1364 | 0.3308 |
Plasmodium falciparum | thioredoxin reductase | 0.0056 | 0.0452 | 0.0364 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0142 | 0.1892 | 0.1892 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0128 | 0.1653 | 0.1653 |
Onchocerca volvulus | Hexokinase homolog | 0.0059 | 0.0505 | 0.3031 |
Loa Loa (eye worm) | glutaminase | 0.0275 | 0.4116 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0112 | 0.1388 | 0.3367 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0123 | 0.0291 |
Trichomonas vaginalis | glutaminase, putative | 0.0275 | 0.4116 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0043 | 0.0229 | 0.0498 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0112 | 0.1388 | 1 |
Leishmania major | hexokinase, putative | 0.0094 | 0.1094 | 0.2379 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0123 | 0.0267 |
Entamoeba histolytica | hexokinase 2 | 0.0094 | 0.1094 | 0.7678 |
Echinococcus multilocularis | hexokinase | 0.0094 | 0.1094 | 0.191 |
Echinococcus granulosus | hexokinase | 0.0094 | 0.1094 | 0.191 |
Echinococcus multilocularis | hexokinase | 0.0094 | 0.1094 | 0.191 |
Loa Loa (eye worm) | hexokinase type II | 0.0094 | 0.1094 | 0.2652 |
Echinococcus multilocularis | chromobox protein 1 | 0.0083 | 0.0896 | 0.1564 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0056 | 0.0452 | 0.0983 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.005 | 0.0347 | 0.1786 |
Trypanosoma brucei | hexokinase | 0.0094 | 0.1094 | 0.2224 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.